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Eosinophilic esophagitis(EE)

MedGen UID:
83318
•Concept ID:
C0341106
•
Disease or Syndrome
Synonyms: Chronic Esophagitides, Eosinophilic; Chronic Esophagitis, Eosinophilic; Eosinophilic Chronic Esophagitides; Eosinophilic Chronic Esophagitis; Eosinophilic Esophagitides; Eosinophilic Esophagitis; Esophagitides, Eosinophilic; Esophagitides, Eosinophilic Chronic; Esophagitis, Eosinophilic; Esophagitis, Eosinophilic Chronic
SNOMED CT: Eosinophilic esophagitis (235599003)
 
Monarch Initiative: MONDO:0005361
OMIM®: 610247
Orphanet: ORPHA73247

Definition

Allergic inflammation of the esophagus. Morphologically, it is characterized by the presence of eosinophils infiltrating the esophageal epithelium. Patients present with swallowing difficulty and heartburn. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Eosinophilic esophagitis in Orphanet.

Professional guidelines

PubMed

International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban M, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
Dysphagia: Evaluation and Collaborative Management.
Wilkinson JM, Codipilly DC, Wilfahrt RP
Am Fam Physician 2021 Jan 15;103(2):97-106. PMID: 33448766
Diagnosis and treatment of eosinophilic esophagitis.
Gonsalves NP, Aceves SS
J Allergy Clin Immunol 2020 Jan;145(1):1-7. doi: 10.1016/j.jaci.2019.11.011. PMID: 31910983Free PMC Article

Recent clinical studies

Etiology

A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions.
Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS
Gastroenterology 2022 Jul;163(1):59-76. Epub 2022 May 20 doi: 10.1053/j.gastro.2022.03.025. PMID: 35606197Free PMC Article
Pediatric eosinophilic esophagitis: a review for the clinician.
Barni S, Arasi S, Mastrorilli C, Pecoraro L, Giovannini M, Mori F, Liotti L, Saretta F, Castagnoli R, Caminiti L, Cianferoni A, Novembre E
Ital J Pediatr 2021 Nov 22;47(1):230. doi: 10.1186/s13052-021-01178-2. PMID: 34809686Free PMC Article
Eosinophilic esophagitis.
Watts MM, Saltoun C, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):462-464. doi: 10.2500/aap.2019.40.4272. PMID: 31690395
Eosinophilic Gastrointestinal Disorders.
Gonsalves N
Clin Rev Allergy Immunol 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1. PMID: 30903439
Epidemiology and Natural History of Eosinophilic Esophagitis.
Dellon ES, Hirano I
Gastroenterology 2018 Jan;154(2):319-332.e3. Epub 2017 Aug 1 doi: 10.1053/j.gastro.2017.06.067. PMID: 28774845Free PMC Article

Diagnosis

Eosinophilic Esophagitis.
Lehman HK, Lam W
Immunol Allergy Clin North Am 2021 Nov;41(4):587-598. doi: 10.1016/j.iac.2021.07.011. PMID: 34602230
Diagnosis and treatment of eosinophilic esophagitis.
Gonsalves NP, Aceves SS
J Allergy Clin Immunol 2020 Jan;145(1):1-7. doi: 10.1016/j.jaci.2019.11.011. PMID: 31910983Free PMC Article
Eosinophilic esophagitis: Current concepts in diagnosis and treatment.
Gómez-Aldana A, Jaramillo-Santos M, Delgado A, Jaramillo C, Lúquez-Mindiola A
World J Gastroenterol 2019 Aug 28;25(32):4598-4613. doi: 10.3748/wjg.v25.i32.4598. PMID: 31528089Free PMC Article
Eosinophilic Esophagitis.
Reed CC, Dellon ES
Med Clin North Am 2019 Jan;103(1):29-42. Epub 2018 Nov 1 doi: 10.1016/j.mcna.2018.08.009. PMID: 30466674Free PMC Article
Eosinophilic Esophagitis.
Furuta GT, Katzka DA
N Engl J Med 2015 Oct 22;373(17):1640-8. doi: 10.1056/NEJMra1502863. PMID: 26488694Free PMC Article

Therapy

Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.
Dellon ES, Rothenberg ME, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Aceves S, Sun X, Kosloski MP, Kamal MA, Hamilton JD, Beazley B, McCann E, Patel K, Mannent LP, Laws E, Akinlade B, Amin N, Lim WK, Wipperman MF, Ruddy M, Patel N, Weinreich DR, Yancopoulos GD, Shumel B, Maloney J, Giannelou A, Shabbir A
N Engl J Med 2022 Dec 22;387(25):2317-2330. doi: 10.1056/NEJMoa2205982. PMID: 36546624
Dupilumab: A Review of Present Indications and Off-Label Uses.
Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
Eosinophilic Esophagitis: A Review.
Muir A, Falk GW
JAMA 2021 Oct 5;326(13):1310-1318. doi: 10.1001/jama.2021.14920. PMID: 34609446Free PMC Article
Diagnosis and treatment of eosinophilic esophagitis.
Gonsalves NP, Aceves SS
J Allergy Clin Immunol 2020 Jan;145(1):1-7. doi: 10.1016/j.jaci.2019.11.011. PMID: 31910983Free PMC Article
Eosinophilic Esophagitis.
Furuta GT, Katzka DA
N Engl J Med 2015 Oct 22;373(17):1640-8. doi: 10.1056/NEJMra1502863. PMID: 26488694Free PMC Article

Prognosis

Lymphocytic Esophagitis: Current Understanding and Controversy.
Pittman ME
Am J Surg Pathol 2022 Jan 1;46(1):e55-e63. doi: 10.1097/PAS.0000000000001667. PMID: 33481383
Diagnosis and Treatment of Esophageal Candidiasis: Current Updates.
Mohamed AA, Lu XL, Mounmin FA
Can J Gastroenterol Hepatol 2019;2019:3585136. Epub 2019 Oct 20 doi: 10.1155/2019/3585136. PMID: 31772927Free PMC Article
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ
Gastroenterology 2018 Oct;155(4):1022-1033.e10. Epub 2018 Sep 6 doi: 10.1053/j.gastro.2018.07.009. PMID: 30009819Free PMC Article
Epidemiology and Natural History of Eosinophilic Esophagitis.
Dellon ES, Hirano I
Gastroenterology 2018 Jan;154(2):319-332.e3. Epub 2017 Aug 1 doi: 10.1053/j.gastro.2017.06.067. PMID: 28774845Free PMC Article
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.
Sicherer SH, Sampson HA
J Allergy Clin Immunol 2014 Feb;133(2):291-307; quiz 308. Epub 2013 Dec 31 doi: 10.1016/j.jaci.2013.11.020. PMID: 24388012

Clinical prediction guides

Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.
Dellon ES, Rothenberg ME, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Aceves S, Sun X, Kosloski MP, Kamal MA, Hamilton JD, Beazley B, McCann E, Patel K, Mannent LP, Laws E, Akinlade B, Amin N, Lim WK, Wipperman MF, Ruddy M, Patel N, Weinreich DR, Yancopoulos GD, Shumel B, Maloney J, Giannelou A, Shabbir A
N Engl J Med 2022 Dec 22;387(25):2317-2330. doi: 10.1056/NEJMoa2205982. PMID: 36546624
Lymphocytic Esophagitis: Current Understanding and Controversy.
Pittman ME
Am J Surg Pathol 2022 Jan 1;46(1):e55-e63. doi: 10.1097/PAS.0000000000001667. PMID: 33481383
Eosinophilic Esophagitis: A Review.
Muir A, Falk GW
JAMA 2021 Oct 5;326(13):1310-1318. doi: 10.1001/jama.2021.14920. PMID: 34609446Free PMC Article
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ
Gastroenterology 2018 Oct;155(4):1022-1033.e10. Epub 2018 Sep 6 doi: 10.1053/j.gastro.2018.07.009. PMID: 30009819Free PMC Article
Epidemiology and Natural History of Eosinophilic Esophagitis.
Dellon ES, Hirano I
Gastroenterology 2018 Jan;154(2):319-332.e3. Epub 2017 Aug 1 doi: 10.1053/j.gastro.2017.06.067. PMID: 28774845Free PMC Article

Recent systematic reviews

Efficacy of Elimination Diets in Eosinophilic Esophagitis: A Systematic Review and Meta-analysis.
Mayerhofer C, Kavallar AM, Aldrian D, Lindner AK, Müller T, Vogel GF
Clin Gastroenterol Hepatol 2023 Aug;21(9):2197-2210.e3. Epub 2023 Jan 31 doi: 10.1016/j.cgh.2023.01.019. PMID: 36731591
Eosinophilic Esophagitis due to Aeroallergens: A Systematic Review and Update.
Gratacós Gómez AR, Gómez Torrijos E
J Investig Allergol Clin Immunol 2022 Dec 15;32(6):438-450. Epub 2022 Aug 24 doi: 10.18176/jiaci.0853. PMID: 36000828
The microbiota in eosinophilic esophagitis: A systematic review.
Angerami Almeida K, de Queiroz Andrade E, Burns G, Hoedt EC, Mattes J, Keely S, Collison A
J Gastroenterol Hepatol 2022 Sep;37(9):1673-1684. Epub 2022 Jul 12 doi: 10.1111/jgh.15921. PMID: 35730344Free PMC Article
British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults.
Dhar A, Haboubi HN, Attwood SE, Auth MKH, Dunn JM, Sweis R, Morris D, Epstein J, Novelli MR, Hunter H, Cordell A, Hall S, Hayat JO, Kapur K, Moore AR, Read C, Sami SS, Turner PJ, Trudgill NJ
Gut 2022 Aug;71(8):1459-1487. Epub 2022 May 23 doi: 10.1136/gutjnl-2022-327326. PMID: 35606089Free PMC Article
Dupilumab ocular side effects in patients with atopic dermatitis: a systematic review.
Neagu N, Dianzani C, Avallone G, Dell'Aquila C, Morariu SH, Zalaudek I, Conforti C
J Eur Acad Dermatol Venereol 2022 Jun;36(6):820-835. Epub 2022 Feb 17 doi: 10.1111/jdv.17981. PMID: 35122335

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