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Neoplasm of the scrotum

MedGen UID:
83328
•Concept ID:
C0341790
•
Neoplastic Process
Synonyms: Neoplasia of the scrotum; Neoplasm of scrotum; Neoplasm of Scrotum; neoplasm of scrotum; Neoplasm of the Scrotum; neoplasm of the scrotum; scrotal Ca; Scrotal Neoplasm; scrotal neoplasm; Scrotal Tumor; scrotal tumor; scrotal tumour; scrotum neoplasm; scrotum neoplasm (disease); Scrotum tumor; scrotum tumor; Scrotum tumour; scrotum tumour; Tumor of scrotum; Tumor of Scrotum; tumor of scrotum; Tumor of the Scrotum; tumor of the scrotum; tumour of scrotum; tumour of the scrotum
SNOMED CT: Neoplasm of scrotum (126905005); Tumor of scrotum (126905005)
 
HPO: HP:0100849
Monarch Initiative: MONDO:0003319

Definition

A tumor (abnormal growth of tissue) of the scrotum. [from HPO]

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Surgical management and gynecologic care of the transgender patient.
Schmidt M, Ditrio L, Shute B, Luciano D
Curr Opin Obstet Gynecol 2019 Aug;31(4):228-234. doi: 10.1097/GCO.0000000000000553. PMID: 31045656
Diagnosis and management of spermatic cord tumors.
Moschini M, Mattei A
Curr Opin Urol 2017 Jan;27(1):76-79. doi: 10.1097/MOU.0000000000000318. PMID: 27262142

Recent clinical studies

Etiology

Cryptorchidism and puberty.
Rodprasert W, Virtanen HE, Toppari J
Front Endocrinol (Lausanne) 2024;15:1347435. Epub 2024 Mar 12 doi: 10.3389/fendo.2024.1347435. PMID: 38532895Free PMC Article
WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Scrotal Masses.
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
MRI of testicular malignancies.
Tsili AC, Sofikitis N, Stiliara E, Argyropoulou MI
Abdom Radiol (NY) 2019 Mar;44(3):1070-1082. doi: 10.1007/s00261-018-1816-5. PMID: 30386879

Diagnosis

Ultrasonography of the scrotum: Revisiting a classic technique.
Tsili AC, Bougia CK, Pappa O, Argyropoulou MI
Eur J Radiol 2021 Dec;145:110000. Epub 2021 Oct 23 doi: 10.1016/j.ejrad.2021.110000. PMID: 34741987
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Penoscrotal Paget's disease.
Dauendorffer JN, Herms F, Baroudjian B, Basset-Seguin N, Cavelier-Balloy B, Fouéré S, Bagot M, Lebbé C
Ann Dermatol Venereol 2021 Jun;148(2):71-76. Epub 2021 Jan 16 doi: 10.1016/j.annder.2020.08.051. PMID: 33461789
Imaging of scrotal masses.
Sharbidre KG, Lockhart ME
Abdom Radiol (NY) 2020 Jul;45(7):2087-2108. doi: 10.1007/s00261-019-02395-4. PMID: 31919649
Scrotal imaging.
Watanabe Y
Curr Opin Urol 2002 Mar;12(2):149-53. doi: 10.1097/00042307-200203000-00012. PMID: 11859263

Therapy

Effects of the prenatal environment on cryptorchidism: A narrative review.
Mitsui T
Int J Urol 2021 Sep;28(9):882-889. Epub 2021 Jun 1 doi: 10.1111/iju.14600. PMID: 34075642
The role of multiparametric ultrasound in the diagnosis of paediatric scrotal pathology.
Huang DY, Pesapane F, Rafailidis V, Deganello A, Sellars ME, Sidhu PS
Br J Radiol 2020 Jun;93(1110):20200063. Epub 2020 Apr 23 doi: 10.1259/bjr.20200063. PMID: 32271626Free PMC Article
Cryptorchidism --disease or symptom?
Toppari J, Rodprasert W, Virtanen HE
Ann Endocrinol (Paris) 2014 May;75(2):72-6. Epub 2014 Apr 29 doi: 10.1016/j.ando.2014.04.010. PMID: 24786701
Extramammary Paget disease.
Hartman R, Chu J, Patel R, Meehan S, Stein JA
Dermatol Online J 2011 Oct 15;17(10):4. PMID: 22031630
Epidemiology of testicular cancer.
Manecksha RP, Fitzpatrick JM
BJU Int 2009 Nov;104(9 Pt B):1329-33. doi: 10.1111/j.1464-410X.2009.08854.x. PMID: 19840008

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Cryptorchidism.
Hutson JM, Balic A, Nation T, Southwell B
Semin Pediatr Surg 2010 Aug;19(3):215-24. doi: 10.1053/j.sempedsurg.2010.04.001. PMID: 20610195
Exenterative pelvic surgery.
Lopez MJ, Spratt JS
J Surg Oncol 1999 Oct;72(2):102-14. doi: 10.1002/(sici)1096-9098(199910)72:2<102::aid-jso12>3.0.co;2-1. PMID: 10518108

Clinical prediction guides

Scrotal Masses.
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
MRI of testicular malignancies.
Tsili AC, Sofikitis N, Stiliara E, Argyropoulou MI
Abdom Radiol (NY) 2019 Mar;44(3):1070-1082. doi: 10.1007/s00261-018-1816-5. PMID: 30386879
The regulation of testicular descent and the effects of cryptorchidism.
Hutson JM, Southwell BR, Li R, Lie G, Ismail K, Harisis G, Chen N
Endocr Rev 2013 Oct;34(5):725-52. Epub 2013 May 10 doi: 10.1210/er.2012-1089. PMID: 23666148
Cryptorchidism.
Hutson JM, Balic A, Nation T, Southwell B
Semin Pediatr Surg 2010 Aug;19(3):215-24. doi: 10.1053/j.sempedsurg.2010.04.001. PMID: 20610195

Recent systematic reviews

Radiological features characterising indeterminate testes masses: a systematic review and meta-analysis.
Ager M, Donegan S, Boeri L, de Castro JM, Donaldson JF, Omar MI, Dimitropoulos K, Tharakan T, Janisch F, Muilwijk T, Yuan C, Tudur-Smith C, Nijman RJM, Radmayr C, Salonia A, Laguna Pes MP, Minhas S
BJU Int 2023 Mar;131(3):288-300. Epub 2022 Oct 9 doi: 10.1111/bju.15869. PMID: 35980855
Testis-sparing surgery and scrotal violation for testicular masses suspicious for malignancy: A systematic review and meta-analysis.
Patel HD, Gupta M, Cheaib JG, Sharma R, Zhang A, Bass EB, Pierorazio PM
Urol Oncol 2020 May;38(5):344-353. Epub 2020 Mar 17 doi: 10.1016/j.urolonc.2020.02.023. PMID: 32192891
Systematic Review of Surgical Treatment and Outcomes After Local Surgery of Primary Cutaneous Melanomas of the Penis and Scrotum.
Bittar JM, Bittar PG, Wan MT, Kovell RC, Guzzo TJ, Shin TM, Etzkorn JR, Sobanko JF, Miller CJ
Dermatol Surg 2018 Sep;44(9):1159-1169. doi: 10.1097/DSS.0000000000001579. PMID: 29985865
Scrotal Melanoma: A Systematic Review of Presentation, Treatment, and Outcomes.
Zikry J, Chapman LW, Korta DZ, Smith J
Dermatol Surg 2017 Jun;43(6):765-770. doi: 10.1097/DSS.0000000000001072. PMID: 28291064
Adult inguinoscrotal sarcomas: outcome analysis of 21 cases, systematic review of the literature and meta-analysis.
Froehner M, Koch R, Lossnitzer A, Schober RR, Schuler M, Wirth MP
World J Urol 2014 Apr;32(2):445-51. Epub 2013 Jul 9 doi: 10.1007/s00345-013-1124-1. PMID: 23836016

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