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Acute myeloid leukemia by FAB classification

MedGen UID:
833409
•Concept ID:
CN200094
•
Finding
Synonym: Unclassified acute myeloid leukemia
 
Monarch Initiative: MONDO:0015667
Orphanet: ORPHA167714

Definition

Acute myeloid leukemias that do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related. This category includes entities classified according to the French-American-British classification scheme. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute myeloid leukemia by FAB classification
Follow this link to review classifications for Acute myeloid leukemia by FAB classification in Orphanet.

Professional guidelines

PubMed

AMLnet, A deep-learning pipeline for the differential diagnosis of acute myeloid leukemia from bone marrow smears.
Yu Z, Li J, Wen X, Han Y, Jiang P, Zhu M, Wang M, Gao X, Shen D, Zhang T, Zhao S, Zhu Y, Tong J, Yuan S, Zhu H, Huang H, Qian P
J Hematol Oncol 2023 Mar 21;16(1):27. doi: 10.1186/s13045-023-01419-3. PMID: 36945063Free PMC Article
Azacitidine: a review of its use in the management of myelodysplastic syndromes/acute myeloid leukaemia.
Keating GM
Drugs 2012 May 28;72(8):1111-36. doi: 10.2165/11209430-000000000-00000. PMID: 22571445
Diagnostic criteria and classification of mastocytosis: a consensus proposal.
Valent P, Horny HP, Escribano L, Longley BJ, Li CY, Schwartz LB, Marone G, Nuñez R, Akin C, Sotlar K, Sperr WR, Wolff K, Brunning RD, Parwaresch RM, Austen KF, Lennert K, Metcalfe DD, Vardiman JW, Bennett JM
Leuk Res 2001 Jul;25(7):603-25. doi: 10.1016/s0145-2126(01)00038-8. PMID: 11377686

Recent clinical studies

Etiology

Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia.
Lin MS, Zhong HY, Yim RL, Chen QY, Du HL, He HQ, Lin K, Zhao P, Gao R, Gao F, Zhang MY
BMC Cancer 2022 Oct 15;22(1):1068. doi: 10.1186/s12885-022-10155-9. PMID: 36243694Free PMC Article
Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR.
Handschuh L, Kaźmierczak M, Milewski MC, Góralski M, Łuczak M, Wojtaszewska M, Uszczyńska-Ratajczak B, Lewandowski K, Komarnicki M, Figlerowicz M
Int J Oncol 2018 Mar;52(3):656-678. Epub 2017 Dec 28 doi: 10.3892/ijo.2017.4233. PMID: 29286103Free PMC Article
Acute megakaryoblastic leukemia.
Gassmann W, Löffler H
Leuk Lymphoma 1995;18 Suppl 1:69-73. doi: 10.3109/10428199509075307. PMID: 7496359
Mixed acute leukaemias.
Hoffbrand AV, Leber BF, Browett PJ, Norton JD
Blood Rev 1988 Mar;2(1):9-15. doi: 10.1016/0268-960x(88)90003-3. PMID: 3289656
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Diagnosis

Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR.
Handschuh L, Kaźmierczak M, Milewski MC, Góralski M, Łuczak M, Wojtaszewska M, Uszczyńska-Ratajczak B, Lewandowski K, Komarnicki M, Figlerowicz M
Int J Oncol 2018 Mar;52(3):656-678. Epub 2017 Dec 28 doi: 10.3892/ijo.2017.4233. PMID: 29286103Free PMC Article
Recurrent Cytogenetic Abnormalities in Acute Myeloid Leukemia.
Yang JJ, Park TS, Wan TS
Methods Mol Biol 2017;1541:223-245. doi: 10.1007/978-1-4939-6703-2_19. PMID: 27910027
Acute megakaryoblastic leukemia.
Gassmann W, Löffler H
Leuk Lymphoma 1995;18 Suppl 1:69-73. doi: 10.3109/10428199509075307. PMID: 7496359
Mixed acute leukaemias.
Hoffbrand AV, Leber BF, Browett PJ, Norton JD
Blood Rev 1988 Mar;2(1):9-15. doi: 10.1016/0268-960x(88)90003-3. PMID: 3289656
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Therapy

Classification of acute myeloid leukemia M1 and M2 subtypes using machine learning.
Liu K, Hu J
Comput Biol Med 2022 Aug;147:105741. Epub 2022 Jun 15 doi: 10.1016/j.compbiomed.2022.105741. PMID: 35738057
Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR.
Handschuh L, Kaźmierczak M, Milewski MC, Góralski M, Łuczak M, Wojtaszewska M, Uszczyńska-Ratajczak B, Lewandowski K, Komarnicki M, Figlerowicz M
Int J Oncol 2018 Mar;52(3):656-678. Epub 2017 Dec 28 doi: 10.3892/ijo.2017.4233. PMID: 29286103Free PMC Article
E-26 Transformation-specific Related Gene Expression and Outcomes in Cytogenetically Normal Acute Myeloid Leukemia: A Meta-analysis.
Fang JF, Yuan HN, Song YF, Sun PB, Zheng XL, Wang XJ
Chin Med J (Engl) 2017 Jun 20;130(12):1481-1490. doi: 10.4103/0366-6999.207474. PMID: 28584213Free PMC Article
Cytogenetics of pediatric acute myeloid leukemia.
Manola KN
Eur J Haematol 2009 Nov;83(5):391-405. Epub 2009 Jun 25 doi: 10.1111/j.1600-0609.2009.01308.x. PMID: 19563518
Immunologic classification of leukemia and lymphoma.
Foon KA, Todd RF 3rd
Blood 1986 Jul;68(1):1-31. PMID: 2941082

Prognosis

Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia.
Lin MS, Zhong HY, Yim RL, Chen QY, Du HL, He HQ, Lin K, Zhao P, Gao R, Gao F, Zhang MY
BMC Cancer 2022 Oct 15;22(1):1068. doi: 10.1186/s12885-022-10155-9. PMID: 36243694Free PMC Article
Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR.
Handschuh L, Kaźmierczak M, Milewski MC, Góralski M, Łuczak M, Wojtaszewska M, Uszczyńska-Ratajczak B, Lewandowski K, Komarnicki M, Figlerowicz M
Int J Oncol 2018 Mar;52(3):656-678. Epub 2017 Dec 28 doi: 10.3892/ijo.2017.4233. PMID: 29286103Free PMC Article
Cytogenetics of pediatric acute myeloid leukemia.
Manola KN
Eur J Haematol 2009 Nov;83(5):391-405. Epub 2009 Jun 25 doi: 10.1111/j.1600-0609.2009.01308.x. PMID: 19563518
Mixed acute leukaemias.
Hoffbrand AV, Leber BF, Browett PJ, Norton JD
Blood Rev 1988 Mar;2(1):9-15. doi: 10.1016/0268-960x(88)90003-3. PMID: 3289656
Classification of acute myeloid leukemias--a comparison of FAB and immunophenotyping.
Drexler HG
Leukemia 1987 Oct;1(10):697-705. PMID: 3312833

Clinical prediction guides

Classification of acute myeloid leukemia M1 and M2 subtypes using machine learning.
Liu K, Hu J
Comput Biol Med 2022 Aug;147:105741. Epub 2022 Jun 15 doi: 10.1016/j.compbiomed.2022.105741. PMID: 35738057
Clinical significance of dysregulation of miR-381 in pediatric acute myeloid leukemia.
Zhang P, Sun D, Sun X, Li H
Eur J Med Res 2020 Sep 16;25(1):42. doi: 10.1186/s40001-020-00442-1. PMID: 32938467Free PMC Article
Prognostic significance of CXCR4 expression in acute myeloid leukemia.
Du W, Lu C, Zhu X, Hu D, Chen X, Li J, Liu W, Zhu J, He Y, Yao J
Cancer Med 2019 Nov;8(15):6595-6603. Epub 2019 Sep 13 doi: 10.1002/cam4.2535. PMID: 31518054Free PMC Article
Gene expression profiling in acute myeloid leukaemia.
de Jonge HJ, Huls G, de Bont ES
Neth J Med 2011 Apr;69(4):167-76. PMID: 21527803
Mixed acute leukaemias.
Hoffbrand AV, Leber BF, Browett PJ, Norton JD
Blood Rev 1988 Mar;2(1):9-15. doi: 10.1016/0268-960x(88)90003-3. PMID: 3289656

Recent systematic reviews

E-26 Transformation-specific Related Gene Expression and Outcomes in Cytogenetically Normal Acute Myeloid Leukemia: A Meta-analysis.
Fang JF, Yuan HN, Song YF, Sun PB, Zheng XL, Wang XJ
Chin Med J (Engl) 2017 Jun 20;130(12):1481-1490. doi: 10.4103/0366-6999.207474. PMID: 28584213Free PMC Article

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