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Adrenocortical hyperplasia

MedGen UID:
83343
•Concept ID:
C0342494
•
Disease or Syndrome
Synonyms: Adrenal Cortex Hyperplasia; Adrenal Cortical Hyperplasia; Adrenocortical Hyperplasia; Hyperplasia of Adrenal Cortex; Hyperplasia of the Adrenal Cortex
SNOMED CT: Adrenocortical hyperplasia (237777008)
 
HPO: HP:6000152

Definition

A non-malignant growth, or enlargement, of the adrenal glands, specifically the cortex, although the cortex cannot be definitively identified by conventional imaging. Adrenal cortical hyperplasia is defined radiologically as a non-malignant growth, or enlargement, of the adrenal glands. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenocortical hyperplasia

Professional guidelines

PubMed

Key to the Treatment of Primary Aldosteronism in Secondary Hypertension: Subtype Diagnosis.
Zuo R, Liu S, Xu L, Pang H
Curr Hypertens Rep 2023 Dec;25(12):471-480. Epub 2023 Oct 3 doi: 10.1007/s11906-023-01269-x. PMID: 37787864
Prevalence, diagnosis and outcomes of treatment for primary aldosteronism.
Yang Y, Reincke M, Williams TA
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101365. Epub 2019 Dec 5 doi: 10.1016/j.beem.2019.101365. PMID: 31837980
Genetic causes of primary aldosteronism.
Seidel E, Schewe J, Scholl UI
Exp Mol Med 2019 Nov 6;51(11):1-12. doi: 10.1038/s12276-019-0337-9. PMID: 31695023Free PMC Article

Recent clinical studies

Etiology

Prevalence, diagnosis and outcomes of treatment for primary aldosteronism.
Yang Y, Reincke M, Williams TA
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101365. Epub 2019 Dec 5 doi: 10.1016/j.beem.2019.101365. PMID: 31837980
Adrenal venous sampling: cosyntropin stimulation or not?
Deinum J, Groenewoud H, van der Wilt GJ, Lenzini L, Rossi GP
Eur J Endocrinol 2019 Sep;181(3):D15-D26. doi: 10.1530/EJE-18-0844. PMID: 31176302
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Faillot S, Assie G
Eur J Endocrinol 2016 Jun;174(6):R249-65. Epub 2016 Jan 6 doi: 10.1530/EJE-15-1118. PMID: 26739091
cAMP signaling in cortisol-producing adrenal adenoma.
Calebiro D, Di Dalmazi G, Bathon K, Ronchi CL, Beuschlein F
Eur J Endocrinol 2015 Oct;173(4):M99-106. Epub 2015 Jul 2 doi: 10.1530/EJE-15-0353. PMID: 26139209
Clinicopathological correlates of adrenal Cushing's syndrome.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Mar;68(3):175-86. Epub 2014 Nov 25 doi: 10.1136/jclinpath-2014-202612. PMID: 25425660

Diagnosis

Adrenocortical hyperplasia: A multifaceted disease.
Bourdeau I, Parisien-La Salle S, Lacroix A
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101386. Epub 2020 Feb 4 doi: 10.1016/j.beem.2020.101386. PMID: 32115357
Genomics of benign adrenocortical tumors.
Jouinot A, Armignacco R, Assié G
J Steroid Biochem Mol Biol 2019 Oct;193:105414. Epub 2019 Jun 14 doi: 10.1016/j.jsbmb.2019.105414. PMID: 31207362
Cushing's Syndrome in Pediatrics: An Update.
Lodish MB, Keil MF, Stratakis CA
Endocrinol Metab Clin North Am 2018 Jun;47(2):451-462. doi: 10.1016/j.ecl.2018.02.008. PMID: 29754644Free PMC Article
An update on Cushing syndrome in pediatrics.
Stratakis CA
Ann Endocrinol (Paris) 2018 Jun;79(3):125-131. Epub 2018 Apr 9 doi: 10.1016/j.ando.2018.03.010. PMID: 29650225
Cushing's disease.
Bertagna X, Guignat L, Groussin L, Bertherat J
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):607-23. doi: 10.1016/j.beem.2009.06.001. PMID: 19945026

Therapy

Key to the Treatment of Primary Aldosteronism in Secondary Hypertension: Subtype Diagnosis.
Zuo R, Liu S, Xu L, Pang H
Curr Hypertens Rep 2023 Dec;25(12):471-480. Epub 2023 Oct 3 doi: 10.1007/s11906-023-01269-x. PMID: 37787864
c-KIT oncogene expression in PRKAR1A-mutant adrenal cortex.
Nadella K, Faucz FR, Stratakis CA
Endocr Relat Cancer 2020 Oct;27(10):591-599. doi: 10.1530/ERC-20-0270. PMID: 32738126Free PMC Article
Adrenal venous sampling: cosyntropin stimulation or not?
Deinum J, Groenewoud H, van der Wilt GJ, Lenzini L, Rossi GP
Eur J Endocrinol 2019 Sep;181(3):D15-D26. doi: 10.1530/EJE-18-0844. PMID: 31176302
Adrenal morphology and associated comorbidities in congenital adrenal hyperplasia.
El-Maouche D, Hannah-Shmouni F, Mallappa A, Hargreaves CJ, Avila NA, Merke DP
Clin Endocrinol (Oxf) 2019 Aug;91(2):247-255. Epub 2019 May 7 doi: 10.1111/cen.13996. PMID: 31001843Free PMC Article
An update on Cushing syndrome in pediatrics.
Stratakis CA
Ann Endocrinol (Paris) 2018 Jun;79(3):125-131. Epub 2018 Apr 9 doi: 10.1016/j.ando.2018.03.010. PMID: 29650225

Prognosis

Prevalence, diagnosis and outcomes of treatment for primary aldosteronism.
Yang Y, Reincke M, Williams TA
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101365. Epub 2019 Dec 5 doi: 10.1016/j.beem.2019.101365. PMID: 31837980
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Faillot S, Assie G
Eur J Endocrinol 2016 Jun;174(6):R249-65. Epub 2016 Jan 6 doi: 10.1530/EJE-15-1118. PMID: 26739091
Clinicopathological correlates of adrenal Cushing's syndrome.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Mar;68(3):175-86. Epub 2014 Nov 25 doi: 10.1136/jclinpath-2014-202612. PMID: 25425660
Cushing's disease.
Bertagna X, Guignat L, Groussin L, Bertherat J
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):607-23. doi: 10.1016/j.beem.2009.06.001. PMID: 19945026
Adrenal incidentalomas and subclinical Cushing's syndrome: diagnosis and treatment.
Mazzuco TL, Bourdeau I, Lacroix A
Curr Opin Endocrinol Diabetes Obes 2009 Jun;16(3):203-10. doi: 10.1097/MED.0b013e32832b7043. PMID: 19390321

Clinical prediction guides

Morphological Harbingers of ARMC5-Pathogenic Variant-Related Bilateral Macronodular Adrenocortical Disease.
de Arruda Botelho MLA, Nishi MY, Ribeiro KB, Zerbini MCN
Endocr Pathol 2023 Jun;34(2):200-212. Epub 2023 Apr 12 doi: 10.1007/s12022-023-09761-5. PMID: 37043100
Morphologic and Molecular Characterization of Adrenals and Adrenal Rest Affected by Congenital Adrenal Hyperplasia.
Kolli V, da Cunha IW, Kim S, Iben JR, Mallappa A, Li T, Gaynor A, Coon SL, Quezado MM, Merke DP
Front Endocrinol (Lausanne) 2021;12:730947. Epub 2021 Sep 20 doi: 10.3389/fendo.2021.730947. PMID: 34616364Free PMC Article
Adrenal morphology and associated comorbidities in congenital adrenal hyperplasia.
El-Maouche D, Hannah-Shmouni F, Mallappa A, Hargreaves CJ, Avila NA, Merke DP
Clin Endocrinol (Oxf) 2019 Aug;91(2):247-255. Epub 2019 May 7 doi: 10.1111/cen.13996. PMID: 31001843Free PMC Article
Clinicopathological correlates of adrenal Cushing's syndrome.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Mar;68(3):175-86. Epub 2014 Nov 25 doi: 10.1136/jclinpath-2014-202612. PMID: 25425660
Is the adrenal cortex a target for gonadotropins?
Bernichtein S, Alevizaki M, Huhtaniemi I
Trends Endocrinol Metab 2008 Sep;19(7):231-8. Epub 2008 Aug 6 doi: 10.1016/j.tem.2008.06.003. PMID: 18691899

Recent systematic reviews

Aromatase deficiency: A case series of 46, XX Chinese children and a systematic review of the literature.
Fan L, Zhang B, Li L, Gong C
Clin Endocrinol (Oxf) 2020 Dec;93(6):687-695. Epub 2020 Jul 27 doi: 10.1111/cen.14277. PMID: 32623730

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