U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adrenocortical hyperplasia

MedGen UID:
83343
•Concept ID:
C0342494
•
Disease or Syndrome
Synonyms: Adrenal Cortex Hyperplasia; Adrenal Cortical Hyperplasia; Adrenocortical Hyperplasia; Hyperplasia of Adrenal Cortex; Hyperplasia of the Adrenal Cortex
SNOMED CT: Adrenocortical hyperplasia (237777008)

Definition

Congenital or acquired hyperplasia of the cells of the adrenal cortex. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenocortical hyperplasia

Professional guidelines

PubMed

Prevalence, diagnosis and outcomes of treatment for primary aldosteronism.
Yang Y, Reincke M, Williams TA
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101365. Epub 2019 Dec 5 doi: 10.1016/j.beem.2019.101365. PMID: 31837980
Genetic causes of primary aldosteronism.
Seidel E, Schewe J, Scholl UI
Exp Mol Med 2019 Nov 6;51(11):1-12. doi: 10.1038/s12276-019-0337-9. PMID: 31695023Free PMC Article
Adrenal incidentalomas and subclinical Cushing's syndrome: diagnosis and treatment.
Mazzuco TL, Bourdeau I, Lacroix A
Curr Opin Endocrinol Diabetes Obes 2009 Jun;16(3):203-10. doi: 10.1097/MED.0b013e32832b7043. PMID: 19390321

Recent clinical studies

Etiology

Prevalence, diagnosis and outcomes of treatment for primary aldosteronism.
Yang Y, Reincke M, Williams TA
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101365. Epub 2019 Dec 5 doi: 10.1016/j.beem.2019.101365. PMID: 31837980
Adrenal venous sampling: cosyntropin stimulation or not?
Deinum J, Groenewoud H, van der Wilt GJ, Lenzini L, Rossi GP
Eur J Endocrinol 2019 Sep;181(3):D15-D26. doi: 10.1530/EJE-18-0844. PMID: 31176302
Adrenal morphology and associated comorbidities in congenital adrenal hyperplasia.
El-Maouche D, Hannah-Shmouni F, Mallappa A, Hargreaves CJ, Avila NA, Merke DP
Clin Endocrinol (Oxf) 2019 Aug;91(2):247-255. Epub 2019 May 7 doi: 10.1111/cen.13996. PMID: 31001843Free PMC Article
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Faillot S, Assie G
Eur J Endocrinol 2016 Jun;174(6):R249-65. Epub 2016 Jan 6 doi: 10.1530/EJE-15-1118. PMID: 26739091
cAMP signaling in cortisol-producing adrenal adenoma.
Calebiro D, Di Dalmazi G, Bathon K, Ronchi CL, Beuschlein F
Eur J Endocrinol 2015 Oct;173(4):M99-106. Epub 2015 Jul 2 doi: 10.1530/EJE-15-0353. PMID: 26139209

Diagnosis

Adrenocortical hyperplasia: A multifaceted disease.
Bourdeau I, Parisien-La Salle S, Lacroix A
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101386. Epub 2020 Feb 4 doi: 10.1016/j.beem.2020.101386. PMID: 32115357
Adrenocortical hyperplasia: a review of clinical presentation and imaging.
Morani AC, Jensen CT, Habra MA, Agrons MM, Menias CO, Wagner-Bartak NA, Shaaban AM, Roman-Colon AM, Elsayes KM
Abdom Radiol (NY) 2020 Apr;45(4):917-927. doi: 10.1007/s00261-019-02048-6. PMID: 31093730
Genomics of benign adrenocortical tumors.
Jouinot A, Armignacco R, Assié G
J Steroid Biochem Mol Biol 2019 Oct;193:105414. Epub 2019 Jun 14 doi: 10.1016/j.jsbmb.2019.105414. PMID: 31207362
Cushing's Syndrome in Pediatrics: An Update.
Lodish MB, Keil MF, Stratakis CA
Endocrinol Metab Clin North Am 2018 Jun;47(2):451-462. doi: 10.1016/j.ecl.2018.02.008. PMID: 29754644Free PMC Article
Cushing's disease.
Bertagna X, Guignat L, Groussin L, Bertherat J
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):607-23. doi: 10.1016/j.beem.2009.06.001. PMID: 19945026

Therapy

c-KIT oncogene expression in PRKAR1A-mutant adrenal cortex.
Nadella K, Faucz FR, Stratakis CA
Endocr Relat Cancer 2020 Oct;27(10):591-599. doi: 10.1530/ERC-20-0270. PMID: 32738126Free PMC Article
Adrenal venous sampling: cosyntropin stimulation or not?
Deinum J, Groenewoud H, van der Wilt GJ, Lenzini L, Rossi GP
Eur J Endocrinol 2019 Sep;181(3):D15-D26. doi: 10.1530/EJE-18-0844. PMID: 31176302
Adrenal morphology and associated comorbidities in congenital adrenal hyperplasia.
El-Maouche D, Hannah-Shmouni F, Mallappa A, Hargreaves CJ, Avila NA, Merke DP
Clin Endocrinol (Oxf) 2019 Aug;91(2):247-255. Epub 2019 May 7 doi: 10.1111/cen.13996. PMID: 31001843Free PMC Article
An update on Cushing syndrome in pediatrics.
Stratakis CA
Ann Endocrinol (Paris) 2018 Jun;79(3):125-131. Epub 2018 Apr 9 doi: 10.1016/j.ando.2018.03.010. PMID: 29650225
Molecular genetics of adrenocortical tumor formation and potential pharmacologic targets.
Rauschecker M, Stratakis CA
Minerva Endocrinol 2012 Jun;37(2):133-9. PMID: 22691887Free PMC Article

Prognosis

Morphologic and Molecular Characterization of Adrenals and Adrenal Rest Affected by Congenital Adrenal Hyperplasia.
Kolli V, da Cunha IW, Kim S, Iben JR, Mallappa A, Li T, Gaynor A, Coon SL, Quezado MM, Merke DP
Front Endocrinol (Lausanne) 2021;12:730947. Epub 2021 Sep 20 doi: 10.3389/fendo.2021.730947. PMID: 34616364Free PMC Article
Prevalence, diagnosis and outcomes of treatment for primary aldosteronism.
Yang Y, Reincke M, Williams TA
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101365. Epub 2019 Dec 5 doi: 10.1016/j.beem.2019.101365. PMID: 31837980
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Faillot S, Assie G
Eur J Endocrinol 2016 Jun;174(6):R249-65. Epub 2016 Jan 6 doi: 10.1530/EJE-15-1118. PMID: 26739091
Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin.
Heaton JH, Wood MA, Kim AC, Lima LO, Barlaskar FM, Almeida MQ, Fragoso MC, Kuick R, Lerario AM, Simon DP, Soares IC, Starnes E, Thomas DG, Latronico AC, Giordano TJ, Hammer GD
Am J Pathol 2012 Sep;181(3):1017-33. Epub 2012 Jul 15 doi: 10.1016/j.ajpath.2012.05.026. PMID: 22800756Free PMC Article
Cushing's disease.
Bertagna X, Guignat L, Groussin L, Bertherat J
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):607-23. doi: 10.1016/j.beem.2009.06.001. PMID: 19945026

Clinical prediction guides

Morphologic and Molecular Characterization of Adrenals and Adrenal Rest Affected by Congenital Adrenal Hyperplasia.
Kolli V, da Cunha IW, Kim S, Iben JR, Mallappa A, Li T, Gaynor A, Coon SL, Quezado MM, Merke DP
Front Endocrinol (Lausanne) 2021;12:730947. Epub 2021 Sep 20 doi: 10.3389/fendo.2021.730947. PMID: 34616364Free PMC Article
Adrenal morphology and associated comorbidities in congenital adrenal hyperplasia.
El-Maouche D, Hannah-Shmouni F, Mallappa A, Hargreaves CJ, Avila NA, Merke DP
Clin Endocrinol (Oxf) 2019 Aug;91(2):247-255. Epub 2019 May 7 doi: 10.1111/cen.13996. PMID: 31001843Free PMC Article
Clinicopathological correlates of adrenal Cushing's syndrome.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Mar;68(3):175-86. Epub 2014 Nov 25 doi: 10.1136/jclinpath-2014-202612. PMID: 25425660
Adrenal incidentalomas and subclinical Cushing's syndrome: diagnosis and treatment.
Mazzuco TL, Bourdeau I, Lacroix A
Curr Opin Endocrinol Diabetes Obes 2009 Jun;16(3):203-10. doi: 10.1097/MED.0b013e32832b7043. PMID: 19390321
Is the adrenal cortex a target for gonadotropins?
Bernichtein S, Alevizaki M, Huhtaniemi I
Trends Endocrinol Metab 2008 Sep;19(7):231-8. Epub 2008 Aug 6 doi: 10.1016/j.tem.2008.06.003. PMID: 18691899

Recent systematic reviews

Aromatase deficiency: A case series of 46, XX Chinese children and a systematic review of the literature.
Fan L, Zhang B, Li L, Gong C
Clin Endocrinol (Oxf) 2020 Dec;93(6):687-695. Epub 2020 Jul 27 doi: 10.1111/cen.14277. PMID: 32623730

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...