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Adrenal mass

MedGen UID:
83344
•Concept ID:
C0342500
•
Finding
Synonyms: Adrenal Mass; Mass of adrenal gland
SNOMED CT: Mass of adrenal gland (237783006); Adrenal mass (237783006)
 
HPO: HP:0034880

Definition

A swelling or enlargment localized to the adrenal gland. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenal mass

Professional guidelines

PubMed

Recent Updates on the Management of Adrenal Incidentalomas.
Park SS, Kim JH
Endocrinol Metab (Seoul) 2023 Aug;38(4):373-380. Epub 2023 Aug 16 doi: 10.3803/EnM.2023.1779. PMID: 37583083Free PMC Article
European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Arlt W, Bancos I, Dralle H, Newell-Price J, Sahdev A, Tabarin A, Terzolo M, Tsagarakis S, Dekkers OM
Eur J Endocrinol 2016 Aug;175(2):G1-G34. doi: 10.1530/EJE-16-0467. PMID: 27390021

Recent clinical studies

Etiology

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Approach to the Patient With Adrenal Incidentaloma.
Bancos I, Prete A
J Clin Endocrinol Metab 2021 Oct 21;106(11):3331-3353. doi: 10.1210/clinem/dgab512. PMID: 34260734Free PMC Article
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
Modern Management of Mild Autonomous Cortisol Secretion.
Delivanis DA, Athimulam S, Bancos I
Clin Pharmacol Ther 2019 Dec;106(6):1209-1221. Epub 2019 Aug 6 doi: 10.1002/cpt.1551. PMID: 31206616
Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Arlt W, Bancos I, Dralle H, Newell-Price J, Sahdev A, Tabarin A, Terzolo M, Tsagarakis S, Dekkers OM
Eur J Endocrinol 2016 Aug;175(2):G1-G34. doi: 10.1530/EJE-16-0467. PMID: 27390021

Diagnosis

Approach to the Patient With Adrenal Incidentaloma.
Bancos I, Prete A
J Clin Endocrinol Metab 2021 Oct 21;106(11):3331-3353. doi: 10.1210/clinem/dgab512. PMID: 34260734Free PMC Article
Modern Management of Mild Autonomous Cortisol Secretion.
Delivanis DA, Athimulam S, Bancos I
Clin Pharmacol Ther 2019 Dec;106(6):1209-1221. Epub 2019 Aug 6 doi: 10.1002/cpt.1551. PMID: 31206616
Adrenal incidentaloma: differential diagnosis and management strategies.
Morelli V, Palmieri S
Minerva Endocrinol 2019 Mar;44(1):4-18. Epub 2018 May 28 doi: 10.23736/S0391-1977.18.02868-7. PMID: 29808642
Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Arlt W, Bancos I, Dralle H, Newell-Price J, Sahdev A, Tabarin A, Terzolo M, Tsagarakis S, Dekkers OM
Eur J Endocrinol 2016 Aug;175(2):G1-G34. doi: 10.1530/EJE-16-0467. PMID: 27390021
Adrenal metastases.
Wagnerova H, Lazurova I, Felsoci M
Bratisl Lek Listy 2013;114(4):237-40. doi: 10.4149/bll_2013_049. PMID: 23514559

Therapy

Primary aldosteronism in pregnancy.
Forestiero V, Sconfienza E, Mulatero P, Monticone S
Rev Endocr Metab Disord 2023 Feb;24(1):39-48. Epub 2022 May 10 doi: 10.1007/s11154-022-09729-6. PMID: 35536535Free PMC Article
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
Modern Management of Mild Autonomous Cortisol Secretion.
Delivanis DA, Athimulam S, Bancos I
Clin Pharmacol Ther 2019 Dec;106(6):1209-1221. Epub 2019 Aug 6 doi: 10.1002/cpt.1551. PMID: 31206616
Adrenal biopsy: performance and use.
Zhang CD, Delivanis DA, Eiken PW, Atwell TD, Bancos I
Minerva Endocrinol 2019 Sep;44(3):288-300. Epub 2019 Feb 6 doi: 10.23736/S0391-1977.19.02969-9. PMID: 30732427
Adrenal incidentalomas.
Aron D, Terzolo M, Cawood TJ
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):69-82. doi: 10.1016/j.beem.2011.06.012. PMID: 22305453

Prognosis

Primary aldosteronism in pregnancy.
Forestiero V, Sconfienza E, Mulatero P, Monticone S
Rev Endocr Metab Disord 2023 Feb;24(1):39-48. Epub 2022 May 10 doi: 10.1007/s11154-022-09729-6. PMID: 35536535Free PMC Article
Approach to the Patient With Adrenal Incidentaloma.
Bancos I, Prete A
J Clin Endocrinol Metab 2021 Oct 21;106(11):3331-3353. doi: 10.1210/clinem/dgab512. PMID: 34260734Free PMC Article
Modern Management of Mild Autonomous Cortisol Secretion.
Delivanis DA, Athimulam S, Bancos I
Clin Pharmacol Ther 2019 Dec;106(6):1209-1221. Epub 2019 Aug 6 doi: 10.1002/cpt.1551. PMID: 31206616
Adrenal metastases.
Wagnerova H, Lazurova I, Felsoci M
Bratisl Lek Listy 2013;114(4):237-40. doi: 10.4149/bll_2013_049. PMID: 23514559
Neonatal neuroblastoma.
Fisher JPH, Tweddle DA
Semin Fetal Neonatal Med 2012 Aug;17(4):207-215. Epub 2012 Jun 4 doi: 10.1016/j.siny.2012.05.002. PMID: 22673527

Clinical prediction guides

Pediatric Metastatic Pheochromocytoma and Paraganglioma: Clinical Presentation and Diagnosis, Genetics, and Therapeutic Approaches.
Kuo MJM, Nazari MA, Jha A, Pacak K
Front Endocrinol (Lausanne) 2022;13:936178. Epub 2022 Jul 12 doi: 10.3389/fendo.2022.936178. PMID: 35903274Free PMC Article
Neonatal neuroblastoma.
Fisher JPH, Tweddle DA
Semin Fetal Neonatal Med 2012 Aug;17(4):207-215. Epub 2012 Jun 4 doi: 10.1016/j.siny.2012.05.002. PMID: 22673527
The indeterminate adrenal mass.
Harrison B
Langenbecks Arch Surg 2012 Feb;397(2):147-54. Epub 2011 Sep 23 doi: 10.1007/s00423-011-0845-0. PMID: 21947480
Subclinical Cushing's syndrome.
Terzolo M, Bovio S, Pia A, Osella G, Borretta G, Angeli A, Reimondo G
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1272-9. doi: 10.1590/s0004-27302007000800013. PMID: 18209865
Adrenal incidentalomas.
Bertherat J, Mosnier-Pudar H, Bertagna X
Curr Opin Oncol 2002 Jan;14(1):58-63. doi: 10.1097/00001622-200201000-00011. PMID: 11790982

Recent systematic reviews

Diagnosis, Management, and Follow-Up of the Incidentally Discovered Adrenal Mass: CUA Guideline Endorsed by the AUA.
Rowe NE, Kumar R, Schieda N, Siddiqi F, McGregor T, McAlpine K, Violette P, Bathini V, Eng M, Izard J
J Urol 2023 Oct;210(4):590-599. Epub 2023 Aug 9 doi: 10.1097/JU.0000000000003644. PMID: 37556768
Diagnostic Accuracy of CT Texture Analysis in Adrenal Masses: A Systematic Review.
Crimì F, Quaia E, Cabrelle G, Zanon C, Pepe A, Regazzo D, Tizianel I, Scaroni C, Ceccato F
Int J Mol Sci 2022 Jan 7;23(2) doi: 10.3390/ijms23020637. PMID: 35054823Free PMC Article
Presentation and outcomes of adrenal ganglioneuromas: A cohort study and a systematic review of literature.
Dages KN, Kohlenberg JD, Young WF Jr, Murad MH, Prokop L, Rivera M, Dy B, Foster T, Lyden M, McKenzie T, Thompson G, Bancos I
Clin Endocrinol (Oxf) 2021 Jul;95(1):47-57. Epub 2021 Mar 22 doi: 10.1111/cen.14460. PMID: 33721367Free PMC Article
Ectopic ACTH- and/or CRH-Producing Pheochromocytomas.
Elliott PF, Berhane T, Ragnarsson O, Falhammar H
J Clin Endocrinol Metab 2021 Jan 23;106(2):598-608. doi: 10.1210/clinem/dgaa488. PMID: 32710791
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196

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