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Cutaneous polyarteritis nodosa

MedGen UID:
83358
•Concept ID:
C0343190
•
Disease or Syndrome
Synonyms: Cutaneous livedo with nodules; Cutaneous PAN; cutaneous PAN; Cutaneous periarteritis nodosa; cutaneous periarteritis nodosa; Cutaneous Polyarteritis Nodosa; cutaneous polyarteritis nodosa; Nodular livedo
SNOMED CT: Cutaneous polyarteritis nodosa (239926000); Cutaneous livedo with nodules (239926000); Nodular livedo (239926000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018592
Orphanet: ORPHA439729

Definition

Cutaneous polyarteritis nodosa (CPAN) is a rare limited form of polyarteritis nodosa (PAN, see this term), characterized by cutaneous vasculitis and mild and transient extracutaneous manifestations such as mild arthralgia, arthritis,myalgia, and rarely peripheral neuropathy. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous polyarteritis nodosa

Professional guidelines

PubMed

Letter from the Editor: Management of cutaneous polyarteritis nodosa.
Elston DM
J Am Acad Dermatol 2022 Dec;87(6):1273-1274. Epub 2022 May 26 doi: 10.1016/j.jaad.2022.05.043. PMID: 35643240
Management of cutaneous vasculitis.
Micheletti RG, Pagnoux C
Presse Med 2020 Oct;49(3):104033. Epub 2020 Jul 6 doi: 10.1016/j.lpm.2020.104033. PMID: 32645416
Diagnosis and management of cutaneous vasculitis in children.
Ting TV
Pediatr Clin North Am 2014 Apr;61(2):321-46. Epub 2014 Jan 21 doi: 10.1016/j.pcl.2013.11.007. PMID: 24636649

Recent clinical studies

Etiology

Panniculitides of particular interest to the rheumatologist.
Morita TCAB, Trés GFS, García MSC, Halpern I, Criado PR, de Carvalho JF
Adv Rheumatol 2019 Aug 1;59(1):35. doi: 10.1186/s42358-019-0077-5. PMID: 31370889
The nonsystemic vasculitic neuropathies.
Collins MP, Hadden RD
Nat Rev Neurol 2017 Apr 27;13(5):302-316. doi: 10.1038/nrneurol.2017.42. PMID: 28447661
Granulomatous Vasculitis.
Sharma A, Dogra S, Sharma K
Dermatol Clin 2015 Jul;33(3):475-87. doi: 10.1016/j.det.2015.03.012. PMID: 26143427
Dapsone hypersensitivity syndrome.
Prussick R, Shear NH
J Am Acad Dermatol 1996 Aug;35(2 Pt 2):346-9. doi: 10.1016/s0190-9622(96)90667-2. PMID: 8698924
Superficial thrombophlebitis. II. Secondary hypercoagulable states.
Samlaska CP, James WD
J Am Acad Dermatol 1990 Jul;23(1):1-18. doi: 10.1016/0190-9622(90)70179-l. PMID: 2195069

Diagnosis

A case of VEXAS syndrome associated with EBV-associated hemophagocytic lymphohistiocytosis.
Kao RL, Jacobsen AA, Billington CJ Jr, Yohe SL, Beckman AK, Vercellotti GM, Pearson DR
Blood Cells Mol Dis 2022 Mar;93:102636. Epub 2021 Nov 30 doi: 10.1016/j.bcmd.2021.102636. PMID: 34864445
Management of cutaneous vasculitis.
Micheletti RG, Pagnoux C
Presse Med 2020 Oct;49(3):104033. Epub 2020 Jul 6 doi: 10.1016/j.lpm.2020.104033. PMID: 32645416
Panniculitides of particular interest to the rheumatologist.
Morita TCAB, Trés GFS, García MSC, Halpern I, Criado PR, de Carvalho JF
Adv Rheumatol 2019 Aug 1;59(1):35. doi: 10.1186/s42358-019-0077-5. PMID: 31370889
Granulomatous Vasculitis.
Sharma A, Dogra S, Sharma K
Dermatol Clin 2015 Jul;33(3):475-87. doi: 10.1016/j.det.2015.03.012. PMID: 26143427
Superficial thrombophlebitis.
Luis Rodríguez-Peralto J, Carrillo R, Rosales B, Rodríguez-Gil Y
Semin Cutan Med Surg 2007 Jun;26(2):71-6. doi: 10.1016/j.sder.2007.02.002. PMID: 17544957

Therapy

Management of cutaneous vasculitis.
Micheletti RG, Pagnoux C
Presse Med 2020 Oct;49(3):104033. Epub 2020 Jul 6 doi: 10.1016/j.lpm.2020.104033. PMID: 32645416
Panniculitides of particular interest to the rheumatologist.
Morita TCAB, Trés GFS, García MSC, Halpern I, Criado PR, de Carvalho JF
Adv Rheumatol 2019 Aug 1;59(1):35. doi: 10.1186/s42358-019-0077-5. PMID: 31370889
Lymphocytic Thrombophilic Arteritis: A Possible Association with Minocycline.
Tan CWX, Koh MJA
Pediatr Dermatol 2017 Jul;34(4):e160-e163. Epub 2017 May 26 doi: 10.1111/pde.13165. PMID: 28547757
Granulomatous Vasculitis.
Sharma A, Dogra S, Sharma K
Dermatol Clin 2015 Jul;33(3):475-87. doi: 10.1016/j.det.2015.03.012. PMID: 26143427
Dapsone hypersensitivity syndrome.
Prussick R, Shear NH
J Am Acad Dermatol 1996 Aug;35(2 Pt 2):346-9. doi: 10.1016/s0190-9622(96)90667-2. PMID: 8698924

Prognosis

Cutaneous lymphocytic thrombophilic (macular) arteritis.
Kolivras A, Thompson C
Clin Dermatol 2021 Mar-Apr;39(2):278-282. Epub 2020 Oct 16 doi: 10.1016/j.clindermatol.2020.10.011. PMID: 34272022
Lymphocytic thrombophilic arteritis complicated by systemic involvement.
Wee E, Nikpour M, Balta S, Williams RA, Kelly RI
Australas J Dermatol 2018 Aug;59(3):223-225. Epub 2018 Apr 6 doi: 10.1111/ajd.12798. PMID: 29624649
Cutaneous polyarteritis nodosa: a comprehensive review.
Morgan AJ, Schwartz RA
Int J Dermatol 2010 Jul;49(7):750-6. doi: 10.1111/j.1365-4632.2010.04522.x. PMID: 20618492
Cutaneous polyarteritis nodosa.
Díaz-Pérez JL, De Lagrán ZM, Díaz-Ramón JL, Winkelmann RK
Semin Cutan Med Surg 2007 Jun;26(2):77-86. doi: 10.1016/j.sder.2007.02.003. PMID: 17544958
Cutaneous polyarteritis nodosa.
Bauzá A, España A, Idoate M
Br J Dermatol 2002 Apr;146(4):694-9. doi: 10.1046/j.1365-2133.2002.04624.x. PMID: 11966708

Clinical prediction guides

Efficacy and safety of treatments in cutaneous polyarteritis nodosa: A French observational retrospective study.
Bettuzzi T, Jachiet M, Sbidian E, Frumholtz L, Cordoliani F, Mouthon L, Chasset F, Paule R, Bouaziz JD, Guillevin L, Terrier B, Aractingi S, Dupin N, Régent A
J Am Acad Dermatol 2022 May;86(5):1035-1041. Epub 2021 Jul 2 doi: 10.1016/j.jaad.2021.06.872. PMID: 34224771
Manifestations, clinical course and prognostic markers in cutaneous polyarteritis nodosa.
Munera-Campos M, Bielsa I, Martínez-Morillo M, Aparicio G, Olivé A, Ferrándiz C
J Dtsch Dermatol Ges 2020 Nov;18(11):1250-1259. Epub 2020 Oct 4 doi: 10.1111/ddg.14271. PMID: 33015940
Analysis of the Clinical Characteristics and Follow-up Study of Children with Cutaneous Polyarteritis Nodosa.
He Q, Shu J, Chen F, Zhen XF
Curr Neurovasc Res 2019;16(3):208-214. doi: 10.2174/1567202616666190618112705. PMID: 31237213
Clinical and Laboratory Markers Associated With Relapse in Cutaneous Polyarteritis Nodosa.
Kato A, Hamada T, Miyake T, Morizane S, Hirai Y, Yamasaki O, Iwatsuki K
JAMA Dermatol 2018 Aug 1;154(8):922-926. doi: 10.1001/jamadermatol.2018.1601. PMID: 29955757Free PMC Article
Cutaneous Manifestations of Medium- and Large-Vessel Vasculitis.
Chasset F, Francès C
Clin Rev Allergy Immunol 2017 Dec;53(3):452-468. doi: 10.1007/s12016-017-8612-9. PMID: 28547523

Recent systematic reviews

Therapeutic options for cutaneous polyarteritis nodosa: a systematic review.
Papachristodoulou E, Kakoullis L, Tiniakou E, Parperis K
Rheumatology (Oxford) 2021 Sep 1;60(9):4039-4047. doi: 10.1093/rheumatology/keab402. PMID: 33944902
Dermatological Manifestations in Pediatric Inflammatory Bowel Disease.
Diaconescu S, Strat S, Balan GG, Anton C, Stefanescu G, Ioniuc I, Stanescu AMA
Medicina (Kaunas) 2020 Aug 23;56(9) doi: 10.3390/medicina56090425. PMID: 32842528Free PMC Article

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