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Intradural spinal arachnoid cyst

MedGen UID:
83372
Concept ID:
C0344485
Disease or Syndrome
Synonym: Spinal intradural arachnoid cysts
SNOMED CT: Intradural spinal arachnoid cyst (253164002)
 
Monarch Initiative: MONDO:0008454
OMIM®: 182990

Definition

Spinal intradural arachnoid cysts are cerebrospinal fluid -filled sacs that are located between the spinal cord and the arachnoid membrane (one of the three membranes that cover the brain and spinal cord). The signs and symptoms of the condition vary based on the size and location of the cysts. Some affected people may have no suspicious symptoms while others experience progressive back and leg pain; tingling or numbness in the hands or feet; weakness of the legs; and involuntary muscle spasms (spasticity) that result in slow, stiff movements of the legs. When present, symptoms usually occur when the cysts compress the spinal cord or other nearby nerves. Spinal intradural arachnoid cysts are often present at birth and arecaused by developmental abnormalities in the spinal cord that occur during the pregnancy. They can also result from a previous infection or injury and develop later in life. Although there is disagreement in the medical community regarding when to treat spinal intradural arachnoid cysts, the need for treatment generally depends on the size and location of the cyst and whether or not it is causing symptoms. When indicated, the cysts are typically treated with surgery. [from MONDO]

Clinical features

From HPO
Paraplegia
MedGen UID:
45323
Concept ID:
C0030486
Disease or Syndrome
Severe or complete weakness of both lower extremities with sparing of the upper extremities.
Arachnoid cyst
MedGen UID:
86860
Concept ID:
C0078981
Disease or Syndrome
An extra-parenchymal and intra-arachnoidal collection of fluid with a composition similar to that of cerebrospinal fluid.
Abnormality of the vertebral column
MedGen UID:
892426
Concept ID:
C4021789
Anatomical Abnormality
Any abnormality of the vertebral column.

Professional guidelines

PubMed

Fam MD, Woodroffe RW, Helland L, Noeller J, Dahdaleh NS, Menezes AH, Hitchon PW
J Neurosurg Spine 2018 Dec 1;29(6):711-719. doi: 10.3171/2018.5.SPINE1820. PMID: 30265227
Krings T, Lukas R, Reul J, Spetzger U, Reinges MH, Gilsbach JM, Thron A
Acta Neurochir (Wien) 2001;143(3):227-34; discussion 234-5. doi: 10.1007/s007010170102. PMID: 11460910
PERRET G, GREEN D, KELLER J
Radiology 1962 Sep;79:425-9. doi: 10.1148/79.3.425. PMID: 14485487

Recent clinical studies

Etiology

Wang YB, Wang DH, Deng SL
Spine J 2023 Aug;23(8):1199-1211. Epub 2023 Mar 15 doi: 10.1016/j.spinee.2023.03.002. PMID: 36924909
Moses ZB, Friedman GN, Penn DL, Solomon IH, Chi JH
J Neurosurg Spine 2018 May;28(5):548-554. Epub 2018 Feb 9 doi: 10.3171/2017.8.SPINE17605. PMID: 29424675
Srinivasan VM, Fridley JS, Thomas JG, Omeis I
World Neurosurg 2016 Mar;87:176-86. Epub 2015 Nov 14 doi: 10.1016/j.wneu.2015.11.004. PMID: 26585730

Diagnosis

Wang YB, Wang DH, Deng SL
Spine J 2023 Aug;23(8):1199-1211. Epub 2023 Mar 15 doi: 10.1016/j.spinee.2023.03.002. PMID: 36924909
Haimoto S, Nishimura Y, Ginsberg HJ
J Neurosurg Spine 2018 Nov 23;30(2):193-197. doi: 10.3171/2018.8.SPINE18223. PMID: 30497153
Moses ZB, Friedman GN, Penn DL, Solomon IH, Chi JH
J Neurosurg Spine 2018 May;28(5):548-554. Epub 2018 Feb 9 doi: 10.3171/2017.8.SPINE17605. PMID: 29424675
Viswanathan VK, Manoharan SR, Do H, Minnema A, Shaddy SM, Elder JB, Farhadi HF
World Neurosurg 2017 Sep;105:213-222. Epub 2017 May 31 doi: 10.1016/j.wneu.2017.05.136. PMID: 28578118
Nath PC, Mishra SS, Deo RC, Satapathy MC
World Neurosurg 2016 Jan;85:367.e1-4. Epub 2015 Sep 30 doi: 10.1016/j.wneu.2015.09.058. PMID: 26428320

Therapy

Wang YB, Wang DH, Deng SL
Spine J 2023 Aug;23(8):1199-1211. Epub 2023 Mar 15 doi: 10.1016/j.spinee.2023.03.002. PMID: 36924909
Nath PC, Mishra SS, Deo RC, Satapathy MC
World Neurosurg 2016 Jan;85:367.e1-4. Epub 2015 Sep 30 doi: 10.1016/j.wneu.2015.09.058. PMID: 26428320
Nottmeier EW, Wharen RE, Patel NP
J Neurosurg Spine 2009 Sep;11(3):344-6. doi: 10.3171/2009.3.SPINE08844. PMID: 19769517
Kriss TC, Kriss VM
Spine (Phila Pa 1976) 1997 Mar 1;22(5):568-72. doi: 10.1097/00007632-199703010-00023. PMID: 9076891

Prognosis

Moses ZB, Friedman GN, Penn DL, Solomon IH, Chi JH
J Neurosurg Spine 2018 May;28(5):548-554. Epub 2018 Feb 9 doi: 10.3171/2017.8.SPINE17605. PMID: 29424675
Viswanathan VK, Manoharan SR, Do H, Minnema A, Shaddy SM, Elder JB, Farhadi HF
World Neurosurg 2017 Sep;105:213-222. Epub 2017 May 31 doi: 10.1016/j.wneu.2017.05.136. PMID: 28578118
Kriss TC, Kriss VM
Spine (Phila Pa 1976) 1997 Mar 1;22(5):568-72. doi: 10.1097/00007632-199703010-00023. PMID: 9076891

Clinical prediction guides

Moses ZB, Chi JH, Chavali RVSR
J Neurosurg Spine 2018 Dec 1;29(6):720-724. doi: 10.3171/2018.4.SPINE171182. PMID: 30192219
Viswanathan VK, Manoharan SR, Do H, Minnema A, Shaddy SM, Elder JB, Farhadi HF
World Neurosurg 2017 Sep;105:213-222. Epub 2017 May 31 doi: 10.1016/j.wneu.2017.05.136. PMID: 28578118

Recent systematic reviews

Wang YB, Wang DH, Deng SL
Spine J 2023 Aug;23(8):1199-1211. Epub 2023 Mar 15 doi: 10.1016/j.spinee.2023.03.002. PMID: 36924909

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