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Undifferentiated ovarian carcinoma

MedGen UID:
83410
•Concept ID:
C0346167
•
Neoplastic Process
Synonyms: Anaplastic Carcinoma of Ovary; anaplastic carcinoma of ovary; Anaplastic Carcinoma of the Ovary; anaplastic carcinoma of the ovary; Anaplastic Ovarian Carcinoma; anaplastic ovarian carcinoma; Ovarian Undifferentiated Carcinoma; ovarian undifferentiated carcinoma; ovary undifferentiated carcinoma; Undifferentiated carcinoma of ovary; Undifferentiated Carcinoma of Ovary; undifferentiated carcinoma of ovary; Undifferentiated Carcinoma of the Ovary; undifferentiated carcinoma of the ovary; Undifferentiated ovarian cancer; undifferentiated ovarian cancer; Undifferentiated Ovarian Carcinoma; undifferentiated ovarian carcinoma
SNOMED CT: Undifferentiated ovarian cancer (254856004); Undifferentiated carcinoma of ovary (254856004)
 
Monarch Initiative: MONDO:0006477

Definition

An aggressive carcinoma arising from the ovary. Most patients present with advanced disease. Microscopically, it is characterized by significant cytologic atypia, increased mitotic activity, and necrosis. The prognosis is usually poor. [from NCI]

Professional guidelines

PubMed

Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120

Recent clinical studies

Etiology

Undifferentiated carcinoma of the ovary.
Silva EG, Tornos C, Bailey MA, Morris M
Arch Pathol Lab Med 1991 Apr;115(4):377-81. PMID: 1672813

Diagnosis

Rapidly progressive primary undifferentiated ovarian carcinoma: presentation of a rare case.
Sofoudis C, Koumousidis A, Politi E, Koutoulidis V, Hasiakos D, Salakos N
Eur J Gynaecol Oncol 2016;37(3):436-8. PMID: 27352583
Establishment of a New Ovarian Cancer Cell Line CA5171.
Chiang YC, Cheng WF, Chang MC, Lu TP, Kuo KT, Lin HP, Hsieh CY, Chen CA
Reprod Sci 2015 Jun;22(6):725-34. Epub 2014 Nov 12 doi: 10.1177/1933719114557893. PMID: 25394645Free PMC Article
Lymphoepithelioma-like carcinoma of the ovary: a case report and review of the literature.
Brun JL, Randriambelomanana J, Cherier L, Lafon ME, Trufflandier N, Le Bail B
Int J Gynecol Pathol 2010 Sep;29(5):427-31. doi: 10.1097/PGP.0b013e3181db69da. PMID: 20736767
Primary undifferentiated ovarian carcinoma diagnosed by its metastasis to brain: an unusual case report.
Bakar B, Tekkök IH
Turk Neurosurg 2008 Oct;18(4):431-5. PMID: 19107695
Ovarian undifferentiated carcinoma resembling giant cell carcinoma of the lung.
Yasunaga M, Ohishi Y, Nishimura I, Tamiya S, Iwasa A, Takagi E, Inoue T, Yahata H, Kobayashi H, Wake N, Tsuneyoshi M
Pathol Int 2008 Apr;58(4):244-8. doi: 10.1111/j.1440-1827.2008.02218.x. PMID: 18324918

Therapy

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study.
Gelmon KA, Tischkowitz M, Mackay H, Swenerton K, Robidoux A, Tonkin K, Hirte H, Huntsman D, Clemons M, Gilks B, Yerushalmi R, Macpherson E, Carmichael J, Oza A
Lancet Oncol 2011 Sep;12(9):852-61. Epub 2011 Aug 19 doi: 10.1016/S1470-2045(11)70214-5. PMID: 21862407
Ovarian undifferentiated carcinoma resembling giant cell carcinoma of the lung.
Yasunaga M, Ohishi Y, Nishimura I, Tamiya S, Iwasa A, Takagi E, Inoue T, Yahata H, Kobayashi H, Wake N, Tsuneyoshi M
Pathol Int 2008 Apr;58(4):244-8. doi: 10.1111/j.1440-1827.2008.02218.x. PMID: 18324918
Carboplatin chemotherapy in a pregnant patient with undifferentiated ovarian carcinoma: case report and review of the literature.
Tabata T, Nishiura K, Tanida K, Kondo E, Okugawa T, Sagawa N
Int J Gynecol Cancer 2008 Jan-Feb;18(1):181-4. Epub 2007 Apr 26 doi: 10.1111/j.1525-1438.2007.00974.x. PMID: 17466045

Prognosis

Rapidly progressive primary undifferentiated ovarian carcinoma: presentation of a rare case.
Sofoudis C, Koumousidis A, Politi E, Koutoulidis V, Hasiakos D, Salakos N
Eur J Gynaecol Oncol 2016;37(3):436-8. PMID: 27352583
Lymphoepithelioma-like carcinoma of the ovary: a case report and review of the literature.
Brun JL, Randriambelomanana J, Cherier L, Lafon ME, Trufflandier N, Le Bail B
Int J Gynecol Pathol 2010 Sep;29(5):427-31. doi: 10.1097/PGP.0b013e3181db69da. PMID: 20736767
Carboplatin chemotherapy in a pregnant patient with undifferentiated ovarian carcinoma: case report and review of the literature.
Tabata T, Nishiura K, Tanida K, Kondo E, Okugawa T, Sagawa N
Int J Gynecol Cancer 2008 Jan-Feb;18(1):181-4. Epub 2007 Apr 26 doi: 10.1111/j.1525-1438.2007.00974.x. PMID: 17466045
Undifferentiated carcinoma of the ovary.
Silva EG, Tornos C, Bailey MA, Morris M
Arch Pathol Lab Med 1991 Apr;115(4):377-81. PMID: 1672813

Clinical prediction guides

Undifferentiated ovarian carcinoma associated with leukemoid reaction.
Chuang SS, Lin CN, Lin YS
Zhonghua Yi Xue Za Zhi (Taipei) 2001 Oct;64(10):592-6. PMID: 11791947

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