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Ovarian yolk sac tumor

MedGen UID:
83415
•Concept ID:
C0346188
•
Neoplastic Process
Synonyms: Endodermal Sinus Neoplasm of Ovary; endodermal sinus neoplasm of ovary; Endodermal Sinus Neoplasm of the Ovary; endodermal sinus neoplasm of the ovary; Endodermal sinus tumor of ovary; Endodermal Sinus Tumor of Ovary; endodermal sinus tumor of ovary; Endodermal Sinus Tumor of the Ovary; endodermal sinus tumor of the ovary; endodermal sinus tumour of ovary; endodermal sinus tumour of the ovary; Germ Cell Endodermal Sinus Neoplasm of Ovary; germ cell endodermal sinus neoplasm of ovary; Germ Cell Endodermal Sinus Neoplasm of the Ovary; germ cell endodermal sinus neoplasm of the ovary; Germ Cell Endodermal Sinus Tumor of Ovary; germ cell endodermal sinus tumor of ovary; Germ Cell Endodermal Sinus Tumor of the Ovary; germ cell endodermal sinus tumor of the ovary; germ cell endodermal sinus tumour of ovary; germ cell endodermal sinus tumour of the ovary; Ovarian Endodermal Sinus Neoplasm; ovarian endodermal sinus neoplasm; Ovarian Endodermal Sinus Tumor; ovarian endodermal sinus tumor; ovarian endodermal sinus tumour; Ovarian Germ Cell Endodermal Sinus Neoplasm; ovarian germ cell endodermal sinus neoplasm; Ovarian Germ Cell Endodermal Sinus Tumor; ovarian germ cell endodermal sinus tumor; ovarian germ cell endodermal sinus tumour; Ovarian Yolk Sac Neoplasm; ovarian yolk Sac neoplasm; Ovarian Yolk Sac Tumor; ovarian yolk sac tumor; ovary yolk sac tumor; ovary yolk sac tumour; Yolk Sac Neoplasm of Ovary; yolk Sac neoplasm of ovary; Yolk Sac Neoplasm of the Ovary; yolk Sac neoplasm of the ovary; yolk sac tumor; Yolk sac tumor of ovary; Yolk Sac Tumor of Ovary; yolk Sac tumor of ovary; Yolk Sac Tumor of the Ovary; yolk Sac tumor of the ovary; yolk sac tumour; yolk Sac tumour of ovary; yolk Sac tumour of the ovary
SNOMED CT: Endodermal sinus tumor of ovary (254876005); Yolk sac tumor of ovary (254876005)
 
Monarch Initiative: MONDO:0006344

Definition

A usually rapidly growing malignant germ cell tumor arising from the ovary. It usually occurs in children and adolescents. Signs and symptoms include abdominal pain and a large abdominal or pelvic mass. The serum alpha-fetoprotein is almost always elevated preoperatively. Morphologically, there is marked heterogeneity due to numerous patterns of differentiation coexisting in the same tumor. The most common pattern is reticular. [from NCI]

Professional guidelines

PubMed

CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis.
Li YK, Zheng Y, Lin JB, Xu GX, Cai AQ, Zhou XG, Zhang GJ
Sci Rep 2015 Jun 15;5:11000. doi: 10.1038/srep11000. PMID: 26074455Free PMC Article
Role of neoadjuvant chemotherapy in the management of advanced ovarian yolk sac tumor.
Lu Y, Yang J, Cao D, Huang H, Wu M, You Y, Chen J, Lang J, Shen K
Gynecol Oncol 2014 Jul;134(1):78-83. Epub 2014 Feb 28 doi: 10.1016/j.ygyno.2014.02.029. PMID: 24582864

Recent clinical studies

Etiology

Ovarian yolk sac tumor in a premenarchal girl.
Miletić AI, Habek D, Medić F, Prka M, Berić Lerotić S, Knežević F
Wien Med Wochenschr 2023 Mar;173(3-4):70-73. Epub 2023 Jan 13 doi: 10.1007/s10354-022-00996-1. PMID: 36637654
Clinicopathological features, prognosis, and fertility outcomes in Chinese Han women treated for ovarian yolk sac tumor: A retrospective case series study from two tertiary-care academic medical centers.
Qin L, Wang B, Wang Z, He D
Medicine (Baltimore) 2022 Jul 22;101(29):e29868. doi: 10.1097/MD.0000000000029868. PMID: 35866762Free PMC Article
Ovarian Yolk Sac Tumors; Does Age Matter?
Faure Conter C, Xia C, Gershenson D, Hurteau J, Covens A, Pashankar F, Krailo M, Billmire D, Patte C, Fresneau B, Shaikh F, Stoneham S, Nicholson J, Murray M, Frazier AL
Int J Gynecol Cancer 2018 Jan;28(1):77-84. doi: 10.1097/IGC.0000000000001149. PMID: 29194189
Ovarian Yolk Sac Tumor: The Experience of a Regional Cancer Center.
Wang X, Ma Z, Li Y
Int J Gynecol Cancer 2016 Jun;26(5):884-91. doi: 10.1097/IGC.0000000000000704. PMID: 27104939
CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis.
Li YK, Zheng Y, Lin JB, Xu GX, Cai AQ, Zhou XG, Zhang GJ
Sci Rep 2015 Jun 15;5:11000. doi: 10.1038/srep11000. PMID: 26074455Free PMC Article

Diagnosis

Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review.
Wang Y, Yang J, Yu M, Cao D, Zhang Y, Zong X, Shen K
Medicine (Baltimore) 2018 Aug;97(33):e11838. doi: 10.1097/MD.0000000000011838. PMID: 30113473Free PMC Article
Ovarian Yolk Sac Tumors; Does Age Matter?
Faure Conter C, Xia C, Gershenson D, Hurteau J, Covens A, Pashankar F, Krailo M, Billmire D, Patte C, Fresneau B, Shaikh F, Stoneham S, Nicholson J, Murray M, Frazier AL
Int J Gynecol Cancer 2018 Jan;28(1):77-84. doi: 10.1097/IGC.0000000000001149. PMID: 29194189
Ovarian yolk sac tumor in postmenopausal females: a report of five cases and a literature review.
Wang X, He J, Li Y
Eur J Gynaecol Oncol 2016;37(3):374-9. PMID: 27352567
Ovarian Yolk Sac Tumor: The Experience of a Regional Cancer Center.
Wang X, Ma Z, Li Y
Int J Gynecol Cancer 2016 Jun;26(5):884-91. doi: 10.1097/IGC.0000000000000704. PMID: 27104939
Prognosis of hepatoid yolk sac tumor in women: what's up, Doc?
Rittiluechai K, Wilcox R, Lisle J, Everett E, Wallace HJ 3rd, Verschraegen CF
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:25-9. Epub 2014 Jan 3 doi: 10.1016/j.ejogrb.2013.12.029. PMID: 24462393

Therapy

Pregnancy and Delivery After Ovarian Yolk Sac Tumor: A Case Report.
Alrjoub MM, Sindiani A, Alshriedeh O, Amarin Z
Am J Case Rep 2021 Aug 19;22:e932091. doi: 10.12659/AJCR.932091. PMID: 34408122Free PMC Article
Establishment and characterization of an ovarian yolk sac tumor patient-derived xenograft model.
Luo M, He Y, Xie B, Li S, Gan F, Zhang S, Luo P
Pediatr Surg Int 2021 Aug;37(8):1031-1040. Epub 2021 May 24 doi: 10.1007/s00383-021-04895-1. PMID: 34031745
Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review.
Wang Y, Yang J, Yu M, Cao D, Zhang Y, Zong X, Shen K
Medicine (Baltimore) 2018 Aug;97(33):e11838. doi: 10.1097/MD.0000000000011838. PMID: 30113473Free PMC Article
Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line.
Shibata K, Umezu T, Sakurai M, Kajiyama H, Yamamoto E, Ino K, Nawa A, Kikkawa F
Gynecol Obstet Invest 2011;71(2):104-11. Epub 2010 Dec 9 doi: 10.1159/000320744. PMID: 21150160
Ovarian yolk sac tumor associated with endometrioid carcinoma and mucinous cystadenoma of the ovary.
Lopez JM, Malpica A, Deavers MT, Ayala AG
Ann Diagn Pathol 2003 Oct;7(5):300-5. doi: 10.1016/s1092-9134(03)00081-9. PMID: 14571433

Prognosis

Clinicopathological features, prognosis, and fertility outcomes in Chinese Han women treated for ovarian yolk sac tumor: A retrospective case series study from two tertiary-care academic medical centers.
Qin L, Wang B, Wang Z, He D
Medicine (Baltimore) 2022 Jul 22;101(29):e29868. doi: 10.1097/MD.0000000000029868. PMID: 35866762Free PMC Article
Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review.
Wang Y, Yang J, Yu M, Cao D, Zhang Y, Zong X, Shen K
Medicine (Baltimore) 2018 Aug;97(33):e11838. doi: 10.1097/MD.0000000000011838. PMID: 30113473Free PMC Article
Ovarian Yolk Sac Tumors; Does Age Matter?
Faure Conter C, Xia C, Gershenson D, Hurteau J, Covens A, Pashankar F, Krailo M, Billmire D, Patte C, Fresneau B, Shaikh F, Stoneham S, Nicholson J, Murray M, Frazier AL
Int J Gynecol Cancer 2018 Jan;28(1):77-84. doi: 10.1097/IGC.0000000000001149. PMID: 29194189
Ovarian Yolk Sac Tumor: The Experience of a Regional Cancer Center.
Wang X, Ma Z, Li Y
Int J Gynecol Cancer 2016 Jun;26(5):884-91. doi: 10.1097/IGC.0000000000000704. PMID: 27104939
Prognosis of hepatoid yolk sac tumor in women: what's up, Doc?
Rittiluechai K, Wilcox R, Lisle J, Everett E, Wallace HJ 3rd, Verschraegen CF
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:25-9. Epub 2014 Jan 3 doi: 10.1016/j.ejogrb.2013.12.029. PMID: 24462393

Clinical prediction guides

Acute abdominal pain in an adolescent girl with an ovarian yolk sac tumor.
Stefanelli E, Talarico V, Scavone M, Carboni E, Stranieri G, Galati MC, Salerno D, Raiola G
Acta Biomed 2019 Dec 23;90(4):599-602. doi: 10.23750/abm.v90i4.9017. PMID: 31910193Free PMC Article
Prognostic significance of an early decline in serum alpha-fetoprotein during chemotherapy for ovarian yolk sac tumors.
de la Motte Rouge T, Pautier P, Genestie C, Rey A, Gouy S, Leary A, Haie-Meder C, Kerbrat P, Culine S, Fizazi K, Lhommé C
Gynecol Oncol 2016 Sep;142(3):452-7. Epub 2016 Jul 8 doi: 10.1016/j.ygyno.2016.07.005. PMID: 27401840
A case of ovarian endometrioid adenocarcinoma with yolk sac tumor component in a postmenopausal woman.
Kamoi S, Ohaki Y, Mori O, Okada S, Seto M, Matsushita N, Kawamura T, Araki T
APMIS 2002 Jun;110(6):508-14. doi: 10.1034/j.1600-0463.2002.100609.x. PMID: 12193212
Endometrioid-like variant of ovarian yolk sac tumor with foci of carcinoid: an ultrastructural study.
Dickersin GR, Oliva E, Young RH
Ultrastruct Pathol 1995 Sep-Oct;19(5):421-9. doi: 10.3109/01913129509021914. PMID: 7483018
The incidence of yolk sac tumor (endodermal sinus tumor) elements in germ cell tumors of the testis in adults.
Talerman A
Cancer 1975 Jul;36(1):211-5. doi: 10.1002/1097-0142(197507)36:1<211::aid-cncr2820360122>3.0.co;2-w. PMID: 1203848

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