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Intravenous leiomyomatosis

MedGen UID:
83417
•Concept ID:
C0346200
•
Neoplastic Process
Synonyms: Intravascular Leiomyomatosis of the Uterus; Intravascular Leiomyomatosis of Uterus; Intravenous Leiomyomatosis; intravenous leiomyomatosis; Intravenous Leiomyomatosis of the Uterus; Intravenous Leiomyomatosis of Uterus; Uterine Corpus Intravenous Leiomyomatosis
SNOMED CT: Intravenous leiomyomatosis (254883003); Intravenous leiomyomatosis (1157175007)
 
Monarch Initiative: MONDO:0003614

Definition

A rare benign neoplasm characterized by the presence of smooth muscle cells growing within the veins of the uterine corpus. The intravascular neoplasm growth occurs outside the confines of an adjacent leiomyoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntravenous leiomyomatosis
  • Intravenous leiomyomatosis
    • Intravenous leiomyomatosis
      • Intravenous leiomyomatosis
        • Intravenous leiomyomatosis
          • Intravenous leiomyomatosis
            • Intravenous leiomyomatosis
              • Intravenous leiomyomatosis

Professional guidelines

PubMed

Surgical Treatment Strategies of Intravenous Leiomyomatosis withRight Cardiac Cavities Extension.
Ma GT, Miao Q, Liu XR, Zhang CJ, Zheng YH, Shao J, Cheng NH, DU SD, Liu JZ, Jiang C
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2016 Aug;38(4):438-43. doi: 10.3881/j.issn.1000-503X.2016.04.013. PMID: 27594158
Surgical Treatment of Intracardiac-Extending Intravenous Leiomyomatosis: A Single Center Experience.
Li Y, Yang N, Lu L, Ma F, Yao J
Heart Surg Forum 2016 May 9;19(3):E094-6. doi: 10.1532/hsf.1362. PMID: 27355139
Management of intravenous leiomyomatosis with intracaval and intracardiac extension.
Wang J, Yang J, Huang H, Li Y, Miao Q, Lu X, Li Y, Yang N, Huang Y, Chen J, Cao D, Wu M, Pan L, Lang J, Shen K
Obstet Gynecol 2012 Dec;120(6):1400-6. doi: 10.1097/aog.0b013e31826ebb90. PMID: 23168766

Recent clinical studies

Etiology

Intracardiac Extension of Intravenous Leiomyomatosis.
Price JD, Anagnostopoulos C, Benvenisty A, Kothuru RK, Balaram SK
Ann Thorac Surg 2017 Feb;103(2):e145-e147. doi: 10.1016/j.athoracsur.2016.07.037. PMID: 28109375
Giant intravenous leiomyomatosis with intracardiac extension.
Zhang H, Miao Q, Liu J, Wang C, Zhang C, Zhai H
Ann Thorac Surg 2012 Sep;94(3):1013. doi: 10.1016/j.athoracsur.2012.02.047. PMID: 22916760
Intravenous leiomyomatosis with intracardiac extension.
Zhang C, Miao Q, Liu X, Zhang H, Ma G, Chen G, Deng H
Ann Thorac Surg 2010 May;89(5):1641-3. doi: 10.1016/j.athoracsur.2009.09.044. PMID: 20417800
Leiomyomatosis peritonealis disseminata presenting with intravascular extension and coexisting with endometriosis: a case report.
Haberal A, Kayikcioglu F, Caglar GS, Cavusoglu D
J Reprod Med 2007 May;52(5):422-4. PMID: 17583244
Intravenous leiomyomatosis of the uterus: a clinicopathologic study of 22 cases.
Mulvany NJ, Slavin JL, Ostör AG, Fortune DW
Int J Gynecol Pathol 1994 Jan;13(1):1-9. doi: 10.1097/00004347-199401000-00001. PMID: 8112951

Diagnosis

Woman in Her 50s With an Intravenous Mass Extending to the Right Cardiac Chamber.
Li J, Li Q, Shu C
JAMA Cardiol 2023 Nov 1;8(11):1099. doi: 10.1001/jamacardio.2023.3385. PMID: 37792355
Intravenous leiomyomatosis-a case report.
Zaidi AZ, Hawley I, Zaidi J
J Obstet Gynaecol 2021 Aug;41(6):996-997. Epub 2020 Apr 15 doi: 10.1080/01443615.2020.1738362. PMID: 32293219
Intravenous leiomyomatosis.
Ahmed M, Zangos S, Bechstein WO, Vogl TJ
Eur Radiol 2004 Jul;14(7):1316-7. Epub 2004 Jan 6 doi: 10.1007/s00330-003-2186-z. PMID: 14710312
Intravenous leiomyomatosis.
Grella L, Arnold TE, Kvilekval KH, Giron F
J Vasc Surg 1994 Dec;20(6):987-94. doi: 10.1016/0741-5214(94)90237-2. PMID: 7990195
Intravenous leiomyomatosis.
Konrad P, Mellblom L
Acta Obstet Gynecol Scand 1989;68(4):371-6. doi: 10.3109/00016348909028675. PMID: 2618625

Therapy

Treatment of Disseminated Intravenous Leiomyomatosis With ALK Targeting Crizotinib: A Successful Case Report.
Barreto-Coelho P, Rosenberg A, Subhawong T, Costa P, Espejo-Freire AP, Bialick S, Jonczak E, Trent JC, D'Amato GZ
JCO Precis Oncol 2022 Feb;6:e2100336. doi: 10.1200/PO.21.00336. PMID: 35108034
Intravenous leiomyomatosis without extrapelvic involvement.
Mata RP, Urzal C, Belo AI, Guerreiro F
BMJ Case Rep 2020 Mar 18;13(3) doi: 10.1136/bcr-2020-234864. PMID: 32193185Free PMC Article
Anesthesia management for surgical resection of inferior vena caval tumor thrombus extending into right cardiac cavities.
Zhu B, Huang YG, Miao Q
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2014 Jun;36(3):336-9. doi: 10.3881/j.issn.1000-503X.2014.03.021. PMID: 24997830
Uterine smooth-muscle tumors with unusual growth patterns.
Vaquero ME, Magrina JF, Leslie KO
J Minim Invasive Gynecol 2009 May-Jun;16(3):263-8. doi: 10.1016/j.jmig.2009.01.013. PMID: 19423058
Intracardiac leiomyomatosis. Case report and literature review.
Lo KW, Lau TK
Arch Gynecol Obstet 2001 Jan;264(4):209-10. doi: 10.1007/s004040000115. PMID: 11205711

Prognosis

Intravenous leiomyomatosis involving the right heart: Comprehensive evaluation using echocardiography combined with abdominal ultrasonography.
Han X, Nie F, Li J, Zhao Y, Wang X
Echocardiography 2023 Aug;40(8):852-855. Epub 2023 Jun 4 doi: 10.1111/echo.15565. PMID: 37270687
Computed tomography evaluation of extensive intravenous angioleiomyoma: a case report.
Sun R, Guan H, Li H, Bai Y, Wang F, Li C
BMC Med Imaging 2020 Feb 7;20(1):13. doi: 10.1186/s12880-020-0417-2. PMID: 32028907Free PMC Article
Giant intravenous leiomyomatosis with intracardiac extension.
Zhang H, Miao Q, Liu J, Wang C, Zhang C, Zhai H
Ann Thorac Surg 2012 Sep;94(3):1013. doi: 10.1016/j.athoracsur.2012.02.047. PMID: 22916760
Intravenous leiomyomatosis with intracardiac extension.
Zhang C, Miao Q, Liu X, Zhang H, Ma G, Chen G, Deng H
Ann Thorac Surg 2010 May;89(5):1641-3. doi: 10.1016/j.athoracsur.2009.09.044. PMID: 20417800
Intravenous leiomyomatosis.
Konrad P, Mellblom L
Acta Obstet Gynecol Scand 1989;68(4):371-6. doi: 10.3109/00016348909028675. PMID: 2618625

Clinical prediction guides

A 'Groot'∗ in the heart: Rare intravascular leiomyomatosis mimicking central pulmonary embolism.
Wu P, Konugres G, Kern MJ
J Cardiovasc Comput Tomogr 2024 Mar-Apr;18(2):e5-e7. Epub 2023 Dec 12 doi: 10.1016/j.jcct.2023.12.002. PMID: 38092637
Primary leiomyoma of the inferior vena cava mimicking a cystic neoplasm of the pancreas: a case report.
Gao B, Zhou D, Qian X, Zhang W, Ying L, Wang W
Cardiovasc Pathol 2020 May-Jun;46:107097. Epub 2018 Dec 4 doi: 10.1016/j.carpath.2018.11.003. PMID: 32086002
A case of uterine leiomyoma with intravenous leiomyomatosis--histological investigation of the pathological condition--.
Fukuyama A, Yokoyama Y, Futagami M, Shigeto T, Wada R, Mizunuma H
Pathol Oncol Res 2011 Mar;17(1):171-4. Epub 2010 Apr 10 doi: 10.1007/s12253-010-9265-7. PMID: 20383619
An unusual case of recurrent mass in the right atrium: intravenous leiomyomatosis.
Ozer N, Engin H, Akgül E, Sahiner L, Atalar E, Aksöyek S, Ovünç K, Ozmen F, Kes S
Echocardiography 2005 Jul;22(6):514-6. doi: 10.1111/j.1540-8175.2005.04053.x. PMID: 15966937
Perinodular hydropic degeneration of a uterine leiomyoma: a diagnostic challenge.
Coad JE, Sulaiman RA, Das K, Staley N
Hum Pathol 1997 Feb;28(2):249-51. doi: 10.1016/s0046-8177(97)90115-5. PMID: 9023411

Recent systematic reviews

Manifestation and management of intravenous leiomyomatosis: A systematic review of the literature.
Lim WH, Lamaro VP, Sivagnanam V
Surg Oncol 2022 Dec;45:101879. Epub 2022 Oct 17 doi: 10.1016/j.suronc.2022.101879. PMID: 36332557
The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis.
Liang J, Lei R, Xie M, Lin S, Xu J, Ling X, Xie Q
Orphanet J Rare Dis 2021 Oct 29;16(1):453. doi: 10.1186/s13023-021-02087-7. PMID: 34715881Free PMC Article
The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343
Successful extraction of cardiac-extending intravenous leiomyomatosis through gonadal vein.
Matsuo K, Fleischman F, Ghattas CS, Gabrielyan AS, Ballard CA, Roman LD, Morrow CP
Fertil Steril 2012 Nov;98(5):1341-5.e1. Epub 2012 Aug 15 doi: 10.1016/j.fertnstert.2012.07.1121. PMID: 22902061

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