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Intravenous leiomyomatosis

MedGen UID:
83417
•Concept ID:
C0346200
•
Neoplastic Process
Synonyms: Intravascular Leiomyomatosis of the Uterus; Intravascular Leiomyomatosis of Uterus; Intravenous Leiomyomatosis; intravenous leiomyomatosis; Intravenous Leiomyomatosis of the Uterus; Intravenous Leiomyomatosis of Uterus; Uterine Corpus Intravenous Leiomyomatosis
SNOMED CT: Intravenous leiomyomatosis (254883003); Intravenous leiomyomatosis (1157175007)
 
Monarch Initiative: MONDO:0003614

Definition

A rare benign neoplasm characterized by the presence of smooth muscle cells growing within the veins of the uterine corpus. The intravascular neoplasm growth occurs outside the confines of an adjacent leiomyoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntravenous leiomyomatosis
  • Intravenous leiomyomatosis
    • Intravenous leiomyomatosis
      • Intravenous leiomyomatosis
        • Intravenous leiomyomatosis
          • Intravenous leiomyomatosis
            • Intravenous leiomyomatosis
              • Intravenous leiomyomatosis

Professional guidelines

PubMed

Surgical Treatment Strategies of Intravenous Leiomyomatosis withRight Cardiac Cavities Extension.
Ma GT, Miao Q, Liu XR, Zhang CJ, Zheng YH, Shao J, Cheng NH, DU SD, Liu JZ, Jiang C
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2016 Aug;38(4):438-43. doi: 10.3881/j.issn.1000-503X.2016.04.013. PMID: 27594158
Surgical Treatment of Intracardiac-Extending Intravenous Leiomyomatosis: A Single Center Experience.
Li Y, Yang N, Lu L, Ma F, Yao J
Heart Surg Forum 2016 May 9;19(3):E094-6. doi: 10.1532/hsf.1362. PMID: 27355139
Management of intravenous leiomyomatosis with intracaval and intracardiac extension.
Wang J, Yang J, Huang H, Li Y, Miao Q, Lu X, Li Y, Yang N, Huang Y, Chen J, Cao D, Wu M, Pan L, Lang J, Shen K
Obstet Gynecol 2012 Dec;120(6):1400-6. doi: 10.1097/aog.0b013e31826ebb90. PMID: 23168766

Recent clinical studies

Etiology

Clinicopathologic features and clinical outcomes of intravenous leiomyomatosis of the uterus: A case series.
Yu X, Fu J, Cao T, Huang L, Qie M, Ouyang Y
Medicine (Baltimore) 2021 Jan 8;100(1):e24228. doi: 10.1097/MD.0000000000024228. PMID: 33429819Free PMC Article
Experience in the diagnosis and treatment of intravenous leiomyomatosis involving the inferior vena cava and/or right cardiac chambers.
Lian C, Yin S, Qiu J, Cui J, Hu Z, Chang G, Wang S, Wang J
J Vasc Surg Venous Lymphat Disord 2021 Mar;9(2):452-460. Epub 2020 May 25 doi: 10.1016/j.jvsv.2020.05.011. PMID: 32464287
Molecular and clinicopathologic characterization of intravenous leiomyomatosis.
Ordulu Z, Chai H, Peng G, McDonald AG, De Nictolis M, Garcia-Fernandez E, Hardisson D, Prat J, Li P, Hui P, Oliva E, Buza N
Mod Pathol 2020 Sep;33(9):1844-1860. Epub 2020 Apr 27 doi: 10.1038/s41379-020-0546-8. PMID: 32341498Free PMC Article
Contrast-enhanced CT findings of intravenous leiomyomatosis.
Wang H, Nie P, Chen B, Hou F, Dong C, He F, Xu W
Clin Radiol 2018 May;73(5):503.e1-503.e6. Epub 2018 Feb 1 doi: 10.1016/j.crad.2017.12.016. PMID: 29395222
Intravenous leiomyomatosis with intracardiac extension: echocardiographic study and literature review.
Li R, Shen Y, Sun Y, Zhang C, Yang Y, Yang J, Su R, Jiang B
Tex Heart Inst J 2014 Oct;41(5):502-6. Epub 2014 Oct 1 doi: 10.14503/THIJ-13-3533. PMID: 25425982Free PMC Article

Diagnosis

"Evolution" of intravascular leiomyomatosis.
Chen L, Yang Y, Zhao C
BMC Womens Health 2023 Sep 11;23(1):483. doi: 10.1186/s12905-023-02618-3. PMID: 37697329Free PMC Article
Intravenous Leiomyomatosis of the Uterus: A Retrospective Single-Center Study in 14 Cases.
Su Q, Zhang X, Zhang H, Liu Y, Dong Z, Li G, Ding X, Liu Y, Jiang J
Biomed Res Int 2020;2020:9758302. Epub 2020 Feb 14 doi: 10.1155/2020/9758302. PMID: 32337287Free PMC Article
Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization.
Kainsbak J, Hansen ES, Dueholm M
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:130-7. Epub 2015 Jun 11 doi: 10.1016/j.ejogrb.2015.05.018. PMID: 26117442
Intravenous leiomyomatosis with intracardiac extension: echocardiographic study and literature review.
Li R, Shen Y, Sun Y, Zhang C, Yang Y, Yang J, Su R, Jiang B
Tex Heart Inst J 2014 Oct;41(5):502-6. Epub 2014 Oct 1 doi: 10.14503/THIJ-13-3533. PMID: 25425982Free PMC Article
Leiomyomas beyond the uterus: unusual locations, rare manifestations.
Fasih N, Prasad Shanbhogue AK, Macdonald DB, Fraser-Hill MA, Papadatos D, Kielar AZ, Doherty GP, Walsh C, McInnes M, Atri M
Radiographics 2008 Nov-Dec;28(7):1931-48. doi: 10.1148/rg.287085095. PMID: 19001649

Therapy

Safety and efficacy of sirolimus in recurrent intravenous leiomyomatosis, pulmonary benign metastatic leiomyomatosis, and leiomyomatosis peritonealis disseminata: a pilot study.
Zhang G, Fan R, Yang H, Su H, Yu X, Wang Y, Feng F, Zhu L
BMC Med 2024 Mar 13;22(1):119. doi: 10.1186/s12916-024-03344-9. PMID: 38481209Free PMC Article
The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis.
Liang J, Lei R, Xie M, Lin S, Xu J, Ling X, Xie Q
Orphanet J Rare Dis 2021 Oct 29;16(1):453. doi: 10.1186/s13023-021-02087-7. PMID: 34715881Free PMC Article
Intravenous leiomyomatosis of the uterus: A clinicopathological analysis of nine cases and literature review.
Low HY, Zhao Y, Huang KS, Shen HP, Wu PJ, Tseng CJ
Taiwan J Obstet Gynecol 2017 Jun;56(3):362-365. doi: 10.1016/j.tjog.2017.04.017. PMID: 28600049
Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization.
Kainsbak J, Hansen ES, Dueholm M
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:130-7. Epub 2015 Jun 11 doi: 10.1016/j.ejogrb.2015.05.018. PMID: 26117442
Management of intravenous leiomyomatosis with intracaval and intracardiac extension.
Wang J, Yang J, Huang H, Li Y, Miao Q, Lu X, Li Y, Yang N, Huang Y, Chen J, Cao D, Wu M, Pan L, Lang J, Shen K
Obstet Gynecol 2012 Dec;120(6):1400-6. doi: 10.1097/aog.0b013e31826ebb90. PMID: 23168766

Prognosis

Intravenous Leiomyomatosis of the Uterus: A Retrospective Single-Center Study in 14 Cases.
Su Q, Zhang X, Zhang H, Liu Y, Dong Z, Li G, Ding X, Liu Y, Jiang J
Biomed Res Int 2020;2020:9758302. Epub 2020 Feb 14 doi: 10.1155/2020/9758302. PMID: 32337287Free PMC Article
Subserosal Leiomyoma with Intravenous Leiomyomatosis Extending into Inferior Vena Cava and Right-sided Cardiac Chambers.
Gul P, Gul K, Gul P, Jogezai S
J Coll Physicians Surg Pak 2019 Aug;29(8):775-777. doi: 10.29271/jcpsp.2019.08.775. PMID: 31358103
Intravenous leiomyomatosis of the uterus: A clinicopathological analysis of nine cases and literature review.
Low HY, Zhao Y, Huang KS, Shen HP, Wu PJ, Tseng CJ
Taiwan J Obstet Gynecol 2017 Jun;56(3):362-365. doi: 10.1016/j.tjog.2017.04.017. PMID: 28600049
Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization.
Kainsbak J, Hansen ES, Dueholm M
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:130-7. Epub 2015 Jun 11 doi: 10.1016/j.ejogrb.2015.05.018. PMID: 26117442
Intravenous leiomyomatosis.
Konrad P, Mellblom L
Acta Obstet Gynecol Scand 1989;68(4):371-6. doi: 10.3109/00016348909028675. PMID: 2618625

Clinical prediction guides

"Evolution" of intravascular leiomyomatosis.
Chen L, Yang Y, Zhao C
BMC Womens Health 2023 Sep 11;23(1):483. doi: 10.1186/s12905-023-02618-3. PMID: 37697329Free PMC Article
Two oncomiRs, miR-182-5p and miR-103a-3p, Involved in Intravenous Leiomyomatosis.
Barnaś E, Skręt-Magierło JE, Paszek S, Kaznowska E, Potocka N, Skręt A, Sakowicz A, Zawlik I
Genes (Basel) 2023 Mar 14;14(3) doi: 10.3390/genes14030712. PMID: 36980984Free PMC Article
Echocardiographic Characteristics and Contrast-Enhanced Imaging of Intravenous Leiomyomatosis With Intracardiac Extension.
Ma H, Niu Y, Yang Z, Zheng M
J Ultrasound Med 2022 May;41(5):1101-1108. Epub 2021 Aug 11 doi: 10.1002/jum.15799. PMID: 34382236
Molecular and clinicopathologic characterization of intravenous leiomyomatosis.
Ordulu Z, Chai H, Peng G, McDonald AG, De Nictolis M, Garcia-Fernandez E, Hardisson D, Prat J, Li P, Hui P, Oliva E, Buza N
Mod Pathol 2020 Sep;33(9):1844-1860. Epub 2020 Apr 27 doi: 10.1038/s41379-020-0546-8. PMID: 32341498Free PMC Article
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397

Recent systematic reviews

Manifestation and management of intravenous leiomyomatosis: A systematic review of the literature.
Lim WH, Lamaro VP, Sivagnanam V
Surg Oncol 2022 Dec;45:101879. Epub 2022 Oct 17 doi: 10.1016/j.suronc.2022.101879. PMID: 36332557
The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis.
Liang J, Lei R, Xie M, Lin S, Xu J, Ling X, Xie Q
Orphanet J Rare Dis 2021 Oct 29;16(1):453. doi: 10.1186/s13023-021-02087-7. PMID: 34715881Free PMC Article
The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343
Successful extraction of cardiac-extending intravenous leiomyomatosis through gonadal vein.
Matsuo K, Fleischman F, Ghattas CS, Gabrielyan AS, Ballard CA, Roman LD, Morrow CP
Fertil Steril 2012 Nov;98(5):1341-5.e1. Epub 2012 Aug 15 doi: 10.1016/j.fertnstert.2012.07.1121. PMID: 22902061

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