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Iris nevus

MedGen UID:
83423
Concept ID:
C0346376
Neoplastic Process
Synonyms: Benign melanoma of iris; Eye freckle; Iris Nevus; Nevus of iris; Nevus of Iris; Nevus of the Iris
SNOMED CT: Benign melanoma of iris (95711003); Nevus of iris (95711003); Iris nevus (95711003)
 
HPO: HP:0011525

Definition

A benign brown pigmented area over the iris representing proliferation of melanocyte cells in the stromal layer of the iris. An iris nevus can be flat or occasionally slightly elevated. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIris nevus

Professional guidelines

PubMed

Shields JA, Sanborn GE, Augsburger JJ
Ophthalmology 1983 Jun;90(6):716-20. doi: 10.1016/s0161-6420(83)34500-0. PMID: 6888862

Recent clinical studies

Etiology

Grimaldos Ruiz P
Int Ophthalmol 2021 Apr;41(4):1381-1393. Epub 2021 Jan 23 doi: 10.1007/s10792-021-01693-5. PMID: 33484383Free PMC Article
Shields CL, Kels JG, Shields JA
Clin Dermatol 2015 Mar-Apr;33(2):183-96. Epub 2015 Jan 14 doi: 10.1016/j.clindermatol.2014.10.010. PMID: 25704938
Schwab C, Zalaudek I, Mayer C, Riedl R, Wackernagel W, Juch H, Aigner B, Brunasso AM, Langmann G, Richtig E
Br J Ophthalmol 2015 May;99(5):644-9. Epub 2014 Oct 30 doi: 10.1136/bjophthalmol-2014-305849. PMID: 25359901
Shields CL, Kaliki S, Hutchinson A, Nickerson S, Patel J, Kancherla S, Peshtani A, Nakhoda S, Kocher K, Kolbus E, Jacobs E, Garoon R, Walker B, Rogers B, Shields JA
Ophthalmology 2013 Apr;120(4):766-72. Epub 2013 Jan 3 doi: 10.1016/j.ophtha.2012.09.042. PMID: 23290981
Ticho BH, Tso MO, Kishi S
J Pediatr Ophthalmol Strabismus 1989 Sep-Oct;26(5):244-50. doi: 10.3928/0191-3913-19890901-10. PMID: 2795414

Diagnosis

Xavier C, Hipolito-Fernandes D, Cardigos J, Magriço A
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-237269. PMID: 33318246Free PMC Article
Shields JA, Shields CL
Asia Pac J Ophthalmol (Phila) 2017 Jan-Feb;6(1):64-69. doi: 10.22608/APO.201613. PMID: 28161919
Saldaña-Garrido JD, Martínez-Hergueta MC, Martínez-Rubio MM
Arch Soc Esp Oftalmol 2017 Jul;92(7):347-350. Epub 2016 Jun 1 doi: 10.1016/j.oftal.2016.04.005. PMID: 27262610
Mahdavi Fard A, Pourafkari L, Nader ND
QJM 2016 Feb;109(2):137. Epub 2015 Oct 1 doi: 10.1093/qjmed/hcv169. PMID: 26428339
Gokhale R, Medina CA, Biscotti CV, Singh AD
Asia Pac J Ophthalmol (Phila) 2015 Mar-Apr;4(2):89-91. doi: 10.1097/APO.0000000000000083. PMID: 26065351

Therapy

Grimaldos Ruiz P
Int Ophthalmol 2021 Apr;41(4):1381-1393. Epub 2021 Jan 23 doi: 10.1007/s10792-021-01693-5. PMID: 33484383Free PMC Article
Harley MR, Rao R, Lally SE, Shields CL
J AAPOS 2017 Aug;21(4):340-342. Epub 2017 Jun 16 doi: 10.1016/j.jaapos.2017.06.007. PMID: 28630029
Schwab C, Zalaudek I, Mayer C, Riedl R, Wackernagel W, Juch H, Aigner B, Brunasso AM, Langmann G, Richtig E
Br J Ophthalmol 2015 May;99(5):644-9. Epub 2014 Oct 30 doi: 10.1136/bjophthalmol-2014-305849. PMID: 25359901
Ozdemir Y, Onder F, Coşar CB, Usubütün A, Kural G
Acta Ophthalmol Scand 1999 Apr;77(2):234-7. doi: 10.1034/j.1600-0420.1999.770226.x. PMID: 10321548

Prognosis

Oyemade KA, Xu TT, Lopez Dominguez J, Dumbrava MG, Hodge DO, White LJ, Dalvin LA
Br J Ophthalmol 2023 Sep;107(9):1369-1376. Epub 2022 Apr 21 doi: 10.1136/bjophthalmol-2021-320682. PMID: 35450938Free PMC Article
Grimaldos Ruiz P
Int Ophthalmol 2021 Apr;41(4):1381-1393. Epub 2021 Jan 23 doi: 10.1007/s10792-021-01693-5. PMID: 33484383Free PMC Article
Xavier C, Hipolito-Fernandes D, Cardigos J, Magriço A
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-237269. PMID: 33318246Free PMC Article
Shields CL, Kels JG, Shields JA
Clin Dermatol 2015 Mar-Apr;33(2):183-96. Epub 2015 Jan 14 doi: 10.1016/j.clindermatol.2014.10.010. PMID: 25704938
Shields CL, Kaliki S, Hutchinson A, Nickerson S, Patel J, Kancherla S, Peshtani A, Nakhoda S, Kocher K, Kolbus E, Jacobs E, Garoon R, Walker B, Rogers B, Shields JA
Ophthalmology 2013 Apr;120(4):766-72. Epub 2013 Jan 3 doi: 10.1016/j.ophtha.2012.09.042. PMID: 23290981

Clinical prediction guides

Grimaldos Ruiz P
Int Ophthalmol 2021 Apr;41(4):1381-1393. Epub 2021 Jan 23 doi: 10.1007/s10792-021-01693-5. PMID: 33484383Free PMC Article
Shields JA, Shields CL
Asia Pac J Ophthalmol (Phila) 2017 Jan-Feb;6(1):64-69. doi: 10.22608/APO.201613. PMID: 28161919
Saldaña-Garrido JD, Martínez-Hergueta MC, Martínez-Rubio MM
Arch Soc Esp Oftalmol 2017 Jul;92(7):347-350. Epub 2016 Jun 1 doi: 10.1016/j.oftal.2016.04.005. PMID: 27262610
Schwab C, Zalaudek I, Mayer C, Riedl R, Wackernagel W, Juch H, Aigner B, Brunasso AM, Langmann G, Richtig E
Br J Ophthalmol 2015 May;99(5):644-9. Epub 2014 Oct 30 doi: 10.1136/bjophthalmol-2014-305849. PMID: 25359901
Shields CL, Kaliki S, Hutchinson A, Nickerson S, Patel J, Kancherla S, Peshtani A, Nakhoda S, Kocher K, Kolbus E, Jacobs E, Garoon R, Walker B, Rogers B, Shields JA
Ophthalmology 2013 Apr;120(4):766-72. Epub 2013 Jan 3 doi: 10.1016/j.ophtha.2012.09.042. PMID: 23290981

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