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Disorder of kidney due to diabetes mellitus

MedGen UID:
8352
•Concept ID:
C0011881
•
Disease or Syndrome
Synonyms: Diabetic Kidney Disease; Diabetic Kidney Diseases; Diabetic Nephropathies; Diabetic Nephropathy; Kidney Disease, Diabetic; Kidney Diseases, Diabetic; Nephropathies, Diabetic; Nephropathy, Diabetic
SNOMED CT: Diabetic nephropathy (127013003); Renal disorder associated with diabetes mellitus (127013003); Diabetic renal disease (127013003); Kidney disorder due to diabetes mellitus (127013003); Disorder of kidney due to diabetes mellitus (127013003)

Definition

Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of kidney due to diabetes mellitus

Professional guidelines

PubMed

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment.
Samsu N
Biomed Res Int 2021;2021:1497449. Epub 2021 Jul 8 doi: 10.1155/2021/1497449. PMID: 34307650Free PMC Article
Classification and Differential Diagnosis of Diabetic Nephropathy.
Qi C, Mao X, Zhang Z, Wu H
J Diabetes Res 2017;2017:8637138. Epub 2017 Feb 20 doi: 10.1155/2017/8637138. PMID: 28316995Free PMC Article

Recent clinical studies

Etiology

Molecular mechanisms and therapeutic targets for diabetic kidney disease.
Tuttle KR, Agarwal R, Alpers CE, Bakris GL, Brosius FC, Kolkhof P, Uribarri J
Kidney Int 2022 Aug;102(2):248-260. Epub 2022 Jun 3 doi: 10.1016/j.kint.2022.05.012. PMID: 35661785
Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment.
Samsu N
Biomed Res Int 2021;2021:1497449. Epub 2021 Jul 8 doi: 10.1155/2021/1497449. PMID: 34307650Free PMC Article
Diabetic Kidney Disease.
Bonner R, Albajrami O, Hudspeth J, Upadhyay A
Prim Care 2020 Dec;47(4):645-659. Epub 2020 Sep 23 doi: 10.1016/j.pop.2020.08.004. PMID: 33121634
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
Alicic RZ, Rooney MT, Tuttle KR
Clin J Am Soc Nephrol 2017 Dec 7;12(12):2032-2045. Epub 2017 May 18 doi: 10.2215/CJN.11491116. PMID: 28522654Free PMC Article
Diabetic kidney disease.
Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S, Rossing P, Groop PH, Cooper ME
Nat Rev Dis Primers 2015 Jul 30;1:15018. doi: 10.1038/nrdp.2015.18. PMID: 27188921Free PMC Article

Diagnosis

Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature.
Thipsawat S
Diab Vasc Dis Res 2021 Nov-Dec;18(6):14791641211058856. doi: 10.1177/14791641211058856. PMID: 34791910Free PMC Article
Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment.
Samsu N
Biomed Res Int 2021;2021:1497449. Epub 2021 Jul 8 doi: 10.1155/2021/1497449. PMID: 34307650Free PMC Article
Diabetic Kidney Disease.
Bonner R, Albajrami O, Hudspeth J, Upadhyay A
Prim Care 2020 Dec;47(4):645-659. Epub 2020 Sep 23 doi: 10.1016/j.pop.2020.08.004. PMID: 33121634
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
Alicic RZ, Rooney MT, Tuttle KR
Clin J Am Soc Nephrol 2017 Dec 7;12(12):2032-2045. Epub 2017 May 18 doi: 10.2215/CJN.11491116. PMID: 28522654Free PMC Article
Classification and Differential Diagnosis of Diabetic Nephropathy.
Qi C, Mao X, Zhang Z, Wu H
J Diabetes Res 2017;2017:8637138. Epub 2017 Feb 20 doi: 10.1155/2017/8637138. PMID: 28316995Free PMC Article

Therapy

SGLT2 inhibitors in non-diabetic kidney disease.
Tesař V
Adv Clin Exp Med 2022 Feb;31(2):105-107. doi: 10.17219/acem/145734. PMID: 35077036
Treatment of Diabetic Kidney Disease: Current and Future.
Yamazaki T, Mimura I, Tanaka T, Nangaku M
Diabetes Metab J 2021 Jan;45(1):11-26. Epub 2021 Jan 22 doi: 10.4093/dmj.2020.0217. PMID: 33508907Free PMC Article
The dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial: baseline characteristics.
Wheeler DC, Stefansson BV, Batiushin M, Bilchenko O, Cherney DZI, Chertow GM, Douthat W, Dwyer JP, Escudero E, Pecoits-Filho R, Furuland H, Górriz JL, Greene T, Haller H, Hou FF, Kang SW, Isidto R, Khullar D, Mark PB, McMurray JJV, Kashihara N, Nowicki M, Persson F, Correa-Rotter R, Rossing P, Toto RD, Umanath K, Van Bui P, Wittmann I, Lindberg M, Sjöström CD, Langkilde AM, Heerspink HJL
Nephrol Dial Transplant 2020 Oct 1;35(10):1700-1711. doi: 10.1093/ndt/gfaa234. PMID: 32862232Free PMC Article
Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
Kristensen SL, Rørth R, Jhund PS, Docherty KF, Sattar N, Preiss D, Køber L, Petrie MC, McMurray JJV
Lancet Diabetes Endocrinol 2019 Oct;7(10):776-785. Epub 2019 Aug 14 doi: 10.1016/S2213-8587(19)30249-9. PMID: 31422062
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
Alicic RZ, Rooney MT, Tuttle KR
Clin J Am Soc Nephrol 2017 Dec 7;12(12):2032-2045. Epub 2017 May 18 doi: 10.2215/CJN.11491116. PMID: 28522654Free PMC Article

Prognosis

Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019.
Deng Y, Li N, Wu Y, Wang M, Yang S, Zheng Y, Deng X, Xiang D, Zhu Y, Xu P, Zhai Z, Zhang D, Dai Z, Gao J
Front Endocrinol (Lausanne) 2021;12:672350. Epub 2021 Jul 1 doi: 10.3389/fendo.2021.672350. PMID: 34276558Free PMC Article
Significance of Metformin Use in Diabetic Kidney Disease.
Kawanami D, Takashi Y, Tanabe M
Int J Mol Sci 2020 Jun 14;21(12) doi: 10.3390/ijms21124239. PMID: 32545901Free PMC Article
Progression of diabetic kidney disease and trajectory of kidney function decline in Chinese patients with Type 2 diabetes.
Jiang G, Luk AOY, Tam CHT, Xie F, Carstensen B, Lau ESH, Lim CKP, Lee HM, Ng ACW, Ng MCY, Ozaki R, Kong APS, Chow CC, Yang X, Lan HY, Tsui SKW, Fan X, Szeto CC, So WY, Chan JCN, Ma RCW; Hong Kong Diabetes Register TRS Study Group
Kidney Int 2019 Jan;95(1):178-187. Epub 2018 Nov 8 doi: 10.1016/j.kint.2018.08.026. PMID: 30415941
Inflammation, oxidative stress, apoptosis, and autophagy in diabetes mellitus and diabetic kidney disease: the Four Horsemen of the Apocalypse.
Turkmen K
Int Urol Nephrol 2017 May;49(5):837-844. Epub 2016 Dec 29 doi: 10.1007/s11255-016-1488-4. PMID: 28035619
Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease.
Thomas MC, Cooper ME, Zimmet P
Nat Rev Nephrol 2016 Feb;12(2):73-81. Epub 2015 Nov 10 doi: 10.1038/nrneph.2015.173. PMID: 26553517

Clinical prediction guides

Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature.
Thipsawat S
Diab Vasc Dis Res 2021 Nov-Dec;18(6):14791641211058856. doi: 10.1177/14791641211058856. PMID: 34791910Free PMC Article
Macrophage Phenotype and Fibrosis in Diabetic Nephropathy.
Calle P, Hotter G
Int J Mol Sci 2020 Apr 17;21(8) doi: 10.3390/ijms21082806. PMID: 32316547Free PMC Article
Classification and Differential Diagnosis of Diabetic Nephropathy.
Qi C, Mao X, Zhang Z, Wu H
J Diabetes Res 2017;2017:8637138. Epub 2017 Feb 20 doi: 10.1155/2017/8637138. PMID: 28316995Free PMC Article
Diagnosis and Management of Type 2 Diabetic Kidney Disease.
Doshi SM, Friedman AN
Clin J Am Soc Nephrol 2017 Aug 7;12(8):1366-1373. Epub 2017 Mar 9 doi: 10.2215/CJN.11111016. PMID: 28280116Free PMC Article
Molecular mechanisms of diabetic kidney disease.
Reidy K, Kang HM, Hostetter T, Susztak K
J Clin Invest 2014 Jun;124(6):2333-40. Epub 2014 Jun 2 doi: 10.1172/JCI72271. PMID: 24892707Free PMC Article

Recent systematic reviews

Association of SGLT2 inhibitors with cardiovascular, kidney, and safety outcomes among patients with diabetic kidney disease: a meta-analysis.
Kaze AD, Zhuo M, Kim SC, Patorno E, Paik JM
Cardiovasc Diabetol 2022 Mar 23;21(1):47. doi: 10.1186/s12933-022-01476-x. PMID: 35321742Free PMC Article
SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis.
Neuen BL, Young T, Heerspink HJL, Neal B, Perkovic V, Billot L, Mahaffey KW, Charytan DM, Wheeler DC, Arnott C, Bompoint S, Levin A, Jardine MJ
Lancet Diabetes Endocrinol 2019 Nov;7(11):845-854. Epub 2019 Sep 5 doi: 10.1016/S2213-8587(19)30256-6. PMID: 31495651
Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
Kristensen SL, Rørth R, Jhund PS, Docherty KF, Sattar N, Preiss D, Køber L, Petrie MC, McMurray JJV
Lancet Diabetes Endocrinol 2019 Oct;7(10):776-785. Epub 2019 Aug 14 doi: 10.1016/S2213-8587(19)30249-9. PMID: 31422062
Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta-analysis.
Toyama T, Neuen BL, Jun M, Ohkuma T, Neal B, Jardine MJ, Heerspink HL, Wong MG, Ninomiya T, Wada T, Perkovic V
Diabetes Obes Metab 2019 May;21(5):1237-1250. Epub 2019 Mar 4 doi: 10.1111/dom.13648. PMID: 30697905
SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
Zelniker TA, Wiviott SD, Raz I, Im K, Goodrich EL, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Furtado RHM, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Sabatine MS
Lancet 2019 Jan 5;393(10166):31-39. Epub 2018 Nov 10 doi: 10.1016/S0140-6736(18)32590-X. PMID: 30424892

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