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Diabetic kidney disease

MedGen UID:
8352
•Concept ID:
C0011881
•
Disease or Syndrome
Synonym: Diabetic nephropathy
SNOMED CT: Diabetic nephropathy (127013003); Renal disorder associated with diabetes mellitus (127013003); Diabetic renal disease (127013003); Kidney disorder due to diabetes mellitus (127013003); Disorder of kidney due to diabetes mellitus (127013003)
 
Monarch Initiative: MONDO:0005016

Definition

Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiabetic kidney disease

Professional guidelines

PubMed

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Treatment of Diabetic Kidney Disease: Current and Future.
Yamazaki T, Mimura I, Tanaka T, Nangaku M
Diabetes Metab J 2021 Jan;45(1):11-26. Epub 2021 Jan 22 doi: 10.4093/dmj.2020.0217. PMID: 33508907Free PMC Article
Update of pathophysiology and management of diabetic kidney disease.
Lin YC, Chang YH, Yang SY, Wu KD, Chu TS
J Formos Med Assoc 2018 Aug;117(8):662-675. Epub 2018 Mar 2 doi: 10.1016/j.jfma.2018.02.007. PMID: 29486908

Recent clinical studies

Etiology

Molecular mechanisms and therapeutic targets for diabetic kidney disease.
Tuttle KR, Agarwal R, Alpers CE, Bakris GL, Brosius FC, Kolkhof P, Uribarri J
Kidney Int 2022 Aug;102(2):248-260. Epub 2022 Jun 3 doi: 10.1016/j.kint.2022.05.012. PMID: 35661785
Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease.
Jung CY, Yoo TH
Diabetes Metab J 2022 Mar;46(2):181-197. Epub 2022 Mar 24 doi: 10.4093/dmj.2021.0329. PMID: 35385633Free PMC Article
Diabetic Kidney Disease.
Bonner R, Albajrami O, Hudspeth J, Upadhyay A
Prim Care 2020 Dec;47(4):645-659. Epub 2020 Sep 23 doi: 10.1016/j.pop.2020.08.004. PMID: 33121634
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
Alicic RZ, Rooney MT, Tuttle KR
Clin J Am Soc Nephrol 2017 Dec 7;12(12):2032-2045. Epub 2017 May 18 doi: 10.2215/CJN.11491116. PMID: 28522654Free PMC Article
Diabetic kidney disease.
Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S, Rossing P, Groop PH, Cooper ME
Nat Rev Dis Primers 2015 Jul 30;1:15018. doi: 10.1038/nrdp.2015.18. PMID: 27188921Free PMC Article

Diagnosis

Diabetic Kidney Disease: An Update.
Gupta S, Dominguez M, Golestaneh L
Med Clin North Am 2023 Jul;107(4):689-705. Epub 2023 Apr 7 doi: 10.1016/j.mcna.2023.03.004. PMID: 37258007
Diabetic Kidney Disease.
Bonner R, Albajrami O, Hudspeth J, Upadhyay A
Prim Care 2020 Dec;47(4):645-659. Epub 2020 Sep 23 doi: 10.1016/j.pop.2020.08.004. PMID: 33121634
Diabetic Kidney Disease: Past and Present.
Akhtar M, Taha NM, Nauman A, Mujeeb IB, Al-Nabet ADMH
Adv Anat Pathol 2020 Mar;27(2):87-97. doi: 10.1097/PAP.0000000000000257. PMID: 31876542
Update of pathophysiology and management of diabetic kidney disease.
Lin YC, Chang YH, Yang SY, Wu KD, Chu TS
J Formos Med Assoc 2018 Aug;117(8):662-675. Epub 2018 Mar 2 doi: 10.1016/j.jfma.2018.02.007. PMID: 29486908
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
Alicic RZ, Rooney MT, Tuttle KR
Clin J Am Soc Nephrol 2017 Dec 7;12(12):2032-2045. Epub 2017 May 18 doi: 10.2215/CJN.11491116. PMID: 28522654Free PMC Article

Therapy

The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease.
Rossing P, Baeres FMM, Bakris G, Bosch-Traberg H, Gislum M, Gough SCL, Idorn T, Lawson J, Mahaffey KW, Mann JFE, Mersebach H, Perkovic V, Tuttle K, Pratley R
Nephrol Dial Transplant 2023 Aug 31;38(9):2041-2051. doi: 10.1093/ndt/gfad009. PMID: 36651820Free PMC Article
Targeting inflammation to treat diabetic kidney disease: the road to 2030.
Rayego-Mateos S, Rodrigues-Diez RR, Fernandez-Fernandez B, Mora-Fernández C, Marchant V, Donate-Correa J, Navarro-González JF, Ortiz A, Ruiz-Ortega M
Kidney Int 2023 Feb;103(2):282-296. Epub 2022 Dec 5 doi: 10.1016/j.kint.2022.10.030. PMID: 36470394
Treatment of Diabetic Kidney Disease: Current and Future.
Yamazaki T, Mimura I, Tanaka T, Nangaku M
Diabetes Metab J 2021 Jan;45(1):11-26. Epub 2021 Jan 22 doi: 10.4093/dmj.2020.0217. PMID: 33508907Free PMC Article
Diabetic Kidney Disease.
Bonner R, Albajrami O, Hudspeth J, Upadhyay A
Prim Care 2020 Dec;47(4):645-659. Epub 2020 Sep 23 doi: 10.1016/j.pop.2020.08.004. PMID: 33121634
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
Alicic RZ, Rooney MT, Tuttle KR
Clin J Am Soc Nephrol 2017 Dec 7;12(12):2032-2045. Epub 2017 May 18 doi: 10.2215/CJN.11491116. PMID: 28522654Free PMC Article

Prognosis

Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease.
Jung CY, Yoo TH
Diabetes Metab J 2022 Mar;46(2):181-197. Epub 2022 Mar 24 doi: 10.4093/dmj.2021.0329. PMID: 35385633Free PMC Article
Prevention of Microvascular Complications of Diabetes.
Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Biomarkers of diabetic kidney disease.
Colhoun HM, Marcovecchio ML
Diabetologia 2018 May;61(5):996-1011. Epub 2018 Mar 8 doi: 10.1007/s00125-018-4567-5. PMID: 29520581Free PMC Article
Diabetic kidney disease.
Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S, Rossing P, Groop PH, Cooper ME
Nat Rev Dis Primers 2015 Jul 30;1:15018. doi: 10.1038/nrdp.2015.18. PMID: 27188921Free PMC Article
Molecular mechanisms of diabetic kidney disease.
Reidy K, Kang HM, Hostetter T, Susztak K
J Clin Invest 2014 Jun;124(6):2333-40. Epub 2014 Jun 2 doi: 10.1172/JCI72271. PMID: 24892707Free PMC Article

Clinical prediction guides

Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease.
Jung CY, Yoo TH
Diabetes Metab J 2022 Mar;46(2):181-197. Epub 2022 Mar 24 doi: 10.4093/dmj.2021.0329. PMID: 35385633Free PMC Article
Prevention of Microvascular Complications of Diabetes.
Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Biomarkers of diabetic kidney disease.
Colhoun HM, Marcovecchio ML
Diabetologia 2018 May;61(5):996-1011. Epub 2018 Mar 8 doi: 10.1007/s00125-018-4567-5. PMID: 29520581Free PMC Article
Diagnosis and Management of Type 2 Diabetic Kidney Disease.
Doshi SM, Friedman AN
Clin J Am Soc Nephrol 2017 Aug 7;12(8):1366-1373. Epub 2017 Mar 9 doi: 10.2215/CJN.11111016. PMID: 28280116Free PMC Article
Molecular mechanisms of diabetic kidney disease.
Reidy K, Kang HM, Hostetter T, Susztak K
J Clin Invest 2014 Jun;124(6):2333-40. Epub 2014 Jun 2 doi: 10.1172/JCI72271. PMID: 24892707Free PMC Article

Recent systematic reviews

Efficacy and safety of drugs for people with type 2 diabetes mellitus and chronic kidney disease on kidney and cardiovascular outcomes: A systematic review and network meta-analysis of randomized controlled trials.
Yang Q, Lang Y, Yang W, Yang F, Yang J, Wu Y, Xiao X, Qin C, Zou Y, Zhao Y, Kang D, Liu F
Diabetes Res Clin Pract 2023 Apr;198:110592. Epub 2023 Feb 25 doi: 10.1016/j.diabres.2023.110592. PMID: 36842477
Protein restriction for diabetic kidney disease.
Jiang S, Fang J, Li W
Cochrane Database Syst Rev 2023 Jan 3;1(1):CD014906. doi: 10.1002/14651858.CD014906.pub2. PMID: 36594428Free PMC Article
Finerenone in diabetic kidney disease: A systematic review and critical appraisal.
Singh AK, Singh A, Singh R, Misra A
Diabetes Metab Syndr 2022 Oct;16(10):102638. Epub 2022 Oct 4 doi: 10.1016/j.dsx.2022.102638. PMID: 36223666
Association of SGLT2 inhibitors with cardiovascular, kidney, and safety outcomes among patients with diabetic kidney disease: a meta-analysis.
Kaze AD, Zhuo M, Kim SC, Patorno E, Paik JM
Cardiovasc Diabetol 2022 Mar 23;21(1):47. doi: 10.1186/s12933-022-01476-x. PMID: 35321742Free PMC Article
Establishment and Validation of a Risk Prediction Model for Early Diabetic Kidney Disease Based on a Systematic Review and Meta-Analysis of 20 Cohorts.
Jiang W, Wang J, Shen X, Lu W, Wang Y, Li W, Gao Z, Xu J, Li X, Liu R, Zheng M, Chang B, Li J, Yang J, Chang B
Diabetes Care 2020 Apr;43(4):925-933. doi: 10.2337/dc19-1897. PMID: 32198286

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