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Adult Mixed Cellularity Classic Hodgkin Lymphoma

MedGen UID:
83521
•Concept ID:
C0279542
•
Neoplastic Process
Synonyms: Adult MCHD; Adult Mixed Cellularity Classical Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin's Disease; Adult Mixed Cellularity Hodgkin's Lymphoma

Definition

Mixed cellularity classic Hodgkin lymphoma occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Mixed Cellularity Classic Hodgkin Lymphoma

Professional guidelines

PubMed

Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management.
Ansell SM
Am J Hematol 2020 Aug;95(8):978-989. Epub 2020 Jun 8 doi: 10.1002/ajh.25856. PMID: 32384177
Lymphoma: Diagnosis and Treatment.
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937
Treatment of classical Hodgkin's lymphoma in children and adolescents.
Gómez-Almaguer D, González-Llano O, Jiménez-Antolinez V, Gómez-De León A
Expert Opin Pharmacother 2019 Jul;20(10):1227-1234. Epub 2019 Apr 25 doi: 10.1080/14656566.2019.1606212. PMID: 31021660

Recent clinical studies

Etiology

Classic Hodgkin lymphoma in young people.
Gupta S, Craig JW
Semin Diagn Pathol 2023 Nov;40(6):379-391. Epub 2023 Jun 30 doi: 10.1053/j.semdp.2023.06.005. PMID: 37451943
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management.
Ansell SM
Am J Hematol 2020 Aug;95(8):978-989. Epub 2020 Jun 8 doi: 10.1002/ajh.25856. PMID: 32384177
Hodgkin Lymphoma in Adults.
Bröckelmann PJ, Eichenauer DA, Jakob T, Follmann M, Engert A, Skoetz N
Dtsch Arztebl Int 2018 Aug 6;115(31-32):535-540. doi: 10.3238/arztebl.2018.0535. PMID: 30149835Free PMC Article
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Diagnosis

Mediastinal Lymphoproliferative Disorders.
Pina-Oviedo S
Adv Anat Pathol 2021 Sep 1;28(5):307-334. doi: 10.1097/PAP.0000000000000305. PMID: 34074861
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Hodgkin lymphoma.
Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953
Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management.
Ansell SM
Am J Hematol 2020 Aug;95(8):978-989. Epub 2020 Jun 8 doi: 10.1002/ajh.25856. PMID: 32384177
Hodgkin Lymphoma in Adults.
Bröckelmann PJ, Eichenauer DA, Jakob T, Follmann M, Engert A, Skoetz N
Dtsch Arztebl Int 2018 Aug 6;115(31-32):535-540. doi: 10.3238/arztebl.2018.0535. PMID: 30149835Free PMC Article

Therapy

AYA Considerations for Aggressive Lymphomas.
Llaurador G, Giulino-Roth L
Curr Hematol Malig Rep 2021 Feb;16(1):61-71. Epub 2021 Mar 16 doi: 10.1007/s11899-021-00607-7. PMID: 33728589
Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management.
Ansell SM
Am J Hematol 2020 Aug;95(8):978-989. Epub 2020 Jun 8 doi: 10.1002/ajh.25856. PMID: 32384177
Hodgkin Lymphoma in Adults.
Bröckelmann PJ, Eichenauer DA, Jakob T, Follmann M, Engert A, Skoetz N
Dtsch Arztebl Int 2018 Aug 6;115(31-32):535-540. doi: 10.3238/arztebl.2018.0535. PMID: 30149835Free PMC Article
Hodgkin lymphoma in elderly patients.
Borchmann S, Engert A, Böll B
Curr Opin Oncol 2018 Sep;30(5):308-316. doi: 10.1097/CCO.0000000000000464. PMID: 29994901
Hodgkin's lymphoma.
Yung L, Linch D
Lancet 2003 Mar 15;361(9361):943-51. doi: 10.1016/S0140-6736(03)12777-8. PMID: 12648984

Prognosis

Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results.
Advani RH, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Christian BA, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF
Blood 2021 Aug 12;138(6):427-438. doi: 10.1182/blood.2020009178. PMID: 33827139
Hodgkin lymphoma.
Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953
Current treatment paradigms for advanced stage Hodgkin lymphoma.
Longley J, Johnson PWM
Br J Haematol 2019 Jan;184(1):60-71. Epub 2018 Nov 8 doi: 10.1111/bjh.15622. PMID: 30408156
Five-year PFS from the AETHERA trial of brentuximab vedotin for Hodgkin lymphoma at high risk of progression or relapse.
Moskowitz CH, Walewski J, Nademanee A, Masszi T, Agura E, Holowiecki J, Abidi MH, Chen AI, Stiff P, Viviani S, Bachanova V, Sureda A, McClendon T, Lee C, Lisano J, Sweetenham J
Blood 2018 Dec 20;132(25):2639-2642. Epub 2018 Sep 28 doi: 10.1182/blood-2018-07-861641. PMID: 30266774
Hodgkin's disease.
Medeiros LJ, Greiner TC
Cancer 1995 Jan 1;75(1 Suppl):357-69. doi: 10.1002/1097-0142(19950101)75:1+<357::aid-cncr2820751318>3.0.co;2-a. PMID: 8001007

Clinical prediction guides

AYA Considerations for Aggressive Lymphomas.
Llaurador G, Giulino-Roth L
Curr Hematol Malig Rep 2021 Feb;16(1):61-71. Epub 2021 Mar 16 doi: 10.1007/s11899-021-00607-7. PMID: 33728589
Hodgkin lymphoma.
Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953
Hodgkin's lymphoma in adults.
Townsend W, Linch D
Lancet 2012 Sep 1;380(9844):836-47. Epub 2012 Jul 25 doi: 10.1016/S0140-6736(12)60035-X. PMID: 22835602
Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome.
Carbone A, Spina M, Gloghini A, Tirelli U
Am J Hematol 2011 Feb;86(2):170-9. doi: 10.1002/ajh.21910. PMID: 21264899
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Recent systematic reviews

Antibody response after vaccination against SARS-CoV-2 in adults with hematological malignancies: a systematic review and meta-analysis.
Gagelmann N, Passamonti F, Wolschke C, Massoud R, Niederwieser C, Adjallé R, Mora B, Ayuk F, Kröger N
Haematologica 2022 Aug 1;107(8):1840-1849. doi: 10.3324/haematol.2021.280163. PMID: 34911284Free PMC Article
Chemotherapy for non-Hodgkin lymphoma in the hemodialysis patient: A comprehensive review.
Yasuda H, Yasuda M, Komatsu N
Cancer Sci 2021 Jul;112(7):2607-2624. Epub 2021 Jun 11 doi: 10.1111/cas.14933. PMID: 33938097Free PMC Article
Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis.
Hill HA, Qi X, Jain P, Nomie K, Wang Y, Zhou S, Wang ML
Blood Adv 2020 Jul 14;4(13):2927-2938. doi: 10.1182/bloodadvances.2019001350. PMID: 32598477Free PMC Article
Hodgkin Lymphoma in Adults.
Bröckelmann PJ, Eichenauer DA, Jakob T, Follmann M, Engert A, Skoetz N
Dtsch Arztebl Int 2018 Aug 6;115(31-32):535-540. doi: 10.3238/arztebl.2018.0535. PMID: 30149835Free PMC Article
Challenges and opportunities in primary CNS lymphoma: A systematic review.
Kerbauy MN, Moraes FY, Lok BH, Ma J, Kerbauy LN, Spratt DE, Santos FP, Perini GF, Berlin A, Chung C, Hamerschlak N, Yahalom J
Radiother Oncol 2017 Mar;122(3):352-361. Epub 2017 Jan 16 doi: 10.1016/j.radonc.2016.12.033. PMID: 28104300

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