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Adult Rhabdomyosarcoma

MedGen UID:
83524
•Concept ID:
C0279550
•
Neoplastic Process

Definition

An aggressive malignant mesenchymal neoplasm arising from skeletal muscle in adults. [from NCI]

Professional guidelines

PubMed

Practical Management of Adult Ultra-Rare Primary Retroperitoneal Soft Tissue Sarcoma: A Focus on Perivascular Epithelioid Tumours and Extraosseous Ewing Sarcoma.
Apte SS, Mor E, Mitchell C, Gyorki DE
Curr Oncol 2023 Jun 21;30(7):5953-5972. doi: 10.3390/curroncol30070445. PMID: 37504306Free PMC Article
Adult rhabdomyosarcoma: Multimodality management and results.
Salunke AA, Shah J, Gupta N, Pandit J
J Cancer Res Ther 2017 Apr-Jun;13(2):384. doi: 10.4103/0973-1482.180606. PMID: 28643768
Treatment of adult rhabdomyosarcoma.
Ogilvie CM, Crawford EA, Slotcavage RL, King JJ, Lackman RD, Hartner L, Staddon AP
Am J Clin Oncol 2010 Apr;33(2):128-31. doi: 10.1097/COC.0b013e3181979222. PMID: 19770626

Recent clinical studies

Etiology

The VAC regimen for adult rhabdomyosarcoma: Differences between adolescent/young adult and older patients.
Nakano K, Ae K, Matsumoto S, Takahashi S
Asia Pac J Clin Oncol 2020 Apr;16(2):e47-e52. Epub 2019 Oct 28 doi: 10.1111/ajco.13279. PMID: 31657883
Treatment Outcome and Predictors of Survival in Thai Adult Rhabdomyosarcoma Cases.
Sookprasert A, Ungareewittaya P, Manotepitipongse A, Wirasorn K, Chindaprasirt J
Asian Pac J Cancer Prev 2016;17(3):1449-52. doi: 10.7314/apjcp.2016.17.3.1449. PMID: 27039788
Adult rhabdomyosarcoma: Clinical presentation, treatment, and outcome.
Khosla D, Sapkota S, Kapoor R, Kumar R, Sharma SC
J Cancer Res Ther 2015 Oct-Dec;11(4):830-4. doi: 10.4103/0973-1482.144637. PMID: 26881526
Management and outcome of 239 adolescent and adult rhabdomyosarcoma patients.
Dumont SN, Araujo DM, Munsell MF, Salganick JA, Dumont AG, Raymond KA, Linassier C, Patel S, Benjamin RS, Trent JC
Cancer Med 2013 Aug;2(4):553-63. Epub 2013 Jul 15 doi: 10.1002/cam4.92. PMID: 24156028Free PMC Article
Treatment of adult rhabdomyosarcoma.
Ogilvie CM, Crawford EA, Slotcavage RL, King JJ, Lackman RD, Hartner L, Staddon AP
Am J Clin Oncol 2010 Apr;33(2):128-31. doi: 10.1097/COC.0b013e3181979222. PMID: 19770626

Diagnosis

Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging.
Gennaro N, Marrari A, Renne SL, Cananzi FCM, Quagliuolo VL, Di Brina L, Scorsetti M, Pepe G, Chiti A, Santoro A, Balzarini L, Politi LS, Bertuzzi AF
Br J Radiol 2020 Aug;93(1112):20200250. Epub 2020 Jun 26 doi: 10.1259/bjr.20200250. PMID: 32559113Free PMC Article
The VAC regimen for adult rhabdomyosarcoma: Differences between adolescent/young adult and older patients.
Nakano K, Ae K, Matsumoto S, Takahashi S
Asia Pac J Clin Oncol 2020 Apr;16(2):e47-e52. Epub 2019 Oct 28 doi: 10.1111/ajco.13279. PMID: 31657883
Treatment Outcome and Predictors of Survival in Thai Adult Rhabdomyosarcoma Cases.
Sookprasert A, Ungareewittaya P, Manotepitipongse A, Wirasorn K, Chindaprasirt J
Asian Pac J Cancer Prev 2016;17(3):1449-52. doi: 10.7314/apjcp.2016.17.3.1449. PMID: 27039788
Imaging features of primary and secondary adult rhabdomyosarcoma.
Saboo SS, Krajewski KM, Zukotynski K, Howard S, Jagannathan JP, Hornick JL, Ramaiya N
AJR Am J Roentgenol 2012 Dec;199(6):W694-703. doi: 10.2214/AJR.11.8213. PMID: 23169742
Laryngeal pleomorphic rhabdomyosarcoma.
Schrock A, Jakob M, Zhou H, Bootz F
Auris Nasus Larynx 2007 Dec;34(4):553-6. Epub 2007 May 3 doi: 10.1016/j.anl.2007.02.009. PMID: 17481838

Therapy

The VAC regimen for adult rhabdomyosarcoma: Differences between adolescent/young adult and older patients.
Nakano K, Ae K, Matsumoto S, Takahashi S
Asia Pac J Clin Oncol 2020 Apr;16(2):e47-e52. Epub 2019 Oct 28 doi: 10.1111/ajco.13279. PMID: 31657883
Management of Low and Intermediate Risk Adult Rhabdomyosarcoma: A Pooled Survival Analysis of 553 Patients.
Elsebaie MAT, Amgad M, Elkashash A, Elgebaly AS, Ashal GGEL, Shash E, Elsayed Z
Sci Rep 2018 Jun 19;8(1):9337. doi: 10.1038/s41598-018-27556-1. PMID: 29921891Free PMC Article
Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients.
Elsebaie MA, Elsayed Z
Arch Gynecol Obstet 2018 Mar;297(3):559-572. Epub 2017 Nov 20 doi: 10.1007/s00404-017-4591-6. PMID: 29159540
Treatment of adult rhabdomyosarcoma.
Ogilvie CM, Crawford EA, Slotcavage RL, King JJ, Lackman RD, Hartner L, Staddon AP
Am J Clin Oncol 2010 Apr;33(2):128-31. doi: 10.1097/COC.0b013e3181979222. PMID: 19770626
Response to chemotherapy and predictors of survival in adult rhabdomyosarcoma.
Esnaola NF, Rubin BP, Baldini EH, Vasudevan N, Demetri GD, Fletcher CD, Singer S
Ann Surg 2001 Aug;234(2):215-23. doi: 10.1097/00000658-200108000-00012. PMID: 11505068Free PMC Article

Prognosis

The VAC regimen for adult rhabdomyosarcoma: Differences between adolescent/young adult and older patients.
Nakano K, Ae K, Matsumoto S, Takahashi S
Asia Pac J Clin Oncol 2020 Apr;16(2):e47-e52. Epub 2019 Oct 28 doi: 10.1111/ajco.13279. PMID: 31657883
Treatment Outcome and Predictors of Survival in Thai Adult Rhabdomyosarcoma Cases.
Sookprasert A, Ungareewittaya P, Manotepitipongse A, Wirasorn K, Chindaprasirt J
Asian Pac J Cancer Prev 2016;17(3):1449-52. doi: 10.7314/apjcp.2016.17.3.1449. PMID: 27039788
Adult rhabdomyosarcoma: Clinical presentation, treatment, and outcome.
Khosla D, Sapkota S, Kapoor R, Kumar R, Sharma SC
J Cancer Res Ther 2015 Oct-Dec;11(4):830-4. doi: 10.4103/0973-1482.144637. PMID: 26881526
Treatment of adult rhabdomyosarcoma.
Ogilvie CM, Crawford EA, Slotcavage RL, King JJ, Lackman RD, Hartner L, Staddon AP
Am J Clin Oncol 2010 Apr;33(2):128-31. doi: 10.1097/COC.0b013e3181979222. PMID: 19770626
Laryngeal pleomorphic rhabdomyosarcoma.
Schrock A, Jakob M, Zhou H, Bootz F
Auris Nasus Larynx 2007 Dec;34(4):553-6. Epub 2007 May 3 doi: 10.1016/j.anl.2007.02.009. PMID: 17481838

Clinical prediction guides

Next generation sequencing predicting clinical effect of immunotherapy on adult rhabdomyosarcoma patient: A case report.
Sun X, Wang X, Zhou J, Xu Y, Zhang H, Xu M, Shen J, Shi X, Song W, Li J
Medicine (Baltimore) 2023 May 26;102(21):e33858. doi: 10.1097/MD.0000000000033858. PMID: 37233406Free PMC Article
Head and Neck Rhabdomyosarcoma: Clinical and Pathologic Characterization of Seven Cases.
Chen E, Ricciotti R, Futran N, Oda D
Head Neck Pathol 2017 Sep;11(3):321-326. Epub 2016 Nov 28 doi: 10.1007/s12105-016-0771-0. PMID: 27896667Free PMC Article
Treatment Outcome and Predictors of Survival in Thai Adult Rhabdomyosarcoma Cases.
Sookprasert A, Ungareewittaya P, Manotepitipongse A, Wirasorn K, Chindaprasirt J
Asian Pac J Cancer Prev 2016;17(3):1449-52. doi: 10.7314/apjcp.2016.17.3.1449. PMID: 27039788
Adult rhabdomyosarcoma: Clinical presentation, treatment, and outcome.
Khosla D, Sapkota S, Kapoor R, Kumar R, Sharma SC
J Cancer Res Ther 2015 Oct-Dec;11(4):830-4. doi: 10.4103/0973-1482.144637. PMID: 26881526
Response to chemotherapy and predictors of survival in adult rhabdomyosarcoma.
Esnaola NF, Rubin BP, Baldini EH, Vasudevan N, Demetri GD, Fletcher CD, Singer S
Ann Surg 2001 Aug;234(2):215-23. doi: 10.1097/00000658-200108000-00012. PMID: 11505068Free PMC Article

Recent systematic reviews

Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients.
Elsebaie MA, Elsayed Z
Arch Gynecol Obstet 2018 Mar;297(3):559-572. Epub 2017 Nov 20 doi: 10.1007/s00404-017-4591-6. PMID: 29159540

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