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B-cell childhood acute lymphoblastic leukemia

MedGen UID:
83526
•Concept ID:
C0279584
•
Neoplastic Process
Synonyms: B Cell Childhood Acute Lymphoblastic Leukemia; B cell childhood acute lymphoblastic leukemia; B cell childhood acute lymphocytic leukemia; B Cell Childhood ALL; B cell childhood ALL; B Cell Pediatric Acute Lymphoblastic Leukemia; B cell pediatric acute lymphoblastic leukemia; B cell pediatric acute lymphocytic leukemia; B Cell Pediatric ALL; B cell pediatric ALL; B-Cell Childhood Acute Lymphoblastic Leukemia; B-cell childhood acute lymphocytic leukemia; B-cell childhood acute lymphogenous leukemia; B-cell childhood acute lymphoid leukemia; B-Cell Childhood ALL; B-cell childhood ALL; B-Cell Pediatric Acute Lymphoblastic Leukemia; B-cell pediatric acute lymphoblastic leukemia; B-cell pediatric acute lymphocytic leukemia; B-cell pediatric acute lymphogenous leukemia; B-cell pediatric acute lymphoid leukemia; B-Cell Pediatric ALL; B-cell pediatric ALL; Childhood B Acute Lymphoblastic Leukemia; childhood B acute lymphoblastic leukemia; childhood B-ALL; Childhood Precursor B-Lymphoblastic Leukemia; childhood precursor B-lymphoblastic leukemia
 
Monarch Initiative: MONDO:0000872

Definition

An acute B-lymphoblastic leukemia occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB-cell childhood acute lymphoblastic leukemia

Professional guidelines

PubMed

Leukapheresis guidance and best practices for optimal chimeric antigen receptor T-cell manufacturing.
Qayed M, McGuirk JP, Myers GD, Parameswaran V, Waller EK, Holman P, Rodrigues M, Clough LF, Willert J
Cytotherapy 2022 Sep;24(9):869-878. Epub 2022 Jun 17 doi: 10.1016/j.jcyt.2022.05.003. PMID: 35718701
CAR-T cell persistence in the treatment of leukemia and lymphoma.
Gupta A, Gill S
Leuk Lymphoma 2021 Nov;62(11):2587-2599. Epub 2021 Apr 19 doi: 10.1080/10428194.2021.1913146. PMID: 33872091
Clinical diagnostics and treatment strategies for Philadelphia chromosome-like acute lymphoblastic leukemia.
Harvey RC, Tasian SK
Blood Adv 2020 Jan 14;4(1):218-228. doi: 10.1182/bloodadvances.2019000163. PMID: 31935290Free PMC Article

Recent clinical studies

Etiology

Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.
Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896Free PMC Article
Pediatric acute lymphoblastic leukemia.
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article
Clinical diagnostics and treatment strategies for Philadelphia chromosome-like acute lymphoblastic leukemia.
Harvey RC, Tasian SK
Blood Adv 2020 Jan 14;4(1):218-228. doi: 10.1182/bloodadvances.2019000163. PMID: 31935290Free PMC Article
Comparative features and outcomes between paediatric T-cell and B-cell acute lymphoblastic leukaemia.
Teachey DT, Pui CH
Lancet Oncol 2019 Mar;20(3):e142-e154. doi: 10.1016/S1470-2045(19)30031-2. PMID: 30842058Free PMC Article
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article

Diagnosis

Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Pediatric acute lymphoblastic leukemia.
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article
Clinical diagnostics and treatment strategies for Philadelphia chromosome-like acute lymphoblastic leukemia.
Harvey RC, Tasian SK
Blood Adv 2020 Jan 14;4(1):218-228. doi: 10.1182/bloodadvances.2019000163. PMID: 31935290Free PMC Article
Genetic Basis of Acute Lymphoblastic Leukemia.
Iacobucci I, Mullighan CG
J Clin Oncol 2017 Mar 20;35(9):975-983. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.70.7836. PMID: 28297628Free PMC Article
B-acute lymphoblastic leukemia/lymphoblastic lymphoma.
Loghavi S, Kutok JL, Jorgensen JL
Am J Clin Pathol 2015 Sep;144(3):393-410. doi: 10.1309/AJCPAN7BH5DNYWZB. PMID: 26276770

Therapy

Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia.
van der Sluis IM, de Lorenzo P, Kotecha RS, Attarbaschi A, Escherich G, Nysom K, Stary J, Ferster A, Brethon B, Locatelli F, Schrappe M, Scholte-van Houtem PE, Valsecchi MG, Pieters R
N Engl J Med 2023 Apr 27;388(17):1572-1581. doi: 10.1056/NEJMoa2214171. PMID: 37099340
Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, Raetz EA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Pulsipher MA, Hunger SP, Loh ML
JAMA 2021 Mar 2;325(9):833-842. doi: 10.1001/jama.2021.0669. PMID: 33651090Free PMC Article
Molecular markers in ALL: Clinical implications.
Kimura S, Mullighan CG
Best Pract Res Clin Haematol 2020 Sep;33(3):101193. Epub 2020 Jun 7 doi: 10.1016/j.beha.2020.101193. PMID: 33038982Free PMC Article
Clinical diagnostics and treatment strategies for Philadelphia chromosome-like acute lymphoblastic leukemia.
Harvey RC, Tasian SK
Blood Adv 2020 Jan 14;4(1):218-228. doi: 10.1182/bloodadvances.2019000163. PMID: 31935290Free PMC Article
Mechanisms of resistance to CAR T cell therapy.
Shah NN, Fry TJ
Nat Rev Clin Oncol 2019 Jun;16(6):372-385. doi: 10.1038/s41571-019-0184-6. PMID: 30837712Free PMC Article

Prognosis

Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.
Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896Free PMC Article
Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation.
Lee RD, Munro SA, Knutson TP, LaRue RS, Heltemes-Harris LM, Farrar MA
Nat Commun 2021 Nov 25;12(1):6843. doi: 10.1038/s41467-021-27232-5. PMID: 34824268Free PMC Article
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article

Clinical prediction guides

Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.
Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896Free PMC Article
Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis.
Zhang Y, Wang S, Zhang J, Liu C, Li X, Guo W, Duan Y, Chen X, Zong S, Zheng J, Wu Y, Chen X, Cheng X, Chang Y, Wang Y, Ding F, Yang W, Chen X, Guo Y, Zhang L, Chen Y, Zou Y, Zhu X, Gu J, Cheng T
Nat Cell Biol 2022 Feb;24(2):242-252. Epub 2022 Feb 10 doi: 10.1038/s41556-021-00814-7. PMID: 35145224
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia.
Kruse A, Abdel-Azim N, Kim HN, Ruan Y, Phan V, Ogana H, Wang W, Lee R, Gang EJ, Khazal S, Kim YM
Int J Mol Sci 2020 Feb 5;21(3) doi: 10.3390/ijms21031054. PMID: 32033444Free PMC Article
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, Bader P, Verneris MR, Stefanski HE, Myers GD, Qayed M, De Moerloose B, Hiramatsu H, Schlis K, Davis KL, Martin PL, Nemecek ER, Yanik GA, Peters C, Baruchel A, Boissel N, Mechinaud F, Balduzzi A, Krueger J, June CH, Levine BL, Wood P, Taran T, Leung M, Mueller KT, Zhang Y, Sen K, Lebwohl D, Pulsipher MA, Grupp SA
N Engl J Med 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866. PMID: 29385370Free PMC Article

Recent systematic reviews

lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review.
Illarregi U, Telleria J, Bilbao-Aldaiturriaga N, Lopez-Lopez E, Ballesteros J, Martin-Guerrero I, Gutierrez-Camino A
Int J Oncol 2022 May;60(5) Epub 2022 Apr 8 doi: 10.3892/ijo.2022.5348. PMID: 35419612
Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Philadelphia-Like Acute Lymphoblastic Leukemia: A Systematic Review.
Yadav V, Ganesan P, Veeramani R, Kumar V D
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e57-e65. Epub 2020 Aug 18 doi: 10.1016/j.clml.2020.08.011. PMID: 33485429
Anti-CD19 chimeric antigen receptor T-cell therapy in acute lymphocytic leukaemia: a systematic review and meta-analysis.
Anagnostou T, Riaz IB, Hashmi SK, Murad MH, Kenderian SS
Lancet Haematol 2020 Nov;7(11):e816-e826. doi: 10.1016/S2352-3026(20)30277-5. PMID: 33091355
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292

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