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Diabetic neuropathy

MedGen UID:
8353
•Concept ID:
C0011882
•
Disease or Syndrome
Synonyms: Diabetic Neuropathies; Diabetic Neuropathy; Neuropathies, Diabetic; Neuropathy, Diabetic
SNOMED CT: Diabetic neuropathy (230572002); Diabetes mellitus with neuropathy (230572002); Neuropathy due to diabetes mellitus (230572002)
 
Monarch Initiative: MONDO:0006626

Definition

A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiabetic neuropathy

Professional guidelines

PubMed

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
The diabetic foot: Pathophysiology, evaluation, and treatment.
Bandyk DF
Semin Vasc Surg 2018 Jun-Dec;31(2-4):43-48. Epub 2019 Feb 6 doi: 10.1053/j.semvascsurg.2019.02.001. PMID: 30876640

Curated

UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

Recent clinical studies

Etiology

Prevention of Microvascular Complications of Diabetes.
Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Diabetic neuropathy.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article
Diabetic neuropathy.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):41. doi: 10.1038/s41572-019-0092-1. PMID: 31197153
Efficacy of α-lipoic acid in diabetic neuropathy.
Papanas N, Ziegler D
Expert Opin Pharmacother 2014 Dec;15(18):2721-31. Epub 2014 Nov 10 doi: 10.1517/14656566.2014.972935. PMID: 25381809
Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments.
Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P; Toronto Diabetic Neuropathy Expert Group
Diabetes Care 2010 Oct;33(10):2285-93. doi: 10.2337/dc10-1303. PMID: 20876709Free PMC Article

Diagnosis

Prevention of Microvascular Complications of Diabetes.
Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Challenges of neuropathic pain: focus on diabetic neuropathy.
Rosenberger DC, Blechschmidt V, Timmerman H, Wolff A, Treede RD
J Neural Transm (Vienna) 2020 Apr;127(4):589-624. Epub 2020 Feb 8 doi: 10.1007/s00702-020-02145-7. PMID: 32036431Free PMC Article
Diabetic Neuropathy.
Zakin E, Abrams R, Simpson DM
Semin Neurol 2019 Oct;39(5):560-569. Epub 2019 Oct 22 doi: 10.1055/s-0039-1688978. PMID: 31639839
Diabetic neuropathy.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article
Diabetic neuropathy.
Vinik AI, Nevoret ML, Casellini C, Parson H
Endocrinol Metab Clin North Am 2013 Dec;42(4):747-87. doi: 10.1016/j.ecl.2013.06.001. PMID: 24286949

Therapy

Combination therapy for painful diabetic neuropathy is safe and effective.
Saul H, Deeney B, Imison C, Tesfaye S
BMJ 2023 Apr 21;381:866. doi: 10.1136/bmj.p866. PMID: 37085164
Diagnosis and management of sensory polyneuropathy.
Gwathmey KG, Pearson KT
BMJ 2019 May 8;365:l1108. doi: 10.1136/bmj.l1108. PMID: 31068323
Gabapentin for chronic neuropathic pain in adults.
Wiffen PJ, Derry S, Bell RF, Rice AS, Tölle TR, Phillips T, Moore RA
Cochrane Database Syst Rev 2017 Jun 9;6(6):CD007938. doi: 10.1002/14651858.CD007938.pub4. PMID: 28597471Free PMC Article
Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Dimitrova A, Murchison C, Oken B
J Altern Complement Med 2017 Mar;23(3):164-179. Epub 2017 Jan 23 doi: 10.1089/acm.2016.0155. PMID: 28112552Free PMC Article
Efficacy of α-lipoic acid in diabetic neuropathy.
Papanas N, Ziegler D
Expert Opin Pharmacother 2014 Dec;15(18):2721-31. Epub 2014 Nov 10 doi: 10.1517/14656566.2014.972935. PMID: 25381809

Prognosis

Blood biomarkers of peripheral neuropathy.
Rossor AM, Reilly MM
Acta Neurol Scand 2022 Oct;146(4):325-331. Epub 2022 May 25 doi: 10.1111/ane.13650. PMID: 35611606Free PMC Article
Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Prevention of Microvascular Complications of Diabetes.
Crasto W, Patel V, Davies MJ, Khunti K
Endocrinol Metab Clin North Am 2021 Sep;50(3):431-455. doi: 10.1016/j.ecl.2021.05.005. PMID: 34399955
Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management.
Jensen TS, Karlsson P, Gylfadottir SS, Andersen ST, Bennett DL, Tankisi H, Finnerup NB, Terkelsen AJ, Khan K, Themistocleous AC, Kristensen AG, Itani M, Sindrup SH, Andersen H, Charles M, Feldman EL, Callaghan BC
Brain 2021 Jul 28;144(6):1632-1645. doi: 10.1093/brain/awab079. PMID: 33711103Free PMC Article
Diabetic Lumbosacral Radiculoplexus Neuropathy (Diabetic Amyotrophy).
Glenn MD, Jabari D
Neurol Clin 2020 Aug;38(3):553-564. doi: 10.1016/j.ncl.2020.03.010. PMID: 32703468

Clinical prediction guides

Clinical correlation of diabetic retinopathy with nephropathy and neuropathy.
Saini DC, Kochar A, Poonia R
Indian J Ophthalmol 2021 Nov;69(11):3364-3368. doi: 10.4103/ijo.IJO_1237_21. PMID: 34708806Free PMC Article
Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
Didangelos T, Karlafti E, Kotzakioulafi E, Margariti E, Giannoulaki P, Batanis G, Tesfaye S, Kantartzis K
Nutrients 2021 Jan 27;13(2) doi: 10.3390/nu13020395. PMID: 33513879Free PMC Article
The diabetic foot: Pathophysiology, evaluation, and treatment.
Bandyk DF
Semin Vasc Surg 2018 Jun-Dec;31(2-4):43-48. Epub 2019 Feb 6 doi: 10.1053/j.semvascsurg.2019.02.001. PMID: 30876640
Cardiac Autonomic Neuropathy in Diabetes Mellitus.
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article
Diabetic foot management: multidisciplinary approach for advanced lesion rescue.
Brocco E, Ninkovic S, Marin M, Whisstock C, Bruseghin M, Boschetti G, Viti R, Forlini W, Volpe A
J Cardiovasc Surg (Torino) 2018 Oct;59(5):670-684. Epub 2018 May 29 doi: 10.23736/S0021-9509.18.10606-9. PMID: 29808982

Recent systematic reviews

Evidence-Based Treatment of Painful Diabetic Neuropathy: a Systematic Review.
D'Souza RS, Barman R, Joseph A, Abd-Elsayed A
Curr Pain Headache Rep 2022 Aug;26(8):583-594. Epub 2022 Jun 18 doi: 10.1007/s11916-022-01061-7. PMID: 35716275
Effectiveness of Conservative Treatment According to Severity and Systemic Disease in Carpal Tunnel Syndrome: A Systematic Review.
Hernández-Secorún M, Montaña-Cortés R, Hidalgo-García C, Rodríguez-Sanz J, Corral-de-Toro J, Monti-Ballano S, Hamam-Alcober S, Tricás-Moreno JM, Lucha-López MO
Int J Environ Res Public Health 2021 Feb 28;18(5) doi: 10.3390/ijerph18052365. PMID: 33671060Free PMC Article
Footwear and insole design features for offloading the diabetic at risk foot-A systematic review and meta-analyses.
Collings R, Freeman J, Latour JM, Paton J
Endocrinol Diabetes Metab 2021 Jan;4(1):e00132. Epub 2020 Apr 11 doi: 10.1002/edm2.132. PMID: 33532602Free PMC Article
Gabapentin for chronic neuropathic pain in adults.
Wiffen PJ, Derry S, Bell RF, Rice AS, Tölle TR, Phillips T, Moore RA
Cochrane Database Syst Rev 2017 Jun 9;6(6):CD007938. doi: 10.1002/14651858.CD007938.pub4. PMID: 28597471Free PMC Article
Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Dimitrova A, Murchison C, Oken B
J Altern Complement Med 2017 Mar;23(3):164-179. Epub 2017 Jan 23 doi: 10.1089/acm.2016.0155. PMID: 28112552Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

    Consumer resources

    Reviews

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