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Recurrent Malignant Hypopharyngeal Neoplasm

MedGen UID:
83559
•Concept ID:
C0279803
•
Neoplastic Process

Definition

The reemergence of a hypopharyngeal malignant neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Malignant Hypopharyngeal Neoplasm

Professional guidelines

PubMed

Radiotherapy for hypopharynx cancers.
Pointreau Y, Biau J, Delaby N, Thariat J, Lapeyre M
Cancer Radiother 2022 Feb-Apr;26(1-2):199-205. Epub 2021 Dec 22 doi: 10.1016/j.canrad.2021.10.006. PMID: 34953703
Salvage Treatment Options after Failed Primary Treatment of Hypopharyngeal Cancer.
Simo R, Rovira A, Townley W
Adv Otorhinolaryngol 2019;83:135-147. Epub 2019 Feb 12 doi: 10.1159/000492357. PMID: 30943500
Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.
Grégoire V, Grau C, Lapeyre M, Maingon P
Oral Oncol 2018 Dec;87:131-137. Epub 2018 Nov 3 doi: 10.1016/j.oraloncology.2018.10.034. PMID: 30527228

Recent clinical studies

Etiology

Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
YTHDF1-enhanced iron metabolism depends on TFRC m(6)A methylation.
Ye J, Wang Z, Chen X, Jiang X, Dong Z, Hu S, Li W, Liu Y, Liao B, Han W, Shen J, Xiao M
Theranostics 2020;10(26):12072-12089. Epub 2020 Oct 26 doi: 10.7150/thno.51231. PMID: 33204330Free PMC Article
Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.
Grégoire V, Grau C, Lapeyre M, Maingon P
Oral Oncol 2018 Dec;87:131-137. Epub 2018 Nov 3 doi: 10.1016/j.oraloncology.2018.10.034. PMID: 30527228
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article

Diagnosis

Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article
Laryngeal and hypopharyngeal carcinomas after (chemo)radiotherapy: a diagnostic dilemma.
Zbären P, Weidner S, Thoeny HC
Curr Opin Otolaryngol Head Neck Surg 2008 Apr;16(2):147-53. doi: 10.1097/MOO.0b013e3282f702a9. PMID: 18327034
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590
Larynx and hypopharynx.
Becker M
Radiol Clin North Am 1998 Sep;36(5):891-920, vi. doi: 10.1016/s0033-8389(05)70068-3. PMID: 9747193

Therapy

Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy.
Lin C, Chen Y, Zhang F, Liu B, Xie C, Song Y
Cell Death Dis 2022 Feb 22;13(2):171. doi: 10.1038/s41419-022-04627-w. PMID: 35194030Free PMC Article
Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis.
Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F
Radiother Oncol 2021 May;158:13-20. Epub 2021 Feb 13 doi: 10.1016/j.radonc.2021.02.001. PMID: 33587969
Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre experience.
Akbaba S, Held T, Lang K, Hoerner-Rieber J, Zaoui K, Forster T, Rieken S, Plinkert P, Debus J, Adeberg S
Radiat Oncol 2019 Feb 19;14(1):34. doi: 10.1186/s13014-019-1238-8. PMID: 30782197Free PMC Article
Head and neck cancer: guidelines for chemotherapy.
Catimel G
Drugs 1996 Jan;51(1):73-88. doi: 10.2165/00003495-199651010-00006. PMID: 8741233

Prognosis

The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis.
Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F
Radiother Oncol 2021 May;158:13-20. Epub 2021 Feb 13 doi: 10.1016/j.radonc.2021.02.001. PMID: 33587969
YTHDF1-enhanced iron metabolism depends on TFRC m(6)A methylation.
Ye J, Wang Z, Chen X, Jiang X, Dong Z, Hu S, Li W, Liu Y, Liao B, Han W, Shen J, Xiao M
Theranostics 2020;10(26):12072-12089. Epub 2020 Oct 26 doi: 10.7150/thno.51231. PMID: 33204330Free PMC Article
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
Surgical salvage of recurrent cancer of the head and neck.
Zafereo M
Curr Oncol Rep 2014 May;16(5):386. doi: 10.1007/s11912-014-0386-0. PMID: 24623521
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Clinical prediction guides

Oncologic Outcomes After Clinically Node-Negative Salvage Laryngectomy.
Gross JH, Patel MR, Switchenko JM, Chan TG, Baddour HM, Kaka A, Boyce BJ, Saba NF, Beitler JJ, El-Deiry M
JAMA Otolaryngol Head Neck Surg 2023 Jan 1;149(1):24-33. doi: 10.1001/jamaoto.2022.3597. PMID: 36394866Free PMC Article
Prediction of Disease Free Survival in Laryngeal and Hypopharyngeal Cancers Using CT Perfusion and Radiomic Features: A Pilot Study.
Woolen S, Virkud A, Hadjiiski L, Cha K, Chan HP, Swiecicki P, Worden F, Srinivasan A
Tomography 2021 Mar;7(1):10-19. Epub 2021 Feb 5 doi: 10.3390/tomography7010002. PMID: 33681460Free PMC Article
The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis.
Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F
Radiother Oncol 2021 May;158:13-20. Epub 2021 Feb 13 doi: 10.1016/j.radonc.2021.02.001. PMID: 33587969
Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma.
Acuña G, Gomà M, Temprana-Salvador J, Garcia-Bragado F, Alós L, Ordi J, Cardesa A, Nadal A
Mod Pathol 2019 May;32(5):621-626. Epub 2018 Dec 14 doi: 10.1038/s41379-018-0188-2. PMID: 30552415
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article

Recent systematic reviews

Treatment options for resectable hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis of randomized controlled trials.
Panda S, Sakthivel P, Gurusamy KS, Sharma A, Thakar A
PLoS One 2022;17(11):e0277460. Epub 2022 Nov 29 doi: 10.1371/journal.pone.0277460. PMID: 36445884Free PMC Article
Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic review and meta-analysis.
Smits HJG, Assili S, Kauw F, Philippens MEP, de Bree R, Dankbaar JW
Head Neck 2021 Jul;43(7):2202-2215. Epub 2021 Apr 2 doi: 10.1002/hed.26698. PMID: 33797818Free PMC Article
Carcinomas of the hypopharynx and cervical esophagus: A systematic review and quality of evidence assessment.
Schizas D, Theochari NA, Ziogas IA, Economopoulos KP, Mylonas KS
J BUON 2021 Jan-Feb;26(1):39-50. PMID: 33721430
The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis.
Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F
Radiother Oncol 2021 May;158:13-20. Epub 2021 Feb 13 doi: 10.1016/j.radonc.2021.02.001. PMID: 33587969
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081

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