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Undifferentiated Carcinoma of Unknown Primary

MedGen UID:
83597
•Concept ID:
C0280098
•
Neoplastic Process

Definition

An undifferentiated carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated Carcinoma of Unknown Primary

Professional guidelines

PubMed

Diagnosis and Management of Squamous Cell Carcinoma of Unknown Primary in the Head and Neck: ASCO Guideline.
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update.
Biau J, Lapeyre M, Troussier I, Budach W, Giralt J, Grau C, Kazmierska J, Langendijk JA, Ozsahin M, O'Sullivan B, Bourhis J, Grégoire V
Radiother Oncol 2019 May;134:1-9. Epub 2019 Jan 30 doi: 10.1016/j.radonc.2019.01.018. PMID: 31005201

Recent clinical studies

Etiology

Paclitaxel and carboplatin vs gemcitabine and vinorelbine in patients with adeno- or undifferentiated carcinoma of unknown primary: a randomised prospective phase II trial.
Huebner G, Link H, Kohne CH, Stahl M, Kretzschmar A, Steinbach S, Folprecht G, Bernhard H, Al-Batran SE, Schoffski P, Burkart C, Kullmann F, Otremba B, Menges M, Hoffmann M, Kaiser U, Aldaoud A, Jahn A; German CUP Study Group
Br J Cancer 2009 Jan 13;100(1):44-9. Epub 2008 Dec 9 doi: 10.1038/sj.bjc.6604818. PMID: 19066607Free PMC Article
FDG PET in patients with cancer of an unknown primary.
Kolesnikov-Gauthier H, Levy E, Merlet P, Kirova J, Syrota A, Carpentier P, Meignan M, Piedbois P
Nucl Med Commun 2005 Dec;26(12):1059-66. doi: 10.1097/00006231-200512000-00003. PMID: 16264351
Simple prognostic model to predict survival in patients with undifferentiated carcinoma of unknown primary site.
van der Gaast A, Verweij J, Planting AS, Hop WC, Stoter G
J Clin Oncol 1995 Jul;13(7):1720-5. doi: 10.1200/JCO.1995.13.7.1720. PMID: 7541451
Metastatic adenocarcinoma of unknown primary site. A randomized study of two combination chemotherapy regimens.
Milliken ST, Tattersall MH, Woods RL, Coates AS, Levi JA, Fox RM, Raghavan D
Eur J Cancer Clin Oncol 1987 Nov;23(11):1645-8. doi: 10.1016/0277-5379(87)90443-3. PMID: 2448145
Metastatic adenocarcinoma of unknown primary site: abnormalities of cellular DNA content and survival.
Hedley DW, Leary JA, Kirsten F
Eur J Cancer Clin Oncol 1985 Feb;21(2):185-9. doi: 10.1016/0277-5379(85)90171-3. PMID: 3987755

Diagnosis

Warburg's effect on solid tumors.
El Imad T, El Khoury L, Geara AS
Saudi J Kidney Dis Transpl 2014 Nov;25(6):1270-7. doi: 10.4103/1319-2442.144266. PMID: 25394449
Phase II trial of capecitabine and oxaliplatin in patients with adeno- and undifferentiated carcinoma of unknown primary.
Schuette K, Folprecht G, Kretzschmar A, Link H, Koehne CH, Gruenwald V, Stahl M, Huebner G
Onkologie 2009 Apr;32(4):162-6. Epub 2009 Mar 13 doi: 10.1159/000201125. PMID: 19372710
FDG PET in patients with cancer of an unknown primary.
Kolesnikov-Gauthier H, Levy E, Merlet P, Kirova J, Syrota A, Carpentier P, Meignan M, Piedbois P
Nucl Med Commun 2005 Dec;26(12):1059-66. doi: 10.1097/00006231-200512000-00003. PMID: 16264351
Severe lactic acidosis in a 14-year-old female with metastatic undifferentiated carcinoma of unknown primary.
Cheng JC, Esparza SD, Knez VM, Sakamoto KM, Moore TB
J Pediatr Hematol Oncol 2004 Nov;26(11):780-2. doi: 10.1097/00043426-200411000-00021. PMID: 15543020
The value of immunohistochemistry in patients with poorly differentiated adenocarcinomas and undifferentiated carcinomas of unknown primary.
van der Gaast A, Verwij J, Planting AS, Stoter G, Henzen-Logmans SC
J Cancer Res Clin Oncol 1996;122(3):181-85. doi: 10.1007/BF01366960. PMID: 8601568

Therapy

Phase II trial of capecitabine and oxaliplatin in patients with adeno- and undifferentiated carcinoma of unknown primary.
Schuette K, Folprecht G, Kretzschmar A, Link H, Koehne CH, Gruenwald V, Stahl M, Huebner G
Onkologie 2009 Apr;32(4):162-6. Epub 2009 Mar 13 doi: 10.1159/000201125. PMID: 19372710
Paclitaxel and carboplatin vs gemcitabine and vinorelbine in patients with adeno- or undifferentiated carcinoma of unknown primary: a randomised prospective phase II trial.
Huebner G, Link H, Kohne CH, Stahl M, Kretzschmar A, Steinbach S, Folprecht G, Bernhard H, Al-Batran SE, Schoffski P, Burkart C, Kullmann F, Otremba B, Menges M, Hoffmann M, Kaiser U, Aldaoud A, Jahn A; German CUP Study Group
Br J Cancer 2009 Jan 13;100(1):44-9. Epub 2008 Dec 9 doi: 10.1038/sj.bjc.6604818. PMID: 19066607Free PMC Article
A long-term survivor after pancreaticoduodenectomy for metastatic undifferentiated carcinoma of an unknown primary.
Nakagawa Y, Todoroki T, Morishita Y, Mori K, Nakahaashi C, Ohkohchi N, Matsumoto H
Hepatogastroenterology 2008 Sep-Oct;55(86-87):1557-61. PMID: 19102342
Simple prognostic model to predict survival in patients with undifferentiated carcinoma of unknown primary site.
van der Gaast A, Verweij J, Planting AS, Hop WC, Stoter G
J Clin Oncol 1995 Jul;13(7):1720-5. doi: 10.1200/JCO.1995.13.7.1720. PMID: 7541451
Metastatic adenocarcinoma of unknown primary site. A randomized study of two combination chemotherapy regimens.
Milliken ST, Tattersall MH, Woods RL, Coates AS, Levi JA, Fox RM, Raghavan D
Eur J Cancer Clin Oncol 1987 Nov;23(11):1645-8. doi: 10.1016/0277-5379(87)90443-3. PMID: 2448145

Prognosis

Phase II trial of capecitabine and oxaliplatin in patients with adeno- and undifferentiated carcinoma of unknown primary.
Schuette K, Folprecht G, Kretzschmar A, Link H, Koehne CH, Gruenwald V, Stahl M, Huebner G
Onkologie 2009 Apr;32(4):162-6. Epub 2009 Mar 13 doi: 10.1159/000201125. PMID: 19372710
A long-term survivor after pancreaticoduodenectomy for metastatic undifferentiated carcinoma of an unknown primary.
Nakagawa Y, Todoroki T, Morishita Y, Mori K, Nakahaashi C, Ohkohchi N, Matsumoto H
Hepatogastroenterology 2008 Sep-Oct;55(86-87):1557-61. PMID: 19102342
The value of immunohistochemistry in patients with poorly differentiated adenocarcinomas and undifferentiated carcinomas of unknown primary.
van der Gaast A, Verwij J, Planting AS, Stoter G, Henzen-Logmans SC
J Cancer Res Clin Oncol 1996;122(3):181-85. doi: 10.1007/BF01366960. PMID: 8601568
Simple prognostic model to predict survival in patients with undifferentiated carcinoma of unknown primary site.
van der Gaast A, Verweij J, Planting AS, Hop WC, Stoter G
J Clin Oncol 1995 Jul;13(7):1720-5. doi: 10.1200/JCO.1995.13.7.1720. PMID: 7541451
Metastatic adenocarcinoma of unknown primary site: abnormalities of cellular DNA content and survival.
Hedley DW, Leary JA, Kirsten F
Eur J Cancer Clin Oncol 1985 Feb;21(2):185-9. doi: 10.1016/0277-5379(85)90171-3. PMID: 3987755

Clinical prediction guides

Phase II trial of capecitabine and oxaliplatin in patients with adeno- and undifferentiated carcinoma of unknown primary.
Schuette K, Folprecht G, Kretzschmar A, Link H, Koehne CH, Gruenwald V, Stahl M, Huebner G
Onkologie 2009 Apr;32(4):162-6. Epub 2009 Mar 13 doi: 10.1159/000201125. PMID: 19372710
Simple prognostic model to predict survival in patients with undifferentiated carcinoma of unknown primary site.
van der Gaast A, Verweij J, Planting AS, Hop WC, Stoter G
J Clin Oncol 1995 Jul;13(7):1720-5. doi: 10.1200/JCO.1995.13.7.1720. PMID: 7541451

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