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Stage II Adult Diffuse Large Cell Lymphoma

MedGen UID:
83605
Concept ID:
C0280149
Neoplastic Process

Definition

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ) [from NCI]

Professional guidelines

PubMed

Fairchild A, McCall CM, Oyekunle T, Niedzwiecki D, Champ C, McKinney M, Kelsey CR
Clin Lymphoma Myeloma Leuk 2021 May;21(5):e464-e469. Epub 2020 Dec 30 doi: 10.1016/j.clml.2020.12.015. PMID: 33487576
van Besien K, Kelta M, Bahaguna P
J Clin Oncol 2001 Mar 15;19(6):1855-64. doi: 10.1200/JCO.2001.19.6.1855. PMID: 11251018
Sullivan MP
Cancer 1975 Mar;35(3 suppl):991-5. doi: 10.1002/1097-0142(197503)35:3+<991::aid-cncr2820350721>3.0.co;2-s. PMID: 1089476

Recent clinical studies

Etiology

Persky DO, Li H, Stephens DM, Park SI, Bartlett NL, Swinnen LJ, Barr PM, Winegarden JD 3rd, Constine LS, Fitzgerald TJ, Leonard JP, Kahl BS, LeBlanc ML, Song JY, Fisher RI, Rimsza LM, Smith SM, Miller TP, Friedberg JW
J Clin Oncol 2020 Sep 10;38(26):3003-3011. Epub 2020 Jul 13 doi: 10.1200/JCO.20.00999. PMID: 32658627Free PMC Article
Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Manley T, Francis S, Sharma M, Moskowitz AJ
J Clin Oncol 2019 Nov 20;37(33):3081-3089. Epub 2019 Aug 9 doi: 10.1200/JCO.19.01492. PMID: 31398081Free PMC Article
Dunleavy K, Fanale MA, Abramson JS, Noy A, Caimi PF, Pittaluga S, Parekh S, Lacasce A, Hayslip JW, Jagadeesh D, Nagpal S, Lechowicz MJ, Gaur R, Lucas A, Melani C, Roschewski M, Steinberg SM, Jaffe ES, Kahl B, Friedberg JW, Little RF, Bartlett NL, Wilson WH
Lancet Haematol 2018 Dec;5(12):e609-e617. doi: 10.1016/S2352-3026(18)30177-7. PMID: 30501868Free PMC Article
Pfreundschuh M, Kuhnt E, Trümper L, Osterborg A, Trneny M, Shepherd L, Gill DS, Walewski J, Pettengell R, Jaeger U, Zinzani PL, Shpilberg O, Kvaloy S, de Nully Brown P, Stahel R, Milpied N, López-Guillermo A, Poeschel V, Grass S, Loeffler M, Murawski N; MabThera International Trial (MInT) Group
Lancet Oncol 2011 Oct;12(11):1013-22. Epub 2011 Sep 21 doi: 10.1016/S1470-2045(11)70235-2. PMID: 21940214

Diagnosis

Yin K, Brydges H, Lawrence KW, Wei Y, Karlson KJ, McAneny DB, Edwards NM, Reardon MJ, Dobrilovic N
J Thorac Cardiovasc Surg 2022 Aug;164(2):573-580.e1. Epub 2020 Oct 7 doi: 10.1016/j.jtcvs.2020.09.102. PMID: 33158567
Al-Juhaishi T, Al-Kindi SG
Int J Cardiol 2021 Sep 15;339:146-149. Epub 2021 Jul 26 doi: 10.1016/j.ijcard.2021.07.043. PMID: 34324949
Fairchild A, McCall CM, Oyekunle T, Niedzwiecki D, Champ C, McKinney M, Kelsey CR
Clin Lymphoma Myeloma Leuk 2021 May;21(5):e464-e469. Epub 2020 Dec 30 doi: 10.1016/j.clml.2020.12.015. PMID: 33487576
Persky DO, Li H, Stephens DM, Park SI, Bartlett NL, Swinnen LJ, Barr PM, Winegarden JD 3rd, Constine LS, Fitzgerald TJ, Leonard JP, Kahl BS, LeBlanc ML, Song JY, Fisher RI, Rimsza LM, Smith SM, Miller TP, Friedberg JW
J Clin Oncol 2020 Sep 10;38(26):3003-3011. Epub 2020 Jul 13 doi: 10.1200/JCO.20.00999. PMID: 32658627Free PMC Article
Pfreundschuh M, Trümper L, Osterborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani PL, Stahel R, Kvaloy S, Shpilberg O, Jaeger U, Hansen M, Lehtinen T, López-Guillermo A, Corrado C, Scheliga A, Milpied N, Mendila M, Rashford M, Kuhnt E, Loeffler M; MabThera International Trial Group
Lancet Oncol 2006 May;7(5):379-91. doi: 10.1016/S1470-2045(06)70664-7. PMID: 16648042

Therapy

Persky DO, Li H, Stephens DM, Park SI, Bartlett NL, Swinnen LJ, Barr PM, Winegarden JD 3rd, Constine LS, Fitzgerald TJ, Leonard JP, Kahl BS, LeBlanc ML, Song JY, Fisher RI, Rimsza LM, Smith SM, Miller TP, Friedberg JW
J Clin Oncol 2020 Sep 10;38(26):3003-3011. Epub 2020 Jul 13 doi: 10.1200/JCO.20.00999. PMID: 32658627Free PMC Article
Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Manley T, Francis S, Sharma M, Moskowitz AJ
J Clin Oncol 2019 Nov 20;37(33):3081-3089. Epub 2019 Aug 9 doi: 10.1200/JCO.19.01492. PMID: 31398081Free PMC Article
Dunleavy K, Fanale MA, Abramson JS, Noy A, Caimi PF, Pittaluga S, Parekh S, Lacasce A, Hayslip JW, Jagadeesh D, Nagpal S, Lechowicz MJ, Gaur R, Lucas A, Melani C, Roschewski M, Steinberg SM, Jaffe ES, Kahl B, Friedberg JW, Little RF, Bartlett NL, Wilson WH
Lancet Haematol 2018 Dec;5(12):e609-e617. doi: 10.1016/S2352-3026(18)30177-7. PMID: 30501868Free PMC Article
López A, Gutiérrez A, Palacios A, Blancas I, Navarrete M, Morey M, Perelló A, Alarcón J, Martínez J, Rodríguez J
Eur J Haematol 2008 Feb;80(2):127-32. Epub 2007 Nov 20 doi: 10.1111/j.1600-0609.2007.00996.x. PMID: 18005385

Prognosis

Yin K, Brydges H, Lawrence KW, Wei Y, Karlson KJ, McAneny DB, Edwards NM, Reardon MJ, Dobrilovic N
J Thorac Cardiovasc Surg 2022 Aug;164(2):573-580.e1. Epub 2020 Oct 7 doi: 10.1016/j.jtcvs.2020.09.102. PMID: 33158567
Persky DO, Li H, Stephens DM, Park SI, Bartlett NL, Swinnen LJ, Barr PM, Winegarden JD 3rd, Constine LS, Fitzgerald TJ, Leonard JP, Kahl BS, LeBlanc ML, Song JY, Fisher RI, Rimsza LM, Smith SM, Miller TP, Friedberg JW
J Clin Oncol 2020 Sep 10;38(26):3003-3011. Epub 2020 Jul 13 doi: 10.1200/JCO.20.00999. PMID: 32658627Free PMC Article
Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Dunleavy K, Fanale MA, Abramson JS, Noy A, Caimi PF, Pittaluga S, Parekh S, Lacasce A, Hayslip JW, Jagadeesh D, Nagpal S, Lechowicz MJ, Gaur R, Lucas A, Melani C, Roschewski M, Steinberg SM, Jaffe ES, Kahl B, Friedberg JW, Little RF, Bartlett NL, Wilson WH
Lancet Haematol 2018 Dec;5(12):e609-e617. doi: 10.1016/S2352-3026(18)30177-7. PMID: 30501868Free PMC Article
Pfreundschuh M, Kuhnt E, Trümper L, Osterborg A, Trneny M, Shepherd L, Gill DS, Walewski J, Pettengell R, Jaeger U, Zinzani PL, Shpilberg O, Kvaloy S, de Nully Brown P, Stahel R, Milpied N, López-Guillermo A, Poeschel V, Grass S, Loeffler M, Murawski N; MabThera International Trial (MInT) Group
Lancet Oncol 2011 Oct;12(11):1013-22. Epub 2011 Sep 21 doi: 10.1016/S1470-2045(11)70235-2. PMID: 21940214

Clinical prediction guides

Gini G, Tani M, Tucci A, Marcheselli L, Cesaretti M, Bellei M, Pascarella A, Ballerini F, Petrini M, Merli F, Olivieri A, Lanza F, Annibali O, Zilioli VR, Liberati AM, Tisi MC, Arcari A, Marino D, Musuraca G, Pavone V, Fabbri A, Pozzi S, Mannina D, Plenteda C, Celli M, Luminari S
Blood 2023 Oct 26;142(17):1438-1447. doi: 10.1182/blood.2022019173. PMID: 37418685
Persky DO, Li H, Stephens DM, Park SI, Bartlett NL, Swinnen LJ, Barr PM, Winegarden JD 3rd, Constine LS, Fitzgerald TJ, Leonard JP, Kahl BS, LeBlanc ML, Song JY, Fisher RI, Rimsza LM, Smith SM, Miller TP, Friedberg JW
J Clin Oncol 2020 Sep 10;38(26):3003-3011. Epub 2020 Jul 13 doi: 10.1200/JCO.20.00999. PMID: 32658627Free PMC Article
Dunleavy K, Fanale MA, Abramson JS, Noy A, Caimi PF, Pittaluga S, Parekh S, Lacasce A, Hayslip JW, Jagadeesh D, Nagpal S, Lechowicz MJ, Gaur R, Lucas A, Melani C, Roschewski M, Steinberg SM, Jaffe ES, Kahl B, Friedberg JW, Little RF, Bartlett NL, Wilson WH
Lancet Haematol 2018 Dec;5(12):e609-e617. doi: 10.1016/S2352-3026(18)30177-7. PMID: 30501868Free PMC Article
Pfreundschuh M, Kuhnt E, Trümper L, Osterborg A, Trneny M, Shepherd L, Gill DS, Walewski J, Pettengell R, Jaeger U, Zinzani PL, Shpilberg O, Kvaloy S, de Nully Brown P, Stahel R, Milpied N, López-Guillermo A, Poeschel V, Grass S, Loeffler M, Murawski N; MabThera International Trial (MInT) Group
Lancet Oncol 2011 Oct;12(11):1013-22. Epub 2011 Sep 21 doi: 10.1016/S1470-2045(11)70235-2. PMID: 21940214
López A, Gutiérrez A, Palacios A, Blancas I, Navarrete M, Morey M, Perelló A, Alarcón J, Martínez J, Rodríguez J
Eur J Haematol 2008 Feb;80(2):127-32. Epub 2007 Nov 20 doi: 10.1111/j.1600-0609.2007.00996.x. PMID: 18005385

Recent systematic reviews

Chen Y, Chen Y, Chen S, Wu L, Xu L, Lian G, Yang K, Li Y, Zeng L, Huang K
Medicine (Baltimore) 2015 Nov;94(47):e2119. doi: 10.1097/MD.0000000000002119. PMID: 26632732Free PMC Article
Knight C, Hind D, Brewer N, Abbott V
Health Technol Assess 2004 Sep;8(37):iii, ix-xi, 1-82. doi: 10.3310/hta8370. PMID: 15361313
Kimby E, Brandt L, Nygren P, Glimelius B; SBU-group. Swedish Council of Technology Assessment in Health Care
Acta Oncol 2001;40(2-3):198-212. doi: 10.1080/02841860151116268. PMID: 11441932

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