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Uterine carcinosarcoma

MedGen UID:
83678
•Concept ID:
C0280630
•
Neoplastic Process
Synonyms: Carcinosarcoma of the Uterus; carcinosarcoma of the uterus; Carcinosarcoma of uterus; Malignant Mixed Mesodermal (Mullerian) Tumor of the Uterus; malignant mixed mesodermal (Mullerian) tumor of the uterus; Malignant Mixed Mesodermal (Müllerian) Tumor of the Uterus; malignant mixed mesodermal (Müllerian) tumor of the uterus; Malignant mixed Mullerian tumor of uterus; mixed mullerian sarcoma of uterus; Uterine Carcinosarcoma; uterine carcinosarcoma; uterine carcinosarcoma/uterine malignant mixed mullerian tumor; Uterine Malignant Mixed Mesodermal (Mullerian) Tumor; uterine malignant mixed mesodermal (Mullerian) tumor; Uterine Malignant Mixed Mesodermal (Müllerian) Tumor; uterine malignant mixed mesodermal (Müllerian) tumor; uterus carcinosarcoma
SNOMED CT: Uterine carcinosarcoma (702369008); Carcinosarcoma of uterus (702369008); Malignant mixed Mullerian tumor of uterus (702369008)
 
Monarch Initiative: MONDO:0006485

Definition

A usually aggressive malignant neoplasm arising from the uterine corpus and less often the cervix. It is characterized by the presence of two components: a malignant epithelial component and a sarcomatous component. In the uterine corpus the epithelial component is usually glandular whereas in the cervix is usually non-glandular. Carcinosarcoma of the cervix, although it is aggressive, it may have a better prognosis compared to the uterine corpus carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Management and Prognosis of Patients with Recurrent or Persistent/Progressive Uterine Carcinosarcoma.
Tung HJ, Chiang CY, Chang WY, Wu RC, Huang HJ, Yang LY, Lin CY, Wang CC, Chao A, Lai CH
Curr Oncol 2022 Oct 13;29(10):7607-7623. doi: 10.3390/curroncol29100601. PMID: 36290878Free PMC Article
Beyond Serous: Treatment Options for Rare Endometrial Cancers.
Crane E
Curr Treat Options Oncol 2022 Nov;23(11):1590-1600. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01014-7. PMID: 36205807
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231

Recent clinical studies

Etiology

Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2-Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial.
Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Prognostic value of the TCGA molecular classification in uterine carcinosarcoma.
Travaglino A, Raffone A, Raimondo D, Arciuolo D, Angelico G, Valente M, Scaglione G, D'alessandris N, Casadio P, Inzani F, Mollo A, Santoro A, Seracchioli R, Franco Zannoni G
Int J Gynaecol Obstet 2022 Jul;158(1):13-20. Epub 2021 Oct 11 doi: 10.1002/ijgo.13937. PMID: 34536971Free PMC Article
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231

Diagnosis

Prognostic value of the TCGA molecular classification in uterine carcinosarcoma.
Travaglino A, Raffone A, Raimondo D, Arciuolo D, Angelico G, Valente M, Scaglione G, D'alessandris N, Casadio P, Inzani F, Mollo A, Santoro A, Seracchioli R, Franco Zannoni G
Int J Gynaecol Obstet 2022 Jul;158(1):13-20. Epub 2021 Oct 11 doi: 10.1002/ijgo.13937. PMID: 34536971Free PMC Article
Uterine carcinosarcoma: An overview.
Pezzicoli G, Moscaritolo F, Silvestris E, Silvestris F, Cormio G, Porta C, D'Oronzo S
Crit Rev Oncol Hematol 2021 Jul;163:103369. Epub 2021 May 27 doi: 10.1016/j.critrevonc.2021.103369. PMID: 34051304
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Uterine carcinosarcoma.
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326

Therapy

Randomized Phase III Trial of Paclitaxel and Carboplatin Versus Paclitaxel and Ifosfamide in Patients With Carcinosarcoma of the Uterus or Ovary: An NRG Oncology Trial.
Powell MA, Filiaci VL, Hensley ML, Huang HQ, Moore KN, Tewari KS, Copeland LJ, Secord AA, Mutch DG, Santin A, Warshal DP, Spirtos NM, DiSilvestro PA, Ioffe OB, Miller DS
J Clin Oncol 2022 Mar 20;40(9):968-977. Epub 2022 Jan 10 doi: 10.1200/JCO.21.02050. PMID: 35007153Free PMC Article
Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Uterine carcinosarcoma.
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326
Uterine carcinosarcoma.
El-Nashar SA, Mariani A
Clin Obstet Gynecol 2011 Jun;54(2):292-304. doi: 10.1097/GRF.0b013e31821ac635. PMID: 21508698

Prognosis

Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Uterine carcinosarcoma: An overview.
Pezzicoli G, Moscaritolo F, Silvestris E, Silvestris F, Cormio G, Porta C, D'Oronzo S
Crit Rev Oncol Hematol 2021 Jul;163:103369. Epub 2021 May 27 doi: 10.1016/j.critrevonc.2021.103369. PMID: 34051304
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
Berger AC, Korkut A, Kanchi RS, Hegde AM, Lenoir W, Liu W, Liu Y, Fan H, Shen H, Ravikumar V, Rao A, Schultz A, Li X, Sumazin P, Williams C, Mestdagh P, Gunaratne PH, Yau C, Bowlby R, Robertson AG, Tiezzi DG, Wang C, Cherniack AD, Godwin AK, Kuderer NM, Rader JS, Zuna RE, Sood AK, Lazar AJ, Ojesina AI, Adebamowo C, Adebamowo SN, Baggerly KA, Chen TW, Chiu HS, Lefever S, Liu L, MacKenzie K, Orsulic S, Roszik J, Shelley CS, Song Q, Vellano CP, Wentzensen N; Cancer Genome Atlas Research Network, Weinstein JN, Mills GB, Levine DA, Akbani R
Cancer Cell 2018 Apr 9;33(4):690-705.e9. Epub 2018 Apr 2 doi: 10.1016/j.ccell.2018.03.014. PMID: 29622464Free PMC Article

Clinical prediction guides

Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2-Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial.
Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
cERBB-2/Her-2 Neu Overexpression and Prognostic Significance in Uterine Carcinosarcoma.
Semiz HS, Pala EE, Can B, Atag E, Gungor H, Sanci M
Turk Patoloji Derg 2023;39(1):55-63. doi: 10.5146/tjpath.2022.01588. PMID: 36178283Free PMC Article
The BRCAness Landscape of Cancer.
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
How and where to expect endosalpingiosis intraoperatively.
Burla L, Kalaitzopoulos DR, Mrozek A, Eberhard M, Samartzis N
Fertil Steril 2022 Feb;117(2):461-462. Epub 2022 Jan 2 doi: 10.1016/j.fertnstert.2021.11.016. PMID: 34986982
Ultrasonographic Findings of Uterine Carcinosarcoma.
Zhao F, Xu Y, Zhang H, Ren Y
Gynecol Obstet Invest 2019;84(3):277-282. Epub 2018 Nov 30 doi: 10.1159/000481885. PMID: 30504724

Recent systematic reviews

Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Prognostic value of the TCGA molecular classification in uterine carcinosarcoma.
Travaglino A, Raffone A, Raimondo D, Arciuolo D, Angelico G, Valente M, Scaglione G, D'alessandris N, Casadio P, Inzani F, Mollo A, Santoro A, Seracchioli R, Franco Zannoni G
Int J Gynaecol Obstet 2022 Jul;158(1):13-20. Epub 2021 Oct 11 doi: 10.1002/ijgo.13937. PMID: 34536971Free PMC Article
TCGA Classification of Endometrial Cancer: the Place of Carcinosarcoma.
Travaglino A, Raffone A, Gencarelli A, Mollo A, Guida M, Insabato L, Santoro A, Zannoni GF, Zullo F
Pathol Oncol Res 2020 Oct;26(4):2067-2073. Epub 2020 May 29 doi: 10.1007/s12253-020-00829-9. PMID: 32472441
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma.
Galaal K, van der Heijden E, Godfrey K, Naik R, Kucukmetin A, Bryant A, Das N, Lopes AD
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD006812. doi: 10.1002/14651858.CD006812.pub3. PMID: 23450572Free PMC Article
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma.
Galaal K, Godfrey K, Naik R, Kucukmetin A, Bryant A
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006812. doi: 10.1002/14651858.CD006812.pub2. PMID: 21249682Free PMC Article

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