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Neuroendocrine cell hyperplasia of infancy

MedGen UID:
837309
Concept ID:
C3161105
Disease or Syndrome
Synonyms: chronic tachypnoe of infancy; CTI; NCHI; NEHI; Neuroendocrine Cell Hyperplasia of Infancy; neuroendocrine cell hyperplasia of infancy
SNOMED CT: Neuroendocrine cell hyperplasia of infancy (707435002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016322
Orphanet: ORPHA217560

Definition

Neuroendocrine cell hyperplasia of infancy (NCHI) is a non-lethal pediatric form of interstitial lung disease (ILD, see this term) characterized by tachypnea without respiratory failure. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine cell hyperplasia of infancy

Professional guidelines

PubMed

Fabre C, Thumerelle C, Dervaux M, Abou-Taam R, Bihouee T, Brouard J, Clement A, Delacourt C, Delestrain C, Epaud R, Ghdifan S, Hadchouel A, Houdouin V, Labouret G, Perisson C, Reix P, Renoux MC, Troussier F, Weiss L, Mazenq J, Nathan N, Dubus JC
Eur J Pediatr 2022 Aug;181(8):3067-3073. Epub 2022 Jun 9 doi: 10.1007/s00431-022-04510-y. PMID: 35678871
Gomes VC, Silva MC, Maia Filho JH, Daltro P, Ramos SG, Brody AS, Marchiori E
J Bras Pneumol 2013 Sep-Oct;39(5):569-78. doi: 10.1590/S1806-37132013000500007. PMID: 24310630Free PMC Article

Recent clinical studies

Etiology

Fabre C, Thumerelle C, Dervaux M, Abou-Taam R, Bihouee T, Brouard J, Clement A, Delacourt C, Delestrain C, Epaud R, Ghdifan S, Hadchouel A, Houdouin V, Labouret G, Perisson C, Reix P, Renoux MC, Troussier F, Weiss L, Mazenq J, Nathan N, Dubus JC
Eur J Pediatr 2022 Aug;181(8):3067-3073. Epub 2022 Jun 9 doi: 10.1007/s00431-022-04510-y. PMID: 35678871
Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR
Ann Am Thorac Soc 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152Free PMC Article
Mastej EJ, DeBoer EM, Humphries SM, Cook MC, Hunter KS, Liptzin DR, Weinman JP, Deterding RR
Pediatr Radiol 2018 Nov;48(12):1745-1754. Epub 2018 Jun 28 doi: 10.1007/s00247-018-4189-6. PMID: 29955904
Nogee LM
Semin Fetal Neonatal Med 2017 Aug;22(4):227-233. Epub 2017 Mar 28 doi: 10.1016/j.siny.2017.03.003. PMID: 28363760Free PMC Article
Popler J, Gower WA, Mogayzel PJ Jr, Nogee LM, Langston C, Wilson AC, Hay TC, Deterding RR
Pediatr Pulmonol 2010 Aug;45(8):749-55. doi: 10.1002/ppul.21219. PMID: 20623780

Diagnosis

Dervaux M, Thumerelle C, Fabre C, Abou-Taam R, Bihouee T, Brouard J, Clement A, Delacourt C, Delestrain C, Epaud R, Ghdifan S, Hadchouel A, Houdouin V, Labouret G, Perisson C, Reix P, Renoux MC, Troussier F, Weiss L, Mazenq J, Nathan N, Dubus JC
Eur J Pediatr 2023 Feb;182(2):949-956. Epub 2022 Nov 30 doi: 10.1007/s00431-022-04734-y. PMID: 36449078
Fabre C, Thumerelle C, Dervaux M, Abou-Taam R, Bihouee T, Brouard J, Clement A, Delacourt C, Delestrain C, Epaud R, Ghdifan S, Hadchouel A, Houdouin V, Labouret G, Perisson C, Reix P, Renoux MC, Troussier F, Weiss L, Mazenq J, Nathan N, Dubus JC
Eur J Pediatr 2022 Aug;181(8):3067-3073. Epub 2022 Jun 9 doi: 10.1007/s00431-022-04510-y. PMID: 35678871
Bush A, Gilbert C, Gregory J, Nicholson AG, Semple T, Pabary R
Early Hum Dev 2020 Nov;150:105186. Epub 2020 Sep 15 doi: 10.1016/j.earlhumdev.2020.105186. PMID: 32958330
Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR
Ann Am Thorac Soc 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152Free PMC Article
Nogee LM
Semin Fetal Neonatal Med 2017 Aug;22(4):227-233. Epub 2017 Mar 28 doi: 10.1016/j.siny.2017.03.003. PMID: 28363760Free PMC Article

Therapy

Marczak H, Peradzyńska J, Seidl E, Griese M, Urbankowski T, Lange J, Bogusławski S, Krenke K
Pediatr Pulmonol 2021 Dec;56(12):3952-3959. Epub 2021 Sep 21 doi: 10.1002/ppul.25674. PMID: 34520130
Nevel RJ, Garnett ET, Schaudies DA, Young LR
Pediatr Pulmonol 2018 May;53(5):656-663. Epub 2018 Feb 2 doi: 10.1002/ppul.23958. PMID: 29393588Free PMC Article

Prognosis

Bush A, Gilbert C, Gregory J, Nicholson AG, Semple T, Pabary R
Early Hum Dev 2020 Nov;150:105186. Epub 2020 Sep 15 doi: 10.1016/j.earlhumdev.2020.105186. PMID: 32958330
Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR
Ann Am Thorac Soc 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152Free PMC Article
Nevel RJ, Garnett ET, Schaudies DA, Young LR
Pediatr Pulmonol 2018 May;53(5):656-663. Epub 2018 Feb 2 doi: 10.1002/ppul.23958. PMID: 29393588Free PMC Article
Nogee LM
Semin Fetal Neonatal Med 2017 Aug;22(4):227-233. Epub 2017 Mar 28 doi: 10.1016/j.siny.2017.03.003. PMID: 28363760Free PMC Article
Das S, Langston C, Fan LL
Curr Opin Pediatr 2011 Jun;23(3):325-31. doi: 10.1097/MOP.0b013e3283464a37. PMID: 21572385

Clinical prediction guides

Fabre C, Thumerelle C, Dervaux M, Abou-Taam R, Bihouee T, Brouard J, Clement A, Delacourt C, Delestrain C, Epaud R, Ghdifan S, Hadchouel A, Houdouin V, Labouret G, Perisson C, Reix P, Renoux MC, Troussier F, Weiss L, Mazenq J, Nathan N, Dubus JC
Eur J Pediatr 2022 Aug;181(8):3067-3073. Epub 2022 Jun 9 doi: 10.1007/s00431-022-04510-y. PMID: 35678871
Marczak H, Peradzyńska J, Seidl E, Griese M, Urbankowski T, Lange J, Bogusławski S, Krenke K
Pediatr Pulmonol 2021 Dec;56(12):3952-3959. Epub 2021 Sep 21 doi: 10.1002/ppul.25674. PMID: 34520130
Seidl E, Carlens J, Schwerk N, Wetzke M, Marczak H, Lange J, Krenke K, Mayell SJ, Escribano A, Seidenberg J, Ahrens F, Hebestreit H, Nährlich L, Sismanlar T, Aslan AT, Snijders D, Ullmann N, Kappler M, Griese M
Pediatr Pulmonol 2020 Nov;55(11):3119-3125. Epub 2020 Aug 13 doi: 10.1002/ppul.25004. PMID: 32761949
Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR
Ann Am Thorac Soc 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. PMID: 32109152Free PMC Article
Nevel RJ, Garnett ET, Schaudies DA, Young LR
Pediatr Pulmonol 2018 May;53(5):656-663. Epub 2018 Feb 2 doi: 10.1002/ppul.23958. PMID: 29393588Free PMC Article

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