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Metastatic Malignant Neoplasm in the Pituitary Gland

MedGen UID:
83847
•Concept ID:
C0347015
•
Neoplastic Process
Synonyms: Cancer metastatic to pituitary gland; Metastasis to pituitary; Metastasis to Pituitary Gland; Metastatic malignant neoplasm of pituitary gland; Metastatic malignant neoplasm to pituitary gland; Metastatic Malignant Neoplasm to the Pituitary Gland; Metastatic Neoplasm to the Pituitary Gland; Secondary malignant neoplasm of pituitary gland
SNOMED CT: Metastasis to pituitary (94491007); Secondary malignant neoplasm of pituitary gland (94491007); Metastatic malignant neoplasm to pituitary gland (94491007); Cancer metastatic to pituitary gland (94491007); Metastatic malignant neoplasm of pituitary gland (94491007)

Definition

A malignant neoplasm metastasizing to the pituitary gland from another anatomic site. The vast majority are carcinomas usually arising from the breast, lung, and gastrointestinal tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Pituitary Gland

Professional guidelines

PubMed

The Role of Surgical Approaches in the Multi-Modal Management of Adult Craniopharyngiomas.
Hong CS, Omay SB
Curr Oncol 2022 Feb 24;29(3):1408-1421. doi: 10.3390/curroncol29030118. PMID: 35323318Free PMC Article
Resistant Hypertension: Diagnosis and Management.
Nagarajan N, Jalal D
Adv Chronic Kidney Dis 2019 Mar;26(2):99-109. doi: 10.1053/j.ackd.2019.03.002. PMID: 31023454
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Recent clinical studies

Etiology

Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study.
Deutschbein T, Reimondo G, Di Dalmazi G, Bancos I, Patrova J, Vassiliadi DA, Nekić AB, Debono M, Lardo P, Ceccato F, Petramala L, Prete A, Chiodini I, Ivović M, Pazaitou-Panayiotou K, Alexandraki KI, Hanzu FA, Loli P, Yener S, Langton K, Spyroglou A, Kocjan T, Zacharieva S, Valdés N, Ambroziak U, Suzuki M, Detomas M, Puglisi S, Tucci L, Delivanis DA, Margaritopoulos D, Dusek T, Maggio R, Scaroni C, Concistrè A, Ronchi CL, Altieri B, Mosconi C, Diamantopoulos A, Iñiguez-Ariza NM, Vicennati V, Pia A, Kroiss M, Kaltsas G, Chrisoulidou A, Marina LV, Morelli V, Arlt W, Letizia C, Boscaro M, Stigliano A, Kastelan D, Tsagarakis S, Athimulam S, Pagotto U, Maeder U, Falhammar H, Newell-Price J, Terzolo M, Fassnacht M
Lancet Diabetes Endocrinol 2022 Jul;10(7):499-508. Epub 2022 May 6 doi: 10.1016/S2213-8587(22)00100-0. PMID: 35533704Free PMC Article
The Role of Surgical Approaches in the Multi-Modal Management of Adult Craniopharyngiomas.
Hong CS, Omay SB
Curr Oncol 2022 Feb 24;29(3):1408-1421. doi: 10.3390/curroncol29030118. PMID: 35323318Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Pituitary Apoplexy.
Briet C, Salenave S, Bonneville JF, Laws ER, Chanson P
Endocr Rev 2015 Dec;36(6):622-45. Epub 2015 Sep 28 doi: 10.1210/er.2015-1042. PMID: 26414232
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Diagnosis

Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Craniopharyngiomas.
Hamblin R, Tsermoulas G, Karavitaki N
Presse Med 2021 Dec;50(4):104078. Epub 2021 Oct 22 doi: 10.1016/j.lpm.2021.104078. PMID: 34688870
Empty sella syndrome: Multiple endocrine disorders.
Chiloiro S, Giampietro A, Bianchi A, De Marinis L
Handb Clin Neurol 2021;181:29-40. doi: 10.1016/B978-0-12-820683-6.00003-8. PMID: 34238465
Imaging findings in hypophysitis: a review.
Caranci F, Leone G, Ponsiglione A, Muto M, Tortora F, Muto M, Cirillo S, Brunese L, Cerase A
Radiol Med 2020 Mar;125(3):319-328. Epub 2019 Dec 20 doi: 10.1007/s11547-019-01120-x. PMID: 31863360
Pituitary Apoplexy.
Briet C, Salenave S, Bonneville JF, Laws ER, Chanson P
Endocr Rev 2015 Dec;36(6):622-45. Epub 2015 Sep 28 doi: 10.1210/er.2015-1042. PMID: 26414232

Therapy

Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study.
Deutschbein T, Reimondo G, Di Dalmazi G, Bancos I, Patrova J, Vassiliadi DA, Nekić AB, Debono M, Lardo P, Ceccato F, Petramala L, Prete A, Chiodini I, Ivović M, Pazaitou-Panayiotou K, Alexandraki KI, Hanzu FA, Loli P, Yener S, Langton K, Spyroglou A, Kocjan T, Zacharieva S, Valdés N, Ambroziak U, Suzuki M, Detomas M, Puglisi S, Tucci L, Delivanis DA, Margaritopoulos D, Dusek T, Maggio R, Scaroni C, Concistrè A, Ronchi CL, Altieri B, Mosconi C, Diamantopoulos A, Iñiguez-Ariza NM, Vicennati V, Pia A, Kroiss M, Kaltsas G, Chrisoulidou A, Marina LV, Morelli V, Arlt W, Letizia C, Boscaro M, Stigliano A, Kastelan D, Tsagarakis S, Athimulam S, Pagotto U, Maeder U, Falhammar H, Newell-Price J, Terzolo M, Fassnacht M
Lancet Diabetes Endocrinol 2022 Jul;10(7):499-508. Epub 2022 May 6 doi: 10.1016/S2213-8587(22)00100-0. PMID: 35533704Free PMC Article
Complications in Endoscopic Pituitary Surgery.
Vignolles-Jeong J, Kreatsoulas D, Godil S, Otto B, Carrau R, Prevedello D
Otolaryngol Clin North Am 2022 Apr;55(2):431-448. doi: 10.1016/j.otc.2021.12.011. PMID: 35365316
The imaging of immunotherapy-related hypophysitis and other pituitary lesions in oncology patients.
Lasocki A, Iravani A, Galligan A
Clin Radiol 2021 May;76(5):325-332. Epub 2021 Feb 14 doi: 10.1016/j.crad.2020.12.028. PMID: 33593600
Pituitary Apoplexy.
Briet C, Salenave S, Bonneville JF, Laws ER, Chanson P
Endocr Rev 2015 Dec;36(6):622-45. Epub 2015 Sep 28 doi: 10.1210/er.2015-1042. PMID: 26414232
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Prognosis

Pituitary metastasis: a clinical overview.
Henry A, Nugent A, Wallace IR, Oladipo B, Sheehy O, Johnston PC
Ulster Med J 2021 Sep;90(3):146-150. Epub 2021 Nov 11 PMID: 34815592Free PMC Article
Craniopharyngiomas.
Hamblin R, Tsermoulas G, Karavitaki N
Presse Med 2021 Dec;50(4):104078. Epub 2021 Oct 22 doi: 10.1016/j.lpm.2021.104078. PMID: 34688870
Imaging findings in hypophysitis: a review.
Caranci F, Leone G, Ponsiglione A, Muto M, Tortora F, Muto M, Cirillo S, Brunese L, Cerase A
Radiol Med 2020 Mar;125(3):319-328. Epub 2019 Dec 20 doi: 10.1007/s11547-019-01120-x. PMID: 31863360
MicroRNAs and Target Genes in Pituitary Adenomas.
Feng Y, Mao ZG, Wang X, Du Q, Jian M, Zhu D, Xiao Z, Wang HJ, Zhu YH
Horm Metab Res 2018 Mar;50(3):179-192. Epub 2018 Jan 19 doi: 10.1055/s-0043-123763. PMID: 29351706
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Clinical prediction guides

Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study.
Deutschbein T, Reimondo G, Di Dalmazi G, Bancos I, Patrova J, Vassiliadi DA, Nekić AB, Debono M, Lardo P, Ceccato F, Petramala L, Prete A, Chiodini I, Ivović M, Pazaitou-Panayiotou K, Alexandraki KI, Hanzu FA, Loli P, Yener S, Langton K, Spyroglou A, Kocjan T, Zacharieva S, Valdés N, Ambroziak U, Suzuki M, Detomas M, Puglisi S, Tucci L, Delivanis DA, Margaritopoulos D, Dusek T, Maggio R, Scaroni C, Concistrè A, Ronchi CL, Altieri B, Mosconi C, Diamantopoulos A, Iñiguez-Ariza NM, Vicennati V, Pia A, Kroiss M, Kaltsas G, Chrisoulidou A, Marina LV, Morelli V, Arlt W, Letizia C, Boscaro M, Stigliano A, Kastelan D, Tsagarakis S, Athimulam S, Pagotto U, Maeder U, Falhammar H, Newell-Price J, Terzolo M, Fassnacht M
Lancet Diabetes Endocrinol 2022 Jul;10(7):499-508. Epub 2022 May 6 doi: 10.1016/S2213-8587(22)00100-0. PMID: 35533704Free PMC Article
Imaging findings in hypophysitis: a review.
Caranci F, Leone G, Ponsiglione A, Muto M, Tortora F, Muto M, Cirillo S, Brunese L, Cerase A
Radiol Med 2020 Mar;125(3):319-328. Epub 2019 Dec 20 doi: 10.1007/s11547-019-01120-x. PMID: 31863360
MicroRNAs and Target Genes in Pituitary Adenomas.
Feng Y, Mao ZG, Wang X, Du Q, Jian M, Zhu D, Xiao Z, Wang HJ, Zhu YH
Horm Metab Res 2018 Mar;50(3):179-192. Epub 2018 Jan 19 doi: 10.1055/s-0043-123763. PMID: 29351706
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Recent systematic reviews

Metastatic pituitary tumors: an institutional case series.
Yearley AG, Chalif EJ, Gupta S, Chalif JI, Bernstock JD, Nawabi N, Arnaout O, Smith TR, Reardon DA, Laws ER
Pituitary 2023 Oct;26(5):561-572. Epub 2023 Jul 31 doi: 10.1007/s11102-023-01341-4. PMID: 37523025
Isolated Pituitary Metastasis of Renal Cell Carcinoma: A Case Report and Systematic Review of the Literature.
Öven BB, Demir MK, Çelik S, Moujawaz R, Somay A, Kılıc T
Curr Med Imaging 2022;18(13):1426-1432. doi: 10.2174/0929866529666220426121245. PMID: 35490330
Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review.
Feola T, Gianno F, De Angelis M, Colonnese C, Esposito V, Giangaspero F, Jaffrain-Rea ML
J Endocrinol Invest 2021 Oct;44(10):2103-2122. Epub 2021 May 3 doi: 10.1007/s40618-021-01577-6. PMID: 33939106Free PMC Article
Gene and protein expression in pituitary corticotroph adenomas: a systematic review of the literature.
Seltzer J, Ashton CE, Scotton TC, Pangal D, Carmichael JD, Zada G
Neurosurg Focus 2015 Feb;38(2):E17. doi: 10.3171/2014.10.FOCUS14683. PMID: 25639319
Metastatic involvement of the pituitary gland: a systematic review with pooled individual patient data analysis.
He W, Chen F, Dalm B, Kirby PA, Greenlee JD
Pituitary 2015 Feb;18(1):159-68. doi: 10.1007/s11102-014-0552-2. PMID: 24445565

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