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Carcinoma in situ of cecum

MedGen UID:
83854
•Concept ID:
C0347126
•
Neoplastic Process
Synonyms: caecum carcinoma in situ; caecum in situ carcinoma; carcinoma in situ of caecum; Carcinoma In Situ of Cecum; carcinoma in situ of cecum; Carcinoma In Situ of the Cecum; carcinoma in situ of the cecum; Cecum Carcinoma In Situ; cecum carcinoma in situ; Cecum Carcinoma In Situ AJCC v6; cecum carcinoma in situ aJCC v6; Cecum Carcinoma In Situ AJCC v7; cecum carcinoma in situ aJCC v7; stage 0 caecum carcinoma; Stage 0 Cecum Carcinoma; stage 0 cecum carcinoma
SNOMED CT: Carcinoma in situ of cecum (92559007)
 
Monarch Initiative: MONDO:0021289

Definition

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ: intraepithelial or invasion of lamina propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma in situ of cecum

Professional guidelines

PubMed

In situ cancer vaccination with a replication-conditional HSV for the treatment of liver metastasis of colon cancer.
Endo T, Toda M, Watanabe M, Iizuka Y, Kubota T, Kitajima M, Kawakami Y
Cancer Gene Ther 2002 Feb;9(2):142-8. doi: 10.1038/sj.cgt.7700407. PMID: 11857031
A prospective study of diagnostic methods in adenoma follow-up.
Williams CB, Macrae FA, Bartram CI
Endoscopy 1982 May;14(3):74-8. doi: 10.1055/s-2007-1021584. PMID: 7075563

Recent clinical studies

Etiology

Impact of MLH1 expression on tumor evolution after curative surgical tumor resection in a murine orthotopic xenograft model for human MSI colon cancer.
Meunier K, Ferron M, Calmel C, Fléjou JF, Pocard M, Praz F
Genes Chromosomes Cancer 2017 Sep;56(9):681-690. Epub 2017 Jun 12 doi: 10.1002/gcc.22472. PMID: 28512763
Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.
Kiesslich R, Fritsch J, Holtmann M, Koehler HH, Stolte M, Kanzler S, Nafe B, Jung M, Galle PR, Neurath MF
Gastroenterology 2003 Apr;124(4):880-8. doi: 10.1053/gast.2003.50146. PMID: 12671882
Appendiceal intussusception induced by tubulovillous adenoma with carcinoma in situ: report of a case.
Ohno M, Nakamura T, Hori H, Tabuchi Y, Kuroda Y
Surg Today 2000;30(5):441-4. doi: 10.1007/s005950050620. PMID: 10819482
Experience with 1000 colonoscopic polypectomies.
Webb WA, McDaniel L, Jones L
Ann Surg 1985 May;201(5):626-32. doi: 10.1097/00000658-198505000-00012. PMID: 3873221Free PMC Article
Multiple primary carcinomas of the colon and associated extracolonic primary malignant tumors.
Lee TK, Barringer M, Myers RT, Sterchi JM
Ann Surg 1982 Apr;195(4):501-7. doi: 10.1097/00000658-198204000-00020. PMID: 7065754Free PMC Article

Diagnosis

A case of Epstein-Barr virus-associated lymphoepithelioma-like carcinoma of the colon.
Kanno-Okada H, Takahashi K, Katano H, Shimizu A, Takakuwa E, Miyamoto S, Abiko S, Yamamoto K, Shimoda T, Mitsuhashi T, Hasegawa H, Matsuno Y
Pathol Int 2021 Jun;71(6):420-426. Epub 2021 Mar 31 doi: 10.1111/pin.13095. PMID: 33792098
NUTM1-rearranged neoplasia: a multi-institution experience yields novel fusion partners and expands the histologic spectrum.
Stevens TM, Morlote D, Xiu J, Swensen J, Brandwein-Weber M, Miettinen MM, Gatalica Z, Bridge JA
Mod Pathol 2019 Jun;32(6):764-773. Epub 2019 Feb 5 doi: 10.1038/s41379-019-0206-z. PMID: 30723300Free PMC Article
Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.
Kiesslich R, Fritsch J, Holtmann M, Koehler HH, Stolte M, Kanzler S, Nafe B, Jung M, Galle PR, Neurath MF
Gastroenterology 2003 Apr;124(4):880-8. doi: 10.1053/gast.2003.50146. PMID: 12671882
Appendiceal intussusception induced by tubulovillous adenoma with carcinoma in situ: report of a case.
Ohno M, Nakamura T, Hori H, Tabuchi Y, Kuroda Y
Surg Today 2000;30(5):441-4. doi: 10.1007/s005950050620. PMID: 10819482
Adenocarcinoma in situ of the cervix. Clinicopathologic observations of 11 cases.
Tobón H, Dave H
Int J Gynecol Pathol 1988;7(2):139-51. doi: 10.1097/00004347-198805000-00005. PMID: 3294196

Therapy

Endoscopic submucosal dissection for colorectal laterally spreading tumors.
Hülagü S, Şentürk Ö, Korkmaz U, Şirin G, Duman AE, Dindar G, Çelebi A, Koç DÖ, Bozkurt N, Yılmaz H, Gürbüz Y, Duman D, Tarçın O
Turk J Gastroenterol 2013;24(6):532-40. PMID: 24623293
Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
Yokoi K, Thaker PH, Yazici S, Rebhun RR, Nam DH, He J, Kim SJ, Abbruzzese JL, Hamilton SR, Fidler IJ
Cancer Res 2005 May 1;65(9):3716-25. doi: 10.1158/0008-5472.CAN-04-3700. PMID: 15867367
Endoscopic resection of large colorectal polyps.
Pérez Roldán F, González Carro P, Legaz Huidobro ML, Villafáñez García MC, Soto Fernández S, de Pedro Esteban A, Roncero García-Escribano O, Ruiz Carrillo F
Rev Esp Enferm Dig 2004 Jan;96(1):36-47. doi: 10.4321/s1130-01082004000100006. PMID: 14971996
Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.
Kiesslich R, Fritsch J, Holtmann M, Koehler HH, Stolte M, Kanzler S, Nafe B, Jung M, Galle PR, Neurath MF
Gastroenterology 2003 Apr;124(4):880-8. doi: 10.1053/gast.2003.50146. PMID: 12671882
In situ cancer vaccination with a replication-conditional HSV for the treatment of liver metastasis of colon cancer.
Endo T, Toda M, Watanabe M, Iizuka Y, Kubota T, Kitajima M, Kawakami Y
Cancer Gene Ther 2002 Feb;9(2):142-8. doi: 10.1038/sj.cgt.7700407. PMID: 11857031

Prognosis

Right-sided rhabdoid colorectal tumors might be related to the serrated pathway.
Pancione M, Remo A, Sabatino L, Zanella C, Votino C, Fucci A, Di Blasi A, Lepore G, Daniele B, Fenizia F, Molinari E, Normanno N, Manfrin E, Vendraminelli R, Colantuoni V
Diagn Pathol 2013 Feb 20;8:31. doi: 10.1186/1746-1596-8-31. PMID: 23425390Free PMC Article
Pathological analysis of lesions within intestines resected due to ulcerative colitis.
Wejman J, Bielecki K, Ostrowska J, Baczuk L, Perkowska-Ptasińska A, Tarnowski W
Pol J Pathol 2006;57(2):113-6. PMID: 17019974
Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.
Kiesslich R, Fritsch J, Holtmann M, Koehler HH, Stolte M, Kanzler S, Nafe B, Jung M, Galle PR, Neurath MF
Gastroenterology 2003 Apr;124(4):880-8. doi: 10.1053/gast.2003.50146. PMID: 12671882
Appendiceal intussusception induced by tubulovillous adenoma with carcinoma in situ: report of a case.
Ohno M, Nakamura T, Hori H, Tabuchi Y, Kuroda Y
Surg Today 2000;30(5):441-4. doi: 10.1007/s005950050620. PMID: 10819482
Multiple primary carcinomas of the colon and associated extracolonic primary malignant tumors.
Lee TK, Barringer M, Myers RT, Sterchi JM
Ann Surg 1982 Apr;195(4):501-7. doi: 10.1097/00000658-198204000-00020. PMID: 7065754Free PMC Article

Clinical prediction guides

Right-sided rhabdoid colorectal tumors might be related to the serrated pathway.
Pancione M, Remo A, Sabatino L, Zanella C, Votino C, Fucci A, Di Blasi A, Lepore G, Daniele B, Fenizia F, Molinari E, Normanno N, Manfrin E, Vendraminelli R, Colantuoni V
Diagn Pathol 2013 Feb 20;8:31. doi: 10.1186/1746-1596-8-31. PMID: 23425390Free PMC Article
Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.
Kiesslich R, Fritsch J, Holtmann M, Koehler HH, Stolte M, Kanzler S, Nafe B, Jung M, Galle PR, Neurath MF
Gastroenterology 2003 Apr;124(4):880-8. doi: 10.1053/gast.2003.50146. PMID: 12671882
Adenocarcinoma in situ of the cervix. Clinicopathologic observations of 11 cases.
Tobón H, Dave H
Int J Gynecol Pathol 1988;7(2):139-51. doi: 10.1097/00004347-198805000-00005. PMID: 3294196
Experience with 1000 colonoscopic polypectomies.
Webb WA, McDaniel L, Jones L
Ann Surg 1985 May;201(5):626-32. doi: 10.1097/00000658-198505000-00012. PMID: 3873221Free PMC Article

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