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Benign neoplasm of gum

MedGen UID:
83856
•Concept ID:
C0347201
•
Neoplastic Process
Synonyms: Benign Gingival Neoplasm; benign gingival neoplasm; Benign Gingival Tumor; benign gingival tumor; benign gingival tumour; Benign Gum Neoplasm; benign gum neoplasm; Benign Gum Tumor; benign gum tumor; benign gum tumour; Benign Neoplasm of Gingiva; benign neoplasm of gingiva; Benign Neoplasm of Gum; benign neoplasm of gum; Benign Neoplasm of the Gingiva; benign neoplasm of the gingiva; Benign Neoplasm of the Gum; benign neoplasm of the gum; Benign tumor of alveolar mucosa; Benign tumor of gingiva; Benign Tumor of Gingiva; benign tumor of gingiva; Benign tumor of gum; Benign Tumor of Gum; benign tumor of gum; Benign Tumor of the Gingiva; benign tumor of the gingiva; Benign Tumor of the Gum; benign tumor of the gum; benign tumour of gingiva; benign tumour of gum; benign tumour of the gingiva; benign tumour of the gum; gingiva benign neoplasm
SNOMED CT: Benign tumor of gingiva (92126004); Benign tumor of alveolar mucosa (92126004); Benign tumor of gum (92126004); Benign neoplasm of gum (92126004)
 
Monarch Initiative: MONDO:0021491

Definition

A neoplasm that arises from the upper or lower gingiva and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of gum

Professional guidelines

PubMed

Traversing the diverse avenues of exopolysaccharides-based nanocarriers in the management of cancer.
Paul P, Nair R, Mahajan S, Gupta U, Aalhate M, Maji I, Singh PK
Carbohydr Polym 2023 Jul 15;312:120821. Epub 2023 Mar 20 doi: 10.1016/j.carbpol.2023.120821. PMID: 37059549
Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline.
Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, Coppes RP, Jessen N, Malhotra NK, Murphy B, Rosenthal DI, Vissink A, Wu J, Saunders DP, Peterson DE
J Clin Oncol 2021 Sep 1;39(25):2825-2843. Epub 2021 Jul 20 doi: 10.1200/JCO.21.01208. PMID: 34283635
Stimuli-responsive natural gums-based drug delivery systems for cancer treatment.
Soleimani K, Derakhshankhah H, Jaymand M, Samadian H
Carbohydr Polym 2021 Feb 15;254:117422. Epub 2020 Nov 22 doi: 10.1016/j.carbpol.2020.117422. PMID: 33357903

Recent clinical studies

Etiology

The association between oral hygiene and head and neck cancer: a meta-analysis.
Bai X, Cui C, Yin J, Li H, Gong Q, Wei B, Lu Y
Acta Odontol Scand 2023 Jul;81(5):374-395. Epub 2022 Dec 20 doi: 10.1080/00016357.2022.2158129. PMID: 36538375
Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline.
Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, Coppes RP, Jessen N, Malhotra NK, Murphy B, Rosenthal DI, Vissink A, Wu J, Saunders DP, Peterson DE
J Clin Oncol 2021 Sep 1;39(25):2825-2843. Epub 2021 Jul 20 doi: 10.1200/JCO.21.01208. PMID: 34283635
Prophylaxis for mucositis induced by ambulatory chemotherapy: systematic review.
Manzi Nde M, Silveira RC, dos Reis PE
J Adv Nurs 2016 Apr;72(4):735-46. Epub 2015 Dec 2 doi: 10.1111/jan.12867. PMID: 26626711
Understanding bisphosphonates and osteonecrosis of the jaw: uses and risks.
Rosini S, Rosini S, Bertoldi I, Frediani B
Eur Rev Med Pharmacol Sci 2015 Sep;19(17):3309-17. PMID: 26400539
Update on contraception.
Wilkinson CL, Stirland AM, Massil H
Int J STD AIDS 1997 Apr;8(4):216-22; quiz 223. doi: 10.1258/0956462971919949. PMID: 9147153

Diagnosis

Improving masticatory and swallowing ability of postoperative oral and maxillofacial tumor patients by telerehabilitation-A randomized controlled trial.
Pang P, Lin S, Chen H, Shan Y, Sun C
Clin Rehabil 2023 Sep;37(9):1178-1188. Epub 2023 Mar 29 doi: 10.1177/02692155231166326. PMID: 36991565
EVALUATION OF EFFICIENCY OF CHEWING IN PATIENTS WITH ONCOPATHOLOGY OF THE ORAL CAVITY.
Kushta AO
Wiad Lek 2022;75(12):3000-3003. doi: 10.36740/WLek202212118. PMID: 36723317
Gum polysaccharide/nanometal hybrid biocomposites in cancer diagnosis and therapy.
Makvandi P, Baghbantaraghdari Z, Zhou W, Zhang Y, Manchanda R, Agarwal T, Wu A, Maiti TK, Varma RS, Smith BR
Biotechnol Adv 2021 May-Jun;48:107711. Epub 2021 Feb 14 doi: 10.1016/j.biotechadv.2021.107711. PMID: 33592279
Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles.
Hassani A, Azarian MMS, Ibrahim WN, Hussain SA
Sci Rep 2020 Oct 20;10(1):17808. doi: 10.1038/s41598-020-71175-8. PMID: 33082415Free PMC Article
The diagnosis and management of male genital lichen sclerosus: a retrospective review of 301 patients.
Kravvas G, Shim TN, Doiron PR, Freeman A, Jameson C, Minhas S, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2018 Jan;32(1):91-95. Epub 2017 Aug 16 doi: 10.1111/jdv.14488. PMID: 28750140

Therapy

Mastic (Pistacia lentiscus) gum and oral health: a state-of-the-art review of the literature.
Alwadi MAM, Sidhu A, Khaled MB, Aboul-Enein BH
J Nat Med 2023 Jun;77(3):430-445. Epub 2023 May 6 doi: 10.1007/s11418-023-01704-y. PMID: 37147480
Effect of chewing gum on the management of chemotherapy-induced oral mucositis in children: Systematic review of experimental studies.
Semerci R, Kocaaslan EN
Eur J Cancer Care (Engl) 2022 Nov;31(6):e13727. Epub 2022 Oct 14 doi: 10.1111/ecc.13727. PMID: 36239087
Guggulsterone for Chemoprevention of Cancer.
Shishodia S, Azu N, Rosenzweig JA, Jackson DA
Curr Pharm Des 2016;22(3):294-306. doi: 10.2174/1381612822666151112153117. PMID: 26561056
Understanding bisphosphonates and osteonecrosis of the jaw: uses and risks.
Rosini S, Rosini S, Bertoldi I, Frediani B
Eur Rev Med Pharmacol Sci 2015 Sep;19(17):3309-17. PMID: 26400539
Update on contraception.
Wilkinson CL, Stirland AM, Massil H
Int J STD AIDS 1997 Apr;8(4):216-22; quiz 223. doi: 10.1258/0956462971919949. PMID: 9147153

Prognosis

Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline.
Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, Coppes RP, Jessen N, Malhotra NK, Murphy B, Rosenthal DI, Vissink A, Wu J, Saunders DP, Peterson DE
J Clin Oncol 2021 Sep 1;39(25):2825-2843. Epub 2021 Jul 20 doi: 10.1200/JCO.21.01208. PMID: 34283635
Effects of racial residential segregation on oral squamous cell carcinoma prognosis and survival.
Harris JA, Hunter WP, Ji YD, Hanna GJ
Oral Oncol 2021 Aug;119:105364. Epub 2021 Jun 3 doi: 10.1016/j.oraloncology.2021.105364. PMID: 34091188
Functional Components of Carob Fruit: Linking the Chemical and Biological Space.
Goulas V, Stylos E, Chatziathanasiadou MV, Mavromoustakos T, Tzakos AG
Int J Mol Sci 2016 Nov 10;17(11) doi: 10.3390/ijms17111875. PMID: 27834921Free PMC Article
Renal and extrarenal effects of gum arabic ( Acacia senegal )--what can be learned from animal experiments?
Nasir O
Kidney Blood Press Res 2013;37(4-5):269-79. Epub 2013 Aug 11 doi: 10.1159/000350152. PMID: 24022265
Contemporary smoking cessation.
Westmaas JL, Nath V, Brandon TH
Cancer Control 2000 Jan-Feb;7(1):56-62. doi: 10.1177/107327480000700105. PMID: 10740661

Clinical prediction guides

Sodium-hyaluronate mouthwash on radiotherapy-induced xerostomia: a randomised clinical trial.
Rupe C, Basco A, Gioco G, Patini R, Lucchese A, Micciché F, Massaccesi M, Lajolo C
Support Care Cancer 2023 Oct 18;31(12):644. doi: 10.1007/s00520-023-08090-x. PMID: 37851095Free PMC Article
Improving masticatory and swallowing ability of postoperative oral and maxillofacial tumor patients by telerehabilitation-A randomized controlled trial.
Pang P, Lin S, Chen H, Shan Y, Sun C
Clin Rehabil 2023 Sep;37(9):1178-1188. Epub 2023 Mar 29 doi: 10.1177/02692155231166326. PMID: 36991565
Plasma Cell Leukemia with Successful Upfront Venetoclax in Combination with Allogeneic Transplantation.
Tang ASO, Ahmad Asnawi AW, Koh AZY, Chong SL, Liew PK, Selvaratnam V, Md Fauzi A, Lau NS, Tan SM
Am J Case Rep 2023 Mar 8;24:e938868. doi: 10.12659/AJCR.938868. PMID: 36882990Free PMC Article
Efficacy and Safety of Synbiotics in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Randomized, Double-blinded, Placebo-controlled Pilot Study.
Mizutani Y, Kawamoto S, Takahashi M, Doi H, Wakida K, Tabuchi S, Tanda M, Soga A, Chijiki R, Takakura H, Kawaguchi K, Higashime A, Watanabe M, Ichikawa H, Matsumoto S, Sakai R, Goto H, Kurata K, Kakiuchi S, Miyata Y, Uryu K, Inui Y, Kitao A, Yakushijin K, Matsuoka H, Minami H
Intern Med 2023 Oct 15;62(20):2949-2958. Epub 2023 Feb 15 doi: 10.2169/internalmedicine.1314-22. PMID: 36792187Free PMC Article
Curcumin gum formulation for prevention of oral cavity head and neck squamous cell carcinoma.
Boven L, Holmes SP, Latimer B, McMartin K, Ma X, Moore-Medlin T, Khandelwal AR, McLarty J, Nathan CO
Laryngoscope 2019 Jul;129(7):1597-1603. Epub 2018 Nov 13 doi: 10.1002/lary.27542. PMID: 30421467

Recent systematic reviews

Effect of chewing gum on the management of chemotherapy-induced oral mucositis in children: Systematic review of experimental studies.
Semerci R, Kocaaslan EN
Eur J Cancer Care (Engl) 2022 Nov;31(6):e13727. Epub 2022 Oct 14 doi: 10.1111/ecc.13727. PMID: 36239087
Supportive interventions to improve physiological and psychological health outcomes among patients undergoing cystectomy: a systematic review.
Quirk H, Rosario DJ, Bourke L
BMC Urol 2018 Aug 24;18(1):71. doi: 10.1186/s12894-018-0382-z. PMID: 30143017Free PMC Article
Prophylaxis for mucositis induced by ambulatory chemotherapy: systematic review.
Manzi Nde M, Silveira RC, dos Reis PE
J Adv Nurs 2016 Apr;72(4):735-46. Epub 2015 Dec 2 doi: 10.1111/jan.12867. PMID: 26626711
Systematic literature review: xerostomia in advanced cancer patients.
Hanchanale S, Adkinson L, Daniel S, Fleming M, Oxberry SG
Support Care Cancer 2015 Mar;23(3):881-8. Epub 2014 Oct 18 doi: 10.1007/s00520-014-2477-8. PMID: 25322971
Systematic review of miscellaneous agents for the management of oral mucositis in cancer patients.
Jensen SB, Jarvis V, Zadik Y, Barasch A, Ariyawardana A, Hovan A, Yarom N, Lalla RV, Bowen J, Elad S; Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)
Support Care Cancer 2013 Nov;21(11):3223-32. Epub 2013 Jul 31 doi: 10.1007/s00520-013-1884-6. PMID: 23900593

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