U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign neoplasm of salivary gland

MedGen UID:
83857
•Concept ID:
C0347206
•
Neoplastic Process
Synonyms: Benign Neoplasm of Salivary Gland; benign neoplasm of salivary gland; Benign Neoplasm of the Salivary Gland; benign neoplasm of the salivary gland; Benign Salivary Gland Neoplasm; benign salivary gland neoplasm; Benign Salivary Gland Tumor; benign salivary gland tumor; benign salivary gland tumour; Benign tumor of salivary gland; Benign Tumor of Salivary Gland; benign tumor of salivary gland; Benign Tumor of the Salivary Gland; benign tumor of the salivary gland; benign tumour of salivary gland; benign tumour of the salivary gland; saliva-secreting gland benign neoplasm; Salivary Gland Neoplasm, Benign; salivary gland neoplasm, benign
SNOMED CT: Benign neoplasm of salivary gland (255154009); Benign tumor of salivary gland (255154009)
 
Monarch Initiative: MONDO:0021460

Definition

A neoplasm that arises from the major or minor salivary glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include Warthin tumor, monomorphic adenoma, and pleomorphic adenoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of salivary gland

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Management of Mucoceles, Sialoceles, and Ranulas.
Bowers EMR, Schaitkin B
Otolaryngol Clin North Am 2021 Jun;54(3):543-551. doi: 10.1016/j.otc.2021.03.002. PMID: 34024482
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Recent clinical studies

Etiology

Updated Salivary Gland Immunohistochemistry: A Review.
Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
The tubarial salivary glands: A potential new organ at risk for radiotherapy.
Valstar MH, de Bakker BS, Steenbakkers RJHM, de Jong KH, Smit LA, Klein Nulent TJW, van Es RJJ, Hofland I, de Keizer B, Jasperse B, Balm AJM, van der Schaaf A, Langendijk JA, Smeele LE, Vogel WV
Radiother Oncol 2021 Jan;154:292-298. Epub 2020 Sep 23 doi: 10.1016/j.radonc.2020.09.034. PMID: 32976871
Cytopathology and diagnostics of Warthin's tumour.
Sučić M, Ljubić N, Perković L, Ivanović D, Pažanin L, Sučić Radovanović T, Župnić-Krmek D, Knežević F
Cytopathology 2020 May;31(3):193-207. doi: 10.1111/cyt.12830. PMID: 32259367
Salivary gland carcinomas.
Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859

Diagnosis

Updated Salivary Gland Immunohistochemistry: A Review.
Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867
Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Cancer therapy-related salivary dysfunction.
Paz C, Glassey A, Frick A, Sattar S, Zaorsky NG, Blitzer GC, Kimple RJ
J Clin Invest 2024 Sep 3;134(17) doi: 10.1172/JCI182661. PMID: 39225092Free PMC Article
Epithelial-immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis.
Verstappen GM, Pringle S, Bootsma H, Kroese FGM
Nat Rev Rheumatol 2021 Jun;17(6):333-348. Epub 2021 Apr 28 doi: 10.1038/s41584-021-00605-2. PMID: 33911236Free PMC Article
Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.
Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898Free PMC Article
Alternative Clinical Indications of Botulinum Toxin.
Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116

Prognosis

Salivary Gland-like Tumors of the Breast.
Richardson ET, Jo VY, Schnitt SJ
Arch Pathol Lab Med 2023 Sep 1;147(9):1014-1024. doi: 10.5858/arpa.2023-0038-RA. PMID: 37651394
State-of-the-Art Imaging of Salivary Gland Tumors.
Abdel Razek AAK, Mukherji SK
Neuroimaging Clin N Am 2018 May;28(2):303-317. doi: 10.1016/j.nic.2018.01.009. PMID: 29622121
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
Salivary gland carcinomas.
Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859

Clinical prediction guides

Sjögren's syndrome: one year in review 2023.
Longhino S, Chatzis LG, Dal Pozzolo R, Peretti S, Fulvio G, La Rocca G, Navarro Garcia IC, Orlandi M, Quartuccio L, Baldini C, Bartoloni E
Clin Exp Rheumatol 2023 Dec;41(12):2343-2356. Epub 2023 Dec 23 doi: 10.55563/clinexprheumatol/255qsx. PMID: 38149515
Microsecretory Adenocarcinoma of Salivary Glands.
Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381
Fusion-positive salivary gland carcinomas.
Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211
State-of-the-Art Imaging of Salivary Gland Tumors.
Abdel Razek AAK, Mukherji SK
Neuroimaging Clin N Am 2018 May;28(2):303-317. doi: 10.1016/j.nic.2018.01.009. PMID: 29622121
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Feasibility and advantages of endoscope-assisted parotidectomy: a systematic review and meta-analysis.
Zou HW, Gao J, Liu JX, Qu ZL, Du ZS, Zhao H, Zhao M, Chen HY
Br J Oral Maxillofac Surg 2021 Jun;59(5):503-510. Epub 2020 Aug 19 doi: 10.1016/j.bjoms.2020.08.049. PMID: 33845989
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...