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Benign neoplasm of myocardium

MedGen UID:
83862
•Concept ID:
C0347253
•
Neoplastic Process
Synonyms: Benign Myocardial Neoplasm; benign myocardial neoplasm; Benign Myocardial Tumor; benign myocardial tumor; benign myocardial tumour; Benign Neoplasm of Myocardium; benign neoplasm of myocardium; Benign Neoplasm of the Myocardium; benign neoplasm of the myocardium; Benign tumor of myocardium; Benign Tumor of Myocardium; benign tumor of myocardium; Benign Tumor of the Myocardium; benign tumor of the myocardium; benign tumour of myocardium; benign tumour of the myocardium; myocardium benign neoplasm
SNOMED CT: Benign tumor of myocardium (92238001); Benign neoplasm of myocardium (92238001)
 
Monarch Initiative: MONDO:0021509

Definition

A neoplasm that arises from the myocardium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of myocardium

Professional guidelines

PubMed

MicroRNA in the Diagnosis and Treatment of Doxorubicin-Induced Cardiotoxicity.
Kuang Z, Wu J, Tan Y, Zhu G, Li J, Wu M
Biomolecules 2023 Mar 20;13(3) doi: 10.3390/biom13030568. PMID: 36979503Free PMC Article
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Cardiac Amyloidosis: Diagnosis and Treatment Strategies.
Tuzovic M, Yang EH, Baas AS, Depasquale EC, Deng MC, Cruz D, Vorobiof G
Curr Oncol Rep 2017 Jul;19(7):46. doi: 10.1007/s11912-017-0607-4. PMID: 28528458

Recent clinical studies

Etiology

Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure.
Yuan Y, Mei Z, Qu Z, Li G, Yu S, Liu Y, Liu K, Shen Z, Pu J, Wang Y, Wang C, Sun Z, Liu Q, Pang X, Wang A, Ren Z, Wang T, Liu Y, Hong J, Xie J, Li X, Wang Z, Du W, Yang B
Signal Transduct Target Ther 2023 Mar 27;8(1):121. doi: 10.1038/s41392-023-01336-4. PMID: 36967385Free PMC Article
The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Multiparametric Echocardiography Scores for the Diagnosis of Cardiac Amyloidosis.
Boldrini M, Cappelli F, Chacko L, Restrepo-Cordoba MA, Lopez-Sainz A, Giannoni A, Aimo A, Baggiano A, Martinez-Naharro A, Whelan C, Quarta C, Passino C, Castiglione V, Chubuchnyi V, Spini V, Taddei C, Vergaro G, Petrie A, Ruiz-Guerrero L, Moñivas V, Mingo-Santos S, Mirelis JG, Dominguez F, Gonzalez-Lopez E, Perlini S, Pontone G, Gillmore J, Hawkins PN, Garcia-Pavia P, Emdin M, Fontana M
JACC Cardiovasc Imaging 2020 Apr;13(4):909-920. Epub 2019 Dec 18 doi: 10.1016/j.jcmg.2019.10.011. PMID: 31864973
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article

Diagnosis

Emerging role of PET/MR in the diagnosis and characterization of cardiotoxicity?
Schindler TH, Sivapackiam J, Sharma V
Int J Cardiol 2023 Aug 15;385:82-84. Epub 2023 May 16 doi: 10.1016/j.ijcard.2023.05.022. PMID: 37201611
Cardiac Neoplasms: Radiologic-Pathologic Correlation.
Lichtenberger JP 3rd, Carter BW, Pavio MA, Biko DM
Radiol Clin North Am 2021 Mar;59(2):231-242. Epub 2020 Dec 29 doi: 10.1016/j.rcl.2020.10.002. PMID: 33551084
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
MRI of Cardiotoxicity.
Jordan JH, Hundley WG
Cardiol Clin 2019 Nov;37(4):429-439. Epub 2019 Aug 31 doi: 10.1016/j.ccl.2019.07.007. PMID: 31587784Free PMC Article
Catecholamine-induced cardiomyopathy.
Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM
Endocr Pract 2008 Dec;14(9):1137-49. doi: 10.4158/EP.14.9.1137. PMID: 19158054

Therapy

The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article
MRI of Cardiotoxicity.
Jordan JH, Hundley WG
Cardiol Clin 2019 Nov;37(4):429-439. Epub 2019 Aug 31 doi: 10.1016/j.ccl.2019.07.007. PMID: 31587784Free PMC Article
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article

Prognosis

The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Multiparametric Echocardiography Scores for the Diagnosis of Cardiac Amyloidosis.
Boldrini M, Cappelli F, Chacko L, Restrepo-Cordoba MA, Lopez-Sainz A, Giannoni A, Aimo A, Baggiano A, Martinez-Naharro A, Whelan C, Quarta C, Passino C, Castiglione V, Chubuchnyi V, Spini V, Taddei C, Vergaro G, Petrie A, Ruiz-Guerrero L, Moñivas V, Mingo-Santos S, Mirelis JG, Dominguez F, Gonzalez-Lopez E, Perlini S, Pontone G, Gillmore J, Hawkins PN, Garcia-Pavia P, Emdin M, Fontana M
JACC Cardiovasc Imaging 2020 Apr;13(4):909-920. Epub 2019 Dec 18 doi: 10.1016/j.jcmg.2019.10.011. PMID: 31864973
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article

Clinical prediction guides

Emerging role of PET/MR in the diagnosis and characterization of cardiotoxicity?
Schindler TH, Sivapackiam J, Sharma V
Int J Cardiol 2023 Aug 15;385:82-84. Epub 2023 May 16 doi: 10.1016/j.ijcard.2023.05.022. PMID: 37201611
The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Multiparametric Echocardiography Scores for the Diagnosis of Cardiac Amyloidosis.
Boldrini M, Cappelli F, Chacko L, Restrepo-Cordoba MA, Lopez-Sainz A, Giannoni A, Aimo A, Baggiano A, Martinez-Naharro A, Whelan C, Quarta C, Passino C, Castiglione V, Chubuchnyi V, Spini V, Taddei C, Vergaro G, Petrie A, Ruiz-Guerrero L, Moñivas V, Mingo-Santos S, Mirelis JG, Dominguez F, Gonzalez-Lopez E, Perlini S, Pontone G, Gillmore J, Hawkins PN, Garcia-Pavia P, Emdin M, Fontana M
JACC Cardiovasc Imaging 2020 Apr;13(4):909-920. Epub 2019 Dec 18 doi: 10.1016/j.jcmg.2019.10.011. PMID: 31864973
Metabolic Imaging in Cardio-oncology.
Tong D, Zaha VG
J Cardiovasc Transl Res 2020 Jun;13(3):357-366. Epub 2019 Nov 6 doi: 10.1007/s12265-019-09927-9. PMID: 31696405
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article

Recent systematic reviews

The benign nature and rare occurrence of cardiac myxoma as a possible consequence of the limited cardiac proliferative/ regenerative potential: a systematic review.
Shafi O, Siddiqui G, Jaffry HA
BMC Cancer 2023 Dec 18;23(1):1245. doi: 10.1186/s12885-023-11723-3. PMID: 38110859Free PMC Article
Hamartoma of mature cardiac myocytes: systematic review.
Techasatian W, Gozun M, Morihara C, Pham A, Benavente K, Nagamine T, Nishimura Y
Cardiovasc Pathol 2023 Jul-Aug;65:107538. Epub 2023 Apr 7 doi: 10.1016/j.carpath.2023.107538. PMID: 37031829
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.
Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T
Cells 2021 May 4;10(5) doi: 10.3390/cells10051095. PMID: 34064363Free PMC Article
From pathogenesis to treatment, a systemic review of cardiac lipoma.
Shu S, Wang J, Zheng C
J Cardiothorac Surg 2021 Jan 6;16(1):1. doi: 10.1186/s13019-020-01379-6. PMID: 33407682Free PMC Article
Native T1 Mapping, Extracellular Volume Mapping, and Late Gadolinium Enhancement in Cardiac Amyloidosis: A Meta-Analysis.
Pan JA, Kerwin MJ, Salerno M
JACC Cardiovasc Imaging 2020 Jun;13(6):1299-1310. doi: 10.1016/j.jcmg.2020.03.010. PMID: 32498919Free PMC Article

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