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Benign neoplasm of anus

MedGen UID:
83864
•Concept ID:
C0347276
•
Neoplastic Process
Synonyms: anus benign neoplasm; Benign Anal Neoplasm; benign anal neoplasm; Benign Anal Tumor; benign anal tumor; Benign Neoplasm of Anus; benign neoplasm of anus; Benign Neoplasm of the Anus; benign neoplasm of the anus; Benign tumor of anus; Benign Tumor of Anus; benign tumor of anus; Benign Tumor of the Anus; benign tumor of the anus
SNOMED CT: Benign tumor of anus (91978004); Benign neoplasm of anus (91978004)
 
Monarch Initiative: MONDO:0021469

Definition

A non-metastasizing neoplasm arising from the anus. Representative examples include squamous papilloma and papillary hidradenoma. [from NCI]

Professional guidelines

PubMed

Management of pouch neoplasia: consensus guidelines from the International Ileal Pouch Consortium.
Kiran RP, Kochhar GS, Kariv R, Rex DK, Sugita A, Rubin DT, Navaneethan U, Hull TL, Ko HM, Liu X, Kachnic LA, Strong S, Iacucci M, Bemelman W, Fleshner P, Safyan RA, Kotze PG, D'Hoore A, Faiz O, Lo S, Ashburn JH, Spinelli A, Bernstein CN, Kane SV, Cross RK, Schairer J, McCormick JT, Farraye FA, Chang S, Scherl EJ, Schwartz DA, Bruining DH, Philpott J, Bentley-Hibbert S, Tarabar D, El-Hachem S, Sandborn WJ, Silverberg MS, Pardi DS, Church JM, Shen B
Lancet Gastroenterol Hepatol 2022 Sep;7(9):871-893. Epub 2022 Jul 5 doi: 10.1016/S2468-1253(22)00039-5. PMID: 35798022
Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Rao S, Guren MG, Khan K, Brown G, Renehan AG, Steigen SE, Deutsch E, Martinelli E, Arnold D; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Sep;32(9):1087-1100. Epub 2021 Jun 24 doi: 10.1016/j.annonc.2021.06.015. PMID: 34175386
HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514

Recent clinical studies

Etiology

Follow-up imaging of anal cancer after treatment.
El Homsi M, Sheedy SP, Rauch GM, Ganeshan DM, Ernst RD, Golia Pernicka JS
Abdom Radiol (NY) 2023 Sep;48(9):2888-2897. Epub 2023 Apr 6 doi: 10.1007/s00261-023-03895-0. PMID: 37024606
Neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced rectal cancer: A new era for anal preservation.
Wang Y, Shen L, Wan J, Zhang H, Wu R, Wang J, Wang Y, Xu Y, Cai S, Zhang Z, Xia F
Front Immunol 2022;13:1067036. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.1067036. PMID: 36569918Free PMC Article
Anal Cancer: Emerging Standards in a Rare Disease.
Eng C, Ciombor KK, Cho M, Dorth JA, Rajdev LN, Horowitz DP, Gollub MJ, Jácome AA, Lockney NA, Muldoon RL, Washington MK, O'Brian BA, Benny A, Lebeck Lee CM, Benson AB 3rd, Goodman KA, Morris VK
J Clin Oncol 2022 Aug 20;40(24):2774-2788. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02566. PMID: 35649196
Management options for chronic anal fissure: a systematic review of randomised controlled trials.
Boland PA, Kelly ME, Donlon NE, Bolger JC, Larkin JO, Mehigan BJ, McCormick PH
Int J Colorectal Dis 2020 Oct;35(10):1807-1815. Epub 2020 Jul 25 doi: 10.1007/s00384-020-03699-4. PMID: 32712929
Perineal schwannoma.
Majbar A, Hrora A, Jahid A, Ahallat M, Raiss M
BMC Res Notes 2016 Jun 13;9:304. doi: 10.1186/s13104-016-2108-1. PMID: 27297080Free PMC Article

Diagnosis

Anal Cancer: Emerging Standards in a Rare Disease.
Eng C, Ciombor KK, Cho M, Dorth JA, Rajdev LN, Horowitz DP, Gollub MJ, Jácome AA, Lockney NA, Muldoon RL, Washington MK, O'Brian BA, Benny A, Lebeck Lee CM, Benson AB 3rd, Goodman KA, Morris VK
J Clin Oncol 2022 Aug 20;40(24):2774-2788. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02566. PMID: 35649196
Cancer of the Anal Canal: Diagnosis, Staging and Follow-Up with MRI.
Durot C, Dohan A, Boudiaf M, Servois V, Soyer P, Hoeffel C
Korean J Radiol 2017 Nov-Dec;18(6):946-956. Epub 2017 Sep 21 doi: 10.3348/kjr.2017.18.6.946. PMID: 29089827Free PMC Article
Diagnosis and Diagnostic Imaging of Anal Canal Cancer.
Ciombor KK, Ernst RD, Brown G
Surg Oncol Clin N Am 2017 Jan;26(1):45-55. doi: 10.1016/j.soc.2016.07.002. PMID: 27889036Free PMC Article
Anoscopy.
Ponka D, Baddar F
Can Fam Physician 2013 May;59(5):510. PMID: 23673588Free PMC Article
Anal intraepithelial neoplasia.
Abbasakoor F, Boulos PB
Br J Surg 2005 Mar;92(3):277-90. doi: 10.1002/bjs.4967. PMID: 15736144

Therapy

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Management options for chronic anal fissure: a systematic review of randomised controlled trials.
Boland PA, Kelly ME, Donlon NE, Bolger JC, Larkin JO, Mehigan BJ, McCormick PH
Int J Colorectal Dis 2020 Oct;35(10):1807-1815. Epub 2020 Jul 25 doi: 10.1007/s00384-020-03699-4. PMID: 32712929
Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis for Low Rectal Cancer: A Randomized Clinical Trial.
Biondo S, Trenti L, Espin E, Bianco F, Barrios O, Falato A, De Franciscis S, Solis A, Kreisler E; TURNBULL-BCN Study Group
JAMA Surg 2020 Aug 1;155(8):e201625. Epub 2020 Aug 19 doi: 10.1001/jamasurg.2020.1625. PMID: 32492131Free PMC Article
Treatment possibilities for low anterior resection syndrome: a review of the literature.
Dulskas A, Smolskas E, Kildusiene I, Samalavicius NE
Int J Colorectal Dis 2018 Mar;33(3):251-260. Epub 2018 Jan 8 doi: 10.1007/s00384-017-2954-x. PMID: 29313107
Rectal cancer radiotherapy.
Ramsey S, Tepper JE
Cancer J 2007 May-Jun;13(3):204-9. doi: 10.1097/PPO.0b013e318074def2. PMID: 17620771

Prognosis

Perianal Paget's-an aggressive disease.
Rudnicki Y, Stapleton SM, Batra R, Gan T, Mathis KL, Kelley SR
Colorectal Dis 2023 Jun;25(6):1213-1221. Epub 2023 Mar 21 doi: 10.1111/codi.16549. PMID: 36945125
Neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced rectal cancer: A new era for anal preservation.
Wang Y, Shen L, Wan J, Zhang H, Wu R, Wang J, Wang Y, Xu Y, Cai S, Zhang Z, Xia F
Front Immunol 2022;13:1067036. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.1067036. PMID: 36569918Free PMC Article
Unrecognized digestive toxicities of radiation therapy.
Camprodon G, Huguet F
Cancer Radiother 2021 Oct;25(6-7):723-728. Epub 2021 Aug 11 doi: 10.1016/j.canrad.2021.07.007. PMID: 34391649
Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

Clinical prediction guides

Perianal Paget's-an aggressive disease.
Rudnicki Y, Stapleton SM, Batra R, Gan T, Mathis KL, Kelley SR
Colorectal Dis 2023 Jun;25(6):1213-1221. Epub 2023 Mar 21 doi: 10.1111/codi.16549. PMID: 36945125
Robot-assisted TAMIS: a systematic review of feasibility and outcomes.
Jakobsen PCH, Krarup PM, Jensen KK, Nordholm-Carstensen A
Surg Endosc 2023 May;37(5):3398-3409. Epub 2023 Jan 27 doi: 10.1007/s00464-022-09853-z. PMID: 36707419Free PMC Article
Radiodermatitis: severity, predictive factors and discontinuation of radiotherapy in patients with anal and rectal cancer.
Bastos LJD, Lanzillotti RS, Brandão MAG, da Silva RC, Simões FV
Rev Esc Enferm USP 2022;56:e20210378. Epub 2022 Jun 15 doi: 10.1590/1980-220X-REEUSP-2021-0378en. PMID: 35723900Free PMC Article
The importance of anal cancer screening and high-resolution anoscopy to gastroenterology practice.
Bull-Henry K, Morris B, Buchwald UK
Curr Opin Gastroenterol 2020 Sep;36(5):393-401. doi: 10.1097/MOG.0000000000000661. PMID: 32701604
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

Recent systematic reviews

Meta-analysis of neoadjuvant immunotherapy for non-metastatic colorectal cancer.
Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899Free PMC Article
A systematic review and meta-analysis of cytology and HPV-related biomarkers for anal cancer screening among different risk groups.
Clarke MA, Deshmukh AA, Suk R, Roberts J, Gilson R, Jay N, Stier EA, Wentzensen N
Int J Cancer 2022 Dec 1;151(11):1889-1901. Epub 2022 Aug 6 doi: 10.1002/ijc.34199. PMID: 35793241Free PMC Article
Real-world impact and effectiveness assessment of the quadrivalent HPV vaccine: a systematic review of study designs and data sources.
Wang W, Kothari S, Baay M, Garland SM, Giuliano AR, Nygård M, Velicer C, Tota J, Sinha A, Skufca J, Verstraeten T, Sundström K
Expert Rev Vaccines 2022 Feb;21(2):227-240. Epub 2021 Dec 13 doi: 10.1080/14760584.2022.2008243. PMID: 34845951
Radiation Therapy for Rectal Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.
Wo JY, Anker CJ, Ashman JB, Bhadkamkar NA, Bradfield L, Chang DT, Dorth J, Garcia-Aguilar J, Goff D, Jacqmin D, Kelly P, Newman NB, Olsen J, Raldow AC, Ruiz-Garcia E, Stitzenberg KB, Thomas CR Jr, Wu QJ, Das P
Pract Radiat Oncol 2021 Jan-Feb;11(1):13-25. Epub 2020 Oct 21 doi: 10.1016/j.prro.2020.08.004. PMID: 33097436
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article

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