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Benign neoplasm of anus

MedGen UID:
83864
•Concept ID:
C0347276
•
Neoplastic Process
Synonyms: anus benign neoplasm; Benign Anal Neoplasm; benign anal neoplasm; Benign Anal Tumor; benign anal tumor; benign anal tumour; Benign Neoplasm of Anus; benign neoplasm of anus; Benign Neoplasm of the Anus; benign neoplasm of the anus; Benign tumor of anus; Benign Tumor of Anus; benign tumor of anus; Benign Tumor of the Anus; benign tumor of the anus; benign tumour of anus; benign tumour of the anus
SNOMED CT: Benign tumor of anus (91978004); Benign neoplasm of anus (91978004)
 
Monarch Initiative: MONDO:0021469

Definition

A neoplasm that arises from the anus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Rao S, Guren MG, Khan K, Brown G, Renehan AG, Steigen SE, Deutsch E, Martinelli E, Arnold D; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Sep;32(9):1087-1100. Epub 2021 Jun 24 doi: 10.1016/j.annonc.2021.06.015. PMID: 34175386
HPV: diagnosis, prevention, and treatment.
Hathaway JK
Clin Obstet Gynecol 2012 Sep;55(3):671-80. doi: 10.1097/GRF.0b013e31825caa36. PMID: 22828099

Recent clinical studies

Etiology

Neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced rectal cancer: A new era for anal preservation.
Wang Y, Shen L, Wan J, Zhang H, Wu R, Wang J, Wang Y, Xu Y, Cai S, Zhang Z, Xia F
Front Immunol 2022;13:1067036. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.1067036. PMID: 36569918Free PMC Article
Anal Cancer: Emerging Standards in a Rare Disease.
Eng C, Ciombor KK, Cho M, Dorth JA, Rajdev LN, Horowitz DP, Gollub MJ, Jácome AA, Lockney NA, Muldoon RL, Washington MK, O'Brian BA, Benny A, Lebeck Lee CM, Benson AB 3rd, Goodman KA, Morris VK
J Clin Oncol 2022 Aug 20;40(24):2774-2788. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02566. PMID: 35649196
Diagnosis and Diagnostic Imaging of Anal Canal Cancer.
Ciombor KK, Ernst RD, Brown G
Surg Oncol Clin N Am 2017 Jan;26(1):45-55. doi: 10.1016/j.soc.2016.07.002. PMID: 27889036Free PMC Article
Perineal schwannoma.
Majbar A, Hrora A, Jahid A, Ahallat M, Raiss M
BMC Res Notes 2016 Jun 13;9:304. doi: 10.1186/s13104-016-2108-1. PMID: 27297080Free PMC Article
Anal intraepithelial neoplasia.
Abbasakoor F, Boulos PB
Br J Surg 2005 Mar;92(3):277-90. doi: 10.1002/bjs.4967. PMID: 15736144

Diagnosis

Anal Cancer: Emerging Standards in a Rare Disease.
Eng C, Ciombor KK, Cho M, Dorth JA, Rajdev LN, Horowitz DP, Gollub MJ, Jácome AA, Lockney NA, Muldoon RL, Washington MK, O'Brian BA, Benny A, Lebeck Lee CM, Benson AB 3rd, Goodman KA, Morris VK
J Clin Oncol 2022 Aug 20;40(24):2774-2788. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02566. PMID: 35649196
An overview of anal intraepithelial neoplasia.
Buzard CL, Rizzolo D
JAAPA 2018 Jul;31(7):1-5. doi: 10.1097/01.JAA.0000534979.69236.e7. PMID: 29957613
Cancer of the Anal Canal: Diagnosis, Staging and Follow-Up with MRI.
Durot C, Dohan A, Boudiaf M, Servois V, Soyer P, Hoeffel C
Korean J Radiol 2017 Nov-Dec;18(6):946-956. Epub 2017 Sep 21 doi: 10.3348/kjr.2017.18.6.946. PMID: 29089827Free PMC Article
Diagnosis and Diagnostic Imaging of Anal Canal Cancer.
Ciombor KK, Ernst RD, Brown G
Surg Oncol Clin N Am 2017 Jan;26(1):45-55. doi: 10.1016/j.soc.2016.07.002. PMID: 27889036Free PMC Article
Anal intraepithelial neoplasia.
Abbasakoor F, Boulos PB
Br J Surg 2005 Mar;92(3):277-90. doi: 10.1002/bjs.4967. PMID: 15736144

Therapy

Anal Cancer and Anal Cancer Screening.
Cohen CM, Clarke MA
Clin Obstet Gynecol 2023 Sep 1;66(3):516-533. Epub 2023 Jul 13 doi: 10.1097/GRF.0000000000000789. PMID: 37439541Free PMC Article
ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Compliance to chemoradiation in squamous cell carcinoma of the anus.
Mahmood A, Bhuva N, Fokas E, Glynne-Jones R
Cancer Treat Rev 2022 May;106:102381. Epub 2022 Mar 19 doi: 10.1016/j.ctrv.2022.102381. PMID: 35395434
Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Initial Results From the Pembrolizumab Arm of a Phase 2 Randomized Clinical Trial.
Rahma OE, Yothers G, Hong TS, Russell MM, You YN, Parker W, Jacobs SA, Colangelo LH, Lucas PC, Gollub MJ, Hall WA, Kachnic LA, Vijayvergia N, O'Rourke MA, Faller BA, Valicenti RK, Schefter TE, George S, Kainthla R, Stella PJ, Sigurdson E, Wolmark N, George TJ
JAMA Oncol 2021 Aug 1;7(8):1225-1230. doi: 10.1001/jamaoncol.2021.1683. PMID: 34196693Free PMC Article
Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318

Prognosis

Follow-up imaging of anal cancer after treatment.
El Homsi M, Sheedy SP, Rauch GM, Ganeshan DM, Ernst RD, Golia Pernicka JS
Abdom Radiol (NY) 2023 Sep;48(9):2888-2897. Epub 2023 Apr 6 doi: 10.1007/s00261-023-03895-0. PMID: 37024606
Perianal Paget's-an aggressive disease.
Rudnicki Y, Stapleton SM, Batra R, Gan T, Mathis KL, Kelley SR
Colorectal Dis 2023 Jun;25(6):1213-1221. Epub 2023 Mar 21 doi: 10.1111/codi.16549. PMID: 36945125
Neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced rectal cancer: A new era for anal preservation.
Wang Y, Shen L, Wan J, Zhang H, Wu R, Wang J, Wang Y, Xu Y, Cai S, Zhang Z, Xia F
Front Immunol 2022;13:1067036. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.1067036. PMID: 36569918Free PMC Article
Unrecognized digestive toxicities of radiation therapy.
Camprodon G, Huguet F
Cancer Radiother 2021 Oct;25(6-7):723-728. Epub 2021 Aug 11 doi: 10.1016/j.canrad.2021.07.007. PMID: 34391649
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

Clinical prediction guides

Perianal Paget's-an aggressive disease.
Rudnicki Y, Stapleton SM, Batra R, Gan T, Mathis KL, Kelley SR
Colorectal Dis 2023 Jun;25(6):1213-1221. Epub 2023 Mar 21 doi: 10.1111/codi.16549. PMID: 36945125
Robot-assisted TAMIS: a systematic review of feasibility and outcomes.
Jakobsen PCH, Krarup PM, Jensen KK, Nordholm-Carstensen A
Surg Endosc 2023 May;37(5):3398-3409. Epub 2023 Jan 27 doi: 10.1007/s00464-022-09853-z. PMID: 36707419Free PMC Article
The importance of anal cancer screening and high-resolution anoscopy to gastroenterology practice.
Bull-Henry K, Morris B, Buchwald UK
Curr Opin Gastroenterol 2020 Sep;36(5):393-401. doi: 10.1097/MOG.0000000000000661. PMID: 32701604
LAPAROSCOPIC TREATMENT OF RECTAL CANCER.
Todorov G, Maslyankov S
Khirurgiia (Sofiia) 2015;81(2):13-28. PMID: 26668986
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

Recent systematic reviews

Meta-analysis of neoadjuvant immunotherapy for non-metastatic colorectal cancer.
Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899Free PMC Article
Robot-assisted TAMIS: a systematic review of feasibility and outcomes.
Jakobsen PCH, Krarup PM, Jensen KK, Nordholm-Carstensen A
Surg Endosc 2023 May;37(5):3398-3409. Epub 2023 Jan 27 doi: 10.1007/s00464-022-09853-z. PMID: 36707419Free PMC Article
A systematic review and meta-analysis of cytology and HPV-related biomarkers for anal cancer screening among different risk groups.
Clarke MA, Deshmukh AA, Suk R, Roberts J, Gilson R, Jay N, Stier EA, Wentzensen N
Int J Cancer 2022 Dec 1;151(11):1889-1901. Epub 2022 Aug 6 doi: 10.1002/ijc.34199. PMID: 35793241Free PMC Article
A systematic review and meta-analysis of mortality in anal cancer patients by HIV status.
Sumner L, Kamitani E, Chase S, Wang Y
Cancer Epidemiol 2022 Feb;76:102069. Epub 2021 Dec 2 doi: 10.1016/j.canep.2021.102069. PMID: 34864578
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article

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