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Benign neoplasm of male breast

MedGen UID:
83867
•Concept ID:
C0347482
•
Neoplastic Process
Synonyms: Benign Male Breast Neoplasm; benign Male breast neoplasm; Benign Male Breast Tumor; benign Male breast tumor; benign Male breast tumour; Benign Neoplasm of Male Breast; benign neoplasm of male breast; Benign Neoplasm of the Male Breast; benign neoplasm of the Male breast; Benign Tumor of Male Breast; benign tumor of Male breast; Benign Tumor of the Male Breast; benign tumor of the Male breast; benign tumour of Male breast; benign tumour of the Male breast; male breast benign neoplasm
 
Monarch Initiative: MONDO:0021528

Definition

A neoplasm that arises from the breast in males and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of male breast

Professional guidelines

PubMed

Lymphoma: Diagnosis and Treatment.
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937
Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Aug 1;30(8):1194-1220. doi: 10.1093/annonc/mdz173. PMID: 31161190
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174

Recent clinical studies

Etiology

Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial.
Tolaney SM, Tarantino P, Graham N, Tayob N, Parè L, Villacampa G, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis MJ, Shapira I, Wolff AC, Carey LA, Barroso-Sousa R, Villagrasa P, DeMeo M, DiLullo M, Zanudo JGT, Weiss J, Wagle N, Partridge AH, Waks AG, Hudis CA, Krop IE, Burstein HJ, Prat A, Winer EP
Lancet Oncol 2023 Mar;24(3):273-285. doi: 10.1016/S1470-2045(23)00051-7. PMID: 36858723
Cancer survival in Africa, central and south America, and Asia (SURVCAN-3): a population-based benchmarking study in 32 countries.
Soerjomataram I, Cabasag C, Bardot A, Fidler-Benaoudia MM, Miranda-Filho A, Ferlay J, Parkin DM, Ranganathan R, Piñeros M, Znaor A, Mery L, Joko-Fru YW, Dikshit R, Sankaranarayanan R, Swaminathan R, Bray F; SURVCAN-3 collaborators
Lancet Oncol 2023 Jan;24(1):22-32. doi: 10.1016/S1470-2045(22)00704-5. PMID: 36603919
Low-Grade Ductal Carcinoma In Situ.
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Estrogen and the risk of breast cancer.
Clemons M, Goss P
N Engl J Med 2001 Jan 25;344(4):276-85. doi: 10.1056/NEJM200101253440407. PMID: 11172156

Diagnosis

Cancer survival in Africa, central and south America, and Asia (SURVCAN-3): a population-based benchmarking study in 32 countries.
Soerjomataram I, Cabasag C, Bardot A, Fidler-Benaoudia MM, Miranda-Filho A, Ferlay J, Parkin DM, Ranganathan R, Piñeros M, Znaor A, Mery L, Joko-Fru YW, Dikshit R, Sankaranarayanan R, Swaminathan R, Bray F; SURVCAN-3 collaborators
Lancet Oncol 2023 Jan;24(1):22-32. doi: 10.1016/S1470-2045(22)00704-5. PMID: 36603919
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Extranodal Lymphoproliferative Processes.
Zeppa P, Cozzolino I
Monogr Clin Cytol 2018;23:81-92. Epub 2017 Nov 13 doi: 10.1159/000478884. PMID: 29130993
Male breast disease.
Wise GJ, Roorda AK, Kalter R
J Am Coll Surg 2005 Feb;200(2):255-69. doi: 10.1016/j.jamcollsurg.2004.09.042. PMID: 15664102
Benign breast lesions confused with carcinoma.
Oberman HA
Monogr Pathol 1984;(25):1-33. PMID: 6377045

Therapy

Effectiveness of Complementary Therapies in Cancer Patients: A Systematic Review.
Guerra-Martín MD, Tejedor-Bueno MS, Correa-Casado M
Int J Environ Res Public Health 2021 Jan 24;18(3) doi: 10.3390/ijerph18031017. PMID: 33498883Free PMC Article
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Male breast cancer: a disease distinct from female breast cancer.
Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, Elias AD, Baskin-Bey ES, Cardoso F
Breast Cancer Res Treat 2019 Jan;173(1):37-48. Epub 2018 Sep 28 doi: 10.1007/s10549-018-4921-9. PMID: 30267249Free PMC Article
Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update.
Oktay K, Harvey BE, Partridge AH, Quinn GP, Reinecke J, Taylor HS, Wallace WH, Wang ET, Loren AW
J Clin Oncol 2018 Jul 1;36(19):1994-2001. Epub 2018 Apr 5 doi: 10.1200/JCO.2018.78.1914. PMID: 29620997

Prognosis

Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial.
Tolaney SM, Tarantino P, Graham N, Tayob N, Parè L, Villacampa G, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis MJ, Shapira I, Wolff AC, Carey LA, Barroso-Sousa R, Villagrasa P, DeMeo M, DiLullo M, Zanudo JGT, Weiss J, Wagle N, Partridge AH, Waks AG, Hudis CA, Krop IE, Burstein HJ, Prat A, Winer EP
Lancet Oncol 2023 Mar;24(3):273-285. doi: 10.1016/S1470-2045(23)00051-7. PMID: 36858723
Cancer statistics for adolescents and young adults, 2020.
Miller KD, Fidler-Benaoudia M, Keegan TH, Hipp HS, Jemal A, Siegel RL
CA Cancer J Clin 2020 Nov;70(6):443-459. Epub 2020 Sep 17 doi: 10.3322/caac.21637. PMID: 32940362
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.
Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM
Cancer Res 2014 Jun 1;74(11):2913-21. doi: 10.1158/0008-5472.CAN-14-0155. PMID: 24840647
Cancer statistics, 2010.
Jemal A, Siegel R, Xu J, Ward E
CA Cancer J Clin 2010 Sep-Oct;60(5):277-300. Epub 2010 Jul 7 doi: 10.3322/caac.20073. PMID: 20610543

Clinical prediction guides

Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial.
Tolaney SM, Tarantino P, Graham N, Tayob N, Parè L, Villacampa G, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis MJ, Shapira I, Wolff AC, Carey LA, Barroso-Sousa R, Villagrasa P, DeMeo M, DiLullo M, Zanudo JGT, Weiss J, Wagle N, Partridge AH, Waks AG, Hudis CA, Krop IE, Burstein HJ, Prat A, Winer EP
Lancet Oncol 2023 Mar;24(3):273-285. doi: 10.1016/S1470-2045(23)00051-7. PMID: 36858723
The human tumor microbiome is composed of tumor type-specific intracellular bacteria.
Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT, Rotter-Maskowitz A, Weiser R, Mallel G, Gigi E, Meltser A, Douglas GM, Kamer I, Gopalakrishnan V, Dadosh T, Levin-Zaidman S, Avnet S, Atlan T, Cooper ZA, Arora R, Cogdill AP, Khan MAW, Ologun G, Bussi Y, Weinberger A, Lotan-Pompan M, Golani O, Perry G, Rokah M, Bahar-Shany K, Rozeman EA, Blank CU, Ronai A, Shaoul R, Amit A, Dorfman T, Kremer R, Cohen ZR, Harnof S, Siegal T, Yehuda-Shnaidman E, Gal-Yam EN, Shapira H, Baldini N, Langille MGI, Ben-Nun A, Kaufman B, Nissan A, Golan T, Dadiani M, Levanon K, Bar J, Yust-Katz S, Barshack I, Peeper DS, Raz DJ, Segal E, Wargo JA, Sandbank J, Shental N, Straussman R
Science 2020 May 29;368(6494):973-980. doi: 10.1126/science.aay9189. PMID: 32467386Free PMC Article
Low-Grade Ductal Carcinoma In Situ.
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Breast Cancer Screening, Management, and a Review of Case Study Literature in Transgender Populations.
Deutsch MB, Radix A, Wesp L
Semin Reprod Med 2017 Sep;35(5):434-441. Epub 2017 Oct 26 doi: 10.1055/s-0037-1606103. PMID: 29073682
Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study.
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Recent systematic reviews

Ultra-processed food consumption and cancer risk: A systematic review and meta-analysis.
Isaksen IM, Dankel SN
Clin Nutr 2023 Jun;42(6):919-928. Epub 2023 Mar 30 doi: 10.1016/j.clnu.2023.03.018. PMID: 37087831
The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis.
De Nys L, Anderson K, Ofosu EF, Ryde GC, Connelly J, Whittaker AC
Psychoneuroendocrinology 2022 Sep;143:105843. Epub 2022 Jun 24 doi: 10.1016/j.psyneuen.2022.105843. PMID: 35777076
Sedentary behavior and cancer-an umbrella review and meta-analysis.
Hermelink R, Leitzmann MF, Markozannes G, Tsilidis K, Pukrop T, Berger F, Baurecht H, Jochem C
Eur J Epidemiol 2022 May;37(5):447-460. Epub 2022 May 25 doi: 10.1007/s10654-022-00873-6. PMID: 35612669Free PMC Article
Manual lymphatic drainage treatment for lymphedema: a systematic review of the literature.
Thompson B, Gaitatzis K, Janse de Jonge X, Blackwell R, Koelmeyer LA
J Cancer Surviv 2021 Apr;15(2):244-258. Epub 2020 Aug 15 doi: 10.1007/s11764-020-00928-1. PMID: 32803533
Metabolic syndrome and risk of cancer: a systematic review and meta-analysis.
Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D
Diabetes Care 2012 Nov;35(11):2402-11. doi: 10.2337/dc12-0336. PMID: 23093685Free PMC Article

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