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Benign neoplasm of male breast

MedGen UID:
83867
•Concept ID:
C0347482
•
Neoplastic Process
Synonyms: Benign Male Breast Neoplasm; benign Male breast neoplasm; Benign Male Breast Tumor; benign Male breast tumor; benign Male breast tumour; Benign Neoplasm of Male Breast; benign neoplasm of male breast; Benign Neoplasm of the Male Breast; benign neoplasm of the Male breast; Benign Tumor of Male Breast; benign tumor of Male breast; Benign Tumor of the Male Breast; benign tumor of the Male breast; benign tumour of Male breast; benign tumour of the Male breast; male breast benign neoplasm
SNOMED CT: Benign neoplasm of male breast (92206006)
 
Monarch Initiative: MONDO:0021528

Definition

A neoplasm that arises from the breast in males and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of male breast

Professional guidelines

PubMed

EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.
Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724
Lymphoma: Diagnosis and Treatment.
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937
Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Aug 1;30(8):1194-1220. doi: 10.1093/annonc/mdz173. PMID: 31161190

Recent clinical studies

Etiology

Association Between Breast Arterial Calcifications and Cardiovascular Disease: A Systematic Review and Meta-analysis.
Koh TJW, Tan HJH, Ravi PRJ, Sng JWZ, Yeo TC, Tan BYQ, Chai P, Yeo LLL, Chan MY, Kong WKF, Wong RCC, Teo YH, Ho JSY, Teo YN, Sia CH
Can J Cardiol 2023 Dec;39(12):1941-1950. Epub 2023 Jul 26 doi: 10.1016/j.cjca.2023.07.024. PMID: 37506765
Risk of male breast cancer after Hodgkin lymphoma.
de Vries S, Krul IM, Schaapveld M, Janus CPM, Rademakers SE, Roesink JM, Nijziel MR, Bilgin YM, Aleman BMP, van Leeuwen FE
Blood 2023 Aug 31;142(9):806-811. doi: 10.1182/blood.2023020940. PMID: 37390297
Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial.
Tolaney SM, Tarantino P, Graham N, Tayob N, Parè L, Villacampa G, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis MJ, Shapira I, Wolff AC, Carey LA, Barroso-Sousa R, Villagrasa P, DeMeo M, DiLullo M, Zanudo JGT, Weiss J, Wagle N, Partridge AH, Waks AG, Hudis CA, Krop IE, Burstein HJ, Prat A, Winer EP
Lancet Oncol 2023 Mar;24(3):273-285. doi: 10.1016/S1470-2045(23)00051-7. PMID: 36858723
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487

Diagnosis

Breast lymphoma: General review.
Rezkallah EMN, Elsaify A, Tin SMM, Dey D, Elsaify WM
Breast Dis 2023;42(1):197-205. doi: 10.3233/BD-220051. PMID: 37393489
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Ultrasonographic and Mammographic Findings of Male Breast Disease.
Kim SH, Kim YS
J Ultrasound Med 2019 Jan;38(1):243-252. Epub 2018 Apr 30 doi: 10.1002/jum.14665. PMID: 29708282
Innervation of the Male Breast: Psychological and Physiological Consequences.
Misery L, Talagas M
J Mammary Gland Biol Neoplasia 2017 Jun;22(2):109-115. Epub 2017 May 27 doi: 10.1007/s10911-017-9380-0. PMID: 28551701

Therapy

Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial.
Tolaney SM, Tarantino P, Graham N, Tayob N, Parè L, Villacampa G, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis MJ, Shapira I, Wolff AC, Carey LA, Barroso-Sousa R, Villagrasa P, DeMeo M, DiLullo M, Zanudo JGT, Weiss J, Wagle N, Partridge AH, Waks AG, Hudis CA, Krop IE, Burstein HJ, Prat A, Winer EP
Lancet Oncol 2023 Mar;24(3):273-285. doi: 10.1016/S1470-2045(23)00051-7. PMID: 36858723
Effectiveness of Complementary Therapies in Cancer Patients: A Systematic Review.
Guerra-Martín MD, Tejedor-Bueno MS, Correa-Casado M
Int J Environ Res Public Health 2021 Jan 24;18(3) doi: 10.3390/ijerph18031017. PMID: 33498883Free PMC Article
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Male breast cancer: a disease distinct from female breast cancer.
Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, Elias AD, Baskin-Bey ES, Cardoso F
Breast Cancer Res Treat 2019 Jan;173(1):37-48. Epub 2018 Sep 28 doi: 10.1007/s10549-018-4921-9. PMID: 30267249Free PMC Article
Exercise for the management of cancer-related fatigue in adults.
Cramp F, Byron-Daniel J
Cochrane Database Syst Rev 2012 Nov 14;11(11):CD006145. doi: 10.1002/14651858.CD006145.pub3. PMID: 23152233Free PMC Article

Prognosis

Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial.
Tolaney SM, Tarantino P, Graham N, Tayob N, Parè L, Villacampa G, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis MJ, Shapira I, Wolff AC, Carey LA, Barroso-Sousa R, Villagrasa P, DeMeo M, DiLullo M, Zanudo JGT, Weiss J, Wagle N, Partridge AH, Waks AG, Hudis CA, Krop IE, Burstein HJ, Prat A, Winer EP
Lancet Oncol 2023 Mar;24(3):273-285. doi: 10.1016/S1470-2045(23)00051-7. PMID: 36858723
Cancer statistics for adolescents and young adults, 2020.
Miller KD, Fidler-Benaoudia M, Keegan TH, Hipp HS, Jemal A, Siegel RL
CA Cancer J Clin 2020 Nov;70(6):443-459. Epub 2020 Sep 17 doi: 10.3322/caac.21637. PMID: 32940362
Cancer incidence and mortality projections in the UK until 2035.
Smittenaar CR, Petersen KA, Stewart K, Moitt N
Br J Cancer 2016 Oct 25;115(9):1147-1155. Epub 2016 Oct 11 doi: 10.1038/bjc.2016.304. PMID: 27727232Free PMC Article
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.
Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM
Cancer Res 2014 Jun 1;74(11):2913-21. doi: 10.1158/0008-5472.CAN-14-0155. PMID: 24840647

Clinical prediction guides

Risk of male breast cancer after Hodgkin lymphoma.
de Vries S, Krul IM, Schaapveld M, Janus CPM, Rademakers SE, Roesink JM, Nijziel MR, Bilgin YM, Aleman BMP, van Leeuwen FE
Blood 2023 Aug 31;142(9):806-811. doi: 10.1182/blood.2023020940. PMID: 37390297
Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial.
Tolaney SM, Tarantino P, Graham N, Tayob N, Parè L, Villacampa G, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis MJ, Shapira I, Wolff AC, Carey LA, Barroso-Sousa R, Villagrasa P, DeMeo M, DiLullo M, Zanudo JGT, Weiss J, Wagle N, Partridge AH, Waks AG, Hudis CA, Krop IE, Burstein HJ, Prat A, Winer EP
Lancet Oncol 2023 Mar;24(3):273-285. doi: 10.1016/S1470-2045(23)00051-7. PMID: 36858723
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
The human tumor microbiome is composed of tumor type-specific intracellular bacteria.
Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT, Rotter-Maskowitz A, Weiser R, Mallel G, Gigi E, Meltser A, Douglas GM, Kamer I, Gopalakrishnan V, Dadosh T, Levin-Zaidman S, Avnet S, Atlan T, Cooper ZA, Arora R, Cogdill AP, Khan MAW, Ologun G, Bussi Y, Weinberger A, Lotan-Pompan M, Golani O, Perry G, Rokah M, Bahar-Shany K, Rozeman EA, Blank CU, Ronai A, Shaoul R, Amit A, Dorfman T, Kremer R, Cohen ZR, Harnof S, Siegal T, Yehuda-Shnaidman E, Gal-Yam EN, Shapira H, Baldini N, Langille MGI, Ben-Nun A, Kaufman B, Nissan A, Golan T, Dadiani M, Levanon K, Bar J, Yust-Katz S, Barshack I, Peeper DS, Raz DJ, Segal E, Wargo JA, Sandbank J, Shental N, Straussman R
Science 2020 May 29;368(6494):973-980. doi: 10.1126/science.aay9189. PMID: 32467386Free PMC Article
Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study.
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Recent systematic reviews

Ultra-processed food consumption and cancer risk: A systematic review and meta-analysis.
Isaksen IM, Dankel SN
Clin Nutr 2023 Jun;42(6):919-928. Epub 2023 Mar 30 doi: 10.1016/j.clnu.2023.03.018. PMID: 37087831
Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis.
De Nys L, Anderson K, Ofosu EF, Ryde GC, Connelly J, Whittaker AC
Psychoneuroendocrinology 2022 Sep;143:105843. Epub 2022 Jun 24 doi: 10.1016/j.psyneuen.2022.105843. PMID: 35777076
EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.
Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724
Metabolic syndrome and risk of cancer: a systematic review and meta-analysis.
Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D
Diabetes Care 2012 Nov;35(11):2402-11. doi: 10.2337/dc12-0336. PMID: 23093685Free PMC Article

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