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Fetal hypoxia

MedGen UID:
83884
•Concept ID:
C0349489
•
Disease or Syndrome
Synonyms: Fetal Hypoxia; Hypoxia, Fetal
SNOMED CT: Fetal hypoxia (276638004)

Definition

Hypoxia in utero, caused by conditions such as inadequate placental function (often abruptio placentae), preeclamptic toxicity, prolapse of the umbilical cord, or complications from anesthetic administration. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal hypoxia

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Preeclampsia subtypes: Clinical aspects regarding pathogenesis, signs, and management with special attention to diuretic administration.
Tamás P, Kovács K, Várnagy Á, Farkas B, Alemu Wami G, Bódis J
Eur J Obstet Gynecol Reprod Biol 2022 Jul;274:175-181. Epub 2022 May 31 doi: 10.1016/j.ejogrb.2022.05.033. PMID: 35661540

Recent clinical studies

Etiology

The physiology of intrapartum fetal compromise at term.
Turner JM, Mitchell MD, Kumar SS
Am J Obstet Gynecol 2020 Jan;222(1):17-26. Epub 2019 Jul 24 doi: 10.1016/j.ajog.2019.07.032. PMID: 31351061
Macrosomia.
Araujo Júnior E, Peixoto AB, Zamarian AC, Elito Júnior J, Tonni G
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:83-96. Epub 2016 Sep 15 doi: 10.1016/j.bpobgyn.2016.08.003. PMID: 27727018
Perinatal Asphyxia from the Obstetric Standpoint: Diagnosis and Interventions.
Herrera CA, Silver RM
Clin Perinatol 2016 Sep;43(3):423-38. Epub 2016 Jun 17 doi: 10.1016/j.clp.2016.04.003. PMID: 27524445
Fetal pulse oximetry.
Luttkus AK, Dudenhausen JW
Baillieres Clin Obstet Gynaecol 1996 Jun;10(2):295-306. doi: 10.1016/s0950-3552(96)80039-3. PMID: 8836486
Asphyxia.
Mac Donald D
Baillieres Clin Obstet Gynaecol 1995 Sep;9(3):579-94. doi: 10.1016/s0950-3552(05)80383-9. PMID: 8846558

Diagnosis

Macrosomia.
Araujo Júnior E, Peixoto AB, Zamarian AC, Elito Júnior J, Tonni G
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:83-96. Epub 2016 Sep 15 doi: 10.1016/j.bpobgyn.2016.08.003. PMID: 27727018
Perinatal Asphyxia from the Obstetric Standpoint: Diagnosis and Interventions.
Herrera CA, Silver RM
Clin Perinatol 2016 Sep;43(3):423-38. Epub 2016 Jun 17 doi: 10.1016/j.clp.2016.04.003. PMID: 27524445
Intrapartum fetal surveillance.
Ayres-de-Campos D
Best Pract Res Clin Obstet Gynaecol 2016 Jan;30:1-2. Epub 2015 Aug 11 doi: 10.1016/j.bpobgyn.2015.08.003. PMID: 26302973
Fetal pulse oximetry.
Luttkus AK, Dudenhausen JW
Baillieres Clin Obstet Gynaecol 1996 Jun;10(2):295-306. doi: 10.1016/s0950-3552(96)80039-3. PMID: 8836486
Antepartum fetal surveillance.
Manning FA
Curr Opin Obstet Gynecol 1995 Apr;7(2):146-9. doi: 10.1097/00001703-199504000-00013. PMID: 7787125

Therapy

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Clinical Assessment of Fetal Well-Being and Fetal Safety Indicators.
David AL, Spencer RN
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S67-S78. doi: 10.1002/jcph.2126. PMID: 36106777Free PMC Article
Preeclampsia subtypes: Clinical aspects regarding pathogenesis, signs, and management with special attention to diuretic administration.
Tamás P, Kovács K, Várnagy Á, Farkas B, Alemu Wami G, Bódis J
Eur J Obstet Gynecol Reprod Biol 2022 Jul;274:175-181. Epub 2022 May 31 doi: 10.1016/j.ejogrb.2022.05.033. PMID: 35661540
Epidural analgesia during birth and adverse neonatal outcomes: A population-based cohort study.
Høtoft D, Maimburg RD
Women Birth 2021 May;34(3):e286-e291. Epub 2020 Jun 18 doi: 10.1016/j.wombi.2020.05.012. PMID: 32563571
Smoking and Preterm Birth.
Ion R, Bernal AL
Reprod Sci 2015 Aug;22(8):918-26. Epub 2014 Nov 12 doi: 10.1177/1933719114556486. PMID: 25394641

Prognosis

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Clinical Assessment of Fetal Well-Being and Fetal Safety Indicators.
David AL, Spencer RN
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S67-S78. doi: 10.1002/jcph.2126. PMID: 36106777Free PMC Article
Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways.
Redman CWG, Staff AC, Roberts JM
Am J Obstet Gynecol 2022 Feb;226(2S):S907-S927. Epub 2021 Feb 2 doi: 10.1016/j.ajog.2020.09.047. PMID: 33546842
Fetal growth restriction: current knowledge.
Nardozza LM, Caetano AC, Zamarian AC, Mazzola JB, Silva CP, Marçal VM, Lobo TF, Peixoto AB, Araujo Júnior E
Arch Gynecol Obstet 2017 May;295(5):1061-1077. Epub 2017 Mar 11 doi: 10.1007/s00404-017-4341-9. PMID: 28285426
Macrosomia.
Araujo Júnior E, Peixoto AB, Zamarian AC, Elito Júnior J, Tonni G
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:83-96. Epub 2016 Sep 15 doi: 10.1016/j.bpobgyn.2016.08.003. PMID: 27727018

Clinical prediction guides

Clinical Assessment of Fetal Well-Being and Fetal Safety Indicators.
David AL, Spencer RN
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S67-S78. doi: 10.1002/jcph.2126. PMID: 36106777Free PMC Article
Maternal Oxygen Supplementation Compared With Room Air for Intrauterine Resuscitation: A Systematic Review and Meta-analysis.
Raghuraman N, Temming LA, Doering MM, Stoll CR, Palanisamy A, Stout MJ, Colditz GA, Cahill AG, Tuuli MG
JAMA Pediatr 2021 Apr 1;175(4):368-376. doi: 10.1001/jamapediatrics.2020.5351. PMID: 33394020Free PMC Article
Epidural analgesia during birth and adverse neonatal outcomes: A population-based cohort study.
Høtoft D, Maimburg RD
Women Birth 2021 May;34(3):e286-e291. Epub 2020 Jun 18 doi: 10.1016/j.wombi.2020.05.012. PMID: 32563571
Macrosomia.
Araujo Júnior E, Peixoto AB, Zamarian AC, Elito Júnior J, Tonni G
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:83-96. Epub 2016 Sep 15 doi: 10.1016/j.bpobgyn.2016.08.003. PMID: 27727018
Fetal biophysical profile.
Manning FA
Obstet Gynecol Clin North Am 1999 Dec;26(4):557-77, v. doi: 10.1016/s0889-8545(05)70099-1. PMID: 10587955

Recent systematic reviews

Clinical practice guidelines for intrapartum cardiotocography interpretation: A systematic review.
Brown J, Kanagaretnam D, Zen M
Aust N Z J Obstet Gynaecol 2023 Jun;63(3):278-289. Epub 2023 Mar 10 doi: 10.1111/ajo.13667. PMID: 36898674
Effectiveness of Remote Fetal Monitoring on Maternal-Fetal Outcomes: Systematic Review and Meta-Analysis.
Li S, Yang Q, Niu S, Liu Y
JMIR Mhealth Uhealth 2023 Feb 22;11:e41508. doi: 10.2196/41508. PMID: 36811944Free PMC Article
Maternal Oxygen Supplementation Compared With Room Air for Intrauterine Resuscitation: A Systematic Review and Meta-analysis.
Raghuraman N, Temming LA, Doering MM, Stoll CR, Palanisamy A, Stout MJ, Colditz GA, Cahill AG, Tuuli MG
JAMA Pediatr 2021 Apr 1;175(4):368-376. doi: 10.1001/jamapediatrics.2020.5351. PMID: 33394020Free PMC Article
Cardiotocography versus intermittent auscultation of fetal heart on admission to labour ward for assessment of fetal wellbeing.
Devane D, Lalor JG, Daly S, McGuire W, Cuthbert A, Smith V
Cochrane Database Syst Rev 2017 Jan 26;1(1):CD005122. doi: 10.1002/14651858.CD005122.pub5. PMID: 28125772Free PMC Article
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace.
East CE, Leader LR, Sheehan P, Henshall NE, Colditz PB
Cochrane Database Syst Rev 2010 Mar 17;(3):CD006174. doi: 10.1002/14651858.CD006174.pub2. PMID: 20238343

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