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Fetal hypoxia

MedGen UID:
83884
•Concept ID:
C0349489
•
Disease or Syndrome
Synonyms: Fetal Hypoxia; Hypoxia, Fetal
SNOMED CT: Fetal hypoxia (276638004)

Definition

Hypoxia in utero, caused by conditions such as inadequate placental function (often abruptio placentae), preeclamptic toxicity, prolapse of the umbilical cord, or complications from anesthetic administration. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal hypoxia

Professional guidelines

PubMed

Optimizing the management of acute, prolonged decelerations and fetal bradycardia based on the understanding of fetal pathophysiology.
Chandraharan E, Ghi T, Fieni S, Jia YJ
Am J Obstet Gynecol 2023 Jun;228(6):645-656. doi: 10.1016/j.ajog.2022.05.014. PMID: 37270260
Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396

Recent clinical studies

Etiology

Optimizing the management of acute, prolonged decelerations and fetal bradycardia based on the understanding of fetal pathophysiology.
Chandraharan E, Ghi T, Fieni S, Jia YJ
Am J Obstet Gynecol 2023 Jun;228(6):645-656. doi: 10.1016/j.ajog.2022.05.014. PMID: 37270260
A second look at intrapartum fetal surveillance and future directions.
Ugwumadu A, Arulkumaran S
J Perinat Med 2023 Jan 27;51(1):135-144. Epub 2022 Sep 5 doi: 10.1515/jpm-2022-0292. PMID: 36054840
Cardiac function in fetal growth restriction.
Mappa I, Maqina P, Bitsadze V, Khizroeva J, Makatsarya A, Arduini D, Rizzo G
Minerva Obstet Gynecol 2021 Aug;73(4):423-434. Epub 2021 Apr 27 doi: 10.23736/S2724-606X.21.04787-0. PMID: 33904691
Macrosomia.
Araujo Júnior E, Peixoto AB, Zamarian AC, Elito Júnior J, Tonni G
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:83-96. Epub 2016 Sep 15 doi: 10.1016/j.bpobgyn.2016.08.003. PMID: 27727018
Heart disease link to fetal hypoxia and oxidative stress.
Giussani DA, Niu Y, Herrera EA, Richter HG, Camm EJ, Thakor AS, Kane AD, Hansell JA, Brain KL, Skeffington KL, Itani N, Wooding FB, Cross CM, Allison BJ
Adv Exp Med Biol 2014;814:77-87. doi: 10.1007/978-1-4939-1031-1_7. PMID: 25015802

Diagnosis

Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review.
Cummins G, Kremer J, Bernassau A, Brown A, Bridle HL, Schulze H, Bachmann TT, Crichton M, Denison FC, Desmulliez MPY
Sensors (Basel) 2018 Aug 13;18(8) doi: 10.3390/s18082648. PMID: 30104478Free PMC Article
Macrosomia.
Araujo Júnior E, Peixoto AB, Zamarian AC, Elito Júnior J, Tonni G
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:83-96. Epub 2016 Sep 15 doi: 10.1016/j.bpobgyn.2016.08.003. PMID: 27727018
Early onset fetal growth restriction.
Nawathe A, Lees C
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:24-37. Epub 2016 Sep 15 doi: 10.1016/j.bpobgyn.2016.08.005. PMID: 27693119
Intrapartum fetal surveillance.
Ayres-de-Campos D
Best Pract Res Clin Obstet Gynaecol 2016 Jan;30:1-2. Epub 2015 Aug 11 doi: 10.1016/j.bpobgyn.2015.08.003. PMID: 26302973
Fetal biophysical profile.
Manning FA
Obstet Gynecol Clin North Am 1999 Dec;26(4):557-77, v. doi: 10.1016/s0889-8545(05)70099-1. PMID: 10587955

Therapy

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Effectiveness of Remote Fetal Monitoring on Maternal-Fetal Outcomes: Systematic Review and Meta-Analysis.
Li S, Yang Q, Niu S, Liu Y
JMIR Mhealth Uhealth 2023 Feb 22;11:e41508. doi: 10.2196/41508. PMID: 36811944Free PMC Article
Clinical Assessment of Fetal Well-Being and Fetal Safety Indicators.
David AL, Spencer RN
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S67-S78. doi: 10.1002/jcph.2126. PMID: 36106777Free PMC Article
Infective Endocarditis during pregnancy.
Yuan SM
J Coll Physicians Surg Pak 2015 Feb;25(2):134-9. PMID: 25703759
Smoking and Preterm Birth.
Ion R, Bernal AL
Reprod Sci 2015 Aug;22(8):918-26. Epub 2014 Nov 12 doi: 10.1177/1933719114556486. PMID: 25394641

Prognosis

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways.
Redman CWG, Staff AC, Roberts JM
Am J Obstet Gynecol 2022 Feb;226(2S):S907-S927. Epub 2021 Feb 2 doi: 10.1016/j.ajog.2020.09.047. PMID: 33546842
Fetal growth restriction: current knowledge.
Nardozza LM, Caetano AC, Zamarian AC, Mazzola JB, Silva CP, Marçal VM, Lobo TF, Peixoto AB, Araujo Júnior E
Arch Gynecol Obstet 2017 May;295(5):1061-1077. Epub 2017 Mar 11 doi: 10.1007/s00404-017-4341-9. PMID: 28285426
Macrosomia.
Araujo Júnior E, Peixoto AB, Zamarian AC, Elito Júnior J, Tonni G
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:83-96. Epub 2016 Sep 15 doi: 10.1016/j.bpobgyn.2016.08.003. PMID: 27727018
Hypoxic-ischemic encephalopathy.
Vannucci RC
Am J Perinatol 2000;17(3):113-20. doi: 10.1055/s-2000-9293. PMID: 11012134

Clinical prediction guides

A second look at intrapartum fetal surveillance and future directions.
Ugwumadu A, Arulkumaran S
J Perinat Med 2023 Jan 27;51(1):135-144. Epub 2022 Sep 5 doi: 10.1515/jpm-2022-0292. PMID: 36054840
Clinical Assessment of Fetal Well-Being and Fetal Safety Indicators.
David AL, Spencer RN
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S67-S78. doi: 10.1002/jcph.2126. PMID: 36106777Free PMC Article
Response to category II tracings: Does anything help?
Raghuraman N
Semin Perinatol 2020 Mar;44(2):151217. Epub 2019 Nov 23 doi: 10.1016/j.semperi.2019.151217. PMID: 32007313
Macrosomia.
Araujo Júnior E, Peixoto AB, Zamarian AC, Elito Júnior J, Tonni G
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:83-96. Epub 2016 Sep 15 doi: 10.1016/j.bpobgyn.2016.08.003. PMID: 27727018
Fetal biophysical profile.
Manning FA
Obstet Gynecol Clin North Am 1999 Dec;26(4):557-77, v. doi: 10.1016/s0889-8545(05)70099-1. PMID: 10587955

Recent systematic reviews

Clinical practice guidelines for intrapartum cardiotocography interpretation: A systematic review.
Brown J, Kanagaretnam D, Zen M
Aust N Z J Obstet Gynaecol 2023 Jun;63(3):278-289. Epub 2023 Mar 10 doi: 10.1111/ajo.13667. PMID: 36898674
Effectiveness of Remote Fetal Monitoring on Maternal-Fetal Outcomes: Systematic Review and Meta-Analysis.
Li S, Yang Q, Niu S, Liu Y
JMIR Mhealth Uhealth 2023 Feb 22;11:e41508. doi: 10.2196/41508. PMID: 36811944Free PMC Article
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace.
East CE, Leader LR, Sheehan P, Henshall NE, Colditz PB, Lau R
Cochrane Database Syst Rev 2015 May 1;2015(5):CD006174. doi: 10.1002/14651858.CD006174.pub3. PMID: 25929461Free PMC Article
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace.
East CE, Leader LR, Sheehan P, Henshall NE, Colditz PB
Cochrane Database Syst Rev 2010 Mar 17;(3):CD006174. doi: 10.1002/14651858.CD006174.pub2. PMID: 20238343
Melatonin and pregnancy in the human.
Tamura H, Nakamura Y, Terron MP, Flores LJ, Manchester LC, Tan DX, Sugino N, Reiter RJ
Reprod Toxicol 2008 Apr;25(3):291-303. Epub 2008 Apr 1 doi: 10.1016/j.reprotox.2008.03.005. PMID: 18485664

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