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Trigeminal schwannoma

MedGen UID:
83890
•Concept ID:
C0349582
•
Neoplastic Process
Synonyms: Fifth Cranial Nerve Neurilemmoma; fifth cranial nerve neurilemmoma; Fifth Cranial Nerve Schwannoma; fifth cranial nerve schwannoma; Neurilemmoma of Fifth Cranial Nerve; neurilemmoma of fifth cranial nerve; Neurilemmoma of the Fifth Cranial Nerve; neurilemmoma of the fifth cranial nerve; Neurilemmoma of the Trigeminal Nerve; neurilemmoma of the trigeminal nerve; Neurilemmoma of Trigeminal Nerve; neurilemmoma of trigeminal nerve; Schwannoma of Fifth Cranial Nerve; schwannoma of fifth cranial nerve; Schwannoma of the Fifth Cranial Nerve; schwannoma of the fifth cranial nerve; Schwannoma of the Trigeminal Nerve; schwannoma of the trigeminal nerve; Schwannoma of Trigeminal Nerve; schwannoma of trigeminal nerve; trigeminal nerve schwannoma; Trigeminal Neurilemmoma; trigeminal neurilemmoma; Trigeminal neurilemoma; Trigeminal Schwannoma; trigeminal schwannoma
SNOMED CT: Trigeminal neurilemoma (277185000); Trigeminal schwannoma (277185000)
 
Monarch Initiative: MONDO:0002555

Definition

A benign schwannoma occurring in the trigeminal nerve. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrigeminal schwannoma

Professional guidelines

PubMed

Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part II: Trigeminal and facial nerve schwannomas (CN V, VII).
Bal J, Bruneau M, Berhouma M, Cornelius JF, Cavallo LM, Daniel RT, Froelich S, Jouanneau E, Meling TR, Messerer M, Roche PH, Schroeder HWS, Tatagiba M, Zazpe I, Paraskevopoulos D
Acta Neurochir (Wien) 2022 Feb;164(2):299-319. Epub 2022 Jan 25 doi: 10.1007/s00701-021-05092-8. PMID: 35079891
Intracranial emergencies during pregnancy requiring urgent neurosurgical treatment.
Esmaeilzadeh M, Uksul N, Hong B, von Kaisenberg C, Scheinichen D, Lang JM, Hermann EJ, Hillemanns P, Krauss JK
Clin Neurol Neurosurg 2020 Aug;195:105905. Epub 2020 May 12 doi: 10.1016/j.clineuro.2020.105905. PMID: 32428795
Evolution in the assessment and management of trigeminal schwannoma.
Guthikonda B, Theodosopoulos PV, van Loveren H, Tew JM Jr, Pensak ML
Laryngoscope 2008 Feb;118(2):195-203. doi: 10.1097/MLG.0b013e3181596091. PMID: 18090871

Recent clinical studies

Etiology

Tumor control and trigeminal dysfunction improvement after stereotactic radiosurgery for trigeminal schwannomas: a systematic review and meta-analysis.
Peciu-Florianu I, Régis J, Levivier M, Dedeciusova M, Reyns N, Tuleasca C
Neurosurg Rev 2021 Oct;44(5):2391-2403. Epub 2020 Nov 13 doi: 10.1007/s10143-020-01433-w. PMID: 33185756Free PMC Article
Trigeminal schwannoma: a single-center experience with 43 cases and review of literature.
Li M, Wang X, Chen G, Liang J, Guo H, Song G, Bao Y
Br J Neurosurg 2021 Feb;35(1):49-56. Epub 2020 Jul 6 doi: 10.1080/02688697.2020.1754334. PMID: 32628557
Stereotactic Radiosurgery for Trigeminal Schwannomas: A 28-Year Single-Center Experience and Review of the Literature.
Snyder MH, Shepard MJ, Chen CJ, Sheehan JP
World Neurosurg 2018 Nov;119:e874-e881. Epub 2018 Aug 9 doi: 10.1016/j.wneu.2018.07.289. PMID: 30099184
Intracranial trigeminal schwannoma.
Agarwal A
Neuroradiol J 2015 Feb;28(1):36-41. doi: 10.15274/NRJ-2014-10117. PMID: 25924170Free PMC Article
Evolution in the assessment and management of trigeminal schwannoma.
Guthikonda B, Theodosopoulos PV, van Loveren H, Tew JM Jr, Pensak ML
Laryngoscope 2008 Feb;118(2):195-203. doi: 10.1097/MLG.0b013e3181596091. PMID: 18090871

Diagnosis

Trigeminal schwannoma: a single-center experience with 43 cases and review of literature.
Li M, Wang X, Chen G, Liang J, Guo H, Song G, Bao Y
Br J Neurosurg 2021 Feb;35(1):49-56. Epub 2020 Jul 6 doi: 10.1080/02688697.2020.1754334. PMID: 32628557
Syphilis mimicking trigeminal schwannoma.
Honorio GL, Silva SO, Silva MM, Lima MA
Arq Neuropsiquiatr 2017 Feb;75(2):132. doi: 10.1590/0004-282X20160179. PMID: 28226086
Intracranial trigeminal schwannoma.
Agarwal A
Neuroradiol J 2015 Feb;28(1):36-41. doi: 10.15274/NRJ-2014-10117. PMID: 25924170Free PMC Article
Evolution in the assessment and management of trigeminal schwannoma.
Guthikonda B, Theodosopoulos PV, van Loveren H, Tew JM Jr, Pensak ML
Laryngoscope 2008 Feb;118(2):195-203. doi: 10.1097/MLG.0b013e3181596091. PMID: 18090871
The trigeminal nerve.
Nemzek WR
Top Magn Reson Imaging 1996 Jun;8(3):132-54. PMID: 8840469

Therapy

Management of postoperative CSF rhinorrhea after retrosigmoid craniotomy: how I do it.
Ermolaev A, Yashin K, Dzhindzhikhadze R, Medyanik I
Acta Neurochir (Wien) 2022 Oct;164(10):2559-2562. Epub 2022 Mar 29 doi: 10.1007/s00701-022-05186-x. PMID: 35348898
Stereotactic Radiosurgery for Trigeminal Schwannomas: A 28-Year Single-Center Experience and Review of the Literature.
Snyder MH, Shepard MJ, Chen CJ, Sheehan JP
World Neurosurg 2018 Nov;119:e874-e881. Epub 2018 Aug 9 doi: 10.1016/j.wneu.2018.07.289. PMID: 30099184
Stereotactic radiosurgery for nonvestibular schwannomas.
Hasegawa T
Neurosurg Clin N Am 2013 Oct;24(4):531-42. Epub 2013 Aug 2 doi: 10.1016/j.nec.2013.05.003. PMID: 24093571
Primary malignant lymphoma of the trigeminal region treated with rapid infusion of high-dose MTX and radiation: case report and review of the literature.
Kinoshita M, Izumoto S, Oshino S, Nonaka M, Moriuchi S, Maruno M, Yoshimine T
Surg Neurol 2003 Oct;60(4):343-8; discussion 348. doi: 10.1016/s0090-3019(02)01046-7. PMID: 14505860
Isolated trigeminal nerve sarcoid granuloma mimicking trigeminal schwannoma: case report.
Quinones-Hinojosa A, Chang EF, Khan SA, McDermott MW
Neurosurgery 2003 Mar;52(3):700-5 discussion 704-5. doi: 10.1227/01.neu.0000048481.18726.aa. PMID: 12590697

Prognosis

Trigeminal Schwannoma Surgery: Challenges in Preserving Facial Sensation.
Matsushima K, Kohno M
Adv Tech Stand Neurosurg 2023;46:95-107. doi: 10.1007/978-3-031-28202-7_5. PMID: 37318571
Tumor control and trigeminal dysfunction improvement after stereotactic radiosurgery for trigeminal schwannomas: a systematic review and meta-analysis.
Peciu-Florianu I, Régis J, Levivier M, Dedeciusova M, Reyns N, Tuleasca C
Neurosurg Rev 2021 Oct;44(5):2391-2403. Epub 2020 Nov 13 doi: 10.1007/s10143-020-01433-w. PMID: 33185756Free PMC Article
Stereotactic Radiosurgery for Trigeminal Schwannomas: A 28-Year Single-Center Experience and Review of the Literature.
Snyder MH, Shepard MJ, Chen CJ, Sheehan JP
World Neurosurg 2018 Nov;119:e874-e881. Epub 2018 Aug 9 doi: 10.1016/j.wneu.2018.07.289. PMID: 30099184
Stereotactic radiosurgery for trigeminal schwannoma: tumor control and functional preservation Clinical article.
Kano H, Niranjan A, Kondziolka D, Flickinger JC, Dade Lunsford L
J Neurosurg 2009 Mar;110(3):553-8. doi: 10.3171/2008.7.jns0812. PMID: 19301456
The trigeminal nerve.
Nemzek WR
Top Magn Reson Imaging 1996 Jun;8(3):132-54. PMID: 8840469

Clinical prediction guides

Outcomes following surgical resection of trigeminal schwannomas: a systematic review and meta-analysis.
Karras CL, Texakalidis P, Thirunavu VM, Nandoliya KR, Khazanchi R, Byrne K, Chandler JP, Magill ST
Neurosurg Rev 2023 Aug 30;46(1):215. doi: 10.1007/s10143-023-02121-1. PMID: 37646878
Stereotactic Radiosurgery for Trigeminal Schwannomas: A 28-Year Single-Center Experience and Review of the Literature.
Snyder MH, Shepard MJ, Chen CJ, Sheehan JP
World Neurosurg 2018 Nov;119:e874-e881. Epub 2018 Aug 9 doi: 10.1016/j.wneu.2018.07.289. PMID: 30099184
Stereotactic radiosurgery for trigeminal schwannoma: tumor control and functional preservation Clinical article.
Kano H, Niranjan A, Kondziolka D, Flickinger JC, Dade Lunsford L
J Neurosurg 2009 Mar;110(3):553-8. doi: 10.3171/2008.7.jns0812. PMID: 19301456
Evolution in the assessment and management of trigeminal schwannoma.
Guthikonda B, Theodosopoulos PV, van Loveren H, Tew JM Jr, Pensak ML
Laryngoscope 2008 Feb;118(2):195-203. doi: 10.1097/MLG.0b013e3181596091. PMID: 18090871
The trigeminal nerve.
Nemzek WR
Top Magn Reson Imaging 1996 Jun;8(3):132-54. PMID: 8840469

Recent systematic reviews

Outcomes following surgical resection of trigeminal schwannomas: a systematic review and meta-analysis.
Karras CL, Texakalidis P, Thirunavu VM, Nandoliya KR, Khazanchi R, Byrne K, Chandler JP, Magill ST
Neurosurg Rev 2023 Aug 30;46(1):215. doi: 10.1007/s10143-023-02121-1. PMID: 37646878
Two-Stage Resection of a Giant Trigeminal Schwannoma in a Non-Neurofibromatosis Type 2 Pediatric Patient: A Case Report, Systematic Review, and Intraoperative Video.
Battistin U, Maiti T, Elhammady MS, Roser F
World Neurosurg 2023 Mar;171:e323-e335. Epub 2022 Dec 13 doi: 10.1016/j.wneu.2022.12.017. PMID: 36521756
Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part II: Trigeminal and facial nerve schwannomas (CN V, VII).
Bal J, Bruneau M, Berhouma M, Cornelius JF, Cavallo LM, Daniel RT, Froelich S, Jouanneau E, Meling TR, Messerer M, Roche PH, Schroeder HWS, Tatagiba M, Zazpe I, Paraskevopoulos D
Acta Neurochir (Wien) 2022 Feb;164(2):299-319. Epub 2022 Jan 25 doi: 10.1007/s00701-021-05092-8. PMID: 35079891
Tumor control and trigeminal dysfunction improvement after stereotactic radiosurgery for trigeminal schwannomas: a systematic review and meta-analysis.
Peciu-Florianu I, Régis J, Levivier M, Dedeciusova M, Reyns N, Tuleasca C
Neurosurg Rev 2021 Oct;44(5):2391-2403. Epub 2020 Nov 13 doi: 10.1007/s10143-020-01433-w. PMID: 33185756Free PMC Article
Skull Base Manifestations of Erdheim-Chester Disease: A Case Series and Systematic Review.
Marinelli JP, Peters PA, Vaglio A, Van Gompel JJ, Lane JI, Carlson ML
Neurosurgery 2019 Oct 1;85(4):E693-E701. doi: 10.1093/neuros/nyz027. PMID: 30828728

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