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Neonatal alloimmune thrombocytopenia

MedGen UID:
840004
Concept ID:
C3853779
Disease or Syndrome
Synonyms: Alloimmune Thrombocytopenia, Neonatal; Alloimmune Thrombocytopenias, Neonatal; Neonatal Alloimmune Thrombocytopenia; Neonatal Alloimmune Thrombocytopenias; Neonatal Thrombocytopenia; Neonatal Thrombocytopenias; Thrombocytopenia, Neonatal; Thrombocytopenia, Neonatal Alloimmune; Thrombocytopenias, Neonatal; Thrombocytopenias, Neonatal Alloimmune
SNOMED CT: Neonatal alloimmune thrombocytopenia (240305000); NAIT (240305000); Isoimmune neonatal thrombocytopenia (240305000); Alloimmune neonatal thrombocytopenia (240305000); ANT - Alloimmune neonatal thrombocytopenia (240305000); Neonatal thrombocytopenia due to platelet alloimmunization (240305000)
 
HPO: HP:0004809

Definition

Low platelet count associated with maternal platelet-specific alloantibodies. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal alloimmune thrombocytopenia

Professional guidelines

PubMed

Donato H
Arch Argent Pediatr 2021 Jun;119(3):e202-e214. doi: 10.5546/aap.2021.eng.e202. PMID: 34033425
de Vos TW, Winkelhorst D, de Haas M, Lopriore E, Oepkes D
Transfus Apher Sci 2020 Feb;59(1):102704. Epub 2019 Dec 31 doi: 10.1016/j.transci.2019.102704. PMID: 31974030
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Recent clinical studies

Etiology

Batton E, Leibel SL
Neoreviews 2022 Jul 1;23(7):e462-e471. doi: 10.1542/neo.23-7-e462. PMID: 35773506
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Norton T, Newberry D, Jnah A
Adv Neonatal Care 2021 Apr 1;21(2):115-121. doi: 10.1097/ANC.0000000000000775. PMID: 32657948
de Vos TW, Winkelhorst D, de Haas M, Lopriore E, Oepkes D
Transfus Apher Sci 2020 Feb;59(1):102704. Epub 2019 Dec 31 doi: 10.1016/j.transci.2019.102704. PMID: 31974030
Backes CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ
J Pregnancy 2011;2011:214365. Epub 2011 Apr 4 doi: 10.1155/2011/214365. PMID: 21547086Free PMC Article

Diagnosis

Batton E, Leibel SL
Neoreviews 2022 Jul 1;23(7):e462-e471. doi: 10.1542/neo.23-7-e462. PMID: 35773506
Donato H
Arch Argent Pediatr 2021 Jun;119(3):e202-e214. doi: 10.5546/aap.2021.eng.e202. PMID: 34033425
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Norton T, Newberry D, Jnah A
Adv Neonatal Care 2021 Apr 1;21(2):115-121. doi: 10.1097/ANC.0000000000000775. PMID: 32657948
Backes CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ
J Pregnancy 2011;2011:214365. Epub 2011 Apr 4 doi: 10.1155/2011/214365. PMID: 21547086Free PMC Article

Therapy

Batton E, Leibel SL
Neoreviews 2022 Jul 1;23(7):e462-e471. doi: 10.1542/neo.23-7-e462. PMID: 35773506
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Gunnink SF, Vlug R, Fijnvandraat K, van der Bom JG, Stanworth SJ, Lopriore E
Expert Rev Hematol 2014 Jun;7(3):387-95. Epub 2014 Mar 25 doi: 10.1586/17474086.2014.902301. PMID: 24665958
Sachs UJ
Thromb Res 2013 Jan;131 Suppl 1:S42-6. doi: 10.1016/S0049-3848(13)70020-3. PMID: 23452741

Prognosis

Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
Kamphuis MM, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D
Pediatrics 2014 Apr;133(4):715-21. Epub 2014 Mar 3 doi: 10.1542/peds.2013-3320. PMID: 24590747
Arnold DM, Smith JW, Kelton JG
Transfus Med Rev 2008 Oct;22(4):255-67. doi: 10.1016/j.tmrv.2008.05.003. PMID: 18848153
Roberts I, Stanworth S, Murray NA
Blood Rev 2008 Jul;22(4):173-86. Epub 2008 Apr 22 doi: 10.1016/j.blre.2008.03.004. PMID: 18433954
Porcelijn L, Van den Akker ES, Oepkes D
Semin Fetal Neonatal Med 2008 Aug;13(4):223-30. Epub 2008 Apr 8 doi: 10.1016/j.siny.2008.02.008. PMID: 18400574

Clinical prediction guides

Guillet S, Loustau V, Boutin E, Zarour A, Comont T, Souchaud-Debouverie O, Costedoat Chalumeau N, Pan-Petesch B, Gobert D, Cheze S, Viallard JF, Morin AS, Sauvetre G, Cliquennois M, Royer B, Masseau A, Terriou L, Fieschi C, Lambotte O, Girault S, Lioger B, Audia S, Sacre K, Lega JC, Langlois V, Benachi A, Orvain C, Devidas A, Humbert S, Gambier N, Ruivard M, Zarrouk V, Ebbo M, Willems L, Segaux L, Mahevas M, Haddad B, Michel M, Canoui-Poitrine F, Godeau B
Blood 2023 Jan 5;141(1):11-21. doi: 10.1182/blood.2022017277. PMID: 36054922
Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
Brojer E, Husebekk A, Dębska M, Uhrynowska M, Guz K, Orzińska A, Dębski R, Maślanka K
Arch Immunol Ther Exp (Warsz) 2016 Aug;64(4):279-90. Epub 2015 Nov 12 doi: 10.1007/s00005-015-0371-9. PMID: 26564154Free PMC Article
Strong NK, Eddleman KA
Clin Lab Med 2013 Jun;33(2):311-25. doi: 10.1016/j.cll.2013.03.024. PMID: 23702120
Roberts I, Stanworth S, Murray NA
Blood Rev 2008 Jul;22(4):173-86. Epub 2008 Apr 22 doi: 10.1016/j.blre.2008.03.004. PMID: 18433954

Recent systematic reviews

Kjeldsen-Kragh J, Fergusson DA, Kjaer M, Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia HF, Landry D, Shehata N
Blood Adv 2020 Jul 28;4(14):3368-3377. doi: 10.1182/bloodadvances.2020002137. PMID: 32717028Free PMC Article
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Winkelhorst D, Murphy MF, Greinacher A, Shehata N, Bakchoul T, Massey E, Baker J, Lieberman L, Tanael S, Hume H, Arnold DM, Baidya S, Bertrand G, Bussel J, Kjaer M, Kaplan C, Kjeldsen-Kragh J, Oepkes D, Ryan G
Blood 2017 Mar 16;129(11):1538-1547. Epub 2017 Jan 27 doi: 10.1182/blood-2016-10-739656. PMID: 28130210
Kamphuis MM, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D
Pediatrics 2014 Apr;133(4):715-21. Epub 2014 Mar 3 doi: 10.1542/peds.2013-3320. PMID: 24590747
Bassler D, Greinacher A, Okascharoen C, Klenner A, Ditomasso J, Kiefel V, Chan A, Paes B
Transfusion 2008 Jan;48(1):92-8. Epub 2007 Sep 24 doi: 10.1111/j.1537-2995.2007.01486.x. PMID: 17894790

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