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Neonatal alloimmune thrombocytopenia

MedGen UID:
840004
Concept ID:
C3853779
Disease or Syndrome
Synonyms: Alloimmune Thrombocytopenia, Neonatal; Alloimmune Thrombocytopenias, Neonatal; Neonatal Alloimmune Thrombocytopenia; Neonatal Alloimmune Thrombocytopenias; Neonatal Thrombocytopenia; Neonatal Thrombocytopenias; Thrombocytopenia, Neonatal; Thrombocytopenia, Neonatal Alloimmune; Thrombocytopenias, Neonatal; Thrombocytopenias, Neonatal Alloimmune
SNOMED CT: Neonatal alloimmune thrombocytopenia (240305000); Isoimmune neonatal thrombocytopenia (240305000); Alloimmune neonatal thrombocytopenia (240305000); Neonatal thrombocytopenia due to platelet alloimmunization (240305000); NAIT - neonatal alloimmune thrombocytopenia (240305000)
 
HPO: HP:0004809

Definition

Low platelet count associated with maternal platelet-specific alloantibodies. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal alloimmune thrombocytopenia

Professional guidelines

PubMed

Stanworth SJ, Mumford AD
Blood 2023 Jun 1;141(22):2685-2697. doi: 10.1182/blood.2022018017. PMID: 36787503
Donato H
Arch Argent Pediatr 2021 Jun;119(3):e202-e214. doi: 10.5546/aap.2021.eng.e202. PMID: 34033425
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Recent clinical studies

Etiology

Guillet S, Loustau V, Boutin E, Zarour A, Comont T, Souchaud-Debouverie O, Costedoat Chalumeau N, Pan-Petesch B, Gobert D, Cheze S, Viallard JF, Morin AS, Sauvetre G, Cliquennois M, Royer B, Masseau A, Terriou L, Fieschi C, Lambotte O, Girault S, Lioger B, Audia S, Sacre K, Lega JC, Langlois V, Benachi A, Orvain C, Devidas A, Humbert S, Gambier N, Ruivard M, Zarrouk V, Ebbo M, Willems L, Segaux L, Mahevas M, Haddad B, Michel M, Canoui-Poitrine F, Godeau B
Blood 2023 Jan 5;141(1):11-21. doi: 10.1182/blood.2022017277. PMID: 36054922Free PMC Article
Batton E, Leibel SL
Neoreviews 2022 Jul 1;23(7):e462-e471. doi: 10.1542/neo.23-7-e462. PMID: 35773506
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Norton T, Newberry D, Jnah A
Adv Neonatal Care 2021 Apr 1;21(2):115-121. doi: 10.1097/ANC.0000000000000775. PMID: 32657948
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Diagnosis

Stanworth SJ, Mumford AD
Blood 2023 Jun 1;141(22):2685-2697. doi: 10.1182/blood.2022018017. PMID: 36787503
Donato H
Arch Argent Pediatr 2021 Jun;119(3):e202-e214. doi: 10.5546/aap.2021.eng.e202. PMID: 34033425
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Norton T, Newberry D, Jnah A
Adv Neonatal Care 2021 Apr 1;21(2):115-121. doi: 10.1097/ANC.0000000000000775. PMID: 32657948
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Therapy

Batton E, Leibel SL
Neoreviews 2022 Jul 1;23(7):e462-e471. doi: 10.1542/neo.23-7-e462. PMID: 35773506
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Winkelhorst D, Oepkes D
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:15-27. Epub 2019 Feb 6 doi: 10.1016/j.bpobgyn.2019.01.017. PMID: 30827816
Winkelhorst D, Oepkes D, Lopriore E
Expert Rev Hematol 2017 Aug;10(8):729-737. Epub 2017 Jun 29 doi: 10.1080/17474086.2017.1346471. PMID: 28644735
Sachs UJ
Thromb Res 2013 Jan;131 Suppl 1:S42-6. doi: 10.1016/S0049-3848(13)70020-3. PMID: 23452741

Prognosis

Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
de Vos TW, Winkelhorst D, Árnadóttir V, van der Bom JG, Canals Surís C, Caram-Deelder C, Deschmann E, Haysom HE, Hverven HBC, Lozar Krivec J, McQuilten ZK, Muñiz-Diaz E, Nogués N, Oepkes D, Porcelijn L, van der Schoot CE, Saxonhouse M, Sola-Visner M, Tiblad E, Tiller H, Wood EM, Young V, Železnik M, de Haas M, Lopriore E
Lancet Haematol 2022 Nov;9(11):e844-e853. Epub 2022 Sep 12 doi: 10.1016/S2352-3026(22)00243-5. PMID: 36108655
Kamphuis MM, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D
Pediatrics 2014 Apr;133(4):715-21. Epub 2014 Mar 3 doi: 10.1542/peds.2013-3320. PMID: 24590747
Arnold DM, Smith JW, Kelton JG
Transfus Med Rev 2008 Oct;22(4):255-67. doi: 10.1016/j.tmrv.2008.05.003. PMID: 18848153
Porcelijn L, Van den Akker ES, Oepkes D
Semin Fetal Neonatal Med 2008 Aug;13(4):223-30. Epub 2008 Apr 8 doi: 10.1016/j.siny.2008.02.008. PMID: 18400574

Clinical prediction guides

de Vos TW, van Zagten M, de Haas M, Oepkes D, Tan RNGB, van der Schoot CE, Steggerda SJ, de Vries LS, Lopriore E, van Klink JMM
J Pediatr 2023 Jul;258:113385. Epub 2023 Mar 16 doi: 10.1016/j.jpeds.2023.02.031. PMID: 36933767
Guillet S, Loustau V, Boutin E, Zarour A, Comont T, Souchaud-Debouverie O, Costedoat Chalumeau N, Pan-Petesch B, Gobert D, Cheze S, Viallard JF, Morin AS, Sauvetre G, Cliquennois M, Royer B, Masseau A, Terriou L, Fieschi C, Lambotte O, Girault S, Lioger B, Audia S, Sacre K, Lega JC, Langlois V, Benachi A, Orvain C, Devidas A, Humbert S, Gambier N, Ruivard M, Zarrouk V, Ebbo M, Willems L, Segaux L, Mahevas M, Haddad B, Michel M, Canoui-Poitrine F, Godeau B
Blood 2023 Jan 5;141(1):11-21. doi: 10.1182/blood.2022017277. PMID: 36054922Free PMC Article
Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
Brojer E, Husebekk A, Dębska M, Uhrynowska M, Guz K, Orzińska A, Dębski R, Maślanka K
Arch Immunol Ther Exp (Warsz) 2016 Aug;64(4):279-90. Epub 2015 Nov 12 doi: 10.1007/s00005-015-0371-9. PMID: 26564154Free PMC Article
Santoso S, Kiefel V
Wien Klin Wochenschr 2001 Oct 30;113(20-21):806-13. PMID: 11732116

Recent systematic reviews

Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Winkelhorst D, Murphy MF, Greinacher A, Shehata N, Bakchoul T, Massey E, Baker J, Lieberman L, Tanael S, Hume H, Arnold DM, Baidya S, Bertrand G, Bussel J, Kjaer M, Kaplan C, Kjeldsen-Kragh J, Oepkes D, Ryan G
Blood 2017 Mar 16;129(11):1538-1547. Epub 2017 Jan 27 doi: 10.1182/blood-2016-10-739656. PMID: 28130210
Kamphuis MM, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D
Pediatrics 2014 Apr;133(4):715-21. Epub 2014 Mar 3 doi: 10.1542/peds.2013-3320. PMID: 24590747
Kamphuis MM, Paridaans N, Porcelijn L, De Haas M, Van Der Schoot CE, Brand A, Bonsel GJ, Oepkes D
BJOG 2010 Oct;117(11):1335-43. doi: 10.1111/j.1471-0528.2010.02657.x. PMID: 20618318
Bassler D, Greinacher A, Okascharoen C, Klenner A, Ditomasso J, Kiefel V, Chan A, Paes B
Transfusion 2008 Jan;48(1):92-8. Epub 2007 Sep 24 doi: 10.1111/j.1537-2995.2007.01486.x. PMID: 17894790

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