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Leukostasis

MedGen UID:
84394
Concept ID:
C0282548
Disease or Syndrome
Synonyms: Leukostases; Leukostasis Syndrome; Leukostasis Syndromes; Syndrome, Leukostasis; Syndromes, Leukostasis
SNOMED CT: Leukostasis (30419000)
 
Monarch Initiative: MONDO:0006831

Definition

A disorder involving the aberrant infiltration and aggregation of leukocytes into the vasculature of the body. Leukostasis is typically detected in the brain and lungs of persons with leukemia. It requires substantial ablative modalities to both reduce the number of cells present and to ensure dispersion of the aggregates. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukostasis

Professional guidelines

PubMed

Korkmaz S
Transfus Apher Sci 2018 Feb;57(1):4-7. Epub 2018 Feb 20 doi: 10.1016/j.transci.2018.02.006. PMID: 29477941
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252
Ganzel C, Becker J, Mintz PD, Lazarus HM, Rowe JM
Blood Rev 2012 May;26(3):117-22. Epub 2012 Feb 23 doi: 10.1016/j.blre.2012.01.003. PMID: 22364832

Recent clinical studies

Etiology

Stewart S, Lois N
Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec;7(6):422-426. Epub 2018 Jul 30 doi: 10.22608/APO.2018288. PMID: 30058790
Korkmaz S
Transfus Apher Sci 2018 Feb;57(1):4-7. Epub 2018 Feb 20 doi: 10.1016/j.transci.2018.02.006. PMID: 29477941
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252
Nabavizadeh SA, Stein J, Mohan S
Hematol Oncol Clin North Am 2016 Aug;30(4):823-42. doi: 10.1016/j.hoc.2016.03.006. PMID: 27443999
Porcu P, Cripe LD, Ng EW, Bhatia S, Danielson CM, Orazi A, McCarthy LJ
Leuk Lymphoma 2000 Sep;39(1-2):1-18. doi: 10.3109/10428190009053534. PMID: 10975379

Diagnosis

Macaron W, Sargsyan Z, Short NJ
Leuk Lymphoma 2022 Aug;63(8):1780-1791. Epub 2022 Mar 31 doi: 10.1080/10428194.2022.2056178. PMID: 35357988
Spring J, Munshi L
Crit Care Clin 2021 Jan;37(1):85-103. Epub 2020 Oct 29 doi: 10.1016/j.ccc.2020.08.004. PMID: 33190777
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252
Ali AM, Mirrakhimov AE, Abboud CN, Cashen AF
Hematol Oncol 2016 Jun;34(2):69-78. Epub 2016 Mar 27 doi: 10.1002/hon.2292. PMID: 27018197
Ganzel C, Becker J, Mintz PD, Lazarus HM, Rowe JM
Blood Rev 2012 May;26(3):117-22. Epub 2012 Feb 23 doi: 10.1016/j.blre.2012.01.003. PMID: 22364832

Therapy

Macaron W, Sargsyan Z, Short NJ
Leuk Lymphoma 2022 Aug;63(8):1780-1791. Epub 2022 Mar 31 doi: 10.1080/10428194.2022.2056178. PMID: 35357988
Spring J, Munshi L
Chest 2022 Jul;162(1):120-131. Epub 2022 Feb 12 doi: 10.1016/j.chest.2022.02.004. PMID: 35167862
Stewart S, Lois N
Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec;7(6):422-426. Epub 2018 Jul 30 doi: 10.22608/APO.2018288. PMID: 30058790
Korkmaz S
Transfus Apher Sci 2018 Feb;57(1):4-7. Epub 2018 Feb 20 doi: 10.1016/j.transci.2018.02.006. PMID: 29477941
Ganzel C, Becker J, Mintz PD, Lazarus HM, Rowe JM
Blood Rev 2012 May;26(3):117-22. Epub 2012 Feb 23 doi: 10.1016/j.blre.2012.01.003. PMID: 22364832

Prognosis

Macaron W, Sargsyan Z, Short NJ
Leuk Lymphoma 2022 Aug;63(8):1780-1791. Epub 2022 Mar 31 doi: 10.1080/10428194.2022.2056178. PMID: 35357988
Bewersdorf JP, Zeidan AM
Cells 2020 Oct 17;9(10) doi: 10.3390/cells9102310. PMID: 33080779Free PMC Article
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252
Lutty GA
Invest Ophthalmol Vis Sci 2013 Dec 13;54(14):ORSF81-7. doi: 10.1167/iovs.13-12979. PMID: 24335073Free PMC Article
Ganzel C, Becker J, Mintz PD, Lazarus HM, Rowe JM
Blood Rev 2012 May;26(3):117-22. Epub 2012 Feb 23 doi: 10.1016/j.blre.2012.01.003. PMID: 22364832

Clinical prediction guides

Pourhassan H, Kareem W, Agrawal V, Aldoss I
J Intensive Care Med 2024 Apr;39(4):291-305. Epub 2023 Nov 21 doi: 10.1177/08850666231193955. PMID: 37990559
Cerrano M, Chevret S, Raffoux E, Rabian F, Sébert M, Valade S, Itzykson R, Lemiale V, Adès L, Boissel N, Dombret H, Azoulay E, Lengliné E
Ann Hematol 2023 Apr;102(4):761-768. Epub 2023 Feb 11 doi: 10.1007/s00277-023-05119-3. PMID: 36773040Free PMC Article
Lutty GA
Invest Ophthalmol Vis Sci 2013 Dec 13;54(14):ORSF81-7. doi: 10.1167/iovs.13-12979. PMID: 24335073Free PMC Article
Song MK, Roufogalis BD, Huang TH
Br J Pharmacol 2012 Jan;165(1):4-19. doi: 10.1111/j.1476-5381.2011.01411.x. PMID: 21480863Free PMC Article
Porcu P, Farag S, Marcucci G, Cataland SR, Kennedy MS, Bissell M
Ther Apher 2002 Feb;6(1):15-23. doi: 10.1046/j.1526-0968.2002.00402.x. PMID: 11886572

Recent systematic reviews

Bewersdorf JP, Giri S, Tallman MS, Zeidan AM, Stahl M
Transfusion 2020 Oct;60(10):2360-2369. Epub 2020 Aug 10 doi: 10.1111/trf.15994. PMID: 32776542Free PMC Article
Oberoi S, Lehrnbecher T, Phillips B, Hitzler J, Ethier MC, Beyene J, Sung L
Leuk Res 2014 Apr;38(4):460-8. Epub 2014 Jan 10 doi: 10.1016/j.leukres.2014.01.004. PMID: 24472688

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