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Dumping syndrome

MedGen UID:
8501
•Concept ID:
C0013288
•
Disease or Syndrome
Synonyms: Dumping Syndrome; Dumping Syndromes; Syndrome, Dumping; Syndromes, Dumping
SNOMED CT: Dumping syndrome (80193009)
 
Monarch Initiative: MONDO:0001979

Definition

A disorder of the gastrointestinal tract. It is typically caused by the rapid emptying of undigested food from the stomach to the small intestine following gastroesophageal surgery but may be seen secondary to diabetes or the use of certain medications. Clinical signs may be seen 30-60 minutes after eating (early dumping): cramping, nausea, vomiting and diarrhea or they may be seen 1-3 hours later as a result of hyperinsulinemic hypoglycemia (late dumping): sweating, dizziness, confusion and heart palpitations. Untreated, the clinical course progresses to malnutrition and weight loss. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDumping syndrome

Professional guidelines

PubMed

Nutritional management of gastric cancer.
Carrillo Lozano E, Osés Zárate V, Campos Del Portillo R
Endocrinol Diabetes Nutr (Engl Ed) 2021 Jun-Jul;68(6):428-438. Epub 2021 Oct 12 doi: 10.1016/j.endien.2020.09.005. PMID: 34742476
International consensus on the diagnosis and management of dumping syndrome.
Scarpellini E, Arts J, Karamanolis G, Laurenius A, Siquini W, Suzuki H, Ukleja A, Van Beek A, Vanuytsel T, Bor S, Ceppa E, Di Lorenzo C, Emous M, Hammer H, Hellström P, Laville M, Lundell L, Masclee A, Ritz P, Tack J
Nat Rev Endocrinol 2020 Aug;16(8):448-466. Epub 2020 May 26 doi: 10.1038/s41574-020-0357-5. PMID: 32457534Free PMC Article
Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management.
van Beek AP, Emous M, Laville M, Tack J
Obes Rev 2017 Jan;18(1):68-85. Epub 2016 Oct 17 doi: 10.1111/obr.12467. PMID: 27749997

Recent clinical studies

Etiology

Obesity Surgery.
Fink J, Seifert G, Blüher M, Fichtner-Feigl S, Marjanovic G
Dtsch Arztebl Int 2022 Feb 4;119(5):70-80. doi: 10.3238/arztebl.m2021.0359. PMID: 34819222Free PMC Article
Nutritional management of gastric cancer.
Carrillo Lozano E, Osés Zárate V, Campos Del Portillo R
Endocrinol Diabetes Nutr (Engl Ed) 2021 Jun-Jul;68(6):428-438. Epub 2021 Oct 12 doi: 10.1016/j.endien.2020.09.005. PMID: 34742476
Diet approach before and after bariatric surgery.
Bettini S, Belligoli A, Fabris R, Busetto L
Rev Endocr Metab Disord 2020 Sep;21(3):297-306. doi: 10.1007/s11154-020-09571-8. PMID: 32734395Free PMC Article
Postgastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery.
Davis JL, Ripley RT
Surg Clin North Am 2017 Apr;97(2):277-293. doi: 10.1016/j.suc.2016.11.005. PMID: 28325187
Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment.
Berg P, McCallum R
Dig Dis Sci 2016 Jan;61(1):11-8. Epub 2015 Sep 22 doi: 10.1007/s10620-015-3839-x. PMID: 26396002

Diagnosis

Diet approach before and after bariatric surgery.
Bettini S, Belligoli A, Fabris R, Busetto L
Rev Endocr Metab Disord 2020 Sep;21(3):297-306. doi: 10.1007/s11154-020-09571-8. PMID: 32734395Free PMC Article
International consensus on the diagnosis and management of dumping syndrome.
Scarpellini E, Arts J, Karamanolis G, Laurenius A, Siquini W, Suzuki H, Ukleja A, Van Beek A, Vanuytsel T, Bor S, Ceppa E, Di Lorenzo C, Emous M, Hammer H, Hellström P, Laville M, Lundell L, Masclee A, Ritz P, Tack J
Nat Rev Endocrinol 2020 Aug;16(8):448-466. Epub 2020 May 26 doi: 10.1038/s41574-020-0357-5. PMID: 32457534Free PMC Article
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management.
van Beek AP, Emous M, Laville M, Tack J
Obes Rev 2017 Jan;18(1):68-85. Epub 2016 Oct 17 doi: 10.1111/obr.12467. PMID: 27749997
Recognition and management of hyperinsulinemic hypoglycemia after bariatric surgery.
Malik S, Mitchell JE, Steffen K, Engel S, Wiisanen R, Garcia L, Malik SA
Obes Res Clin Pract 2016 Jan-Feb;10(1):1-14. Epub 2015 Oct 27 doi: 10.1016/j.orcp.2015.07.003. PMID: 26522879Free PMC Article

Therapy

Diet approach before and after bariatric surgery.
Bettini S, Belligoli A, Fabris R, Busetto L
Rev Endocr Metab Disord 2020 Sep;21(3):297-306. doi: 10.1007/s11154-020-09571-8. PMID: 32734395Free PMC Article
International consensus on the diagnosis and management of dumping syndrome.
Scarpellini E, Arts J, Karamanolis G, Laurenius A, Siquini W, Suzuki H, Ukleja A, Van Beek A, Vanuytsel T, Bor S, Ceppa E, Di Lorenzo C, Emous M, Hammer H, Hellström P, Laville M, Lundell L, Masclee A, Ritz P, Tack J
Nat Rev Endocrinol 2020 Aug;16(8):448-466. Epub 2020 May 26 doi: 10.1038/s41574-020-0357-5. PMID: 32457534Free PMC Article
Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management.
van Beek AP, Emous M, Laville M, Tack J
Obes Rev 2017 Jan;18(1):68-85. Epub 2016 Oct 17 doi: 10.1111/obr.12467. PMID: 27749997
Recognition and management of hyperinsulinemic hypoglycemia after bariatric surgery.
Malik S, Mitchell JE, Steffen K, Engel S, Wiisanen R, Garcia L, Malik SA
Obes Res Clin Pract 2016 Jan-Feb;10(1):1-14. Epub 2015 Oct 27 doi: 10.1016/j.orcp.2015.07.003. PMID: 26522879Free PMC Article
Approach to the patient with postprandial hypoglycemia.
Galati SJ, Rayfield EJ
Endocr Pract 2014 Apr;20(4):331-40. doi: 10.4158/EP13132.RA. PMID: 24246338

Prognosis

Follow-up after bariatric surgery: A review.
Bjørklund G, Semenova Y, Pivina L, Costea DO
Nutrition 2020 Oct;78:110831. Epub 2020 Apr 21 doi: 10.1016/j.nut.2020.110831. PMID: 32544850
Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment.
Berg P, McCallum R
Dig Dis Sci 2016 Jan;61(1):11-8. Epub 2015 Sep 22 doi: 10.1007/s10620-015-3839-x. PMID: 26396002
Medical complications of bariatric surgery: focus on malabsorption and dumping syndrome.
Hammer HF
Dig Dis 2012;30(2):182-6. Epub 2012 Jun 20 doi: 10.1159/000336681. PMID: 22722436
Postgastrectomy syndromes.
Eagon JC, Miedema BW, Kelly KA
Surg Clin North Am 1992 Apr;72(2):445-65. doi: 10.1016/s0039-6109(16)45689-6. PMID: 1549803
Postoperative reflux gastritis.
van Heerden JA, Phillips SF, Adson MA, McIlrath DC
Am J Surg 1975 Jan;129(1):82-8. doi: 10.1016/0002-9610(75)90172-5. PMID: 1082249

Clinical prediction guides

Dumping Syndrome and Postbariatric Hypoglycemia: Supporting Evidence for a Common Etiology.
van Furth AM, de Heide LJM, Emous M, Veeger N, van Beek AP
Surg Obes Relat Dis 2021 Nov;17(11):1912-1918. Epub 2021 May 19 doi: 10.1016/j.soard.2021.05.020. PMID: 34144916
Efficacy and safety of lanreotide in postoperative dumping syndrome: A Phase II randomised and placebo-controlled study.
Wauters L, Arts J, Caenepeel P, Holvoet L, Tack J, Bisschops R, Vanuytsel T
United European Gastroenterol J 2019 Oct;7(8):1064-1072. Epub 2019 Jun 27 doi: 10.1177/2050640619862166. PMID: 31662863Free PMC Article
Gastrostomy Placement and Management in Children: A Single-Center Experience.
Di Leo G, Pascolo P, Hamadeh K, Trombetta A, Ghirardo S, Schleef J, Barbi E, Codrich D
Nutrients 2019 Jul 10;11(7) doi: 10.3390/nu11071555. PMID: 31295800Free PMC Article
Prevalence of Dumping Syndrome After Laparoscopic Sleeve Gastrectomy and Comparison with Laparoscopic Roux-en-Y Gastric Bypass.
Ahmad A, Kornrich DB, Krasner H, Eckardt S, Ahmad Z, Braslow A, Broggelwirth B
Obes Surg 2019 May;29(5):1506-1513. doi: 10.1007/s11695-018-03699-y. PMID: 30635813
Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment.
Berg P, McCallum R
Dig Dis Sci 2016 Jan;61(1):11-8. Epub 2015 Sep 22 doi: 10.1007/s10620-015-3839-x. PMID: 26396002

Recent systematic reviews

Herbal Medicine for Dumping Syndrome: A Systematic Review and Meta-Analysis.
Hong S, Park B, Noh H, Choi DJ
Integr Cancer Ther 2019 Jan-Dec;18:1534735419873404. doi: 10.1177/1534735419873404. PMID: 31549529Free PMC Article
Heterogeneity in the Definition and Clinical Characteristics of Dumping Syndrome: a Review of the Literature.
Gys B, Plaeke P, Lamme B, Lafullarde T, Komen N, Beunis A, Hubens G
Obes Surg 2019 Jun;29(6):1984-1989. doi: 10.1007/s11695-019-03818-3. PMID: 30941693
Dumping syndrome after esophagectomy: a systematic review of the literature.
Boshier PR, Huddy JR, Zaninotto G, Hanna GB
Dis Esophagus 2017 Jan 1;30(1):1-9. doi: 10.1111/dote.12488. PMID: 27859950
Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management.
van Beek AP, Emous M, Laville M, Tack J
Obes Rev 2017 Jan;18(1):68-85. Epub 2016 Oct 17 doi: 10.1111/obr.12467. PMID: 27749997
Should we continue to drain the pylorus in patients undergoing an esophagectomy?
Gaur P, Swanson SJ
Dis Esophagus 2014 Aug;27(6):568-73. Epub 2013 Feb 26 doi: 10.1111/dote.12035. PMID: 23442059

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