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Motor Disorders

MedGen UID:
852447
•Concept ID:
C0221163
•
Disease or Syndrome

Definition

Motor skills deficits that significantly and persistently interfere with ACTIVITIES OF DAILY LIVING appropriate to chronological age. (from DSM-5) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMotor Disorders

Professional guidelines

PubMed

Evidence-Based, Implementable Motor Rehabilitation Guidelines for Individuals With Cerebral Palsy.
Demont A, Gedda M, Lager C, de Lattre C, Gary Y, Keroulle E, Feuillerat B, Caudan H, Sancelme Z, Isapof A, Viehweger E, Chatelin M, Hochard M, Boivin J, Vurpillat P, Genès N, de Boissezon X, Fontaine A, Brochard S
Neurology 2022 Aug 16;99(7):283-297. Epub 2022 Jun 24 doi: 10.1212/WNL.0000000000200936. PMID: 35750497
Recent advances in dysphagia management.
Triggs J, Pandolfino J
F1000Res 2019;8 Epub 2019 Aug 29 doi: 10.12688/f1000research.18900.1. PMID: 31508201Free PMC Article
Physiotherapy for functional motor disorders: a consensus recommendation.
Nielsen G, Stone J, Matthews A, Brown M, Sparkes C, Farmer R, Masterton L, Duncan L, Winters A, Daniell L, Lumsden C, Carson A, David AS, Edwards M
J Neurol Neurosurg Psychiatry 2015 Oct;86(10):1113-9. Epub 2014 Nov 28 doi: 10.1136/jnnp-2014-309255. PMID: 25433033Free PMC Article

Recent clinical studies

Etiology

Neurogenetic motor disorders.
Younger DS
Handb Clin Neurol 2023;195:183-250. doi: 10.1016/B978-0-323-98818-6.00003-0. PMID: 37562870
Six-Month Community-Based Brisk Walking and Balance Exercise Alleviates Motor Symptoms and Promotes Functions in People with Parkinson's Disease: A Randomized Controlled Trial.
Mak MKY, Wong-Yu ISK
J Parkinsons Dis 2021;11(3):1431-1441. doi: 10.3233/JPD-202503. PMID: 33967056
The efficacy of dance for improving motor impairments, non-motor symptoms, and quality of life in Parkinson's disease: A systematic review and meta-analysis.
Carapellotti AM, Stevenson R, Doumas M
PLoS One 2020;15(8):e0236820. Epub 2020 Aug 5 doi: 10.1371/journal.pone.0236820. PMID: 32756578Free PMC Article
Red flags of low back pain.
DePalma MG
JAAPA 2020 Aug;33(8):8-11. doi: 10.1097/01.JAA.0000684112.91641.4c. PMID: 32740106
Efficacy of Supporting Play Exploration and Early Development Intervention in the First Months of Life for Infants Born Very Preterm: 3-Arm Randomized Clinical Trial Protocol.
Dusing SC, Burnsed JC, Brown SE, Harper AD, Hendricks-Munoz KD, Stevenson RD, Thacker LR, Molinini RM
Phys Ther 2020 Aug 12;100(8):1343-1352. doi: 10.1093/ptj/pzaa077. PMID: 32329778Free PMC Article

Diagnosis

Neurogenetic motor disorders.
Younger DS
Handb Clin Neurol 2023;195:183-250. doi: 10.1016/B978-0-323-98818-6.00003-0. PMID: 37562870
Red flags of low back pain.
DePalma MG
JAAPA 2020 Aug;33(8):8-11. doi: 10.1097/01.JAA.0000684112.91641.4c. PMID: 32740106
Efficacy of Supporting Play Exploration and Early Development Intervention in the First Months of Life for Infants Born Very Preterm: 3-Arm Randomized Clinical Trial Protocol.
Dusing SC, Burnsed JC, Brown SE, Harper AD, Hendricks-Munoz KD, Stevenson RD, Thacker LR, Molinini RM
Phys Ther 2020 Aug 12;100(8):1343-1352. doi: 10.1093/ptj/pzaa077. PMID: 32329778Free PMC Article
Recent advances in dysphagia management.
Triggs J, Pandolfino J
F1000Res 2019;8 Epub 2019 Aug 29 doi: 10.12688/f1000research.18900.1. PMID: 31508201Free PMC Article
Infantile-onset Pompe disease: Diagnosis and management.
Bay LB, Denzler I, Durand C, Eiroa H, Frabasil J, Fainboim A, Maxit C, Schenone A, Spécola N
Arch Argent Pediatr 2019 Aug 1;117(4):271-278. doi: 10.5546/aap.2019.eng.271. PMID: 31339275

Therapy

Trial of Lixisenatide in Early Parkinson's Disease.
Meissner WG, Remy P, Giordana C, Maltête D, Derkinderen P, Houéto JL, Anheim M, Benatru I, Boraud T, Brefel-Courbon C, Carrière N, Catala H, Colin O, Corvol JC, Damier P, Dellapina E, Devos D, Drapier S, Fabbri M, Ferrier V, Foubert-Samier A, Frismand-Kryloff S, Georget A, Germain C, Grimaldi S, Hardy C, Hopes L, Krystkowiak P, Laurens B, Lefaucheur R, Mariani LL, Marques A, Marse C, Ory-Magne F, Rigalleau V, Salhi H, Saubion A, Stott SRW, Thalamas C, Thiriez C, Tir M, Wyse RK, Benard A, Rascol O; LIXIPARK Study Group
N Engl J Med 2024 Apr 4;390(13):1176-1185. doi: 10.1056/NEJMoa2312323. PMID: 38598572
Red flags of low back pain.
DePalma MG
JAAPA 2020 Aug;33(8):8-11. doi: 10.1097/01.JAA.0000684112.91641.4c. PMID: 32740106
Efficacy of Supporting Play Exploration and Early Development Intervention in the First Months of Life for Infants Born Very Preterm: 3-Arm Randomized Clinical Trial Protocol.
Dusing SC, Burnsed JC, Brown SE, Harper AD, Hendricks-Munoz KD, Stevenson RD, Thacker LR, Molinini RM
Phys Ther 2020 Aug 12;100(8):1343-1352. doi: 10.1093/ptj/pzaa077. PMID: 32329778Free PMC Article
Phytotherapy in treatment of Parkinson's disease: a review.
Rabiei Z, Solati K, Amini-Khoei H
Pharm Biol 2019 Dec;57(1):355-362. doi: 10.1080/13880209.2019.1618344. PMID: 31141426Free PMC Article
Interventions to improve gross motor performance in children with neurodevelopmental disorders: a meta-analysis.
Lucas BR, Elliott EJ, Coggan S, Pinto RZ, Jirikowic T, McCoy SW, Latimer J
BMC Pediatr 2016 Nov 29;16(1):193. doi: 10.1186/s12887-016-0731-6. PMID: 27899082Free PMC Article

Prognosis

Multiple sclerosis: Motor dysfunction.
Younger DS
Handb Clin Neurol 2023;196:119-147. doi: 10.1016/B978-0-323-98817-9.00016-8. PMID: 37620066
Motor rehabilitation after stroke: European Stroke Organisation (ESO) consensus-based definition and guiding framework.
Kwakkel G, Stinear C, Essers B, Munoz-Novoa M, Branscheidt M, Cabanas-Valdés R, Lakičević S, Lampropoulou S, Luft AR, Marque P, Moore SA, Solomon JM, Swinnen E, Turolla A, Alt Murphy M, Verheyden G
Eur Stroke J 2023 Dec;8(4):880-894. Epub 2023 Aug 7 doi: 10.1177/23969873231191304. PMID: 37548025Free PMC Article
Natural history of motor symptoms in Parkinson's disease and the long-duration response to levodopa.
Cilia R, Cereda E, Akpalu A, Sarfo FS, Cham M, Laryea R, Obese V, Oppon K, Del Sorbo F, Bonvegna S, Zecchinelli AL, Pezzoli G
Brain 2020 Aug 1;143(8):2490-2501. doi: 10.1093/brain/awaa181. PMID: 32844196Free PMC Article
Predicting Upper Limb Motor Impairment Recovery after Stroke: A Mixture Model.
van der Vliet R, Selles RW, Andrinopoulou ER, Nijland R, Ribbers GM, Frens MA, Meskers C, Kwakkel G
Ann Neurol 2020 Mar;87(3):383-393. Epub 2020 Jan 25 doi: 10.1002/ana.25679. PMID: 31925838Free PMC Article
Cerebral palsy--don't delay.
McIntyre S, Morgan C, Walker K, Novak I
Dev Disabil Res Rev 2011;17(2):114-29. doi: 10.1002/ddrr.1106. PMID: 23362031

Clinical prediction guides

Motor Control: A Conceptual Framework for Rehabilitation.
Levin MF, Piscitelli D
Motor Control 2022 Oct 1;26(4):497-517. Epub 2022 Jul 8 doi: 10.1123/mc.2022-0026. PMID: 35894963
Six-Month Community-Based Brisk Walking and Balance Exercise Alleviates Motor Symptoms and Promotes Functions in People with Parkinson's Disease: A Randomized Controlled Trial.
Mak MKY, Wong-Yu ISK
J Parkinsons Dis 2021;11(3):1431-1441. doi: 10.3233/JPD-202503. PMID: 33967056
Natural history of motor symptoms in Parkinson's disease and the long-duration response to levodopa.
Cilia R, Cereda E, Akpalu A, Sarfo FS, Cham M, Laryea R, Obese V, Oppon K, Del Sorbo F, Bonvegna S, Zecchinelli AL, Pezzoli G
Brain 2020 Aug 1;143(8):2490-2501. doi: 10.1093/brain/awaa181. PMID: 32844196Free PMC Article
Efficacy of Supporting Play Exploration and Early Development Intervention in the First Months of Life for Infants Born Very Preterm: 3-Arm Randomized Clinical Trial Protocol.
Dusing SC, Burnsed JC, Brown SE, Harper AD, Hendricks-Munoz KD, Stevenson RD, Thacker LR, Molinini RM
Phys Ther 2020 Aug 12;100(8):1343-1352. doi: 10.1093/ptj/pzaa077. PMID: 32329778Free PMC Article
Is Motor Impairment in Autism Spectrum Disorder Distinct From Developmental Coordination Disorder? A Report From the SPARK Study.
Bhat AN
Phys Ther 2020 Apr 17;100(4):633-644. doi: 10.1093/ptj/pzz190. PMID: 32154876Free PMC Article

Recent systematic reviews

A systematic review of cannabidiol trials in neurodevelopmental disorders.
Parrella NF, Hill AT, Enticott PG, Barhoun P, Bower IS, Ford TC
Pharmacol Biochem Behav 2023 Sep;230:173607. Epub 2023 Aug 4 doi: 10.1016/j.pbb.2023.173607. PMID: 37543051
Localized muscle vibration in the treatment of motor impairment and spasticity in post-stroke patients: a systematic review.
Avvantaggiato C, Casale R, Cinone N, Facciorusso S, Turitto A, Stuppiello L, Picelli A, Ranieri M, Intiso D, Fiore P, Ciritella C, Santamato A
Eur J Phys Rehabil Med 2021 Feb;57(1):44-60. Epub 2020 Oct 28 doi: 10.23736/S1973-9087.20.06390-X. PMID: 33111513
The efficacy of dance for improving motor impairments, non-motor symptoms, and quality of life in Parkinson's disease: A systematic review and meta-analysis.
Carapellotti AM, Stevenson R, Doumas M
PLoS One 2020;15(8):e0236820. Epub 2020 Aug 5 doi: 10.1371/journal.pone.0236820. PMID: 32756578Free PMC Article
Aquatic exercise improves motor impairments in people with Parkinson's disease, with similar or greater benefits than land-based exercise: a systematic review.
Cugusi L, Manca A, Bergamin M, Di Blasio A, Monticone M, Deriu F, Mercuro G
J Physiother 2019 Apr;65(2):65-74. Epub 2019 Mar 21 doi: 10.1016/j.jphys.2019.02.003. PMID: 30904467
Interventions to improve gross motor performance in children with neurodevelopmental disorders: a meta-analysis.
Lucas BR, Elliott EJ, Coggan S, Pinto RZ, Jirikowic T, McCoy SW, Latimer J
BMC Pediatr 2016 Nov 29;16(1):193. doi: 10.1186/s12887-016-0731-6. PMID: 27899082Free PMC Article

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