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Untreated Adult Acute Myeloid Leukemia

MedGen UID:
852467
•Concept ID:
C0279089
•
Finding

Definition

A finding of acute myeloid leukemia in adulthood that has not been treated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUntreated Adult Acute Myeloid Leukemia

Professional guidelines

PubMed

Does time from diagnosis to treatment affect the prognosis of patients with newly diagnosed acute myeloid leukemia?
Röllig C, Kramer M, Schliemann C, Mikesch JH, Steffen B, Krämer A, Noppeney R, Schäfer-Eckart K, Krause SW, Hänel M, Herbst R, Kunzmann V, Einsele H, Jost E, Brümmendorf TH, Scholl S, Hochhaus A, Neubauer A, Sohlbach K, Fransecky L, Kaufmann M, Niemann D, Schaich M, Frickhofen N, Kiani A, Heits F, Krümpelmann U, Kaiser U, Kullmer J, Wass M, Stölzel F, von Bonin M, Middeke JM, Thiede C, Schetelig J, Berdel WE, Ehninger G, Baldus CD, Müller-Tidow C, Platzbecker U, Serve H, Bornhäuser M
Blood 2020 Aug 13;136(7):823-830. doi: 10.1182/blood.2019004583. PMID: 32496541
Clofarabine in the treatment of newly diagnosed acute myeloid leukemia in older adults.
Tran H, Yang D
Ann Pharmacother 2012 Jan;46(1):89-96. Epub 2011 Dec 13 doi: 10.1345/aph.1Q295. PMID: 22170975
Treatment of resistant acute myeloid leukemia.
Schiller G
Blood Rev 1991 Dec;5(4):220-6. doi: 10.1016/0268-960x(91)90012-2. PMID: 1782481

Recent clinical studies

Etiology

Addition of cladribine to daunorubicin and cytarabine increases complete remission rate after a single course of induction treatment in acute myeloid leukemia. Multicenter, phase III study.
Holowiecki J, Grosicki S, Robak T, Kyrcz-Krzemien S, Giebel S, Hellmann A, Skotnicki A, Jedrzejczak WW, Konopka L, Kuliczkowski K, Zdziarska B, Dmoszynska A, Marianska B, Pluta A, Zawilska K, Komarnicki M, Kloczko J, Sulek K, Haus O, Stella-Holowiecka B, Baran W, Jakubas B, Paluszewska M, Wierzbowska A, Kielbinski M, Jagoda K; Polish Adult Leukemia Group (PALG)
Leukemia 2004 May;18(5):989-97. doi: 10.1038/sj.leu.2403336. PMID: 14999298

Therapy

Addition of cladribine to daunorubicin and cytarabine increases complete remission rate after a single course of induction treatment in acute myeloid leukemia. Multicenter, phase III study.
Holowiecki J, Grosicki S, Robak T, Kyrcz-Krzemien S, Giebel S, Hellmann A, Skotnicki A, Jedrzejczak WW, Konopka L, Kuliczkowski K, Zdziarska B, Dmoszynska A, Marianska B, Pluta A, Zawilska K, Komarnicki M, Kloczko J, Sulek K, Haus O, Stella-Holowiecka B, Baran W, Jakubas B, Paluszewska M, Wierzbowska A, Kielbinski M, Jagoda K; Polish Adult Leukemia Group (PALG)
Leukemia 2004 May;18(5):989-97. doi: 10.1038/sj.leu.2403336. PMID: 14999298
Idarubicin in the therapy of acute myeloid leukemia: final analysis in 57 previously untreated patients.
Lambertenghi Deliliers G, Annaloro C, Oriani A, Pozzoli E, Cortelezzi A, Cortellaro M, Mozzana R, Della Volpe A, Soligo D, Cofrancesco E
Semin Oncol 1993 Dec;20(6 Suppl 8):27-33. PMID: 8290969

Prognosis

Addition of cladribine to daunorubicin and cytarabine increases complete remission rate after a single course of induction treatment in acute myeloid leukemia. Multicenter, phase III study.
Holowiecki J, Grosicki S, Robak T, Kyrcz-Krzemien S, Giebel S, Hellmann A, Skotnicki A, Jedrzejczak WW, Konopka L, Kuliczkowski K, Zdziarska B, Dmoszynska A, Marianska B, Pluta A, Zawilska K, Komarnicki M, Kloczko J, Sulek K, Haus O, Stella-Holowiecka B, Baran W, Jakubas B, Paluszewska M, Wierzbowska A, Kielbinski M, Jagoda K; Polish Adult Leukemia Group (PALG)
Leukemia 2004 May;18(5):989-97. doi: 10.1038/sj.leu.2403336. PMID: 14999298
Idarubicin in the therapy of acute myeloid leukemia: final analysis in 57 previously untreated patients.
Lambertenghi Deliliers G, Annaloro C, Oriani A, Pozzoli E, Cortelezzi A, Cortellaro M, Mozzana R, Della Volpe A, Soligo D, Cofrancesco E
Semin Oncol 1993 Dec;20(6 Suppl 8):27-33. PMID: 8290969

Clinical prediction guides

Idarubicin in the therapy of acute myeloid leukemia: final analysis in 57 previously untreated patients.
Lambertenghi Deliliers G, Annaloro C, Oriani A, Pozzoli E, Cortelezzi A, Cortellaro M, Mozzana R, Della Volpe A, Soligo D, Cofrancesco E
Semin Oncol 1993 Dec;20(6 Suppl 8):27-33. PMID: 8290969

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