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Early-onset neonatal sepsis

MedGen UID:
853134
•Concept ID:
C1096452
•
Disease or Syndrome
Synonyms: Early-Onset Sepses, Neonatal; Early-Onset Sepsis, Neonatal; Neonatal Early Onset Sepsis; Neonatal Early-Onset Sepses; Neonatal Early-Onset Sepsis; Sepses, Neonatal Early-Onset; Sepsis, Neonatal Early-Onset
SNOMED CT: Early-onset neonatal sepsis (765106006)

Definition

An infectious disorder of newborn infants that is characterized by a systemic inflammatory response within 72 hours of life and is most commonly caused by bacteria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly-onset neonatal sepsis

Professional guidelines

PubMed

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Management of Infants at Risk for Group B Streptococcal Disease.
Puopolo KM, Lynfield R, Cummings JJ; COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2019 Aug;144(2) Epub 2019 Jul 8 doi: 10.1542/peds.2019-1881. PMID: 31285392
Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis.
Puopolo KM, Benitz WE, Zaoutis TE; COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2018 Dec;142(6) doi: 10.1542/peds.2018-2894. PMID: 30455342

Recent clinical studies

Etiology

Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies.
Stoll BJ, Puopolo KM, Hansen NI, Sánchez PJ, Bell EF, Carlo WA, Cotten CM, D'Angio CT, Kazzi SNJ, Poindexter BB, Van Meurs KP, Hale EC, Collins MV, Das A, Baker CJ, Wyckoff MH, Yoder BA, Watterberg KL, Walsh MC, Devaskar U, Laptook AR, Sokol GM, Schrag SJ, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
JAMA Pediatr 2020 Jul 1;174(7):e200593. Epub 2020 Jul 6 doi: 10.1001/jamapediatrics.2020.0593. PMID: 32364598Free PMC Article
Early-onset neonatal sepsis.
Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD
Clin Microbiol Rev 2014 Jan;27(1):21-47. doi: 10.1128/CMR.00031-13. PMID: 24396135Free PMC Article

Diagnosis

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Early-onset neonatal sepsis.
Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD
Clin Microbiol Rev 2014 Jan;27(1):21-47. doi: 10.1128/CMR.00031-13. PMID: 24396135Free PMC Article
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779

Therapy

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Vaginal Microbiome in Preterm Rupture of Membranes.
Bennett PR, Brown RG, MacIntyre DA
Obstet Gynecol Clin North Am 2020 Dec;47(4):503-521. doi: 10.1016/j.ogc.2020.08.001. PMID: 33121642

Prognosis

Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies.
Stoll BJ, Puopolo KM, Hansen NI, Sánchez PJ, Bell EF, Carlo WA, Cotten CM, D'Angio CT, Kazzi SNJ, Poindexter BB, Van Meurs KP, Hale EC, Collins MV, Das A, Baker CJ, Wyckoff MH, Yoder BA, Watterberg KL, Walsh MC, Devaskar U, Laptook AR, Sokol GM, Schrag SJ, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
JAMA Pediatr 2020 Jul 1;174(7):e200593. Epub 2020 Jul 6 doi: 10.1001/jamapediatrics.2020.0593. PMID: 32364598Free PMC Article
Early-onset neonatal sepsis.
Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD
Clin Microbiol Rev 2014 Jan;27(1):21-47. doi: 10.1128/CMR.00031-13. PMID: 24396135Free PMC Article
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779

Clinical prediction guides

Perinatal risk factors for neonatal early-onset sepsis: a meta-analysis of observational studies.
Guo L, Han W, Su Y, Wang N, Chen X, Ma J, Liang J, Hao L, Ren C
J Matern Fetal Neonatal Med 2023 Dec;36(2):2259049. Epub 2023 Sep 24 doi: 10.1080/14767058.2023.2259049. PMID: 37743349
The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications.
Jung E, Romero R, Yeo L, Diaz-Primera R, Marin-Concha J, Para R, Lopez AM, Pacora P, Gomez-Lopez N, Yoon BH, Kim CJ, Berry SM, Hsu CD
Semin Fetal Neonatal Med 2020 Aug;25(4):101146. Epub 2020 Oct 23 doi: 10.1016/j.siny.2020.101146. PMID: 33164775Free PMC Article
Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies.
Stoll BJ, Puopolo KM, Hansen NI, Sánchez PJ, Bell EF, Carlo WA, Cotten CM, D'Angio CT, Kazzi SNJ, Poindexter BB, Van Meurs KP, Hale EC, Collins MV, Das A, Baker CJ, Wyckoff MH, Yoder BA, Watterberg KL, Walsh MC, Devaskar U, Laptook AR, Sokol GM, Schrag SJ, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
JAMA Pediatr 2020 Jul 1;174(7):e200593. Epub 2020 Jul 6 doi: 10.1001/jamapediatrics.2020.0593. PMID: 32364598Free PMC Article
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779

Recent systematic reviews

Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Neonatal early onset sepsis in Middle Eastern countries: a systematic review.
Khalil N, Blunt HB, Li Z, Hartman T
Arch Dis Child 2020 Jul;105(7):639-647. Epub 2020 Jan 22 doi: 10.1136/archdischild-2019-317110. PMID: 31969351
Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37 weeks or more).
Middleton P, Shepherd E, Flenady V, McBain RD, Crowther CA
Cochrane Database Syst Rev 2017 Jan 4;1(1):CD005302. doi: 10.1002/14651858.CD005302.pub3. PMID: 28050900Free PMC Article
Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis.
Chan GJ, Lee AC, Baqui AH, Tan J, Black RE
PLoS Med 2013 Aug;10(8):e1001502. Epub 2013 Aug 20 doi: 10.1371/journal.pmed.1001502. PMID: 23976885Free PMC Article

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