U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Late-onset neonatal sepsis

MedGen UID:
853136
•Concept ID:
C1096721
•
Disease or Syndrome
Synonyms: Late-Onset Sepses, Neonatal; Late-Onset Sepsis, Neonatal; Neonatal Late Onset Sepsis; Neonatal Late-Onset Sepses; Neonatal Late-Onset Sepsis; Sepses, Neonatal Late-Onset; Sepsis, Neonatal Late-Onset
SNOMED CT: Late-onset neonatal sepsis (765107002)

Definition

An infectious disorder of newborn infants that is characterized by a systemic inflammatory response beyond 72 hours of life and is most commonly caused by bacteria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLate-onset neonatal sepsis

Professional guidelines

PubMed

Updates in Late-Onset Sepsis: Risk Assessment, Therapy, and Outcomes.
Coggins SA, Glaser K
Neoreviews 2022 Nov 1;23(11):738-755. doi: 10.1542/neo.23-10-e738. PMID: 36316254Free PMC Article
Efficacy of empiric antibiotic treatment of late-onset neonatal sepsis caused by Enterobacteriaceae: A systematic review.
Akselsen AB, Sheth CC, Veses V
Lett Appl Microbiol 2022 Sep;75(3):500-510. Epub 2022 Jan 7 doi: 10.1111/lam.13640. PMID: 34951709
Considerations in the pharmacologic treatment and prevention of neonatal sepsis.
Stockmann C, Spigarelli MG, Campbell SC, Constance JE, Courter JD, Thorell EA, Olson J, Sherwin CM
Paediatr Drugs 2014 Feb;16(1):67-81. doi: 10.1007/s40272-013-0057-x. PMID: 24218112

Recent clinical studies

Etiology

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Procalcitonin: Between evidence and critical issues.
Aloisio E, Dolci A, Panteghini M
Clin Chim Acta 2019 Sep;496:7-12. Epub 2019 Jun 10 doi: 10.1016/j.cca.2019.06.010. PMID: 31194966
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article

Diagnosis

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Procalcitonin: Between evidence and critical issues.
Aloisio E, Dolci A, Panteghini M
Clin Chim Acta 2019 Sep;496:7-12. Epub 2019 Jun 10 doi: 10.1016/j.cca.2019.06.010. PMID: 31194966
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article

Therapy

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Procalcitonin: Between evidence and critical issues.
Aloisio E, Dolci A, Panteghini M
Clin Chim Acta 2019 Sep;496:7-12. Epub 2019 Jun 10 doi: 10.1016/j.cca.2019.06.010. PMID: 31194966
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article

Prognosis

Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Malignant Infantile Osteopetrosis.
Gillani S, Abbas Z
J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):350-352. PMID: 28718264
Late-onset Neonatal Sepsis-A 10-year Review From North Queensland, Australia.
Gowda H, Norton R, White A, Kandasamy Y
Pediatr Infect Dis J 2017 Sep;36(9):883-888. doi: 10.1097/INF.0000000000001568. PMID: 28178107
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article
Clinical microbiology of early-onset and late-onset neonatal sepsis, particularly among preterm babies.
Kristóf K, Kocsis E, Nagy K
Acta Microbiol Immunol Hung 2009 Mar;56(1):21-51. doi: 10.1556/AMicr.56.2009.1.2. PMID: 19388555

Clinical prediction guides

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Methemoglobinemia Associated with Late-Onset Neonatal Sepsis: A Single-Center Experience.
Schierz IAM, Pinello G, Piro E, Giuffrè M, Corsello G
Am J Perinatol 2019 Dec;36(14):1510-1513. Epub 2019 Feb 1 doi: 10.1055/s-0039-1678556. PMID: 30708394
Malignant Infantile Osteopetrosis.
Gillani S, Abbas Z
J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):350-352. PMID: 28718264

Recent systematic reviews

Efficacy of empiric antibiotic treatment of late-onset neonatal sepsis caused by Enterobacteriaceae: A systematic review.
Akselsen AB, Sheth CC, Veses V
Lett Appl Microbiol 2022 Sep;75(3):500-510. Epub 2022 Jan 7 doi: 10.1111/lam.13640. PMID: 34951709
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Antibiotics for neonates born through meconium-stained amniotic fluid.
Kelly LE, Shivananda S, Murthy P, Srinivasjois R, Shah PS
Cochrane Database Syst Rev 2017 Jun 28;6(6):CD006183. doi: 10.1002/14651858.CD006183.pub2. PMID: 28658507Free PMC Article
Candida parapsilosis is a significant neonatal pathogen: a systematic review and meta-analysis.
Pammi M, Holland L, Butler G, Gacser A, Bliss JM
Pediatr Infect Dis J 2013 May;32(5):e206-16. doi: 10.1097/INF.0b013e3182863a1c. PMID: 23340551Free PMC Article
Antibiotic regimens for suspected late onset sepsis in newborn infants.
Gordon A, Jeffery HE
Cochrane Database Syst Rev 2005 Jul 20;2005(3):CD004501. doi: 10.1002/14651858.CD004501.pub2. PMID: 16034935Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...