U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bilateral cleft lip and palate

MedGen UID:
853256
Concept ID:
C1398522
Congenital Abnormality
Synonym: Bilateral cleft lip/palate
SNOMED CT: Cleft palate and bilateral cleft lip (1085331000119107); Uranostaphyloschisis with bilateral cleft lip (1085331000119107); Cleft hard and soft palate and bilateral cleft lip (1085331000119107)

Professional guidelines

PubMed

Morris L
Curr Opin Otolaryngol Head Neck Surg 2019 Aug;27(4):302-309. doi: 10.1097/MOO.0000000000000558. PMID: 31219831
Hong M, Baek SH
J Craniofac Surg 2018 Mar;29(2):440-444. doi: 10.1097/SCS.0000000000004140. PMID: 29227409
Bittermann GK, de Ruiter AP, Janssen NG, Bittermann AJ, van der Molen AM, van Es RJ, Rosenberg AJ, Koole R
Clin Oral Investig 2016 Mar;20(2):207-17. Epub 2015 Sep 16 doi: 10.1007/s00784-015-1589-y. PMID: 26374747Free PMC Article

Recent clinical studies

Etiology

Traube IM, Cutting CB, Grayson BH, Shetye PR
J Craniofac Surg 2023 Jan-Feb 01;34(1):198-201. Epub 2022 Sep 15 doi: 10.1097/SCS.0000000000007976. PMID: 34260466
Kuang W, Zheng J, Li S, Yuan S, He H, Yuan W
Cleft Palate Craniofac J 2021 Mar;58(3):332-339. Epub 2020 Aug 19 doi: 10.1177/1055665620946982. PMID: 32812438
Liu Y, Huang H, Shi B, Wang Y
J Craniofac Surg 2020 Jul-Aug;31(5):1218-1222. doi: 10.1097/SCS.0000000000006368. PMID: 32282678
O'Mahony A, McNamara C, Ireland A, Sandy J, Puryer J
Br Dent J 2017 May 12;222(9):677-681. doi: 10.1038/sj.bdj.2017.405. PMID: 28496230
de Medeiros Alves AC, Garib DG, Janson G, de Almeida AM, Calil LR
Clin Oral Investig 2016 Sep;20(7):1837-47. Epub 2015 Dec 1 doi: 10.1007/s00784-015-1675-1. PMID: 26620733

Diagnosis

Nimonkar SV, Belkhode VM
Pan Afr Med J 2022;42:316. Epub 2022 Aug 29 doi: 10.11604/pamj.2022.42.316.33040. PMID: 36451981Free PMC Article
O'Mahony A, McNamara C, Ireland A, Sandy J, Puryer J
Br Dent J 2017 May 12;222(9):677-681. doi: 10.1038/sj.bdj.2017.405. PMID: 28496230
Ishmael HA, Begleiter ML, Regier EJ, Butler MG
Am J Med Genet 2002 Jan 15;107(2):169-73. doi: 10.1002/ajmg.10120. PMID: 11807893Free PMC Article
Stoll C, Viville B, Treisser A, Gasser B
Am J Med Genet 1998 Jul 24;78(4):345-9. doi: 10.1002/(sici)1096-8628(19980724)78:4<345::aid-ajmg8>3.0.co;2-k. PMID: 9714437
Le Merrer M, Cikuli M, Ribier J, Briard ML
Am J Med Genet 1989 Jul;33(3):318-22. doi: 10.1002/ajmg.1320330307. PMID: 2801764

Therapy

Fowler PV, Keall H, Kennedy D, Healey D, Thompson JMD
Orthod Craniofac Res 2019 Aug;22(3):147-152. Epub 2019 Mar 3 doi: 10.1111/ocr.12300. PMID: 30742737
Bennun RD, Harfin JH
J Craniofac Surg 2018 Sep;29(6):1441-1444. doi: 10.1097/SCS.0000000000004756. PMID: 30015740
O'Mahony A, McNamara C, Ireland A, Sandy J, Puryer J
Br Dent J 2017 May 12;222(9):677-681. doi: 10.1038/sj.bdj.2017.405. PMID: 28496230
de Medeiros Alves AC, Garib DG, Janson G, de Almeida AM, Calil LR
Clin Oral Investig 2016 Sep;20(7):1837-47. Epub 2015 Dec 1 doi: 10.1007/s00784-015-1675-1. PMID: 26620733
Celikoglu M, Buyuk SK, Sekerci AE, Ersoz M, Celik S, Sisman Y
Am J Orthod Dentofacial Orthop 2014 Nov;146(5):573-8. Epub 2014 Oct 28 doi: 10.1016/j.ajodo.2014.07.005. PMID: 25439207

Prognosis

Gustafsson C, Heliövaara A, Rautio J, Leikola J
Cleft Palate Craniofac J 2023 Oct;60(10):1241-1249. Epub 2022 Jun 20 doi: 10.1177/10556656221102816. PMID: 35726173Free PMC Article
Harrison LM, Hallac RR, Derderian CA
Cleft Palate Craniofac J 2021 Jan;58(1):105-113. Epub 2020 Jul 21 doi: 10.1177/1055665620940190. PMID: 32691613
Bittermann GKP, de Ruiter AP, Bittermann AJ, Mink van de Molen AB, van Es RJ, Koole R, Rosenberg AJ
J Craniomaxillofac Surg 2018 Oct;46(10):1764-1771. Epub 2018 Jul 26 doi: 10.1016/j.jcms.2018.07.014. PMID: 30100383
Celikoglu M, Buyuk SK, Sekerci AE, Ersoz M, Celik S, Sisman Y
Am J Orthod Dentofacial Orthop 2014 Nov;146(5):573-8. Epub 2014 Oct 28 doi: 10.1016/j.ajodo.2014.07.005. PMID: 25439207
Bartzela T, Katsaros C, Rønning E, Rizell S, Semb G, Bronkhorst E, Halazonetis D, Kuijpers-Jagtman AM
Clin Oral Investig 2012 Aug;16(4):1313-24. Epub 2011 Sep 24 doi: 10.1007/s00784-011-0615-y. PMID: 21947868Free PMC Article

Clinical prediction guides

Fowler PV, Keall H, Kennedy D, Healey D, Thompson JMD
Orthod Craniofac Res 2019 Aug;22(3):147-152. Epub 2019 Mar 3 doi: 10.1111/ocr.12300. PMID: 30742737
Bittermann GKP, de Ruiter AP, Bittermann AJ, Mink van de Molen AB, van Es RJ, Koole R, Rosenberg AJ
J Craniomaxillofac Surg 2018 Oct;46(10):1764-1771. Epub 2018 Jul 26 doi: 10.1016/j.jcms.2018.07.014. PMID: 30100383
Garib D, Lauris RC, Calil LR, Alves AC, Janson G, De Almeida AM, Cevidanes LH, Lauris JR
Am J Orthod Dentofacial Orthop 2016 Oct;150(4):564-574. doi: 10.1016/j.ajodo.2016.05.006. PMID: 27692413Free PMC Article
de Medeiros Alves AC, Garib DG, Janson G, de Almeida AM, Calil LR
Clin Oral Investig 2016 Sep;20(7):1837-47. Epub 2015 Dec 1 doi: 10.1007/s00784-015-1675-1. PMID: 26620733
Le Merrer M, Cikuli M, Ribier J, Briard ML
Am J Med Genet 1989 Jul;33(3):318-22. doi: 10.1002/ajmg.1320330307. PMID: 2801764

Recent systematic reviews

Cornefjord M, Arnebrant K, Guné H, Holst J, Klintö K, Stiernman M, Svensson H, Wiedel AP, Becker M
J Plast Surg Hand Surg 2023 Dec 14;58:132-141. doi: 10.2340/jphs.v58.13368. PMID: 38095226
Normande Neto HV, Oliveira-Neto OB, Ribeiro ILH, Andrade CS, Sales PHDH, Lima FJC
Cleft Palate Craniofac J 2023 Oct;60(10):1211-1219. Epub 2022 May 9 doi: 10.1177/10556656221096304. PMID: 35535395
Murugan C, Kailasam V
Cleft Palate Craniofac J 2023 Jan;60(1):39-54. Epub 2021 Nov 17 doi: 10.1177/10556656211053545. PMID: 34787478
Kuang W, Aarts M, Kuijpers-Jagtman AM, He H, Ongkosuwito EM
Cleft Palate Craniofac J 2022 Nov;59(11):1377-1390. Epub 2021 Oct 18 doi: 10.1177/10556656211041883. PMID: 34658258Free PMC Article
Thierens L, Brusselaers N, De Roo N, De Pauw G
Oral Dis 2017 Oct;23(7):889-896. Epub 2017 Jan 24 doi: 10.1111/odi.12613. PMID: 27878905

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...