U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

idiopathic short stature

MedGen UID:
853465
•Concept ID:
C1740819
•
Finding
Synonyms: Idiopathic Short Stature; Idiopathic short stature
SNOMED CT: Idiopathic short stature (133221000119100)

Definition

Height greater than two standard deviations below the mean for the age and sex of the reference population. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVidiopathic short stature

Professional guidelines

PubMed

Management of Growth Disorders in Puberty: GH, GnRHa, and Aromatase Inhibitors: A Clinical Review.
Mauras N, Ross J, Mericq V
Endocr Rev 2023 Jan 12;44(1):1-13. doi: 10.1210/endrev/bnac014. PMID: 35639981
Growth Hormone Treatment for Idiopathic Short Stature.
Cutfield WS, Albert BB
Pediatr Endocrinol Rev 2018 Sep;16(Suppl 1):113-122. doi: 10.17458/per.vol16.2018.ca.ghidiopathicshortstature. PMID: 30378789
Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency.
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013

Recent clinical studies

Etiology

Who to screen and how to screen for celiac disease.
Singh P, Singh AD, Ahuja V, Makharia GK
World J Gastroenterol 2022 Aug 28;28(32):4493-4507. doi: 10.3748/wjg.v28.i32.4493. PMID: 36157923Free PMC Article
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency.
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013
Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature.
Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V
J Clin Endocrinol Metab 2016 Dec;101(12):4984-4993. Epub 2016 Oct 6 doi: 10.1210/jc.2016-2891. PMID: 27710241Free PMC Article
Effects of Growth Hormone on Bone.
Tritos NA, Klibanski A
Prog Mol Biol Transl Sci 2016;138:193-211. Epub 2016 Jan 6 doi: 10.1016/bs.pmbts.2015.10.008. PMID: 26940392

Diagnosis

Who to screen and how to screen for celiac disease.
Singh P, Singh AD, Ahuja V, Makharia GK
World J Gastroenterol 2022 Aug 28;28(32):4493-4507. doi: 10.3748/wjg.v28.i32.4493. PMID: 36157923Free PMC Article
Clinical Indications for Growth Hormone Therapy.
Danowitz M, Grimberg A
Adv Pediatr 2022 Aug;69(1):203-217. Epub 2022 Jun 17 doi: 10.1016/j.yapd.2022.03.005. PMID: 35985710Free PMC Article
Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency.
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013
Evaluation of Short and Tall Stature in Children.
Barstow C, Rerucha C
Am Fam Physician 2015 Jul 1;92(1):43-50. PMID: 26132126
Etiologies and early diagnosis of short stature and growth failure in children and adolescents.
Rogol AD, Hayden GF
J Pediatr 2014 May;164(5 Suppl):S1-14.e6. doi: 10.1016/j.jpeds.2014.02.027. PMID: 24731744

Therapy

Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort.
Maghnie M, Ranke MB, Geffner ME, Vlachopapadopoulou E, Ibáñez L, Carlsson M, Cutfield W, Rooman R, Gomez R, Wajnrajch MP, Linglart A, Stawerska R, Clayton PE, Darendeliler F, Hokken-Koelega ACS, Horikawa R, Tanaka T, Dörr HG, Albertsson-Wikland K, Polak M, Grimberg A
J Clin Endocrinol Metab 2022 Nov 25;107(12):3287-3301. doi: 10.1210/clinem/dgac517. PMID: 36102184Free PMC Article
Clinical Indications for Growth Hormone Therapy.
Danowitz M, Grimberg A
Adv Pediatr 2022 Aug;69(1):203-217. Epub 2022 Jun 17 doi: 10.1016/j.yapd.2022.03.005. PMID: 35985710Free PMC Article
Should Skeletal Maturation Be Manipulated for Extra Height Gain?
Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
Growth hormone treatment for growth hormone deficiency and idiopathic short stature: new guidelines shaped by the presence and absence of evidence.
Grimberg A, Allen DB
Curr Opin Pediatr 2017 Aug;29(4):466-471. doi: 10.1097/MOP.0000000000000505. PMID: 28525404Free PMC Article
Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency.
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013

Prognosis

Should Skeletal Maturation Be Manipulated for Extra Height Gain?
Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
A Novel Diagnostic Predictive Model for Idiopathic Short Stature in Children.
Yuan J, Du Z, Wu Z, Yang Y, Cheng X, Liu X, Jia J
Front Endocrinol (Lausanne) 2021;12:721812. Epub 2021 Sep 17 doi: 10.3389/fendo.2021.721812. PMID: 34603204Free PMC Article
Growth response to growth hormone (GH) treatment in children with GH deficiency (GHD) and those with idiopathic short stature (ISS) based on their pretreatment insulin-like growth factor 1 (IGFI) levels and at diagnosis and IGFI increment on treatment.
Soliman A, Rogol AD, Elsiddig S, Khalil A, Alaaraj N, Alyafie F, Ahmed H, Elawwa A
J Pediatr Endocrinol Metab 2021 Oct 26;34(10):1263-1271. Epub 2021 Jul 22 doi: 10.1515/jpem-2021-0389. PMID: 34291621
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Growth Hormone Treatment for Idiopathic Short Stature.
Cutfield WS, Albert BB
Pediatr Endocrinol Rev 2018 Sep;16(Suppl 1):113-122. doi: 10.17458/per.vol16.2018.ca.ghidiopathicshortstature. PMID: 30378789

Clinical prediction guides

Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort.
Maghnie M, Ranke MB, Geffner ME, Vlachopapadopoulou E, Ibáñez L, Carlsson M, Cutfield W, Rooman R, Gomez R, Wajnrajch MP, Linglart A, Stawerska R, Clayton PE, Darendeliler F, Hokken-Koelega ACS, Horikawa R, Tanaka T, Dörr HG, Albertsson-Wikland K, Polak M, Grimberg A
J Clin Endocrinol Metab 2022 Nov 25;107(12):3287-3301. doi: 10.1210/clinem/dgac517. PMID: 36102184Free PMC Article
Should Skeletal Maturation Be Manipulated for Extra Height Gain?
Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
A Novel Diagnostic Predictive Model for Idiopathic Short Stature in Children.
Yuan J, Du Z, Wu Z, Yang Y, Cheng X, Liu X, Jia J
Front Endocrinol (Lausanne) 2021;12:721812. Epub 2021 Sep 17 doi: 10.3389/fendo.2021.721812. PMID: 34603204Free PMC Article
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Growth Hormone Treatment for Idiopathic Short Stature.
Cutfield WS, Albert BB
Pediatr Endocrinol Rev 2018 Sep;16(Suppl 1):113-122. doi: 10.17458/per.vol16.2018.ca.ghidiopathicshortstature. PMID: 30378789

Recent systematic reviews

Treatment of Short Stature with Aromatase Inhibitors: A Systematic Review and Meta-Analysis.
Liu J, Yin S, Luo Y, Bai X, Chen S, Yang H, Zhu H, Pan H, Ma H
Horm Metab Res 2021 Jun;53(6):391-401. Epub 2021 Jun 21 doi: 10.1055/a-1492-2841. PMID: 34154030
Impact of short stature on quality of life: A systematic literature review.
Backeljauw P, Cappa M, Kiess W, Law L, Cookson C, Sert C, Whalen J, Dattani MT
Growth Horm IGF Res 2021 Apr-Jun;57-58:101392. Epub 2021 Apr 30 doi: 10.1016/j.ghir.2021.101392. PMID: 33975197
Aromatase inhibitors for short stature in male children and adolescents.
McGrath N, O'Grady MJ
Cochrane Database Syst Rev 2015 Oct 8;2015(10):CD010888. doi: 10.1002/14651858.CD010888.pub2. PMID: 26447646Free PMC Article
Recombinant growth hormone for idiopathic short stature in children and adolescents.
Bryant J, Baxter L, Cave CB, Milne R
Cochrane Database Syst Rev 2007 Jul 18;(3):CD004440. doi: 10.1002/14651858.CD004440.pub2. PMID: 17636758
Recombinant growth hormone for idiopathic short stature in children and adolescents.
Bryant J, Cave C, Milne R
Cochrane Database Syst Rev 2003;(4):CD004440. doi: 10.1002/14651858.CD004440. PMID: 14584015

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...