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idiopathic short stature

MedGen UID:
853465
Concept ID:
C1740819
Finding
Synonyms: Idiopathic Short Stature; Idiopathic short stature
SNOMED CT: Idiopathic short stature (133221000119100)

Definition

Height greater than two standard deviations below the mean for the age and sex of the reference population. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVidiopathic short stature

Professional guidelines

PubMed

Mauras N, Ross J, Mericq V
Endocr Rev 2023 Jan 12;44(1):1-13. doi: 10.1210/endrev/bnac014. PMID: 35639981
Grimberg A, Allen DB
Curr Opin Pediatr 2017 Aug;29(4):466-471. doi: 10.1097/MOP.0000000000000505. PMID: 28525404Free PMC Article
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013

Recent clinical studies

Etiology

Hong H, Pan X, Song J, Fang N, Yang R, Xiang L, Wang X, Huang C
Bone Joint J 2023 Mar 15;105-B(4):439-448. doi: 10.1302/0301-620X.105B4.BJJ-2022-0898.R1. PMID: 36924176
Singh P, Singh AD, Ahuja V, Makharia GK
World J Gastroenterol 2022 Aug 28;28(32):4493-4507. doi: 10.3748/wjg.v28.i32.4493. PMID: 36157923Free PMC Article
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013
Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V
J Clin Endocrinol Metab 2016 Dec;101(12):4984-4993. Epub 2016 Oct 6 doi: 10.1210/jc.2016-2891. PMID: 27710241Free PMC Article

Diagnosis

Singh P, Singh AD, Ahuja V, Makharia GK
World J Gastroenterol 2022 Aug 28;28(32):4493-4507. doi: 10.3748/wjg.v28.i32.4493. PMID: 36157923Free PMC Article
Danowitz M, Grimberg A
Adv Pediatr 2022 Aug;69(1):203-217. Epub 2022 Jun 17 doi: 10.1016/j.yapd.2022.03.005. PMID: 35985710Free PMC Article
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013
Rogol AD, Hayden GF
J Pediatr 2014 May;164(5 Suppl):S1-14.e6. doi: 10.1016/j.jpeds.2014.02.027. PMID: 24731744
Pasquino AM, Albanese A, Bozzola M, Butler GE, Buzi F, Cherubini V, Chiarelli F, Cavallo L, Drop SL, Stanhope R, Kelnar CJ; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:967-74. doi: 10.1515/jpem-2001-s209. PMID: 11529403

Therapy

Mauras N, Ross J, Mericq V
Endocr Rev 2023 Jan 12;44(1):1-13. doi: 10.1210/endrev/bnac014. PMID: 35639981
Maghnie M, Ranke MB, Geffner ME, Vlachopapadopoulou E, Ibáñez L, Carlsson M, Cutfield W, Rooman R, Gomez R, Wajnrajch MP, Linglart A, Stawerska R, Clayton PE, Darendeliler F, Hokken-Koelega ACS, Horikawa R, Tanaka T, Dörr HG, Albertsson-Wikland K, Polak M, Grimberg A
J Clin Endocrinol Metab 2022 Nov 25;107(12):3287-3301. doi: 10.1210/clinem/dgac517. PMID: 36102184Free PMC Article
Danowitz M, Grimberg A
Adv Pediatr 2022 Aug;69(1):203-217. Epub 2022 Jun 17 doi: 10.1016/j.yapd.2022.03.005. PMID: 35985710Free PMC Article
Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013

Prognosis

Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Cutfield WS, Albert BB
Pediatr Endocrinol Rev 2018 Sep;16(Suppl 1):113-122. doi: 10.17458/per.vol16.2018.ca.ghidiopathicshortstature. PMID: 30378789
McGrath N, O'Grady MJ
Cochrane Database Syst Rev 2015 Oct 8;2015(10):CD010888. doi: 10.1002/14651858.CD010888.pub2. PMID: 26447646Free PMC Article
Pasquino AM, Albanese A, Bozzola M, Butler GE, Buzi F, Cherubini V, Chiarelli F, Cavallo L, Drop SL, Stanhope R, Kelnar CJ; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:967-74. doi: 10.1515/jpem-2001-s209. PMID: 11529403

Clinical prediction guides

Maghnie M, Ranke MB, Geffner ME, Vlachopapadopoulou E, Ibáñez L, Carlsson M, Cutfield W, Rooman R, Gomez R, Wajnrajch MP, Linglart A, Stawerska R, Clayton PE, Darendeliler F, Hokken-Koelega ACS, Horikawa R, Tanaka T, Dörr HG, Albertsson-Wikland K, Polak M, Grimberg A
J Clin Endocrinol Metab 2022 Nov 25;107(12):3287-3301. doi: 10.1210/clinem/dgac517. PMID: 36102184Free PMC Article
Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V
J Clin Endocrinol Metab 2016 Dec;101(12):4984-4993. Epub 2016 Oct 6 doi: 10.1210/jc.2016-2891. PMID: 27710241Free PMC Article
Pasquino AM, Albanese A, Bozzola M, Butler GE, Buzi F, Cherubini V, Chiarelli F, Cavallo L, Drop SL, Stanhope R, Kelnar CJ; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:967-74. doi: 10.1515/jpem-2001-s209. PMID: 11529403

Recent systematic reviews

Li Y, Chen X, Liu Z, Yang J
PLoS One 2022;17(6):e0270511. Epub 2022 Jun 24 doi: 10.1371/journal.pone.0270511. PMID: 35749540Free PMC Article
Liu J, Yin S, Luo Y, Bai X, Chen S, Yang H, Zhu H, Pan H, Ma H
Horm Metab Res 2021 Jun;53(6):391-401. Epub 2021 Jun 21 doi: 10.1055/a-1492-2841. PMID: 34154030
Backeljauw P, Cappa M, Kiess W, Law L, Cookson C, Sert C, Whalen J, Dattani MT
Growth Horm IGF Res 2021 Apr-Jun;57-58:101392. Epub 2021 Apr 30 doi: 10.1016/j.ghir.2021.101392. PMID: 33975197
McGrath N, O'Grady MJ
Cochrane Database Syst Rev 2015 Oct 8;2015(10):CD010888. doi: 10.1002/14651858.CD010888.pub2. PMID: 26447646Free PMC Article
Bryant J, Baxter L, Cave CB, Milne R
Cochrane Database Syst Rev 2007 Jul 18;(3):CD004440. doi: 10.1002/14651858.CD004440.pub2. PMID: 17636758

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