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Central Nervous System Hodgkin Lymphoma

MedGen UID:
853574
•Concept ID:
C2046622
•
Neoplastic Process

Definition

A Hodgkin lymphoma that arises from the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Hodgkin Lymphoma

Professional guidelines

PubMed

Central Nervous System Lymphoma: Approach to Diagnosis and Treatment.
Correia CE, Schaff LR, Grommes C
Cancer J 2020 May/Jun;26(3):241-252. doi: 10.1097/PPO.0000000000000449. PMID: 32496457

Recent clinical studies

Etiology

Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Primary Central Nervous System Lymphomas.
Chukwueke U, Grommes C, Nayak L
Hematol Oncol Clin North Am 2022 Feb;36(1):147-159. doi: 10.1016/j.hoc.2021.09.004. PMID: 34801161
Histiocytic Sarcoma.
Tocut M, Vaknine H, Potachenko P, Elias S, Zandman-Goddard G
Isr Med Assoc J 2020 Oct;22(10):645-647. PMID: 33070490
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854

Diagnosis

Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.
Chen T, Liu Y, Wang Y, Chang Q, Wu J, Wang Z, Geng D, Yu JT, Li Y, Li XQ, Chen H, Zhuang D, Li J, Wang B, Jiang T, Lyu L, Song Y, Qiu X, Li W, Lin S, Zhang X, Lu D, Lei J, Chen Y, Mao Y
J Hematol Oncol 2022 Sep 29;15(1):136. doi: 10.1186/s13045-022-01356-7. PMID: 36176002Free PMC Article
Histiocytic Sarcoma.
Tocut M, Vaknine H, Potachenko P, Elias S, Zandman-Goddard G
Isr Med Assoc J 2020 Oct;22(10):645-647. PMID: 33070490
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854
Primary CNS Lymphoma.
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article

Therapy

Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.
Chen T, Liu Y, Wang Y, Chang Q, Wu J, Wang Z, Geng D, Yu JT, Li Y, Li XQ, Chen H, Zhuang D, Li J, Wang B, Jiang T, Lyu L, Song Y, Qiu X, Li W, Lin S, Zhang X, Lu D, Lei J, Chen Y, Mao Y
J Hematol Oncol 2022 Sep 29;15(1):136. doi: 10.1186/s13045-022-01356-7. PMID: 36176002Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854
Primary CNS Lymphoma.
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article

Prognosis

The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Histiocytic Sarcoma.
Tocut M, Vaknine H, Potachenko P, Elias S, Zandman-Goddard G
Isr Med Assoc J 2020 Oct;22(10):645-647. PMID: 33070490
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):296-305. doi: 10.1093/neuonc/noy192. PMID: 30418592Free PMC Article
Primary CNS Lymphoma.
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article

Clinical prediction guides

STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.
Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M
Pathol Res Pract 2021 Jul;223:153477. Epub 2021 May 11 doi: 10.1016/j.prp.2021.153477. PMID: 33991851
Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.
Scordo M, Wang TP, Ahn KW, Chen Y, Ahmed S, Awan FT, Beitinjaneh A, Chen A, Chow VA, Dholaria B, Epperla N, Farooq U, Ghosh N, Grover N, Hamad N, Hildebrandt GC, Holmberg L, Hong S, Inwards DJ, Jimenez-Jimenez A, Karmali R, Kenkre VP, Khimani F, Klyuchnikov E, Krem MM, Munshi PN, Nieto Y, Prestidge T, Ramakrishnan Geethakumari P, Rezvani AR, Riedell PA, Seo S, Shah NN, Solh M, Yared JA, Kharfan-Dabaja MA, Herrera A, Hamadani M, Sauter CS
JAMA Oncol 2021 Jul 1;7(7):993-1003. doi: 10.1001/jamaoncol.2021.1074. PMID: 33956047Free PMC Article
Hepatitis C virus-related cryoglobulinemic vasculitis.
Mazzaro C, Mauro E, Ermacora A, Doretto P, Fumagalli S, Tonizzo M, Toffolutti F, Gattei V
Minerva Med 2021 Apr;112(2):175-187. Epub 2020 Nov 16 doi: 10.23736/S0026-4806.20.07120-7. PMID: 33198444
Central Nervous System Lymphomas.
Grommes C
Continuum (Minneap Minn) 2020 Dec;26(6):1476-1494. doi: 10.1212/CON.0000000000000936. PMID: 33273169
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854

Recent systematic reviews

Rituximab in primary central nervous system lymphoma-A systematic review and meta-analysis.
Schmitt AM, Herbrand AK, Fox CP, Bakunina K, Bromberg JEC, Cwynarski K, Doorduijn JK, Ferreri AJM, Illerhaus G, Issa S, Schorb E, Zucca E, Hemkens LG, Schandelmaier S, Kasenda B
Hematol Oncol 2019 Dec;37(5):548-557. Epub 2019 Oct 9 doi: 10.1002/hon.2666. PMID: 31418878
Autologous Stem-Cell Transplantation for Primary Central Nervous System Lymphoma: Systematic Review and Meta-analysis.
Alnahhas I, Jawish M, Alsawas M, Zukas A, Prokop L, Murad MH, Malkin M
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e129-e141. Epub 2018 Nov 24 doi: 10.1016/j.clml.2018.11.018. PMID: 30584023
Novel agents for primary central nervous system lymphoma: evidence and perspectives.
Illerhaus G, Schorb E, Kasenda B
Blood 2018 Aug 16;132(7):681-688. Epub 2018 Jul 9 doi: 10.1182/blood-2018-01-791558. PMID: 29986908
Challenges and opportunities in primary CNS lymphoma: A systematic review.
Kerbauy MN, Moraes FY, Lok BH, Ma J, Kerbauy LN, Spratt DE, Santos FP, Perini GF, Berlin A, Chung C, Hamerschlak N, Yahalom J
Radiother Oncol 2017 Mar;122(3):352-361. Epub 2017 Jan 16 doi: 10.1016/j.radonc.2016.12.033. PMID: 28104300
Role of chemotherapy additional to high-dose methotrexate for primary central nervous system lymphoma (PCNSL).
Bergner N, Monsef I, Illerhaus G, Engert A, Skoetz N
Cochrane Database Syst Rev 2012 Nov 14;11:CD009355. doi: 10.1002/14651858.CD009355.pub2. PMID: 23152274

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