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Idiopathic Precocious Puberty

MedGen UID:
853627
•Concept ID:
C2113596
•
Disease or Syndrome

Definition

Precocious puberty for which no underlying cause can be identified. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic Precocious Puberty

Professional guidelines

PubMed

Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty.
Feuillan PP, Jones JV, Barnes K, Oerter-Klein K, Cutler GB Jr
J Clin Endocrinol Metab 1999 Jan;84(1):44-9. doi: 10.1210/jcem.84.1.5409. PMID: 9920060
Treatment of idiopathic precocious puberty.
MacGillivray MH
N Engl J Med 1982 May 6;306(18):1109-10. doi: 10.1056/NEJM198205063061814. PMID: 7040953
Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone. A preliminary report.
Comite F, Cutler GB Jr, Rivier J, Vale WW, Loriaux DL, Crowley WF Jr
N Engl J Med 1981 Dec 24;305(26):1546-50. doi: 10.1056/NEJM198112243052602. PMID: 6458765

Recent clinical studies

Etiology

Gonadotropin releasing hormone analogue therapy in girls with idiopathic precocious puberty/early-fast puberty: dynamics in adiposity indices, eating habits and quality of life.
Loochi SA, Demol S, Nagelberg N, Lebenthal Y, Phillip M, Yackobovitch-Gavan M
J Pediatr Endocrinol Metab 2021 Mar 26;34(3):373-383. Epub 2021 Feb 22 doi: 10.1515/jpem-2020-0471. PMID: 33609438
Urinary zearalenone levels in girls with premature thelarche and idiopathic central precocious puberty.
Asci A, Durmaz E, Erkekoglu P, Pasli D, Bircan I, Kocer-Gumusel B
Minerva Pediatr 2014 Dec;66(6):571-8. PMID: 25336100
Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty.
Feuillan PP, Jones JV, Barnes K, Oerter-Klein K, Cutler GB Jr
J Clin Endocrinol Metab 1999 Jan;84(1):44-9. doi: 10.1210/jcem.84.1.5409. PMID: 9920060
Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone. A preliminary report.
Comite F, Cutler GB Jr, Rivier J, Vale WW, Loriaux DL, Crowley WF Jr
N Engl J Med 1981 Dec 24;305(26):1546-50. doi: 10.1056/NEJM198112243052602. PMID: 6458765

Diagnosis

Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Optimal therapy of pubertal disorders in precocious/early puberty.
Tatò L, Savage MO, Antoniazzi F, Buzi F, Di Maio S, Oostdijk W, Pasquino AM, Raiola G, Saenger P, Tonini G, Voorhoeve PG; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:985-95. doi: 10.1515/jpem-2001-s211. PMID: 11529405
Gonadotrophin and prolactin secretory dynamics in girls with normal puberty, idiopathic precocious puberty and precocious puberty due to hypothalamic hamartoma.
Uriarte MM, Klein KO, Barnes KM, Pescovitz OH, Loriaux DL, Cutler GB Jr
Clin Endocrinol (Oxf) 1998 Sep;49(3):363-8. doi: 10.1046/j.1365-2265.1998.00518.x. PMID: 9861328
Puberty and its disorders in boys.
Styne DM
Endocrinol Metab Clin North Am 1991 Mar;20(1):43-69. PMID: 2029888
Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone. A preliminary report.
Comite F, Cutler GB Jr, Rivier J, Vale WW, Loriaux DL, Crowley WF Jr
N Engl J Med 1981 Dec 24;305(26):1546-50. doi: 10.1056/NEJM198112243052602. PMID: 6458765

Therapy

Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Optimal therapy of pubertal disorders in precocious/early puberty.
Tatò L, Savage MO, Antoniazzi F, Buzi F, Di Maio S, Oostdijk W, Pasquino AM, Raiola G, Saenger P, Tonini G, Voorhoeve PG; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:985-95. doi: 10.1515/jpem-2001-s211. PMID: 11529405
Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty.
Feuillan PP, Jones JV, Barnes K, Oerter-Klein K, Cutler GB Jr
J Clin Endocrinol Metab 1999 Jan;84(1):44-9. doi: 10.1210/jcem.84.1.5409. PMID: 9920060
Superactive gonadotropin-releasing hormone agonists.
Swerdloff RS, Heber D
Annu Rev Med 1983;34:491-500. doi: 10.1146/annurev.me.34.020183.002423. PMID: 6344774
Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone. A preliminary report.
Comite F, Cutler GB Jr, Rivier J, Vale WW, Loriaux DL, Crowley WF Jr
N Engl J Med 1981 Dec 24;305(26):1546-50. doi: 10.1056/NEJM198112243052602. PMID: 6458765

Prognosis

Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Do all girls with apparent idiopathic precocious puberty require gonadotropin-releasing hormone agonist treatment?
Léger J, Reynaud R, Czernichow P
J Pediatr 2000 Dec;137(6):819-25. doi: 10.1067/mpd.2000.109201. PMID: 11113839
Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty.
Feuillan PP, Jones JV, Barnes K, Oerter-Klein K, Cutler GB Jr
J Clin Endocrinol Metab 1999 Jan;84(1):44-9. doi: 10.1210/jcem.84.1.5409. PMID: 9920060
Idiopathic precocious puberty in girls: long-term effects on adolescent behavior.
Ehrhardt AA, Meyer-Bahlburg HF
Acta Endocrinol Suppl (Copenh) 1986;279:247-53. doi: 10.1530/acta.0.112s247. PMID: 3465165
Height predictions in girls with idiopathic precocious puberty by the Bayley-Pinneau method.
Kirkland JL, Gibbs AR, Kirkland RT, Clayton GW
Pediatrics 1981 Aug;68(2):251-2. PMID: 7267233

Clinical prediction guides

Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Clinical review: Constitutional advancement of growth, a.k.a. early growth acceleration, predicts early puberty and childhood obesity.
Papadimitriou A, Nicolaidou P, Fretzayas A, Chrousos GP
J Clin Endocrinol Metab 2010 Oct;95(10):4535-41. Epub 2010 Jul 7 doi: 10.1210/jc.2010-0895. PMID: 20610589
Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty.
Feuillan PP, Jones JV, Barnes K, Oerter-Klein K, Cutler GB Jr
J Clin Endocrinol Metab 1999 Jan;84(1):44-9. doi: 10.1210/jcem.84.1.5409. PMID: 9920060
Height predictions in girls with idiopathic precocious puberty by the Bayley-Pinneau method.
Kirkland JL, Gibbs AR, Kirkland RT, Clayton GW
Pediatrics 1981 Aug;68(2):251-2. PMID: 7267233
Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone. A preliminary report.
Comite F, Cutler GB Jr, Rivier J, Vale WW, Loriaux DL, Crowley WF Jr
N Engl J Med 1981 Dec 24;305(26):1546-50. doi: 10.1056/NEJM198112243052602. PMID: 6458765

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