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Idiopathic Precocious Puberty

MedGen UID:
853627
•Concept ID:
C2113596
•
Disease or Syndrome

Definition

Precocious puberty for which no underlying cause can be identified. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic Precocious Puberty

Professional guidelines

PubMed

Treatment with Depot Leuprolide Acetate in Girls with Idiopathic Precocious Puberty: What Parameter should be Used in Deciding on the Initial Dose?
Vurallı D, Alikaşifoğlu A, İyigün İ, Canoruç D, Ozon A, Gönç N, Kandemir N
J Clin Res Pediatr Endocrinol 2020 Mar 19;12(1):37-44. Epub 2019 Jul 26 doi: 10.4274/jcrpe.galenos.2019.2019.0060. PMID: 31347350Free PMC Article
The Influence of Gonadotropin-Releasing Hormone Agonist Treatment on Thyroid Function Tests in Children with Central Idiopathic Precocious Puberty.
Naderi F, Soheilirad Z, Haghshenas Z
Med Arch 2019 Apr;73(2):101-103. doi: 10.5455/medarh.2019.73.101-103. PMID: 31391696Free PMC Article
Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone. A preliminary report.
Comite F, Cutler GB Jr, Rivier J, Vale WW, Loriaux DL, Crowley WF Jr
N Engl J Med 1981 Dec 24;305(26):1546-50. doi: 10.1056/NEJM198112243052602. PMID: 6458765

Recent clinical studies

Etiology

Gonadotropin releasing hormone analogue therapy in girls with idiopathic precocious puberty/early-fast puberty: dynamics in adiposity indices, eating habits and quality of life.
Loochi SA, Demol S, Nagelberg N, Lebenthal Y, Phillip M, Yackobovitch-Gavan M
J Pediatr Endocrinol Metab 2021 Mar 26;34(3):373-383. Epub 2021 Feb 22 doi: 10.1515/jpem-2020-0471. PMID: 33609438
Urinary zearalenone levels in girls with premature thelarche and idiopathic central precocious puberty.
Asci A, Durmaz E, Erkekoglu P, Pasli D, Bircan I, Kocer-Gumusel B
Minerva Pediatr 2014 Dec;66(6):571-8. PMID: 25336100
Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Treated and untreated women with idiopathic precocious puberty: long-term follow-up and reproductive outcome between the third and fifth decades.
Lazar L, Meyerovitch J, de Vries L, Phillip M, Lebenthal Y
Clin Endocrinol (Oxf) 2014 Apr;80(4):570-6. Epub 2013 Sep 18 doi: 10.1111/cen.12319. PMID: 24033561
Idiopathic precocious puberty versus puberty in adopted children; auxological response to gonadotrophin-releasing hormone agonist treatment and final height.
Kempers MJ, Otten BJ
Eur J Endocrinol 2002 Nov;147(5):609-16. doi: 10.1530/eje.0.1470609. PMID: 12444892

Diagnosis

Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Effects of growth environments and two environmental endocrine disruptors on children with idiopathic precocious puberty.
Deng F, Tao FB, Liu DY, Xu YY, Hao JH, Sun Y, Su PY
Eur J Endocrinol 2012 May;166(5):803-9. Epub 2012 Feb 8 doi: 10.1530/EJE-11-0876. PMID: 22318748
Optimal therapy of pubertal disorders in precocious/early puberty.
Tatò L, Savage MO, Antoniazzi F, Buzi F, Di Maio S, Oostdijk W, Pasquino AM, Raiola G, Saenger P, Tonini G, Voorhoeve PG; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:985-95. doi: 10.1515/jpem-2001-s211. PMID: 11529405
Psychosis and idiopathic precocious puberty in two 7-year-old boys.
Rosenberg DR, Crowner S, Thomas C, Gourash L
Child Psychiatry Hum Dev 1992 Summer;22(4):287-92. doi: 10.1007/BF00707670. PMID: 1382007
Puberty and its disorders in boys.
Styne DM
Endocrinol Metab Clin North Am 1991 Mar;20(1):43-69. PMID: 2029888

Therapy

Gonadotropin releasing hormone analogue therapy in girls with idiopathic precocious puberty/early-fast puberty: dynamics in adiposity indices, eating habits and quality of life.
Loochi SA, Demol S, Nagelberg N, Lebenthal Y, Phillip M, Yackobovitch-Gavan M
J Pediatr Endocrinol Metab 2021 Mar 26;34(3):373-383. Epub 2021 Feb 22 doi: 10.1515/jpem-2020-0471. PMID: 33609438
Urinary zearalenone levels in girls with premature thelarche and idiopathic central precocious puberty.
Asci A, Durmaz E, Erkekoglu P, Pasli D, Bircan I, Kocer-Gumusel B
Minerva Pediatr 2014 Dec;66(6):571-8. PMID: 25336100
Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Optimal therapy of pubertal disorders in precocious/early puberty.
Tatò L, Savage MO, Antoniazzi F, Buzi F, Di Maio S, Oostdijk W, Pasquino AM, Raiola G, Saenger P, Tonini G, Voorhoeve PG; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:985-95. doi: 10.1515/jpem-2001-s211. PMID: 11529405
Superactive gonadotropin-releasing hormone agonists.
Swerdloff RS, Heber D
Annu Rev Med 1983;34:491-500. doi: 10.1146/annurev.me.34.020183.002423. PMID: 6344774

Prognosis

Treated and untreated women with idiopathic precocious puberty: BMI evolution, metabolic outcome, and general health between third and fifth decades.
Lazar L, Lebenthal Y, Yackobovitch-Gavan M, Shalitin S, de Vries L, Phillip M, Meyerovitch J
J Clin Endocrinol Metab 2015 Apr;100(4):1445-51. Epub 2015 Feb 4 doi: 10.1210/jc.2014-3748. PMID: 25650898
Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Treated and untreated women with idiopathic precocious puberty: long-term follow-up and reproductive outcome between the third and fifth decades.
Lazar L, Meyerovitch J, de Vries L, Phillip M, Lebenthal Y
Clin Endocrinol (Oxf) 2014 Apr;80(4):570-6. Epub 2013 Sep 18 doi: 10.1111/cen.12319. PMID: 24033561
Idiopathic precocious puberty versus puberty in adopted children; auxological response to gonadotrophin-releasing hormone agonist treatment and final height.
Kempers MJ, Otten BJ
Eur J Endocrinol 2002 Nov;147(5):609-16. doi: 10.1530/eje.0.1470609. PMID: 12444892
Monthly urinary gonadotropin and ovarian hormone excretory patterns in normal girls and female patients with idiopathic precocious puberty.
Maesaka H, Tachibana K, Adachi M, Okada T
Pediatr Res 1996 Dec;40(6):853-60. doi: 10.1203/00006450-199612000-00013. PMID: 8947962

Clinical prediction guides

Gonadotropin releasing hormone analogue therapy in girls with idiopathic precocious puberty/early-fast puberty: dynamics in adiposity indices, eating habits and quality of life.
Loochi SA, Demol S, Nagelberg N, Lebenthal Y, Phillip M, Yackobovitch-Gavan M
J Pediatr Endocrinol Metab 2021 Mar 26;34(3):373-383. Epub 2021 Feb 22 doi: 10.1515/jpem-2020-0471. PMID: 33609438
Urinary zearalenone levels in girls with premature thelarche and idiopathic central precocious puberty.
Asci A, Durmaz E, Erkekoglu P, Pasli D, Bircan I, Kocer-Gumusel B
Minerva Pediatr 2014 Dec;66(6):571-8. PMID: 25336100
Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Clinical review: Constitutional advancement of growth, a.k.a. early growth acceleration, predicts early puberty and childhood obesity.
Papadimitriou A, Nicolaidou P, Fretzayas A, Chrousos GP
J Clin Endocrinol Metab 2010 Oct;95(10):4535-41. Epub 2010 Jul 7 doi: 10.1210/jc.2010-0895. PMID: 20610589
Idiopathic precocious puberty versus puberty in adopted children; auxological response to gonadotrophin-releasing hormone agonist treatment and final height.
Kempers MJ, Otten BJ
Eur J Endocrinol 2002 Nov;147(5):609-16. doi: 10.1530/eje.0.1470609. PMID: 12444892

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