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placentomegaly

MedGen UID:
853762
•Concept ID:
C2363734
•
Disease or Syndrome
Synonyms: Placental Hypertrophy; Placentomegaly

Definition

Aberrant growth of the placenta. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVplacentomegaly

Professional guidelines

PubMed

Placental mesenchymal dysplasia - morphology and differential diagnosis.
Daumová M, Hadravská Š, Peteříková AS, Hasch M, Martínek P
Cesk Patol 2021 Winter;57(4):203-207. PMID: 35042352
Prenatal molecular testing and diagnosis of Beckwith-Wiedemann syndrome.
Baker SW, Ryan E, Kalish JM, Ganguly A
Prenat Diagn 2021 Jun;41(7):817-822. Epub 2021 May 18 doi: 10.1002/pd.5953. PMID: 33974722
Prenatal diagnosis of congenital rubella infection and ultrasonography: a preliminary study.
Migliucci A, Di Fraja D, Sarno L, Acampora E, Mazzarelli LL, Quaglia F, Mallia Milanes G, Buffolano W, Napolitano R, Simioli S, Maruotti GM, Martinelli P
Minerva Ginecol 2011 Dec;63(6):485-9. PMID: 22036752

Recent clinical studies

Etiology

Mirror syndrome: a systematic literature review.
Biswas S, Gomez J, Horgan R, Sibai BM, Saad A, Powel JE, Al-Kouatly HB
Am J Obstet Gynecol MFM 2023 Sep;5(9):101067. Epub 2023 Jun 28 doi: 10.1016/j.ajogmf.2023.101067. PMID: 37385374
Fetal factors disrupt placental and maternal iron homeostasis in murine β-thalassemia.
Yu Y, Woloshun RR, Lee JK, Ebea PO, Zhu S, Nemeth E, Garrick LM, Garrick MD, Collins JF
Blood 2023 Jul 13;142(2):185-196. doi: 10.1182/blood.2022018839. PMID: 37146247Free PMC Article
Thick Placenta in Pregnancy: A Review.
Strebeck R, Jensen B, Magann EF
Obstet Gynecol Surv 2022 Sep;77(9):547-557. doi: 10.1097/OGX.0000000000001051. PMID: 36136077
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter?
Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM
J Ultrasound Med 2018 May;37(5):1185-1191. Epub 2017 Oct 27 doi: 10.1002/jum.14462. PMID: 29076544Free PMC Article
Syphilis during pregnancy: a preventable threat to maternal-fetal health.
Rac MW, Revell PA, Eppes CS
Am J Obstet Gynecol 2017 Apr;216(4):352-363. Epub 2016 Dec 9 doi: 10.1016/j.ajog.2016.11.1052. PMID: 27956203

Diagnosis

Mirror syndrome: a systematic literature review.
Biswas S, Gomez J, Horgan R, Sibai BM, Saad A, Powel JE, Al-Kouatly HB
Am J Obstet Gynecol MFM 2023 Sep;5(9):101067. Epub 2023 Jun 28 doi: 10.1016/j.ajogmf.2023.101067. PMID: 37385374
Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart's Disease.
Chaemsaithong P, Luewan S, Taweevisit M, Chiangjong W, Pongchaikul P, Thorner PS, Tongsong T, Chutipongtanate S
Int J Mol Sci 2023 Mar 16;24(6) doi: 10.3390/ijms24065658. PMID: 36982732Free PMC Article
Syphilis during pregnancy: a preventable threat to maternal-fetal health.
Rac MW, Revell PA, Eppes CS
Am J Obstet Gynecol 2017 Apr;216(4):352-363. Epub 2016 Dec 9 doi: 10.1016/j.ajog.2016.11.1052. PMID: 27956203
Placental mesenchymal dysplasia.
Pawoo N, Heller DS
Arch Pathol Lab Med 2014 Sep;138(9):1247-9. doi: 10.5858/arpa.2013-0399-RS. PMID: 25171710
Placental mesenchymal dysplasia.
Parveen Z, Tongson-Ignacio JE, Fraser CR, Killeen JL, Thompson KS
Arch Pathol Lab Med 2007 Jan;131(1):131-7. doi: 10.5858/2007-131-131-PMD. PMID: 17227114

Therapy

Syphilis during pregnancy: a preventable threat to maternal-fetal health.
Rac MW, Revell PA, Eppes CS
Am J Obstet Gynecol 2017 Apr;216(4):352-363. Epub 2016 Dec 9 doi: 10.1016/j.ajog.2016.11.1052. PMID: 27956203
Progression of ultrasound findings of fetal syphilis after maternal treatment.
Rac MW, Bryant SN, McIntire DD, Cantey JB, Twickler DM, Wendel GD Jr, Sheffield JS
Am J Obstet Gynecol 2014 Oct;211(4):426.e1-6. Epub 2014 Jun 4 doi: 10.1016/j.ajog.2014.05.049. PMID: 24907700
Hyperimmunoglobulin for prevention of congenital cytomegalovirus disease.
Nigro G, Adler SP
Clin Infect Dis 2013 Dec;57 Suppl 4:S193-5. doi: 10.1093/cid/cit586. PMID: 24257426
Syndromes and disorders associated with omphalocele (I): Beckwith-Wiedemann syndrome.
Chen CP
Taiwan J Obstet Gynecol 2007 Jun;46(2):96-102. doi: 10.1016/S1028-4559(07)60002-3. PMID: 17638616
Open fetal surgery for life-threatening fetal malformations.
Kitano Y, Flake AW, Crombleholme TM, Johnson MP, Adzick NS
Semin Perinatol 1999 Dec;23(6):448-61. doi: 10.1016/s0146-0005(99)80024-x. PMID: 10630541

Prognosis

Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart's Disease.
Chaemsaithong P, Luewan S, Taweevisit M, Chiangjong W, Pongchaikul P, Thorner PS, Tongsong T, Chutipongtanate S
Int J Mol Sci 2023 Mar 16;24(6) doi: 10.3390/ijms24065658. PMID: 36982732Free PMC Article
Insights into the role of placenta thickness as a predictive marker of perinatal outcome.
Sun X, Shen J, Wang L
J Int Med Res 2021 Feb;49(2):300060521990969. doi: 10.1177/0300060521990969. PMID: 33583234Free PMC Article
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter?
Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM
J Ultrasound Med 2018 May;37(5):1185-1191. Epub 2017 Oct 27 doi: 10.1002/jum.14462. PMID: 29076544Free PMC Article
Predictors of poor prognosis in prenatally diagnosed sacrococcygeal teratoma: A multiinstitutional review.
Akinkuotu AC, Coleman A, Shue E, Sheikh F, Hirose S, Lim FY, Olutoye OO
J Pediatr Surg 2015 May;50(5):771-4. Epub 2015 Feb 20 doi: 10.1016/j.jpedsurg.2015.02.034. PMID: 25783370
Before the horse is out of the barn: fetal surgery for hydrops.
Bullard KM, Harrison MR
Semin Perinatol 1995 Dec;19(6):462-73. doi: 10.1016/s0146-0005(05)80053-9. PMID: 8822330

Clinical prediction guides

Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart's Disease.
Chaemsaithong P, Luewan S, Taweevisit M, Chiangjong W, Pongchaikul P, Thorner PS, Tongsong T, Chutipongtanate S
Int J Mol Sci 2023 Mar 16;24(6) doi: 10.3390/ijms24065658. PMID: 36982732Free PMC Article
Insights into the role of placenta thickness as a predictive marker of perinatal outcome.
Sun X, Shen J, Wang L
J Int Med Res 2021 Feb;49(2):300060521990969. doi: 10.1177/0300060521990969. PMID: 33583234Free PMC Article
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter?
Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM
J Ultrasound Med 2018 May;37(5):1185-1191. Epub 2017 Oct 27 doi: 10.1002/jum.14462. PMID: 29076544Free PMC Article
Placentomegaly and placental mesenchymal dysplasia.
Rohilla M, Siwatch S, Jain V, Nijhawan R
BMJ Case Rep 2012 Dec 23;2012 doi: 10.1136/bcr-2012-007777. PMID: 23266781Free PMC Article
Fetal sacrococcygeal teratoma.
Graf JL, Albanese CT
World J Surg 2003 Jan;27(1):84-6. doi: 10.1007/s00268-002-6741-6. PMID: 12557042

Recent systematic reviews

Prognostic accuracy of factors associated with poor outcome in prenatally diagnosed sacrococcygeal teratoma: A systematic review and meta-analysis.
van Heurn LJ, Coumans A, Haak MC, van der Kaaij A, van Heurn LWE, Pajkrt E, Derikx JPM
Prenat Diagn 2023 Nov;43(12):1495-1505. Epub 2023 Nov 14 doi: 10.1002/pd.6457. PMID: 37964422
Mirror syndrome: a systematic literature review.
Biswas S, Gomez J, Horgan R, Sibai BM, Saad A, Powel JE, Al-Kouatly HB
Am J Obstet Gynecol MFM 2023 Sep;5(9):101067. Epub 2023 Jun 28 doi: 10.1016/j.ajogmf.2023.101067. PMID: 37385374
Systematic review of sonographic findings of placental mesenchymal dysplasia and subsequent pregnancy outcome.
Nayeri UA, West AB, Grossetta Nardini HK, Copel JA, Sfakianaki AK
Ultrasound Obstet Gynecol 2013 Apr;41(4):366-74. doi: 10.1002/uog.12359. PMID: 23239538
Sonographic findings in fetal viral infections: a systematic review.
Degani S
Obstet Gynecol Surv 2006 May;61(5):329-36. doi: 10.1097/01.ogx.0000216518.85796.88. PMID: 16635273

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