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Cerebellar Mutism

MedGen UID:
853935
•Concept ID:
C2938917
•
Pathologic Function

Definition

A syndrome, usually presenting after midline posterior fossa tumor resection, which is characterized by abnormalities of speech, behavioral or affective disturbances, and diffuse cerebellar dysfunction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebellar Mutism

Professional guidelines

PubMed

The Cerebellar Mutism Syndrome: Risk Assessment, Prevention and Treatment.
Grønbæk JK, Boeg Thomsen D, Persson K, Mathiasen R, Juhler M
Adv Tech Stand Neurosurg 2023;46:65-94. doi: 10.1007/978-3-031-28202-7_4. PMID: 37318570
Clinical Characteristics and Prognostic Factors of Treatment in Pediatric Posterior Cranial Fossa Ependymoma.
Ma SC, Li CD, Agazzi S, Jia W
Pediatr Neurosurg 2019;54(2):98-107. Epub 2019 Jan 30 doi: 10.1159/000495809. PMID: 30699434
Treatment developments and the unfolding of the quality of life discussion in childhood medulloblastoma: a review.
Gudrunardottir T, Lannering B, Remke M, Taylor MD, Wells EM, Keating RF, Packer RJ
Childs Nerv Syst 2014 Jun;30(6):979-90. Epub 2014 Feb 26 doi: 10.1007/s00381-014-2388-5. PMID: 24569911

Recent clinical studies

Etiology

Post-operative cerebellar mutism syndrome: rehabilitation issues.
Paquier PF, Walsh KS, Docking KM, Hartley H, Kumar R, Catsman-Berrevoets CE
Childs Nerv Syst 2020 Jun;36(6):1215-1222. Epub 2019 Jun 20 doi: 10.1007/s00381-019-04229-6. PMID: 31222445Free PMC Article
Cerebellar mutism syndrome.
Catsman-Berrevoets C, Patay Z
Handb Clin Neurol 2018;155:273-288. doi: 10.1016/B978-0-444-64189-2.00018-4. PMID: 29891065
Cerebellar mutism syndrome: cause and rehabilitation.
Catsman-Berrevoets CE
Curr Opin Neurol 2017 Apr;30(2):133-139. doi: 10.1097/WCO.0000000000000426. PMID: 28118304
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Cerebellar mutism.
Pitsika M, Tsitouras V
J Neurosurg Pediatr 2013 Dec;12(6):604-14. Epub 2013 Sep 27 doi: 10.3171/2013.8.PEDS13168. PMID: 24073751

Diagnosis

The Cerebellar Mutism Syndrome: Risk Assessment, Prevention and Treatment.
Grønbæk JK, Boeg Thomsen D, Persson K, Mathiasen R, Juhler M
Adv Tech Stand Neurosurg 2023;46:65-94. doi: 10.1007/978-3-031-28202-7_4. PMID: 37318570
Cerebellar Mutism Syndrome in Pediatric Neuro-oncology: A Multidisciplinary Perspective and Call for Research Priorities.
Malbari F, Gill J, Daigle A, Rodriguez LL, Raghubar KP, Davis KC, Scheurer M, Ma MM, Kralik SF, Meoded A, Okcu MF, Chintagumpala MM, Aldave G, Weiner HL, Kahalley LS
Pediatr Neurol 2022 Jul;132:4-10. Epub 2022 May 5 doi: 10.1016/j.pediatrneurol.2022.04.014. PMID: 35598587
The role of the cerebellum in the regulation of language functions.
Starowicz-Filip A, Chrobak AA, Moskała M, Krzyżewski RM, Kwinta B, Kwiatkowski S, Milczarek O, Rajtar-Zembaty A, Przewoźnik D
Psychiatr Pol 2017 Aug 29;51(4):661-671. doi: 10.12740/PP/68547. PMID: 28987056
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Cerebellar mutism.
Küper M, Timmann D
Brain Lang 2013 Dec;127(3):327-33. Epub 2013 Feb 9 doi: 10.1016/j.bandl.2013.01.001. PMID: 23398780

Therapy

The Cerebellar Mutism Syndrome: Risk Assessment, Prevention and Treatment.
Grønbæk JK, Boeg Thomsen D, Persson K, Mathiasen R, Juhler M
Adv Tech Stand Neurosurg 2023;46:65-94. doi: 10.1007/978-3-031-28202-7_4. PMID: 37318570
Cerebellar mutism syndrome.
Catsman-Berrevoets C, Patay Z
Handb Clin Neurol 2018;155:273-288. doi: 10.1016/B978-0-444-64189-2.00018-4. PMID: 29891065
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Cerebellar mutism.
Pitsika M, Tsitouras V
J Neurosurg Pediatr 2013 Dec;12(6):604-14. Epub 2013 Sep 27 doi: 10.3171/2013.8.PEDS13168. PMID: 24073751
Cerebellar mutism: review of the literature.
Gudrunardottir T, Sehested A, Juhler M, Schmiegelow K
Childs Nerv Syst 2011 Mar;27(3):355-63. doi: 10.1007/s00381-010-1328-2. PMID: 21061011

Prognosis

The Cerebellar Mutism Syndrome: Risk Assessment, Prevention and Treatment.
Grønbæk JK, Boeg Thomsen D, Persson K, Mathiasen R, Juhler M
Adv Tech Stand Neurosurg 2023;46:65-94. doi: 10.1007/978-3-031-28202-7_4. PMID: 37318570
Post-operative cerebellar mutism syndrome: rehabilitation issues.
Paquier PF, Walsh KS, Docking KM, Hartley H, Kumar R, Catsman-Berrevoets CE
Childs Nerv Syst 2020 Jun;36(6):1215-1222. Epub 2019 Jun 20 doi: 10.1007/s00381-019-04229-6. PMID: 31222445Free PMC Article
The supplementary motor area syndrome and the cerebellar mutism syndrome: a pathoanatomical relationship?
Grønbæk J, Molinari E, Avula S, Wibroe M, Oettingen G, Juhler M
Childs Nerv Syst 2020 Jun;36(6):1197-1204. Epub 2019 May 24 doi: 10.1007/s00381-019-04202-3. PMID: 31127340
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Cause and outcome of cerebellar mutism: evidence from a systematic review.
Reed-Berendt R, Phillips B, Picton S, Chumas P, Warren D, Livingston JH, Hughes E, Morrall MC
Childs Nerv Syst 2014 Mar;30(3):375-85. Epub 2014 Jan 23 doi: 10.1007/s00381-014-2356-0. PMID: 24452481

Clinical prediction guides

Cerebellar mutism is linked to midbrain volatility and desynchronization from speech cortices.
McAfee SS, Robinson G, Gajjar A, Zhang S, Bag AK, Raches D, Conklin HM, Khan RB, Scoggins MA
Brain 2023 Nov 2;146(11):4755-4765. doi: 10.1093/brain/awad209. PMID: 37343136Free PMC Article
Telovelar surgical approach.
Ghali MGZ
Neurosurg Rev 2021 Feb;44(1):61-76. Epub 2019 Dec 5 doi: 10.1007/s10143-019-01190-5. PMID: 31807931
Cerebellar mutism: the predictive role of preoperative language evaluation.
Bianchi F, Chieffo DPR, Frassanito P, Di Rocco C, Tamburrini G
Childs Nerv Syst 2020 Jun;36(6):1153-1157. Epub 2019 Jun 14 doi: 10.1007/s00381-019-04252-7. PMID: 31201497
Quantitative MRI in post-operative paediatric cerebellar mutism syndrome.
Toescu SM, Hales PW, Aquilina K, Clark CA
Eur J Radiol 2018 Nov;108:43-51. Epub 2018 Sep 10 doi: 10.1016/j.ejrad.2018.09.007. PMID: 30396670
Cause and outcome of cerebellar mutism: evidence from a systematic review.
Reed-Berendt R, Phillips B, Picton S, Chumas P, Warren D, Livingston JH, Hughes E, Morrall MC
Childs Nerv Syst 2014 Mar;30(3):375-85. Epub 2014 Jan 23 doi: 10.1007/s00381-014-2356-0. PMID: 24452481

Recent systematic reviews

Risk factors for postoperative cerebellar mutism syndrome in pediatric patients: a systematic review and meta-analysis.
Pettersson SD, Kitlinski M, Miękisiak G, Ali S, Krakowiak M, Szmuda T
J Neurosurg Pediatr 2022 Apr 1;29(4):467-475. Epub 2021 Dec 31 doi: 10.3171/2021.11.PEDS21445. PMID: 34972081
Association between cerebral perfusion and paediatric postoperative cerebellar mutism syndrome after posterior fossa surgery-a systematic review.
Ahmadian N, van Baarsen KM, Robe PAJT, Hoving EW
Childs Nerv Syst 2021 Sep;37(9):2743-2751. Epub 2021 Jun 21 doi: 10.1007/s00381-021-05225-5. PMID: 34155533Free PMC Article
Functional tracts of the cerebellum-essentials for the neurosurgeon.
Beez T, Munoz-Bendix C, Steiger HJ, Hänggi D
Neurosurg Rev 2021 Feb;44(1):273-278. Epub 2020 Feb 13 doi: 10.1007/s10143-020-01242-1. PMID: 32056026Free PMC Article
Non-surgical transient cerebellar mutism-case report and systematic review.
Makarenko S, Singh N, McDonald PJ
Childs Nerv Syst 2018 Mar;34(3):535-540. Epub 2017 Oct 24 doi: 10.1007/s00381-017-3643-3. PMID: 29067507
Cause and outcome of cerebellar mutism: evidence from a systematic review.
Reed-Berendt R, Phillips B, Picton S, Chumas P, Warren D, Livingston JH, Hughes E, Morrall MC
Childs Nerv Syst 2014 Mar;30(3):375-85. Epub 2014 Jan 23 doi: 10.1007/s00381-014-2356-0. PMID: 24452481

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