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Benign genitourinary tract neoplasm

MedGen UID:
854191
Concept ID:
C3804991
Neoplastic Process
Synonym: Benign genitourinary tract tumors
 
HPO: HP:0006778

Definition

A non-malignant neoplasm of the genitourinary system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign genitourinary tract neoplasm

Conditions with this feature

Muir-Torré syndrome
MedGen UID:
231157
Concept ID:
C1321489
Neoplastic Process
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.

Professional guidelines

PubMed

De La Cruz MS, Buchanan EM
Am Fam Physician 2017 Jan 15;95(2):100-107. PMID: 28084714
American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2016 Nov;128(5):e210-e226. doi: 10.1097/AOG.0000000000001768. PMID: 27776072
Biggs WS, Marks ST
Am Fam Physician 2016 Apr 15;93(8):676-81. PMID: 27175840

Recent clinical studies

Etiology

Adamaki M, Zoumpourlis V
Pharmacol Ther 2021 Dec;228:107932. Epub 2021 Jun 24 doi: 10.1016/j.pharmthera.2021.107932. PMID: 34174272
Peterson LM, Reed HS
Prim Care 2019 Jun;46(2):265-273. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.008. PMID: 31030828
Martignoni G, Pea M, Zampini C, Brunelli M, Segala D, Zamboni G, Bonetti F
Semin Diagn Pathol 2015 Mar;32(2):140-59. Epub 2015 Feb 24 doi: 10.1053/j.semdp.2015.02.006. PMID: 25804448
Powis M
Early Hum Dev 2010 Oct;86(10):607-12. doi: 10.1016/j.earlhumdev.2010.08.018. PMID: 20888153
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137

Diagnosis

Ross J, Li G, Yang XJ
Arch Pathol Lab Med 2020 Mar;144(3):290-304. doi: 10.5858/arpa.2019-0550-RA. PMID: 32101059
Kern SQ, Speir RW, Akgul M, Cary C
Curr Opin Urol 2020 Mar;30(2):235-244. doi: 10.1097/MOU.0000000000000715. PMID: 31922967
Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893
Shamberger RC
Semin Surg Oncol 1999 Mar;16(2):105-20. doi: 10.1002/(sici)1098-2388(199903)16:2<105::aid-ssu4>3.0.co;2-t. PMID: 9988867

Therapy

Adamaki M, Zoumpourlis V
Pharmacol Ther 2021 Dec;228:107932. Epub 2021 Jun 24 doi: 10.1016/j.pharmthera.2021.107932. PMID: 34174272
Zhang Y, Narayanan SP, Mannan R, Raskind G, Wang X, Vats P, Su F, Hosseini N, Cao X, Kumar-Sinha C, Ellison SJ, Giordano TJ, Morgan TM, Pitchiaya S, Alva A, Mehra R, Cieslik M, Dhanasekaran SM, Chinnaiyan AM
Proc Natl Acad Sci U S A 2021 Jun 15;118(24) doi: 10.1073/pnas.2103240118. PMID: 34099557Free PMC Article
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW
Sex Med Rev 2019 Jan;7(1):84-94. Epub 2018 Nov 30 doi: 10.1016/j.sxmr.2018.09.006. PMID: 30503797Free PMC Article
Donnez J, Dolmans MM
Hum Reprod Update 2016 Nov;22(6):665-686. Epub 2016 Jul 27 doi: 10.1093/humupd/dmw023. PMID: 27466209Free PMC Article

Prognosis

Jia L, Deng FM, Kong MX, Wu CL, Yang XJ
Arch Pathol Lab Med 2021 Nov 1;145(11):1387-1404. doi: 10.5858/arpa.2021-0107-RA. PMID: 34673910
Sohlberg EM, Metzner TJ, Leppert JT
Eur Urol Focus 2019 Nov;5(6):943-945. Epub 2019 Mar 21 doi: 10.1016/j.euf.2019.03.006. PMID: 30905599
Merriel SWD, Funston G, Hamilton W
Adv Ther 2018 Sep;35(9):1285-1294. Epub 2018 Aug 10 doi: 10.1007/s12325-018-0766-1. PMID: 30097885Free PMC Article
Arias-Stella JA 3rd, Williamson SR
Surg Pathol Clin 2015 Dec;8(4):755-87. Epub 2015 Oct 23 doi: 10.1016/j.path.2015.09.001. PMID: 26612226
Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841

Clinical prediction guides

Sadowski EA, Rockall A, Thomassin-Naggara I, Barroilhet LM, Wallace SK, Jha P, Gupta A, Shinagare AB, Guo Y, Reinhold C
Radiology 2023 Jun;307(5):e223281. Epub 2023 May 9 doi: 10.1148/radiol.223281. PMID: 37158725
Schuettfort VM, Pradere B, Rink M, Comperat E, Shariat SF
Curr Opin Urol 2020 Nov;30(6):823-831. doi: 10.1097/MOU.0000000000000813. PMID: 32881725
Ström P, Kartasalo K, Olsson H, Solorzano L, Delahunt B, Berney DM, Bostwick DG, Evans AJ, Grignon DJ, Humphrey PA, Iczkowski KA, Kench JG, Kristiansen G, van der Kwast TH, Leite KRM, McKenney JK, Oxley J, Pan CC, Samaratunga H, Srigley JR, Takahashi H, Tsuzuki T, Varma M, Zhou M, Lindberg J, Lindskog C, Ruusuvuori P, Wählby C, Grönberg H, Rantalainen M, Egevad L, Eklund M
Lancet Oncol 2020 Feb;21(2):222-232. Epub 2020 Jan 8 doi: 10.1016/S1470-2045(19)30738-7. PMID: 31926806
Thakur M, Timmerman D
Clin Obstet Gynecol 2017 Mar;60(1):38-45. doi: 10.1097/GRF.0000000000000261. PMID: 28005597
Amin W, Parwani AV
Pathol Res Pract 2010 Oct 15;206(10):659-62. Epub 2010 Jul 8 doi: 10.1016/j.prp.2010.06.001. PMID: 20619548

Recent systematic reviews

Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657Free PMC Article
Lin J, Chen L, Qiu X, Zhang N, Guo Q, Wang Y, Wang M, Gober HJ, Li D, Wang L
Biosci Trends 2017 Jul 24;11(3):267-273. Epub 2017 May 6 doi: 10.5582/bst.2017.01056. PMID: 28484110
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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