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Head and neck carcinoma

MedGen UID:
854345
•Concept ID:
C3887461
•
Neoplastic Process
Synonyms: carcinoma of craniocervical region; Carcinoma of Head and Neck; carcinoma of head and neck; carcinoma of neck; Carcinoma of the Head and Neck; carcinoma of the head and neck; craniocervical region carcinoma; head and neck cancer; Head and Neck Carcinoma; head and neck carcinoma; neck carcinoma
 
Monarch Initiative: MONDO:0002038

Definition

A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHead and neck carcinoma

Professional guidelines

PubMed

Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review.
Wen S, Brito L, Santander J, Conteras G
Acta Odontol Latinoam 2023 Apr 29;36(1):3-14. doi: 10.54589/aol.36/1/3. PMID: 37314054Free PMC Article
Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas.
Wang K, Gui L, Lu H, He X, Li D, Liu C, Liu S, Wang X
Front Immunol 2023;14:1189752. Epub 2023 Jul 31 doi: 10.3389/fimmu.2023.1189752. PMID: 37583698Free PMC Article
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Impact of weight loss in patients with head and neck carcinoma undergoing radiotherapy: is it an underestimated phenomenon? A radiation oncologist's perspective.
Cacicedo J, Dal Pra A, Alongi F, Navarro A
Eur J Clin Nutr 2015 Jul;69(7):757-60. Epub 2015 Apr 29 doi: 10.1038/ejcn.2015.65. PMID: 25920425
The utility of molecular diagnostics to predict recurrence of head and neck carcinoma.
Pena Murillo C, Huang X, Hills A, McGurk M, Lyons A, Jeannon JP, Odell E, Brown A, Lavery K, Barrett W, Sherriff M, Brakenhoff R, Partridge M
Br J Cancer 2012 Sep 25;107(7):1138-43. Epub 2012 Aug 23 doi: 10.1038/bjc.2012.213. PMID: 22918395Free PMC Article
Osteonecrosis in patients irradiated for head and neck carcinoma.
Morrish RB Jr, Chan E, Silverman S Jr, Meyer J, Fu KK, Greenspan D
Cancer 1981 Apr 15;47(8):1980-3. doi: 10.1002/1097-0142(19810415)47:8<1980::aid-cncr2820470813>3.0.co;2-y. PMID: 7226091

Diagnosis

Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Exosomes in head and neck cancer: Roles, mechanisms and applications.
Cao J, Zhang M, Xie F, Lou J, Zhou X, Zhang L, Fang M, Zhou F
Cancer Lett 2020 Dec 1;494:7-16. Epub 2020 Aug 8 doi: 10.1016/j.canlet.2020.07.005. PMID: 32781015
Head and neck carcinoma of unknown primary.
Kennel T, Garrel R, Costes V, Boisselier P, Crampette L, Favier V
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Jun;136(3):185-192. Epub 2019 Apr 17 doi: 10.1016/j.anorl.2019.04.002. PMID: 31005456
The utility of molecular diagnostics to predict recurrence of head and neck carcinoma.
Pena Murillo C, Huang X, Hills A, McGurk M, Lyons A, Jeannon JP, Odell E, Brown A, Lavery K, Barrett W, Sherriff M, Brakenhoff R, Partridge M
Br J Cancer 2012 Sep 25;107(7):1138-43. Epub 2012 Aug 23 doi: 10.1038/bjc.2012.213. PMID: 22918395Free PMC Article

Therapy

NK cells propagate T cell immunity following in situ tumor vaccination.
Jin WJ, Jagodinsky JC, Vera JM, Clark PA, Zuleger CL, Erbe AK, Ong IM, Le T, Tetreault K, Berg T, Rakhmilevich AL, Kim K, Newton MA, Albertini MR, Sondel PM, Morris ZS
Cell Rep 2023 Dec 26;42(12):113556. Epub 2023 Dec 13 doi: 10.1016/j.celrep.2023.113556. PMID: 38096050Free PMC Article
Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas.
Wang K, Gui L, Lu H, He X, Li D, Liu C, Liu S, Wang X
Front Immunol 2023;14:1189752. Epub 2023 Jul 31 doi: 10.3389/fimmu.2023.1189752. PMID: 37583698Free PMC Article
Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review.
Wen S, Brito L, Santander J, Conteras G
Acta Odontol Latinoam 2023 Apr 29;36(1):3-14. doi: 10.54589/aol.36/1/3. PMID: 37314054Free PMC Article
Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
Impact of weight loss in patients with head and neck carcinoma undergoing radiotherapy: is it an underestimated phenomenon? A radiation oncologist's perspective.
Cacicedo J, Dal Pra A, Alongi F, Navarro A
Eur J Clin Nutr 2015 Jul;69(7):757-60. Epub 2015 Apr 29 doi: 10.1038/ejcn.2015.65. PMID: 25920425

Prognosis

ASO Author Reflections: Enhancing Tumor Detection in Head and Neck Carcinoma of Unknown Primary with Transoral Robotic Surgery (TORS) Tongue Base Mucosectomy.
Gupta KK, Garas G
Ann Surg Oncol 2024 Nov;31(12):8216-8217. Epub 2024 Jul 16 doi: 10.1245/s10434-024-15866-w. PMID: 39012462
Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas.
Wang K, Gui L, Lu H, He X, Li D, Liu C, Liu S, Wang X
Front Immunol 2023;14:1189752. Epub 2023 Jul 31 doi: 10.3389/fimmu.2023.1189752. PMID: 37583698Free PMC Article
Human papillomavirus-related oropharyngeal carcinoma.
Saito Y, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R
Jpn J Clin Oncol 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049. PMID: 35383359
Panendoscopy during follow-up in laryngeal carcinoma patients after radiotherapy.
Stanisz I, Janik S, Grasl MC, Erovic BM
Head Neck 2020 Dec;42(12):3601-3608. Epub 2020 Aug 21 doi: 10.1002/hed.26433. PMID: 32827202
The utility of molecular diagnostics to predict recurrence of head and neck carcinoma.
Pena Murillo C, Huang X, Hills A, McGurk M, Lyons A, Jeannon JP, Odell E, Brown A, Lavery K, Barrett W, Sherriff M, Brakenhoff R, Partridge M
Br J Cancer 2012 Sep 25;107(7):1138-43. Epub 2012 Aug 23 doi: 10.1038/bjc.2012.213. PMID: 22918395Free PMC Article

Clinical prediction guides

5'-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells.
Shi E, Wu Z, Karaoglan BS, Schwenk-Zieger S, Kranz G, Abdul Razak N, Reichel CA, Canis M, Baumeister P, Zeidler R, Gires O
J Biomed Sci 2023 Aug 24;30(1):72. doi: 10.1186/s12929-023-00968-6. PMID: 37620936Free PMC Article
Predictive value of transcriptional expression of Krüppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy.
León X, Venegas M, Pujol A, Bulboa C, Llansana A, Casasayas M, Quer M, Camacho M
Clin Transl Oncol 2021 Dec;23(12):2507-2512. Epub 2021 Jun 1 doi: 10.1007/s12094-021-02651-4. PMID: 34061320
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076
The utility of molecular diagnostics to predict recurrence of head and neck carcinoma.
Pena Murillo C, Huang X, Hills A, McGurk M, Lyons A, Jeannon JP, Odell E, Brown A, Lavery K, Barrett W, Sherriff M, Brakenhoff R, Partridge M
Br J Cancer 2012 Sep 25;107(7):1138-43. Epub 2012 Aug 23 doi: 10.1038/bjc.2012.213. PMID: 22918395Free PMC Article

Recent systematic reviews

Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review.
Wen S, Brito L, Santander J, Conteras G
Acta Odontol Latinoam 2023 Apr 29;36(1):3-14. doi: 10.54589/aol.36/1/3. PMID: 37314054Free PMC Article
Pharmacological PI3K inhibition in head and neck squamous cell carcinoma: A systematic review.
Alves LB, Moura AC, Amorim Dos Santos J, Borges GA, Guerra ENS
Toxicol In Vitro 2023 Apr;88:105558. Epub 2023 Jan 18 doi: 10.1016/j.tiv.2023.105558. PMID: 36681288
Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment.
Wang T, Liu X, Ng YY, Tarleton K, Tran A, Tran T, Xue WY, Youssef P, Yuan P, Zhang D, Paolini R, Celentano A
Biomolecules 2022 Feb 10;12(2) doi: 10.3390/biom12020290. PMID: 35204791Free PMC Article
Anti-PD-1 and Anti-PD-L1 in Head and Neck Cancer: A Network Meta-Analysis.
Botticelli A, Cirillo A, Strigari L, Valentini F, Cerbelli B, Scagnoli S, Cerbelli E, Zizzari IG, Rocca CD, D'Amati G, Polimeni A, Nuti M, Merlano MC, Mezi S, Marchetti P
Front Immunol 2021;12:705096. Epub 2021 Aug 9 doi: 10.3389/fimmu.2021.705096. PMID: 34434192Free PMC Article
Chemotherapy and immunotherapy for recurrent and metastatic head and neck cancer: a systematic review.
Guidi A, Codecà C, Ferrari D
Med Oncol 2018 Feb 13;35(3):37. doi: 10.1007/s12032-018-1096-5. PMID: 29441454

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