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Ulceration

MedGen UID:
854391
•Concept ID:
C3887532
•
Pathologic Function
Synonyms: Ulcerated; Ulcerating
SNOMED CT: Ulceration (263913002)

Definition

The formation or development of an ulcer. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUlceration

Professional guidelines

PubMed

Prevention and treatment of pressure ulcers/injuries: The protocol for the second update of the international Clinical Practice Guideline 2019.
Kottner J, Cuddigan J, Carville K, Balzer K, Berlowitz D, Law S, Litchford M, Mitchell P, Moore Z, Pittman J, Sigaudo-Roussel D, Yee CY, Haesler E
J Tissue Viability 2019 May;28(2):51-58. Epub 2019 Jan 11 doi: 10.1016/j.jtv.2019.01.001. PMID: 30658878
Clinical Practice Guideline for the Management of Infantile Hemangiomas.
Krowchuk DP, Frieden IJ, Mancini AJ, Darrow DH, Blei F, Greene AK, Annam A, Baker CN, Frommelt PC, Hodak A, Pate BM, Pelletier JL, Sandrock D, Weinberg ST, Whelan MA; SUBCOMMITTEE ON THE MANAGEMENT OF INFANTILE HEMANGIOMAS
Pediatrics 2019 Jan;143(1) doi: 10.1542/peds.2018-3475. PMID: 30584062
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article

Recent clinical studies

Etiology

Clinical Features, Prognostic Factors, and Treatment Interventions for Ulceration in Patients With Infantile Hemangioma.
Fernández Faith E, Shah S, Witman PM, Harfmann K, Bradley F, Blei F, Pope E, Alsumait A, Gupta D, Covelli I, Streicher JL, Cotton C, Tollefson M, Nguyen H, Hunt R, Moore-Clingenpeel M, Frieden IJ
JAMA Dermatol 2021 May 1;157(5):566-572. doi: 10.1001/jamadermatol.2021.0469. PMID: 33787840Free PMC Article
The cost of diabetic foot ulcers and amputations to the National Health Service in England.
Kerr M, Barron E, Chadwick P, Evans T, Kong WM, Rayman G, Sutton-Smith M, Todd G, Young B, Jeffcoate WJ
Diabet Med 2019 Aug;36(8):995-1002. Epub 2019 Jun 5 doi: 10.1111/dme.13973. PMID: 31004370
Patient education for preventing diabetic foot ulceration.
Dorresteijn JA, Kriegsman DM, Assendelft WJ, Valk GD
Cochrane Database Syst Rev 2014 Dec 16;2014(12):CD001488. doi: 10.1002/14651858.CD001488.pub5. PMID: 25514250Free PMC Article
Diabetic neuropathy and foot complications.
Boulton AJ
Handb Clin Neurol 2014;126:97-107. doi: 10.1016/B978-0-444-53480-4.00008-4. PMID: 25410217
Stress ulcers.
Haglund U
Scand J Gastroenterol Suppl 1990;175:27-33. doi: 10.3109/00365529009093124. PMID: 2237279

Diagnosis

Classification and Staging of Melanoma in the Head and Neck.
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Clinical Features, Prognostic Factors, and Treatment Interventions for Ulceration in Patients With Infantile Hemangioma.
Fernández Faith E, Shah S, Witman PM, Harfmann K, Bradley F, Blei F, Pope E, Alsumait A, Gupta D, Covelli I, Streicher JL, Cotton C, Tollefson M, Nguyen H, Hunt R, Moore-Clingenpeel M, Frieden IJ
JAMA Dermatol 2021 May 1;157(5):566-572. doi: 10.1001/jamadermatol.2021.0469. PMID: 33787840Free PMC Article
Lipschütz's acute vulvar ulcer: a systematic review.
Vismara SA, Lava SAG, Kottanattu L, Simonetti GD, Zgraggen L, Clericetti CM, Bianchetti MG, Milani GP
Eur J Pediatr 2020 Oct;179(10):1559-1567. Epub 2020 Apr 15 doi: 10.1007/s00431-020-03647-y. PMID: 32296983
Diabetic neuropathy and foot complications.
Boulton AJ
Handb Clin Neurol 2014;126:97-107. doi: 10.1016/B978-0-444-53480-4.00008-4. PMID: 25410217
Venous ulcers.
Etufugh CN, Phillips TJ
Clin Dermatol 2007 Jan-Feb;25(1):121-30. doi: 10.1016/j.clindermatol.2006.09.004. PMID: 17276209

Therapy

Beds, overlays and mattresses for preventing and treating pressure ulcers: an overview of Cochrane Reviews and network meta-analysis.
Shi C, Dumville JC, Cullum N, Rhodes S, McInnes E, Goh EL, Norman G
Cochrane Database Syst Rev 2021 Aug 16;8(8):CD013761. doi: 10.1002/14651858.CD013761.pub2. PMID: 34398473Free PMC Article
Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis.
Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A
Medicina (Kaunas) 2019 Jan 22;55(2) doi: 10.3390/medicina55020025. PMID: 30678228Free PMC Article
Education of healthcare professionals for preventing pressure ulcers.
Porter-Armstrong AP, Moore ZE, Bradbury I, McDonough S
Cochrane Database Syst Rev 2018 May 25;5(5):CD011620. doi: 10.1002/14651858.CD011620.pub2. PMID: 29800486Free PMC Article
Support surfaces for pressure ulcer prevention: A network meta-analysis.
Shi C, Dumville JC, Cullum N
PLoS One 2018;13(2):e0192707. Epub 2018 Feb 23 doi: 10.1371/journal.pone.0192707. PMID: 29474359Free PMC Article
Compression for venous leg ulcers.
O'Meara S, Cullum N, Nelson EA, Dumville JC
Cochrane Database Syst Rev 2012 Nov 14;11(11):CD000265. doi: 10.1002/14651858.CD000265.pub3. PMID: 23152202Free PMC Article

Prognosis

Extravasation Injuries of the Limbs in Neonates and Children—Development of a Treatment Algorithm.
Hackenberg RK, Kabir K, Müller A, Heydweiller A, Burger C, Welle K
Dtsch Arztebl Int 2021 Aug 23;118(33-34):547-554. doi: 10.3238/arztebl.m2021.0220. PMID: 34158148Free PMC Article
Education of healthcare professionals for preventing pressure ulcers.
Porter-Armstrong AP, Moore ZE, Bradbury I, McDonough S
Cochrane Database Syst Rev 2018 May 25;5(5):CD011620. doi: 10.1002/14651858.CD011620.pub2. PMID: 29800486Free PMC Article
Support surfaces for pressure ulcer prevention: A network meta-analysis.
Shi C, Dumville JC, Cullum N
PLoS One 2018;13(2):e0192707. Epub 2018 Feb 23 doi: 10.1371/journal.pone.0192707. PMID: 29474359Free PMC Article
Final version of 2009 AJCC melanoma staging and classification.
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty PA, Kirkwood JM, McMasters KM, Mihm MC Jr, Morton DL, Ross MI, Sober AJ, Sondak VK
J Clin Oncol 2009 Dec 20;27(36):6199-206. Epub 2009 Nov 16 doi: 10.1200/JCO.2009.23.4799. PMID: 19917835Free PMC Article
Diabetic foot ulcers.
Jeffcoate WJ, Harding KG
Lancet 2003 May 3;361(9368):1545-51. doi: 10.1016/S0140-6736(03)13169-8. PMID: 12737879

Clinical prediction guides

Carotid Plaque Characteristics Predict Recurrent Ischemic Stroke and TIA: The PARISK (Plaque At RISK) Study.
van Dam-Nolen DHK, Truijman MTB, van der Kolk AG, Liem MI, Schreuder FHBM, Boersma E, Daemen MJAP, Mess WH, van Oostenbrugge RJ, van der Steen AFW, Bos D, Koudstaal PJ, Nederkoorn PJ, Hendrikse J, van der Lugt A, Kooi ME; PARISK Study Group
JACC Cardiovasc Imaging 2022 Oct;15(10):1715-1726. Epub 2022 Jun 15 doi: 10.1016/j.jcmg.2022.04.003. PMID: 36202450
Gold Standard for Diagnosis of DPN.
Yu Y
Front Endocrinol (Lausanne) 2021;12:719356. Epub 2021 Oct 26 doi: 10.3389/fendo.2021.719356. PMID: 34764937Free PMC Article
Global vascular guidelines on the management of chronic limb-threatening ischemia.
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Diabetic foot management: multidisciplinary approach for advanced lesion rescue.
Brocco E, Ninkovic S, Marin M, Whisstock C, Bruseghin M, Boschetti G, Viti R, Forlini W, Volpe A
J Cardiovasc Surg (Torino) 2018 Oct;59(5):670-684. Epub 2018 May 29 doi: 10.23736/S0021-9509.18.10606-9. PMID: 29808982
The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum.
Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, Gillespie DL, Gloviczki ML, Lohr JM, McLafferty RB, Meissner MH, Murad MH, Padberg FT, Pappas PJ, Passman MA, Raffetto JD, Vasquez MA, Wakefield TW; Society for Vascular Surgery; American Venous Forum
J Vasc Surg 2011 May;53(5 Suppl):2S-48S. doi: 10.1016/j.jvs.2011.01.079. PMID: 21536172

Recent systematic reviews

Global vascular guidelines on the management of chronic limb-threatening ischemia.
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis.
Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A
Medicina (Kaunas) 2019 Jan 22;55(2) doi: 10.3390/medicina55020025. PMID: 30678228Free PMC Article
Physical activity and exercise on diabetic foot related outcomes: A systematic review.
Matos M, Mendes R, Silva AB, Sousa N
Diabetes Res Clin Pract 2018 May;139:81-90. Epub 2018 Feb 23 doi: 10.1016/j.diabres.2018.02.020. PMID: 29477503
Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis (†).
Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y
Ann Med 2017 Mar;49(2):106-116. Epub 2016 Nov 3 doi: 10.1080/07853890.2016.1231932. PMID: 27585063
Prevention of foot ulcers in the at-risk patient with diabetes: a systematic review.
van Netten JJ, Price PE, Lavery LA, Monteiro-Soares M, Rasmussen A, Jubiz Y, Bus SA; International Working Group on the Diabetic Foot
Diabetes Metab Res Rev 2016 Jan;32 Suppl 1:84-98. doi: 10.1002/dmrr.2701. PMID: 26340966

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    Practice guidelines

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