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Central sleep apnea syndrome

MedGen UID:
854402
Concept ID:
C3887547
Disease or Syndrome
Synonyms: alveolar hypoventilation, central; alveolar hypoventilations, central; apnea, central; apnea, central sleep; apnea, sleep, central; Apneas, central; Apneas, central sleep; breathing, central sleep-disordered; Breathings, central sleep-disordered; central alveolar hypoventilation; central alveolar hypoventilation syndrome; central apnea; central Apneas; Central sleep apnea; central sleep apnea; Central Sleep Apnea Syndrome; central sleep apnea syndrome; central sleep apnea, secondary; central sleep Apneas; central sleep disordered breathing; central sleep-disordered breathing; central sleep-disordered Breathings; CSA - Central sleep apnea; hypoventilation, central alveolar; hypoventilations, central alveolar; ondine syndrome; sleep apnea, lethal central; sleep Apneas, central; sleep disordered breathing, central; sleep-disordered breathing, central; sleep-disordered Breathings, central
SNOMED CT: CSA - Central sleep apnea (27405005); Central sleep apnea (27405005); Central sleep apnea syndrome (27405005)
 
Monarch Initiative: MONDO:0004731

Definition

A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral sleep apnea syndrome

Professional guidelines

PubMed

Baillieul S, Revol B, Jullian-Desayes I, Joyeux-Faure M, Tamisier R, Pépin JL
Expert Rev Respir Med 2019 Jun;13(6):545-557. Epub 2019 Apr 24 doi: 10.1080/17476348.2019.1604226. PMID: 31014146
Priou P, d'Ortho MP, Damy T, Davy JM, Gagnadoux F, Gentina T, Meurice JC, Pepin JL, Tamisier R, Philippe C
Rev Mal Respir 2015 Dec;32(10):1072-81. Epub 2015 Nov 21 doi: 10.1016/j.rmr.2015.09.007. PMID: 26611197
Fleetham J, Ayas N, Bradley D, Fitzpatrick M, Oliver TK, Morrison D, Ryan F, Series F, Skomro R, Tsai W; Canadian Thoracic Society Sleep Disordered Breathing Committee
Can Respir J 2011 Jan-Feb;18(1):25-47. doi: 10.1155/2011/506189. PMID: 21369547Free PMC Article

Recent clinical studies

Etiology

Okada I, Miyata S, Iwamoto K, Fujishiro H, Noda A, Ozaki N
Sleep Breath 2022 Dec;26(4):1983-1991. Epub 2022 Jan 14 doi: 10.1007/s11325-022-02566-6. PMID: 35029795
Oktay Arslan B, Ucar Hosgor ZZ, Ekinci S, Cetinkol I
Arch Bronconeumol (Engl Ed) 2021 Jun;57(6):393-398. doi: 10.1016/j.arbr.2020.03.030. PMID: 34088390
Boudewyns A, Van de Heyning P, Verhulst S
Sleep Med 2016 Sep;25:93-97. Epub 2016 Sep 13 doi: 10.1016/j.sleep.2016.05.018. PMID: 27823724
Khoury J, Doghramji K
Psychiatr Clin North Am 2015 Dec;38(4):683-704. doi: 10.1016/j.psc.2015.08.002. PMID: 26600103
Banno K, Kryger MH
Sleep Med 2007 Jun;8(4):400-26. Epub 2007 May 2 doi: 10.1016/j.sleep.2007.03.003. PMID: 17478121

Diagnosis

Domínguez-Mayoral A, Sánchez-Gómez J, Guerrero P, Ferrer M, Gutiérrez C, Aguilar M, Fouz-Rosón N, Benítez JM, Pérez-Sánchez S, Gamero-García MÁ, De Torres-Chacón R, Barragán-Prieto A, Algaba P, Ruiz-Bayo L, Montaner J
J Int Med Res 2021 Oct;49(10):3000605211053090. doi: 10.1177/03000605211053090. PMID: 34719990Free PMC Article
Baillieul S, Revol B, Jullian-Desayes I, Joyeux-Faure M, Tamisier R, Pépin JL
Expert Rev Respir Med 2019 Jun;13(6):545-557. Epub 2019 Apr 24 doi: 10.1080/17476348.2019.1604226. PMID: 31014146
Khoury J, Doghramji K
Psychiatr Clin North Am 2015 Dec;38(4):683-704. doi: 10.1016/j.psc.2015.08.002. PMID: 26600103
Fleetham J, Ayas N, Bradley D, Fitzpatrick M, Oliver TK, Morrison D, Ryan F, Series F, Skomro R, Tsai W; Canadian Thoracic Society Sleep Disordered Breathing Committee
Can Respir J 2011 Jan-Feb;18(1):25-47. doi: 10.1155/2011/506189. PMID: 21369547Free PMC Article
Banno K, Kryger MH
Sleep Med 2007 Jun;8(4):400-26. Epub 2007 May 2 doi: 10.1016/j.sleep.2007.03.003. PMID: 17478121

Therapy

Martinot JB, Borel JC, Le-Dong NN, Guénard HJ, Cuthbert V, Silkoff PE, Gozal D, Pepin JL
Respir Res 2017 Apr 20;18(1):66. doi: 10.1186/s12931-017-0551-8. PMID: 28427400Free PMC Article
Dekker LR, Gerritse B, Scheiner A, Kornet L
Pacing Clin Electrophysiol 2017 Mar;40(3):294-300. Epub 2017 Feb 14 doi: 10.1111/pace.13016. PMID: 28054365
Boudewyns A, Van de Heyning P, Verhulst S
Sleep Med 2016 Sep;25:93-97. Epub 2016 Sep 13 doi: 10.1016/j.sleep.2016.05.018. PMID: 27823724
Randerath WJ, Galetke W, Kenter M, Richter K, Schäfer T
Sleep Med 2009 Sep;10(8):898-903. Epub 2009 Mar 20 doi: 10.1016/j.sleep.2008.09.017. PMID: 19303811
Badr MS, Toiber F, Skatrud JB, Dempsey J
J Appl Physiol (1985) 1995 May;78(5):1806-15. doi: 10.1152/jappl.1995.78.5.1806. PMID: 7649916

Prognosis

Okada I, Miyata S, Iwamoto K, Fujishiro H, Noda A, Ozaki N
Sleep Breath 2022 Dec;26(4):1983-1991. Epub 2022 Jan 14 doi: 10.1007/s11325-022-02566-6. PMID: 35029795
Levri JM, Watanabe N, Peng VT, Scharf SM, Diaz-Abad M
Sleep Breath 2022 Mar;26(1):225-230. Epub 2021 May 7 doi: 10.1007/s11325-021-02379-z. PMID: 33961200
Baillieul S, Revol B, Jullian-Desayes I, Joyeux-Faure M, Tamisier R, Pépin JL
Expert Rev Respir Med 2019 Jun;13(6):545-557. Epub 2019 Apr 24 doi: 10.1080/17476348.2019.1604226. PMID: 31014146
Morgenthaler TI, Kagramanov V, Hanak V, Decker PA
Sleep 2006 Sep;29(9):1203-9. doi: 10.1093/sleep/29.9.1203. PMID: 17040008
Bradley TD, McNicholas WT, Rutherford R, Popkin J, Zamel N, Phillipson EA
Am Rev Respir Dis 1986 Aug;134(2):217-21. doi: 10.1164/arrd.1986.134.2.217. PMID: 3740646

Clinical prediction guides

Okada I, Miyata S, Iwamoto K, Fujishiro H, Noda A, Ozaki N
Sleep Breath 2022 Dec;26(4):1983-1991. Epub 2022 Jan 14 doi: 10.1007/s11325-022-02566-6. PMID: 35029795
Levri JM, Watanabe N, Peng VT, Scharf SM, Diaz-Abad M
Sleep Breath 2022 Mar;26(1):225-230. Epub 2021 May 7 doi: 10.1007/s11325-021-02379-z. PMID: 33961200
Baillieul S, Revol B, Jullian-Desayes I, Joyeux-Faure M, Tamisier R, Pépin JL
Expert Rev Respir Med 2019 Jun;13(6):545-557. Epub 2019 Apr 24 doi: 10.1080/17476348.2019.1604226. PMID: 31014146
Boudewyns A, Van de Heyning P, Verhulst S
Sleep Med 2016 Sep;25:93-97. Epub 2016 Sep 13 doi: 10.1016/j.sleep.2016.05.018. PMID: 27823724
Morgenthaler TI, Kagramanov V, Hanak V, Decker PA
Sleep 2006 Sep;29(9):1203-9. doi: 10.1093/sleep/29.9.1203. PMID: 17040008

Recent systematic reviews

Aurora RN, Bista SR, Casey KR, Chowdhuri S, Kristo DA, Mallea JM, Ramar K, Rowley JA, Zak RS, Heald JL
J Clin Sleep Med 2016 May 15;12(5):757-61. doi: 10.5664/jcsm.5812. PMID: 27092695Free PMC Article

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