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Leukemia/lymphoma, b-cell, 2

MedGen UID:
854626
•Concept ID:
C3887918
•
Neoplastic Process
Synonym: LEUKEMIA/LYMPHOMA, B-CELL, 2
 
OMIM®: 151430

Clinical features

From HPO
Non-Hodgkin lymphoma
MedGen UID:
6160
•Concept ID:
C0024305
•
Neoplastic Process
A type of lymphoma characterized microscopically by the absence of multinucleated Reed-Sternberg cells.
See: Feature record | Search on this feature
B-cell lymphoma
MedGen UID:
86953
•Concept ID:
C0079731
•
Neoplastic Process
A type of lymphoma that originates in B-cells.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review.
Shadman M
JAMA 2023 Mar 21;329(11):918-932. doi: 10.1001/jama.2023.1946. PMID: 36943212
Current and future treatment strategies in chronic lymphocytic leukemia.
Patel K, Pagel JM
J Hematol Oncol 2021 Apr 26;14(1):69. doi: 10.1186/s13045-021-01054-w. PMID: 33902665Free PMC Article
De Novo CD5(+) Diffuse Large B-Cell Lymphoma: Biology, Mechanism, and Treatment Advances.
Xu Y, Sun W, Li F
Clin Lymphoma Myeloma Leuk 2020 Oct;20(10):e782-e790. Epub 2020 Jun 19 doi: 10.1016/j.clml.2020.05.003. PMID: 32694049

Recent clinical studies

Etiology

Follicular lymphoma: an update on biology and optimal therapy.
Fischer L, Dreyling M
Leuk Lymphoma 2023 Apr;64(4):761-775. Epub 2023 Feb 9 doi: 10.1080/10428194.2023.2174804. PMID: 37061956
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Additional B-cell malignancies in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL).
Meacham PJ, Williams AM, Strawderman M, Baran AM, Archibald WJ, Wallace DS, Tschernia NP, Burack WR, Barr PM, Zent CS
Leuk Lymphoma 2020 Jul;61(7):1636-1644. Epub 2020 Mar 16 doi: 10.1080/10428194.2020.1737690. PMID: 32175786
Bortezomib in combination with dose-adjusted EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) induces long-term survival in patients with plasmablastic lymphoma: a retrospective analysis.
Dittus C, Grover N, Ellsworth S, Tan X, Park SI
Leuk Lymphoma 2018 Sep;59(9):2121-2127. Epub 2018 Jan 5 doi: 10.1080/10428194.2017.1416365. PMID: 29303024
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Diagnosis

Treatment of older patients with mantle cell lymphoma in the era of novel agents.
Rozental A, Jim HSL, Extermann M
Leuk Lymphoma 2023 Sep;64(9):1514-1526. Epub 2023 Jun 26 doi: 10.1080/10428194.2023.2227748. PMID: 37357622
Follicular lymphoma: an update on biology and optimal therapy.
Fischer L, Dreyling M
Leuk Lymphoma 2023 Apr;64(4):761-775. Epub 2023 Feb 9 doi: 10.1080/10428194.2023.2174804. PMID: 37061956
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in older adults: Current treatment and novel therapies.
O'Dwyer KM, Liesveld JL
Best Pract Res Clin Haematol 2017 Sep;30(3):184-192. Epub 2017 Aug 3 doi: 10.1016/j.beha.2017.08.001. PMID: 29050691
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Therapy

Glofitamab CD20-TCB bispecific antibody.
Minson A, Dickinson M
Leuk Lymphoma 2021 Dec;62(13):3098-3108. Epub 2021 Jul 15 doi: 10.1080/10428194.2021.1953016. PMID: 34263696
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
Enhancer of zeste homolog 2 (EZH2) inhibitors.
Gulati N, Béguelin W, Giulino-Roth L
Leuk Lymphoma 2018 Jul;59(7):1574-1585. Epub 2018 Feb 23 doi: 10.1080/10428194.2018.1430795. PMID: 29473431Free PMC Article
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Prognosis

CD5+ diffuse large B-cell lymphoma: a narrative review.
Durani U, Ansell SM
Leuk Lymphoma 2021 Dec;62(13):3078-3086. Epub 2021 Jul 21 doi: 10.1080/10428194.2021.1953010. PMID: 34284686
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
Structural genomic alterations in primary mediastinal large B-cell lymphoma.
Twa DD, Steidl C
Leuk Lymphoma 2015;56(8):2239-50. Epub 2015 Jan 21 doi: 10.3109/10428194.2014.985673. PMID: 25393674
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Clinical prediction guides

CD5+ diffuse large B-cell lymphoma: a narrative review.
Durani U, Ansell SM
Leuk Lymphoma 2021 Dec;62(13):3078-3086. Epub 2021 Jul 21 doi: 10.1080/10428194.2021.1953010. PMID: 34284686
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
VLA-4 Expression and Activation in B Cell Malignancies: Functional and Clinical Aspects.
Härzschel A, Zucchetto A, Gattei V, Hartmann TN
Int J Mol Sci 2020 Mar 23;21(6) doi: 10.3390/ijms21062206. PMID: 32210016Free PMC Article
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Recent systematic reviews

Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.
Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review.
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347Free PMC Article
Philadelphia-Like Acute Lymphoblastic Leukemia: A Systematic Review.
Yadav V, Ganesan P, Veeramani R, Kumar V D
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e57-e65. Epub 2020 Aug 18 doi: 10.1016/j.clml.2020.08.011. PMID: 33485429
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292
A systematic review of p53 regulation of oxidative stress in skeletal muscle.
Beyfuss K, Hood DA
Redox Rep 2018 Dec;23(1):100-117. Epub 2018 Jan 3 doi: 10.1080/13510002.2017.1416773. PMID: 29298131Free PMC Article

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