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Leukemia/lymphoma, b-cell, 2

MedGen UID:
854626
•Concept ID:
C3887918
•
Neoplastic Process
Synonym: LEUKEMIA/LYMPHOMA, B-CELL, 2
 
OMIM®: 151430

Clinical features

From HPO
Non-Hodgkin lymphoma
MedGen UID:
6160
•Concept ID:
C0024305
•
Neoplastic Process
A type of lymphoma characterized microscopically by the absence of multinucleated Reed-Sternberg cells.
See: Feature record | Search on this feature
B-cell lymphoma
MedGen UID:
86953
•Concept ID:
C0079731
•
Neoplastic Process
A type of lymphoma that originates in B-cells.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review.
Shadman M
JAMA 2023 Mar 21;329(11):918-932. doi: 10.1001/jama.2023.1946. PMID: 36943212
Current and future treatment strategies in chronic lymphocytic leukemia.
Patel K, Pagel JM
J Hematol Oncol 2021 Apr 26;14(1):69. doi: 10.1186/s13045-021-01054-w. PMID: 33902665Free PMC Article
De Novo CD5(+) Diffuse Large B-Cell Lymphoma: Biology, Mechanism, and Treatment Advances.
Xu Y, Sun W, Li F
Clin Lymphoma Myeloma Leuk 2020 Oct;20(10):e782-e790. Epub 2020 Jun 19 doi: 10.1016/j.clml.2020.05.003. PMID: 32694049

Recent clinical studies

Etiology

Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Bortezomib in combination with dose-adjusted EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) induces long-term survival in patients with plasmablastic lymphoma: a retrospective analysis.
Dittus C, Grover N, Ellsworth S, Tan X, Park SI
Leuk Lymphoma 2018 Sep;59(9):2121-2127. Epub 2018 Jan 5 doi: 10.1080/10428194.2017.1416365. PMID: 29303024
Chronic lymphocytic leukemia and small lymphocytic lymphoma: two faces of the same disease.
Tees MT, Flinn IW
Expert Rev Hematol 2017 Feb;10(2):137-146. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270203. PMID: 27936980
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Drexler HG, Eberth S, Nagel S, MacLeod RA
Leuk Lymphoma 2016 May;57(5):1015-20. Epub 2016 Jan 4 doi: 10.3109/10428194.2015.1108414. PMID: 26727417
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Diagnosis

Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in older adults: Current treatment and novel therapies.
O'Dwyer KM, Liesveld JL
Best Pract Res Clin Haematol 2017 Sep;30(3):184-192. Epub 2017 Aug 3 doi: 10.1016/j.beha.2017.08.001. PMID: 29050691
Splenic marginal-zone lymphoma: ontogeny and genetics.
Baliakas P, Strefford JC, Bikos V, Parry M, Stamatopoulos K, Oscier D
Leuk Lymphoma 2015 Feb;56(2):301-10. Epub 2014 Aug 19 doi: 10.3109/10428194.2014.919636. PMID: 24798744
Large B-cell lymphomas with plasmablastic differentiation: a biological and therapeutic challenge.
Montes-Moreno S, Montalbán C, Piris MA
Leuk Lymphoma 2012 Feb;53(2):185-94. Epub 2011 Sep 19 doi: 10.3109/10428194.2011.608447. PMID: 21812534
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Therapy

Glofitamab CD20-TCB bispecific antibody.
Minson A, Dickinson M
Leuk Lymphoma 2021 Dec;62(13):3098-3108. Epub 2021 Jul 15 doi: 10.1080/10428194.2021.1953016. PMID: 34263696
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
Pathways and mechanisms of venetoclax resistance.
Bose P, Gandhi V, Konopleva M
Leuk Lymphoma 2017 Sep;58(9):1-17. Epub 2017 Jan 31 doi: 10.1080/10428194.2017.1283032. PMID: 28140720Free PMC Article
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Prognosis

CD5+ diffuse large B-cell lymphoma: a narrative review.
Durani U, Ansell SM
Leuk Lymphoma 2021 Dec;62(13):3078-3086. Epub 2021 Jul 21 doi: 10.1080/10428194.2021.1953010. PMID: 34284686
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870
T-cell associated antigen-positive B-cell lymphoma.
Inaba T, Shimazaki C, Sumikuma T, Nakagawa M
Leuk Lymphoma 2001 Nov-Dec;42(6):1161-71. doi: 10.3109/10428190109097741. PMID: 11911397

Clinical prediction guides

CD5+ diffuse large B-cell lymphoma: a narrative review.
Durani U, Ansell SM
Leuk Lymphoma 2021 Dec;62(13):3078-3086. Epub 2021 Jul 21 doi: 10.1080/10428194.2021.1953010. PMID: 34284686
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
VLA-4 Expression and Activation in B Cell Malignancies: Functional and Clinical Aspects.
Härzschel A, Zucchetto A, Gattei V, Hartmann TN
Int J Mol Sci 2020 Mar 23;21(6) doi: 10.3390/ijms21062206. PMID: 32210016Free PMC Article
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Recent systematic reviews

Vaccination of Adults With Cancer: ASCO Guideline.
Kamboj M, Bohlke K, Baptiste DM, Dunleavy K, Fueger A, Jones L, Kelkar AH, Law LY, LeFebvre KB, Ljungman P, Miller ED, Meyer LA, Moore HN, Soares HP, Taplitz RA, Woldetsadik ES, Kohn EC
J Clin Oncol 2024 May 10;42(14):1699-1721. Epub 2024 Mar 18 doi: 10.1200/JCO.24.00032. PMID: 38498792Free PMC Article
Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.
Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review.
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347Free PMC Article
Philadelphia-Like Acute Lymphoblastic Leukemia: A Systematic Review.
Yadav V, Ganesan P, Veeramani R, Kumar V D
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e57-e65. Epub 2020 Aug 18 doi: 10.1016/j.clml.2020.08.011. PMID: 33485429
A systematic review of p53 regulation of oxidative stress in skeletal muscle.
Beyfuss K, Hood DA
Redox Rep 2018 Dec;23(1):100-117. Epub 2018 Jan 3 doi: 10.1080/13510002.2017.1416773. PMID: 29298131Free PMC Article

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