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Rheumatoid factor-negative juvenile idiopathic arthritis

MedGen UID:
855549
•Concept ID:
C3890205
•
Disease or Syndrome
Synonyms: Juvenile chronic arthritis, polyarticular seronegative; Juvenile idiopathic arthritis, polyarthritis, rheumatoid factor negative; Juvenile polyarthritis without rheumatoid factor; Juvenile rheumatoid factor-negative polyarthritis; juvenile rheumatoid factor-negative polyarthritis; Juvenile seronegative polyarthritis; polyarthritis without rheumatoid factor; Polyarticular JIA, RF-; Polyarticular Juvenile Idiopathic Arthritis, RF-; Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative; rheumatoid factor-negative JIA; rheumatoid factor-negative juvenile idiopathic arthritis; Rheumatoid factor-negative polyarticular JIA; Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis
SNOMED CT: Juvenile seronegative polyarthritis (410797009); Juvenile chronic arthritis, polyarticular seronegative (410797009); Juvenile idiopathic arthritis, polyarthritis, rheumatoid factor negative (410797009)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0019432
Orphanet: ORPHA85408

Definition

A rare form of polyarticular juvenile idiopathic arthritis characterized by childhood-onset chronic arthritis of unknown cause involving five or more joints at disease onset and absence of rheumatoid factor IgM. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRheumatoid factor-negative juvenile idiopathic arthritis

Professional guidelines

PubMed

Subtype frequency, demographic features, treatment and outcome of Juvenile Arthritis in one Centre in Abu Dhabi in the United Arab Emirates.
Khawaja K, Kalas R, Almasri N
Pediatr Rheumatol Online J 2023 Feb 7;21(1):14. doi: 10.1186/s12969-023-00796-w. PMID: 36750870Free PMC Article
Abatacept: A Review of the Treatment of Polyarticular-Course Juvenile Idiopathic Arthritis.
Brunner HI, Wong R, Nys M, Kou TD, Dominique A, Martini A, Lovell DJ, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)
Paediatr Drugs 2020 Dec;22(6):653-672. Epub 2020 Oct 8 doi: 10.1007/s40272-020-00422-2. PMID: 33029724
Evaluation of the ILAR criteria for juvenile idiopathic arthritis.
Krumrey-Langkammerer M, Häfner R
J Rheumatol 2001 Nov;28(11):2544-7. PMID: 11708431

Recent clinical studies

Etiology

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Diagnosis

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Therapy

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Prognosis

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Clinical prediction guides

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Supplemental Content

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