Rheumatoid factor-positive polyarticular juvenile idiopathic arthritis

MedGen UID:: 855737
•Concept ID:: C3890733
•: Disease or Syndrome

Synonyms:	Juvenile idiopathic rheumatoid factor-positive polyarthritis; juvenile idiopathic rheumatoid factor-positive polyarthritis; Juvenile polyarthritis with rheumatoid factor; polyarthritis with rheumatoid factor; Polyarticular JIA, RF+; polyarticular JIA, RF+; Polyarticular Juvenile Idiopathic Arthritis, RF+; polyarticular juvenile idiopathic arthritis, RF+; Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Positive; polyarticular juvenile idiopathic arthritis, rheumatoid Factor Positive; Rheumatoid factor-positive polyarticular JIA; rheumatoid factor-positive polyarticular JIA; rheumatoid factor-positive polyarticular juvenile idiopathic arthritis
Modes of inheritance:	Unknown inheritance MedGen UID: 989040 •Concept ID: CN307042 • Finding Source: Orphanet Hereditary clinical entity whose mode of inheritance is unknown. See: This record Unknown inheritance (Orphanet)

Monarch Initiative:	MONDO:0019435
Orphanet:	ORPHA85435

Definition

A rare form of juvenile idiopathic arthritis characterized by distal and symmetrical polyarthritis (more than 5 joints) with presence of rheumatoid factor and possible evolution towards the appearance of erosions and joint destruction. [from ORDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRheumatoid factor-positive polyarticular juvenile idiopathic arthritis

Abnormality of the musculoskeletal system
- Abnormality of the skeletal system
  - Abnormal skeletal morphology
    - Abnormal joint morphology
      - Arthritis
        Juvenile idiopathic arthritis
        Rheumatoid factor-positive polyarticular juvenile idiopathic arthritis

Professional guidelines

PubMed

Abatacept: A Review of the Treatment of Polyarticular-Course Juvenile Idiopathic Arthritis.

Brunner HI, Wong R, Nys M, Kou TD, Dominique A, Martini A, Lovell DJ, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)
Paediatr Drugs 2020 Dec;22(6):653-672. Epub 2020 Oct 8 doi: 10.1007/s40272-020-00422-2. PMID: 33029724

Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus.

Martini A, Ravelli A, Avcin T, Beresford MW, Burgos-Vargas R, Cuttica R, Ilowite NT, Khubchandani R, Laxer RM, Lovell DJ, Petty RE, Wallace CA, Wulffraat NM, Pistorio A, Ruperto N; Pediatric Rheumatology International Trials Organization (PRINTO)
J Rheumatol 2019 Feb;46(2):190-197. Epub 2018 Oct 1 doi: 10.3899/jrheum.180168. PMID: 30275259

Update on biologicals for treatment of juvenile idiopathic arthritis.

Horneff G
Expert Opin Biol Ther 2013 Mar;13(3):361-76. Epub 2013 Jan 5 doi: 10.1517/14712598.2013.735657. PMID: 23289865

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Recent clinical studies

Etiology

Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis.

Hinks A, Marion MC, Cobb J, Comeau ME, Sudman M, Ainsworth HC, Bowes J; Juvenile Idiopathic Arthritis Consortium for Immunochip, Becker ML, Bohnsack JF, Haas JP, Lovell DJ, Mellins ED, Nelson JL, Nordal E, Punaro M, Reed AM, Rose CD, Rosenberg AM, Rygg M, Smith SL, Stevens AM, Videm V, Wallace CA, Wedderburn LR, Yarwood A, Yeung RSM, Langefeld CD, Thompson SD, Thomson W, Prahalad S
Arthritis Rheumatol 2018 Jun;70(6):957-962. Epub 2018 Apr 21 doi: 10.1002/art.40443. PMID: 29426059 Free PMC Article

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Diagnosis

A case report of intracranial hypertension and aseptic meningitis: anti-tumor necrosis factor associated or juvenile idiopathic arthritis related.

Akça ÜK, Sökmen O, Bölek EÇ, Demir S, Kılıç L, Çevik IÜ, Bilginer Y
Turk J Pediatr 2021;63(3):522-526. doi: 10.24953/turkjped.2021.03.022. PMID: 34254500

Type 1 interferonopathy presenting as juvenile idiopathic arthritis with interstitial lung disease: report of a new phenotype.

Clarke SLN, Robertson L, Rice GI, Seabra L, Hilliard TN, Crow YJ, Ramanan AV
Pediatr Rheumatol Online J 2020 May 12;18(1):37. doi: 10.1186/s12969-020-00425-w. PMID: 32398023 Free PMC Article

Plasma exchange successfully treated macrophage activation syndrome in rheumatoid factor-positive polyarticular juvenile idiopathic arthritis with co-existing pneumonia.

Shi L, Hu F, Xu C, Zhu H, Qie D, Yuan C, Tao Y, Liu H
Int J Rheum Dis 2018 May;21(5):1142-1145. Epub 2017 Mar 22 doi: 10.1111/1756-185X.13064. PMID: 28328098

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Therapy

Type 1 interferonopathy presenting as juvenile idiopathic arthritis with interstitial lung disease: report of a new phenotype.

Clarke SLN, Robertson L, Rice GI, Seabra L, Hilliard TN, Crow YJ, Ramanan AV
Pediatr Rheumatol Online J 2020 May 12;18(1):37. doi: 10.1186/s12969-020-00425-w. PMID: 32398023 Free PMC Article

Plasma exchange successfully treated macrophage activation syndrome in rheumatoid factor-positive polyarticular juvenile idiopathic arthritis with co-existing pneumonia.

Shi L, Hu F, Xu C, Zhu H, Qie D, Yuan C, Tao Y, Liu H
Int J Rheum Dis 2018 May;21(5):1142-1145. Epub 2017 Mar 22 doi: 10.1111/1756-185X.13064. PMID: 28328098

Switching the therapy from etanercept to infliximab in a child with rheumatoid factor positive polyarticular juvenile idiopathic arthritis.

Nerome Y, Imanaka H, Nonaka Y, Takei S
Mod Rheumatol 2007;17(6):526-8. Epub 2007 Dec 20 doi: 10.1007/s10165-007-0634-3. PMID: 18084710

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